The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles
Open accessAbstract
The ability of nitric oxide (NO)-releasing silica nanoparticles to kill biofilm-based microbial cells is reported. Biofilms of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans were formed in vitro and exposed to NO-releasing silica nanoparticles. Replicative viability experiments revealed that ≥ 99% of cells from each type of biofilm were killed via NO release, with the greatest efficacy (≥ 99.999% killing) against gram-negative P. aeruginosa and E. coli biofilms. Cytotoxicity testing demonstrated that the highest dose of NO-releasing silica nanoparticles inhibited fibroblast proliferation to a lesser extent than clinical concentrations of currently-administered antiseptics (e.g., chlorhexidine) with proven wound-healing benefits. This study demonstrates the promise of employing nanoparticles for delivering an antimicrobial agent to microbial biofilms.
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Cites
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo
Davis, S. C., Ricotti, C., Cazzaniga, A., Welsh, E., Eaglstein, W. H., & Mertz, P. M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00303.x · Cited by 393
Potential application of gaseous nitric oxide as a topical antimicrobial agent
Ghaffari, A., Miller, C. C., McMullin, B., & Ghahary, A. (2006) · Nitric Oxide · doi:10.1016/j.niox.2005.08.003 · Cited by 236
Synergy of Nitric Oxide and Azoles against Candida Species In Vitro
McElhaney-Feser, G. E., Raulli, R. E., & Cihlar, R. L. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.9.2342 · Cited by 41
Cited by
The antimicrobial activity of nanoparticles: present situation and prospects for the future
Wang, L., Hu, C., & Shao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s121956 · Cited by 4,062
Nitric oxide release: Part II. Therapeutic applications
Carpenter, A. W., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15273h · Cited by 964
Self-citationAlternative Antimicrobial Approach: Nano-Antimicrobial Materials
Beyth, N., Houri-Haddad, Y., Domb, A., Khan, W., & Hazan, R. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/246012 · Cited by 837
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
The potential of nitric oxide releasing therapies as antimicrobial agents
Schairer, D. O., Chouake, J. S., Nosanchuk, J. D., & Friedman, A. J. (2012) · Virulence · doi:10.4161/viru.20328 · Cited by 573
Metadata
- Authors
- Hetrick, E. M., Shin, J. H., Paul, H. S., & Schoenfisch, M. H.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 30
- Issue
- 14
- Pages
- 2782-2789
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1987036328
- Cited by
- 406
- References
- 4
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
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