Nitric oxide release: Part II. Therapeutic applications
Open accessAbstract
A wide range of nitric oxide (NO)-releasing materials has emerged as potential therapeutics that exploit NO's vast biological roles. Macromolecular NO-releasing scaffolds are particularly promising due to their ability to store and deliver larger NO payloads in a more controlled and effective manner compared to low molecular weight NO donors. While a variety of scaffolds (e.g., particles, dendrimers, and polymers/films) have been cleverly designed, the ultimate clinical utility of most NO-releasing macromolecules remains unrealized. Although not wholly predictive of clinical success, in vitro and in vivo investigations have enabled a preliminary evaluation of the therapeutic potential of such materials. In this tutorial review, we review the application of macromolecular NO therapies for cardiovascular disease, cancer, bacterial infections, and wound healing.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NO inhibits respiration at the level of complex IV and has a safe record for use as a vasodilator and in dermatologic applications.
“We made use of nitric oxide (NO), which inhibits respiration at the level of complex IV and has a safe record for use as a vasodilator (20) and in dermatologic applications (21).”
From Inhibition of Classical and Alternative Modes of Respiration in <i>Candida albicans</i> Leads to Cell Wall Remodeling and Increased Macrophage Recognition (2019) · cites this paper as [20]
The Introduction describes successful topical dermatological use of gaseous NO, and the Cardiovascular Disease section describes NO-mediated vasodilation. The cited passages do not establish an unqualified safety record; they identify risks and side effects of NO therapies. No passage found supports inhibition of respiration at complex IV. (LLM, conf=0.86)
Experimental — accuracy not yet measuredGiven nitric oxide's roles in the immune response, favorable tissue reactions to nitric oxide-releasing substrates would be expected in vivo.
“Given NO’s roles in the immune response, favorable tissue reactions to NO-releasing substrates would be expected in vivo.217”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [217]
NO-activated sGC reduces intracellular calcium, inhibits platelet PI3-kinase, and reduces affinity and number of fibrinogen binding sites on GPIIb/IIIa.
“The NO activated sGC ultimately results in reduced intracellular calcium, inhibition of platelet phosphoinositide 3-kinase (PI3), and reduced affinity as well as number of surface membrane fibrinogen binding sites on platelets (GPIIb/IIIa).117,121–126”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [117]
cGMP increases cAMP indirectly through phosphodiesterase III, decreasing intracellular calcium.
“In addition, the cGMP increases cyclic adenosine monophosphate (cAMP) levels indirectly through phosphodiesterase III, which will also decrease the intracellular calcium concentration.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [117]
Three main strategies for increasing NO bioavailability are exercise/diet, drugs that alter enzymatic NO production, and modified polymeric materials that deliver NO exogenously.
“There are three main strategies for increasing NO bioavailability: 1) by participating in physical exercise and controlling certain dietary components (e.g., nitrate-rich diet);132,133 2) by administrating drugs that alter the enzymatic production of NO through nitric oxide synthases (NOSs) and increase the biosynthesis of NO endogenously;117 and 3) by using modified polymeric materials that can”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works
Nanoparticle and targeted systems for cancer therapy
Brannon‐Peppas, L., & Blanchette, J. O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.014 · Cited by 2,335 · see citing works
Biomaterials based on chitin and chitosan in wound dressing applications
Jayakumar, R., Prabaharan, M., Kumar, P. T. S., Nair, S. V., & Tamura, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.005 · Cited by 1,927 · see citing works
Arnold, W. P., Mittal, C. K., Katsuki, S., & Murad, F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3203 · Cited by 1,459 · see citing works
Nitric oxide donors: chemical activities and biological applications
Wang, P. G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., & Janczuk, A. J. (2002) · Chemical Reviews · doi:10.1021/cr000040l · Cited by 1,337 · see citing works
Nitric oxide release: part III. Measurement and reporting.
Coneski, P. N., & Schoenfisch, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15271a · Cited by 1,023 · see citing works
Self-citationFolate-mediated delivery of macromolecular anticancer therapeutic agents
Lu, Y. J., & Low, P. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00042-x · Cited by 942 · see citing works
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
Barraud, N., Hassett, D. J., Hwang, S.-H., Rice, S. A., Kjelleberg, S. J., & Webb, J. S. (2006) · Journal of Bacteriology · doi:10.1128/jb.00779-06 · Cited by 786 · see citing works
The multifaceted roles of nitric oxide in cancer
Wink, D. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.711 · Cited by 682 · see citing works
Recent developments in nitric oxide donor drugs
Miller, M. R., & Megson, I. L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707224 · Cited by 626 · see citing works
Novel classes of antibiotics or more of the same?
Coates, A. R. M., Halls, G., & Hu, Y. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01250.x · Cited by 601 · see citing works
INHIBITION OF NITRIC OXIDE SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET
Hobbs, A. J., Higgs, A., & Moncada, S. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.191 · Cited by 596 · see citing works
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide
Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 489 · see citing works
Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities
D, S. M. M., Bronte, V., & Nitti, D. (2006) · Medicinal Research Reviews · doi:10.1002/med.20092 · Cited by 480 · see citing works
Nitric oxide release: Part I. Macromolecular scaffolds
Riccio, D. A., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15272j · Cited by 475 · see citing works
Self-citationNitric Oxide Signaling in Brain Function, Dysfunction, and Dementia
Steinert, J. R., Chernova, T., & Forsythe, I. D. (2010) · The Neuroscientist · doi:10.1177/1073858410366481 · Cited by 464 · see citing works
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles
Hetrick, E. M., Shin, J. H., Paul, H. S., & Schoenfisch, M. H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.052 · Cited by 408 · see citing works
Self-citationBactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles
Hetrick, E. M., Shin, J. H., Stasko, N., Johnson, C. B., Wespe, D. A., Holmuhamedov, E., & Schoenfisch, M. H. (2008) · ACS Nano · doi:10.1021/nn700191f · Cited by 365 · see citing works
Self-citationWhat Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Martinez, L. R., Han, G., Chacko, M., Mihu, M. R., Jacobson, M., Gialanella, P., Friedman, A. J., Nosanchuk, J. D., & Friedman, J. M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.95 · Cited by 244 · see citing works
SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
Maeda, H. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90040-j · Cited by 214 · see citing works
Photodynamic therapy in oncology
Kinsella, T. J., Colussi, V., Oleinick, N. L., & Sibata, C. H. (2001) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2.6.917 · Cited by 212 · see citing works
Nitric Oxide-Releasing Polymers Containing the [N(O)NO]<sup>-</sup>Group
Smith, D. J., Chakravarthy, D., Pulfer, S., Simmons, M. L., Hrabie, J. A., Citro, M. L., Saavedra, J. E., Davies, K. M., Hutsell, T. C., Mooradian, D. L., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950652b · Cited by 208 · see citing works
Nitric oxide-releasing sol–gels as antibacterial coatings for orthopedic implants
Nablo, B. J., Rothrock, A. R., & Schoenfisch, M. H. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.03.031 · Cited by 207 · see citing works
Self-citationYasuda, H. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.04.026 · Cited by 198 · see citing works
Jones, M. L., Ganopolsky, J. G., Labbé, A., Wahl, C., & Prakash, S. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2733-x · Cited by 196 · see citing works
Ostrowski, A. D., & Ford, P. C. (2009) · Dalton Transactions · doi:10.1039/b912898k · Cited by 195 · see citing works
Masters, K. S. B., Leibovich, S. J., Belem, P., West, J. L., & Poole‐Warren, L. A. (2002) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2002.10503.x · Cited by 189 · see citing works
Zhang, H., Annich, G. M., Miskulin, J., Stankiewicz, K., Osterholzer, K., Merz, S. I., Bartlett, R. H., & Meyerhoff, M. E. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0291538 · Cited by 176 · see citing works
Nitric Oxide and Wound Healing
Rizk, M., Witte, M. B., & Barbul, A. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7396-7 · Cited by 169 · see citing works
Dead Bugs Don’t Mutate: Susceptibility Issues in the Emergence of Bacterial Resistance
Stratton, C. W. (2003) · Emerging infectious diseases · doi:10.3201/eid0901.020172 · Cited by 156 · see citing works
Nitric Oxide and Cancer Therapy: The Emperor has NO Clothes
Hickok, J. R., & Thomas, D. D. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790232149 · Cited by 155 · see citing works
Functionalization of biomolecules on nanoparticles: specialized for antibacterial applications
Veerapandian, M., & Yun, K. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3291-6 · Cited by 153 · see citing works
Nitric oxide – the endothelium-derived relaxing factor and its role in endothelial functions
Bauer, V., & Sotníková, R. (2010) · General Physiology and Biophysics · doi:10.4149/gpb_2010_04_319 · Cited by 151 · see citing works
van Hal, S. J., Paterson, D. L., & Gosbell, I. B. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1128-3 · Cited by 139 · see citing works
Sol−Gel Derived Nitric-Oxide Releasing Materials that Reduce Bacterial Adhesion
Nablo, B. J., Chen, T.-Y., & Schoenfisch, M. H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja0165077 · Cited by 134 · see citing works
Self-citationMajor, T. C., Brant, D. O., Reynolds, M. M., Bartlett, R. H., Meyerhoff, M. E., Handa, H., & Annich, G. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.028 · Cited by 134 · see citing works
Influence of Scaffold Size on Bactericidal Activity of Nitric Oxide-Releasing Silica Nanoparticles
Carpenter, A. W., Slomberg, D. L., Rao, K. S., & Schoenfisch, M. H. (2011) · ACS Nano · doi:10.1021/nn202054f · Cited by 134 · see citing works
Self-citationNitric oxide and nanotechnology: A novel approach to inhibit neointimal hyperplasia
Kapadia, M. R., Chow, L. W., Tsihlis, N. D., Ahanchi, S. S., Eng, J. W. ‐., Murar, J., Martínez, J., Popowich, D. A., Jiang, Q., Hrabie, J. A., et al. (2008) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.09.005 · Cited by 130 · see citing works
The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles
Mayer, B., & Beretta, M. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.263 · Cited by 123 · see citing works
<i>S</i>-Nitrosothiol-Modified Dendrimers as Nitric Oxide Delivery Vehicles
Stasko, N. A., Fischer, T. H., & Schoenfisch, M. H. (2008) · Biomacromolecules · doi:10.1021/bm7011746 · Cited by 123 · see citing works
Self-citationSchoenfisch, M. H., Mowery, K. A., Rader, M. V., Baliga, N., Wahr, J. A., & Meyerhoff, M. E. (2000) · Analytical Chemistry · doi:10.1021/ac991370c · Cited by 121 · see citing works
Self-citationHuang, S.-L., Kee, P. H., Kim, H., Moody, M. R., Chrzanowski, S. M., MacDonald, R. C., & McPherson, D. D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.039 · Cited by 120 · see citing works
Keefer, L. K. (2005) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026054679380 · Cited by 119 · see citing works
Reduced bacterial adhesion to fibrinogen-coated substrates via nitric oxide release
Charville, G. W., Hetrick, E. M., Geer, C. B., & Schoenfisch, M. H. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.005 · Cited by 114 · see citing works
Self-citationTumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug
Findlay, V. J., Townsend, D. M., Saavedra, J. E., Buzard, G. S., Citro, M. L., Keefer, L. K., Ji, X., & Tew, K. D. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1070 · Cited by 113 · see citing works
Nitric oxide-releasing S-nitrosothiol-modified xerogels
Riccio, D. A., Dobmeier, K. P., Hetrick, E. M., Privett, B. J., Paul, H. S., & Schoenfisch, M. H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.05.006 · Cited by 107 · see citing works
Self-citationNitric Oxide-Releasing Silica Nanoparticle Inhibition of Ovarian Cancer Cell Growth
Stevens, E. V., Carpenter, A. W., Shin, J. H., Liu, J., Der, C. J., & Schoenfisch, M. H. (2010) · Molecular Pharmaceutics · doi:10.1021/mp9002865 · Cited by 105 · see citing works
Self-citationS‐nitrosoglutathione‐containing hydrogel accelerates rat cutaneous wound repair
Amadeu, T. P., Seabra, A. B., Oliveira, M. D., & Monte‐Alto‐Costa, A. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.02032.x · Cited by 105 · see citing works
Preparation of Nitric Oxide (NO)-Releasing Sol−Gels for Biomaterial Applications
Marxer, S. M., Rothrock, A. R., Nablo, B. J., Robbins, M. E., & Schoenfisch, M. H. (2003) · Chemistry of Materials · doi:10.1021/cm034347n · Cited by 104 · see citing works
Self-citationHetrick, E. M., & Schoenfisch, M. H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.006 · Cited by 104 · see citing works
Self-citationKumar, V., Hong, S. Y., Maciag, A. E., Saavedra, J. E., Adamson, D. H., Prud’homme, R. K., Keefer, L. K., & Chakrapani, H. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900245h · Cited by 98 · see citing works
Nitric Oxide Donor Improves Healing if Applied on Inflammatory and Proliferative Phase
Amadeu, T. P., Seabra, A. B., de Oliveira, M. G., & Monte‐Alto‐Costa, A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.10.015 · Cited by 96 · see citing works
Nitric oxide donor drugs: current status and future trends
Webb, D. J., & Megson, I. L. (2002) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.11.5.587 · Cited by 95 · see citing works
Frost, M. C., Rudich, S. M., Zhang, H., Maraschio, M., & Meyerhoff, M. E. (2002) · Analytical Chemistry · doi:10.1021/ac025944g · Cited by 93 · see citing works
Deupree, S. M., & Schoenfisch, M. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.01.025 · Cited by 88 · see citing works
Self-citationSeabra, A., Martins, D., Simões, M. M. S. G., da Silva, R., Brocchi, M., & de Oliveira, M. G. (2010) · Artificial Organs · doi:10.1111/j.1525-1594.2010.00998.x · Cited by 83 · see citing works
Sustained release nitric oxide from long-lived circulating nanoparticles
Cabrales, P., Han, G., Roche, C. J., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.034 · Cited by 83 · see citing works
Antibacterial properties of nitric oxide–releasing sol‐gels
Nablo, B. J., & Schoenfisch, M. H. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.20030 · Cited by 78 · see citing works
Self-citationEroy‐Reveles, A. A., & Mascharak, P. K. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.111 · Cited by 75 · see citing works
Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia
Pearce, C. G., Najjar, S. F., Kapadia, M. R., Murar, J., Eng, J. W. ‐., Lyle, B., Aalami, O., Jiang, Q., Hrabie, J. A., Saavedra, J. E., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.09.010 · Cited by 75 · see citing works
Folate receptor targeted delivery of liposomal daunorubicin into tumor cells.
Ni, S., Stephenson, S. M., & Lee, R. J. (2002) · PubMed · Cited by 75 · see citing works
Nitric oxide donor drugs: an update on pathophysiology and therapeutic potential
Scatena, R., Bottoni, P., Martorana, G. E., & Giardina, B. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.7.835 · Cited by 74 · see citing works
Nanoscale Particle Therapies for Wounds and Ulcers
Cortivo, R., Vindigni, V., Iacobellis, L., Abatangelo, G., Pinton, P., & Zavan, B. (2010) · Nanomedicine · doi:10.2217/nnm.10.32 · Cited by 74 · see citing works
Nitric Oxide in Cancer Therapeutics: Interaction with Cytotoxic Chemotherapy
Hirst, D., & Robson, T. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790232185 · Cited by 72 · see citing works
Coneski, P. N., Rao, K. S., & Schoenfisch, M. H. (2010) · Biomacromolecules · doi:10.1021/bm1006823 · Cited by 63 · see citing works
Self-citationSeabra, A. B., Da Silva, R., De Souza, G. F. P., & De Oliveira, M. G. (2008) · Artificial Organs · doi:10.1111/j.1525-1594.2008.00540.x · Cited by 63 · see citing works
Microbiology: Breaking Down Biofilms
Stephens, C. M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00706-6 · Cited by 58 · see citing works
Ishima, Y., Sawa, T., Kragh‐Hansen, U., Miyamoto, Y., Matsushita, S., Akaike, T., & Otagiri, M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.114959 · Cited by 57 · see citing works
Reduced ischemia/reperfusion injury via glutathione-initiated nitric oxide-releasing dendrimers
Johnson, T. A., Stasko, N., Matthews, J. L., Cascio, W. E., Holmuhamedov, E., Johnson, C. B., & Schoenfisch, M. H. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.11.002 · Cited by 57 · see citing works
Self-citationWound Healing Agents: The Role of Natural and Non-Natural Products in Drug Development
de Fátima, Â., Modolo, L. V., Sanches, A. C. C., & Porto, R. R. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708785132738 · Cited by 55 · see citing works
Novel agents for cancer prevention based on nitric oxide
Rigas, B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351364 · Cited by 53 · see citing works
Nitric Oxide: Perspectives and Emerging Studies of a Well Known Cytotoxin
Paradise, W. A., Vesper, B. J., Goel, A., Waltonen, J. D., Altman, K. W., Haines, G. K., & Radosevich, J. A. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11072715 · Cited by 53 · see citing works
Katsumi, H., Nishikawa, M., Yamashita, F., & Hashida, M. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087429 · Cited by 52 · see citing works
New antibiotic agents and approaches to treat biofilm-associated infections
Lynch, A. S., & Abbanat, D. (2010) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2010.505923 · Cited by 52 · see citing works
Halpenny, G. M., Gandhi, K., & Mascharak, P. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml1000646 · Cited by 48 · see citing works
Nablo, B. J., & Schoenfisch, M. H. (2004) · Biomacromolecules · doi:10.1021/bm049727w · Cited by 44 · see citing works
Self-citationBhagat, K., & Vallance, P. J. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608901204 · Cited by 44 · see citing works
Building a better aspirin: gaseous solutions to a century‐old problem
Wallace, J. L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707396 · Cited by 43 · see citing works
Synthesis and Characterization of Nitric Oxide-Releasing Sol−Gel Microarrays
Robbins, M. E., Hopper, E. D., & Schoenfisch, M. H. (2004) · Langmuir · doi:10.1021/la048368n · Cited by 42 · see citing works
Self-citationNitric oxide synthase gene therapy: progress and prospects
O’Connor, D. M. A., & O’Brien, T. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903002047 · Cited by 42 · see citing works
Nitric oxide photocaging platinum nanoparticles with anticancer potential
Barone, M., Sciortino, M. T., Zaccaria, D., Mazzaglia, A., & Sortino, S. (2008) · Journal of Materials Chemistry · doi:10.1039/b809121h · Cited by 41 · see citing works
Current Status and Future Possibilities of Nitric Oxide-Donor Drugs: Focus on S-Nitrosothiols
Al‐Sa'doni, H. H., & Ferro, A. (2005) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557053175399 · Cited by 40 · see citing works
Antibacterial Properties of Nitric Oxide-Releasing Sol−Gel Microarrays
Dobmeier, K. P., & Schoenfisch, M. H. (2004) · Biomacromolecules · doi:10.1021/bm049632u · Cited by 37 · see citing works
Self-citationNitric oxide, health and disease
Ferrari, C. K. B., França, E. L., & Honório‐França, A. C. (2009) · Journal of Applied Biomedicine · doi:10.32725/jab.2009.019 · Cited by 37 · see citing works
McCarthy, H. O., Coulter, J. A., Robson, T., & Hirst, D. G. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.8.0007 · Cited by 35 · see citing works
Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice
Katsumi, H., Nishikawa, M., Yasui, H., et al. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.07.013 · Cited by 29 · see citing works
Asanuma, H., Nakai, K., Sanada, S., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.12.001 · Cited by 24 · see citing works
Sol−Gel Derived Potentiometric pH Sensors
Marxer, S. M., & Schoenfisch, M. H. (2004) · Analytical Chemistry · doi:10.1021/ac0486995 · Cited by 24 · see citing works
Self-citationSol–gel derived nitric oxide-releasing oxygen sensors
Marxer, S. M., Robbins, M. E., & Schoenfisch, M. H. (2005) · The Analyst · doi:10.1039/b412079e · Cited by 23 · see citing works
Self-citationLaursen, B. E., Stankevıčıus, E., Pilegaard, H. K., Mulvany, M. J., & Simonsen, U. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00247.x · Cited by 22 · see citing works
Specificity of inducible nitric-oxide synthase inhibitors: prospects for their clinical therapy.
Liu, Z., Wildhirt, S. M., & Zhou, H. (1999) · PubMed · Cited by 13 · see citing works
Preclinical Profile of PF9404C, a Nitric Oxide Donor with β Receptor Blocking Properties
Villarroya, M., López, M. G., de Pascual, R., et al. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2005.tb00162.x · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 13
- [10]Al-Sa’doni HH Ferro A Mini Rev. Med. Chem 2005 5 247 254 15777259
- [12]Megson IL Webb DJ Expert Opin. Investig. Drugs 2002 11 587 601 11996642
- [18]Maddaford S Annedi SC Ramnauth J Rakhit S Ann. Rep. Med. Chem 2009 44 27 Elsevier Academic Press Inc San Diego Editon 44
- [21]Liu ZQ Wildhirt SM Zhou HH Acta Pharmacol. Sin 1999 20 1052 1056 11270974
- [23]Miller MR Megson IL Br. J. Pharmacol 2007 151 305 321 17401442 PMC2013979
- [25]Eroy-Reveles AA Mascharak PK Future Med. Chem 2009 1 1497 1507 21426062
- [26]Mocellein S Bronte V Nitti D Med. Res. Rev 2007 27 317 352 16991100
- [27]Ignarro LJ Nitric Oxide: Biology and Pathobiology 2000 Academic Press San Diego, CA
- [28]Loscalzo J Vita JA Nitric oxide and the cardiovascular system 2000 Humana Press, Inc. Totowa, New Jersey
- [54]Kennovin GD Hirst DG Stratford MRL Flitney FW Moncada S Feelisch M Busse R Higgs EA The biology of nitric oxide 1994 259 263 Portland Press London Editon
- [57]Brannon-Peppas L Blanchette JO Adv. Drug Delivery Rev 2004 56 1649 1659 15350294
- [59]Ni S Stephenson SM Lee RJ Anticancer Res 2002 22 2131 2135 12174894
- [66]Sibata CH Colussi VC Oleinick NL Kinsella TJ Expert Opin. Pharmacother 2001 2 917 927 11585008
Cited by
Sorted by citations
Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control
Liu, Y., Shi, L., Su, L., van der Mei, H. C., Jutte, P. C., Ren, Y., & Busscher, H. J. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00807d · Cited by 737 · see citing works
Nitric oxide release: Part I. Macromolecular scaffolds
Riccio, D. A., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15272j · Cited by 475 · see citing works
Self-citationBiocompatible Materials for Continuous Glucose Monitoring Devices
Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013) · Chemical Reviews · doi:10.1021/cr300387j · Cited by 347 · see citing works
Self-citationWo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Liu, R., Xiao, W., Hu, C., Xie, R., & Gao, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.04.005 · Cited by 250 · see citing works
Nitric oxide–releasing macromolecular scaffolds for antibacterial applications
Yang, L., Feura, E. S., Ahonen, M. J. R., & Schoenfisch, M. H. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800155 · Cited by 218 · see citing works
Self-citationNitric oxide regulation of bacterial biofilms
Arora, D. P., Hossain, S., Xu, Y., & Boon, E. M. (2015) · Biochemistry · doi:10.1021/bi501476n · Cited by 206 · see citing works
Nitric Oxide Donors for Cardiovascular Implant Applications
Naghavi, N., de Mel, A., Alavijeh, O. S., Cousins, B. G., & Seifalian, A. M. (2013) · Small · doi:10.1002/smll.201200458 · Cited by 188 · see citing works
Seabra, A. B., Justo, G. Z., & Haddad, P. S. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.01.005 · Cited by 151 · see citing works
Carpenter, A. W., Worley, B. V., Slomberg, D. L., & Schoenfisch, M. H. (2012) · Biomacromolecules · doi:10.1021/bm301108x · Cited by 132 · see citing works
Self-citationWo, Y., Li, Z., Brisbois, E. J., Colletta, A., Wu, J., Major, T. C., Xi, C., Bartlett, R. H., Matzger, A. J., & Meyerhoff, M. E. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b07501 · Cited by 128 · see citing works
Neufeld, M. J., Harding, J. L., & Reynolds, M. M. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b08773 · Cited by 116 · see citing works
Kang, Y., Kim, J., Park, J., Lee, Y. M., Saravanakumar, G., Park, K. M., Choi, W., Kim, K., Lee, E., Kim, C., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119297 · Cited by 108 · see citing works
Brisbois, E. J., Davis, R. P., Jones, A. M., Major, T. C., Bartlett, R. H., Meyerhoff, M. E., & Handa, H. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01839g · Cited by 101 · see citing works
Lautner, G., Meyerhoff, M. E., & Schwendeman, S. P. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.056 · Cited by 70 · see citing works
Harding, J. L., Metz, J. M., & Reynolds, M. M. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201402529 · Cited by 67 · see citing works
Duvenage, L., Walker, L. A., Bojarczuk, A., Johnston, S. A., MacCallum, D. M., Munro, C. A., & Gourlay, C. W. (2019) · mBio · doi:10.1128/mbio.02535-18 · Cited by 61 · see citing works
Reighard, K. P., & Schoenfisch, M. H. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01208-15 · Cited by 49 · see citing works
Self-citationHarding, J. L., & Reynolds, M. M. (2014) · J. Mater. Chem. B · doi:10.1039/c3tb21458c · Cited by 43 · see citing works
McCarthy, C. W., Goldman, J., & Frost, M. C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b12548 · Cited by 30 · see citing works
Multifaceted role of nitric oxide in vascular dementia
Yang, Y., Ma, K., Li, S., & Xiong, T. (2025) · Medical Gas Research · doi:10.4103/mgr.medgasres-d-24-00158 · Cited by 13 · see citing works
- Authors
- Carpenter, A. W., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Schoenfisch, Mark H.
- ORCID
- Schoenfisch, Mark H.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 10
- Pages
- 3742
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- PMC
- PMC3341526
- OpenAlex
- W2026954356
- Cited by
- 964
- References
- 93
- Citations by year
- 2026: 50 · 2025: 63 · 2024: 76 · 2023: 92 · 2022: 102 · 2021: 80 · 2020: 88 · 2019: 87 · 2018: 60 · 2017: 62 · 2016: 52 · 2015: 60 · 2014: 44 · 2013: 33 · 2012: 12
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- nitric oxide, nitric oxide donors, cardiovascular disease, cancer therapy, bacterial infection, wound healing, dendrimers, polymers, particles, clinical translation
- MeSH terms
- Animals, Anti-Bacterial Agents, Blood Circulation, Cardiovascular Diseases, Humans, Neoplasms, Nitric Oxide, Thrombosis, Wound Healing, Reperfusion Injury, Free Radical Scavengers, Endothelium-Dependent Relaxing Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
