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Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues
Open accessAbstract
In this review, we compare the reported values of Young's modulus (YM) obtained from indentation and tensile deformations of soft biological tissues. When the method of deformation is ignored, YM values for any given tissue typically span several orders of magnitude. If the method of deformation is considered, then a consistent and less ambiguous result emerges. On average, YM values for soft tissues are consistently lower when obtained by indentation deformations. We discuss the implications and potential impact of this finding.
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Cites
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Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
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Modulus-dependent macrophage adhesion and behavior
Irwin, E. F., Saha, K., Rosenbluth, M., Gamble, L. J., Castner, D. G., & Healy, K. E. (2008) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856208786052407 · Cited by 105
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The stiffness of living tissues and its implications for tissue engineering
Guimarães, C. F., Gasperini, L., Marques, A. P., & Reis, R. L. (2020) · Nature Reviews Materials · doi:10.1038/s41578-019-0169-1 · Cited by 1,515
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Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738
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Feiner, R., & Dvir, T. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.76 · Cited by 595
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Mirdamadi, E., Tashman, J. W., Shiwarski, D. J., Palchesko, R. N., & Feinberg, A. W. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01133 · Cited by 292
Metadata
- Authors
- McKee, C. T., Last, J. A., Russell, P., & Murphy, C. J.
- Venue
- Tissue Engineering Part B: Reviews
- Publisher
- SAGE Publications
- Published
- 2011-06
- Volume
- 17
- Issue
- 3
- Pages
- 155-164
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2039692967
- Cited by
- 708
- References
- 5
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
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- McKee, C. T., Last, J. A., Russell, P., & Murphy, C. J. (2011). Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.teb.2010.0520
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