The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants
Open accessAbstract
Magnesium and its alloys may potentially be applied as degradable metallic materials in orthopaedic implantations due to their degradability and resemblance to human cortical bone. However, the high corrosion rate and accumulation of hydrogen gas upon degradation hinders its clinical application. In this study, we adopt a new approach to control the corrosion rate by coating a controllable polymeric membrane fabricated by polycaprolactone and dichloromethane onto magnesium alloys, in which the pore size was controlled during the manufacturing process. The addition of the polymeric membrane was found to reduce the degradation rate of magnesium, and the bulk mechanical properties were shown to be maintained upon degradation. The in-vitro studies indicated good cytocompatibility of eGFP and SaOS-2 osteoblasts with the polymer-coated samples, which was not observed for the uncoated samples. The in-vivo study indicated that the uncoated sample degraded more rapidly than that of the polymer-coated samples. Although new bone formation was found on both samples, as determined by Micro-CT, higher volumes of new bone were observed on the polymer-coated samples. Histological analysis indicated no inflammation, necrosis or hydrogen gas accumulation on either of the samples during degradation. Collectively, these data suggest that the use of polymeric membrane may be potentially applied for future clinical use.
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Cites
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Cited by
Bone Tissue Engineering: Recent Advances and Challenges
Amini, A. R., Laurencin, C. T., & Nukavarapu, S. P. (2012) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v40.i5.10 · Cited by 2,336
Novel Magnesium Alloys Developed for Biomedical Application: A Review
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Bone biomaterials and interactions with stem cells
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Biodegradable magnesium-based implants in orthopedics-a general review and perspectives
Wang, J., Xu, J., Hopkins, C., Chow, D. H., & Qin, L. (2020) · Advanced Science · doi:10.1002/advs.201902443 · Cited by 574
Metadata
- Authors
- Wong, H. M., Yeung, K. W. K., Lam, K. O., Tam, V., Chu, P. K., Luk, K. D. K., & Cheung, K. M. C.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 31
- Issue
- 8
- Pages
- 2084-2096
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2157951056
- Cited by
- 579
- References
- 28
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Wong, H. M., Yeung, K. W. K., Lam, K. O., Tam, V., Chu, P. K., Luk, K. D. K., & Cheung, K. M. C. (2010). A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. Biomaterials. https://doi.org/10.1016/j.biomaterials.2009.11.111
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