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The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro
Open accessAbstract
Bioactive glasses (BG) which contain strontium have the potential to combine the known bone regenerative properties of BG with the anabolic and anti-catabolic effects of strontium cations. Here we created a BG series (SiO(2)-P(2)O(5)-Na(2)O-CaO) in which 0-100% of the calcium was substituted by strontium and tested their effects on osteoblasts and osteoclasts in vitro. We show that ions released from strontium-substituted BG enhance metabolic activity in osteoblasts. They also inhibit osteoclast activity by both reducing tartrate resistant acid phosphatase activity and inhibiting resorption of calcium phosphate films in a dose-dependent manner. Additionally, osteoblasts cultured in contact with BG show increased proliferation and alkaline phosphatase activity with increasing strontium substitution, while osteoclasts adopt typical resorption morphologies. These results suggest that similarly to the osteoporosis drug strontium ranelate, strontium-substituted BG may promote an anabolic effect on osteoblasts and an anti-catabolic effect on osteoclasts. These effects, when combined with the advantages of BG such as controlled ion release and delivery versatility, may make strontium-substituted BG an effective biomaterial choice for a range of bone regeneration therapies.
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Cites
Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025
Burge, R., Dawson-Hughes, B., Solomon, D. H., Wong, J. B., King, A., & Tosteson, A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061113 · Cited by 4,026
Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy
Weinstein, R. S., Roberson, P. K., & Manolagas, S. C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0802633 · Cited by 391
Cited by
Hoppe, A., Güldal, N. S., & Boccaccini, A. R. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.004 · Cited by 2,608
Osteoimmunomodulation for the development of advanced bone biomaterials
Chen, Z., Klein, T., Murray, R. Z., Crawford, R., Chang, J., Wu, C., & Xiao, Y. (2016) · Materials Today · doi:10.1016/j.mattod.2015.11.004 · Cited by 730
Bioactive Glasses—Structure and Properties
Brauer, D. S. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201405310 · Cited by 447
Bioinorganics and biomaterials: Bone repair
Habibovic, P., & Barralet, J. E. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.03.027 · Cited by 441
Mouriño, V., Cattalini, J. P., & Boccaccini, A. R. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2011.0611 · Cited by 441
Metadata
- Authors
- Gentleman, E., Fredholm, Y. C., Jell, G., Lotfibakhshaiesh, N., O'Donnell, M. D., Hill, R. G., & Stevens, M. M.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 31
- Issue
- 14
- Pages
- 3949-3956
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2010395830
- Cited by
- 635
- References
- 2
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gentleman, E., Fredholm, Y. C., Jell, G., Lotfibakhshaiesh, N., O'Donnell, M. D., Hill, R. G., & Stevens, M. M. (2010). The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. Biomaterials. https://doi.org/10.1016/j.biomaterials.2010.01.121
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