The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs
Open accessAbstract
Premineralized silk fibroin protein scaffolds (mSS) were prepared to combine the osteoconductive properties of biological apatite with aqueous-derived silk scaffold (SS) as a composite scaffold for bone regeneration. The aim of present study was to evaluate the effect of premineralized silk scaffolds combined with bone morphogenetic protein-2 (BMP-2) modified bone marrow stromal cells (bMSCs) to repair mandibular bony defects in a rat model. bMSCs were expanded and transduced with adenovirus AdBMP-2, AdLacZ gene in vitro. These genetically modified bMSCs were then combined with premineralized silk scaffolds to form tissue engineered bone. Mandibular repairs with AdBMP-2 transduced bMSCs/mSS constructs were compared with those treated with AdLacZ transduced bMSCs/mSS constructs, native (nontransduced) bMSCs/mSS constructs and mSS alone. Eight weeks post-operation, the mandibles were explanted and evaluated by radiographic observation, micro-CT, histological analysis and immunohistochemistry. The presence of BMP-2 gene enhanced tissue engineered bone in terms of the most new bone formed and the highest local bone mineral densities (BMD) found. These results demonstrated that premineralized silk scaffold could serve as a potential substrate for bMSCs to construct tissue engineered bone for mandibular bony defects. BMP-2 gene therapy and tissue engineering techniques could be used in mandibular repair and bone regeneration.
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Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
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Cited by
Elastomeric biomaterials for tissue engineering
Chen, Q., Liang, S., & Thouas, G. A. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.05.003 · Cited by 564
Silk scaffolds in bone tissue engineering: An overview
Bhattacharjee, P., Kundu, B., Naskar, D., Kim, H.-W., Maiti, T. K., Bhattacharya, D., & Kundu, S. C. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.09.027 · Cited by 318
Zhang, W., Wang, X., Wang, S., Zhao, J., Xu, L., Zhu, C., Zeng, D., Chen, J., Zhang, Z., Kaplan, D. L., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.047 · Cited by 283
Self-citationXia, L., Lin, K., Jiang, X., Xu, Y., Zhang, M., Chang, J., & Zhang, Z. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20945h · Cited by 146
Self-citationGarcía-Bernal, D., García-Arranz, M., Yáñez, R. M., Hervás-Salcedo, R., Cortés, A., Fernández-García, M., Hernando-Rodríguez, M., Quintana-Bustamante, Ó., Bueren, J. A., García-Olmo, D., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.650664 · Cited by 138
Metadata
- Authors
- Jiang, X., Zhao, J., Wang, S., Sun, X., Zhang, X., Chen, J., Kaplan, D. L., & Zhang, Z.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 30
- Issue
- 27
- Pages
- 4522-4532
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2129336783
- Cited by
- 203
- References
- 1
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Jiang, X., Zhao, J., Wang, S., Sun, X., Zhang, X., Chen, J., Kaplan, D. L., & Zhang, Z. (2009). Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs. Biomaterials. https://doi.org/10.1016/j.biomaterials.2009.05.021
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