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The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells
Open accessAbstract
There has been an increasing interest in understanding how the mechanical properties of the microenvironment influence stem cell fate. We describe studies of the proliferation and differentiation of neural stem cells (NSCs) encapsulated within three-dimensional scaffolds – alginate hydrogels – whose elastic moduli were varied over two orders of magnitude. The rate of proliferation of neural stem cells decreased with increase in the modulus of the hydrogels. Moreover, we observed the greatest enhancement in expression of the neuronal marker β-tubulin III within the softest hydrogels, which had an elastic modulus comparable to that of brain tissues. To our knowledge, this work represents the first demonstration of the influence of modulus on NSC differentiation in three-dimensional scaffolds. Three-dimensional scaffolds that control stem cell fate would be broadly useful for applications in regenerative medicine and tissue engineering.
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Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Myotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties
Ghosh, K., Pan, Z., Guan, E., Ge, S., Liu, Y., Nakamura, T., Ren, X.-D., Rafailovich, M., & Clark, R. A. F. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.038 · Cited by 386
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Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
Li, Y., Rodrigues, J., & Tomás, H. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15203c · Cited by 1,445
Progress in 3D bioprinting technology for tissue/organ regenerative engineering
Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues
McKee, C. T., Last, J. A., Russell, P., & Murphy, C. J. (2011) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2010.0520 · Cited by 708
Marine Polysaccharides from Algae with Potential Biomedical Applications
De Jesus Raposo, M., De Morais, A., & De Morais, R. (2015) · Marine Drugs · doi:10.3390/md13052967 · Cited by 686
Metadata
- Authors
- Banerjee, A., Arha, M., Choudhary, S., Ashton, R. S., Bhatia, S. R., Schaffer, D. V., & Kane, R. S.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 30
- Issue
- 27
- Pages
- 4695-4699
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2098737512
- Cited by
- 673
- References
- 3
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Banerjee, A., Arha, M., Choudhary, S., Ashton, R. S., Bhatia, S. R., Schaffer, D. V., & Kane, R. S. (2009). The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells. Biomaterials. https://doi.org/10.1016/j.biomaterials.2009.05.050
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