Elastomeric biomaterials for tissue engineering
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Many medical devices are implanted in the dynamic mechanical environment of the human body and need to adapt to continuous relaxation and contraction without mechanically stimulating surrounding tissues.
“Many medical devices are implanted in the dynamic mechanical environment of the human body. They need to adapt to states of continuous relaxation and contraction to maintain their own performance without mechanical stimulation of the surrounding tissues [14,15].”
From Synthesis of Poly(l-lactide-co-ε-caprolactone) Copolymer: Structure, Toughness, and Elasticity (2021) · cites this paper as [15]
PHB is a member of the PHA group and shows a good degree of biocompatibility with various cells.
“Polyhyroxybutyrate (PHB) is a member of the PHA group and shows a good degree of biocompatibility with various cells.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [92]
Due to its mechanical strength, PHB is used in the production of bone plates and fillers.
“Due to its mechanical strength, PHB is also used in the production of bone plates and fillers [92].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [92]
PHB can be produced by many types of microorganisms due to its bacterial origin.
“In addition, it can be produced by many types of microorganisms due to its bacterial origin [92].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [92]
The degradation product of PHB is 3HB, which is non-toxic and a natural metabolite occurring in multiple tissues in the human body.
“The degradation product of PHB is 3HB, which is non-toxic and, as mentioned above, a natural metabolite occurring in multiple tissues in the human body [92].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [92]
Naturally occurring PHAs are ubiquitous components of animal cell membranes.
“Naturally occurring PHAs are ubiquitous components of animal cell membranes.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [92]
Low-molecular-weight poly-3-hydroxybutyrate (P3HB) is present in relatively high concentrations in human blood, and 3-hydroxybutyric acid (3HB) is a naturally occurring human metabolite found in the heart, liver, brain, lungs, and muscle tissue.
“Low-molecular-weight poly-3-hydroxybutyrate (P3HB) is present in relatively high concentrations in human blood, and 3-hydroxybutyric acid (3HB) is a naturally occurring human metabolite found in the heart, liver, brain, lungs, and muscle tissue [92].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [92]
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A tough biodegradable elastomer
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
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“In order to design structures for different biomedical applications, especially in tissue engineering, a detailed knowledge of the material's mechanical behaviour and its evolution during degradation is essential (Chen et al., 2013).”
BackgroundMonomer‐scale design of functional protein polymers using consensus repeat sequences
Chang, M. P., Huang, W., & Mai, D. J. (2021) · Journal of Polymer Science · doi:10.1002/pol.20210506 · Cited by 20 · see citing works
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Liu, J., Xu, J., & Hadjichristidis, N. (2026) · Macromolecules · doi:10.1021/acs.macromol.6c00358
- Authors
- Chen, Q., Liang, S., & Thouas, G. A.
- Affiliations
- Monash University (AU)
- The University of Melbourne (AU)
- Corresponding author
- Chen, Qizhi
- Venue
- Progress in Polymer Science
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 38
- Issue
- 3-4
- Pages
- 584-671
- ISSN
- 0079-6700 (ISSN-L)
- OpenAlex
- W1968767333
- Cited by
- 564
- References
- 8
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 27 · 2023: 35 · 2022: 40 · 2021: 45 · 2020: 40 · 2019: 43 · 2018: 50 · 2017: 50 · 2016: 59 · 2015: 40 · 2014: 45 · 2013: 31 · 2012: 1
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Polymer Science (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- tissue engineering, extracellular matrix mimicry, elasticity, thermoplastic elastomers, elastic proteins, biocompatibility, biodegradability, mechanical properties, soft tissue repair, polymer synthesis
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