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The effect of VEGF functionalization of titanium on endothelial cells in vitro
Abstract
One of the key challenges in bone healing and regeneration is the engineering of an implant with surface properties that can enhance revascularization to meet the metabolic demands of recovery. Successful implant integration into the surrounding tissue is highly dependent on the crucial role of blood supply in driving bone repair and development. Therapeutic application of vascular endothelial growth factor (VEGF) is a promising approach to enhance blood supply and healing through revascularization around an engineered implant in a regulated manner. In this in vitro study, we investigated the effects of immobilized VEGF on titanium alloy substrates coated with thin adherent polydopamine film. X-ray photoelectron spectroscopy (XPS) was used to determine the chemical composition of the surfaces at various stages of surface functionalization to verify the successful deposition of polydopamine and VEGF on the metal surface. Surface topography was evaluated from the surface profile determined by atomic force microscopy (AFM). The functionalized surfaces showed a significant increase in human dermal microvascular endothelial cells (HDMECs) attachment, viability and proliferation compared to the pristine substrate. Furthermore the immobilized VEGF was able to induce the differentiation of human mesenchymal stem cells (hMSCs) into endothelial cells. Therefore utilizing the reactivity of polydopamine films to immobilize VEGF onto metal substrates may provide a promising approach for a…
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“Although most polymeric biomaterials are biodegradable, biocompatible, and erosion-resistant and have appropriate mechanical properties, they lack satisfactory osteointegration [90].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [90]
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Metadata
- Authors
- Poh, C. K., Shi, Z., Lim, T. Y., Neoh, K. G., & Wang, W.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Wang, Wilson
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 31
- Issue
- 7
- Pages
- 1578-1585
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1996465454
- Cited by
- 236
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 18 · 2018: 23 · 2017: 13 · 2016: 24 · 2015: 18 · 2014: 26 · 2013: 32 · 2012: 22
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Keywords
- vascular endothelial growth factor, titanium implants, polydopamine coating, endothelial cell adhesion, human dermal microvascular endothelial cells, human mesenchymal stem cells, endothelial differentiation, revascularization, bone regeneration, implant integration, surface functionalization
- MeSH terms
- Cell Adhesion, Cell Count, Cell Survival, Elements, Fluorescent Antibody Technique, Humans, Microscopy, Electron, Scanning, Surface Properties, Titanium, Cell Death, Dermis, Vascular Endothelial Growth Factor A, Endothelial Cells, Cell Proliferation, Microvessels, Photoelectron Spectroscopy, Mesenchymal Stem Cells
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