The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery
Abstract
Multimodal imaging and imaging-guided therapies have become a new trend in the current development of cancer theranostics. In this work, we encapsulate hydrophobic upconversion nanoparticles (UCNPs) together with iron oxide nanoparticles (IONPs) by using an amphiphilic block copolymer, poly (styrene-block-allyl alcohol) (PS(16)-b-PAA(10)), via a microemulsion method, obtaining an UC-IO@Polymer multi-functional nanocomposite system. Fluorescent dye and anti-cancer drug molecules can be further loaded inside the UC-IO@Polymer nanocomposite for additional functionalities. Utilizing the Squaraine (SQ) dye loaded nanocomposite (UC-IO@Polymer-SQ), triple-modal upconversion luminescence (UCL)/down-conversion fluorescence (FL)/magnetic resonance (MR) imaging is demonstrated in vitro and in vivo, and also applied for in vivo cancer cell tracking in mice. On the other hand, a chemotherapy drug, doxorubicin, is also loaded into the nanocomposite, forming an UC-IO@Polymer-DOX complex, which enables novel imaging-guided and magnetic targeted drug delivery. Our work provides a method to fabricate a nanocomposite system with highly integrated functionalities for multimodal biomedical imaging and cancer therapy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [6]
Citations
Cites
Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Sun, S., Zeng, H., Robinson, D., Raoux, S., Rice, P. M., Wang, S. X., & Li, G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0380852 · Cited by 3,484
Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals
Wang, F., & Liu, X. (2009) · Chemical Society Reviews · doi:10.1039/b809132n · Cited by 3,007
Upconversion nanoparticles in biological labeling, imaging, and therapy
Wang, F., Banerjee, D., Liu, Y., Chen, X., & Liu, X. (2010) · The Analyst · doi:10.1039/c0an00144a · Cited by 1,409
Multifunctional magnetic nanoparticles for targeted imaging and therapy
MCCARTHY, J., & WEISSLEDER, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.014 · Cited by 892
Wang, C., Tao, H., Cheng, L., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.007 · Cited by 825
Wang, C., Cheng, L., & Liu, Z. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.069 · Cited by 675
Rare earth fluoride nano-/microcrystals: synthesis, surface modification and application
Li, C., & Lin, J. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00031k · Cited by 672
Cheng, L., Yang, K., Li, Y., Chen, J., Wang, C., Shao, M., Lee, S., & Liu, Z. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201101447 · Cited by 651
Chen, G., Ohulchanskyy, T. Y., Kumar, R., Ågren, H., & Prasad, P. N. (2010) · ACS Nano · doi:10.1021/nn100457j · Cited by 632
Combined Optical and MR Bioimaging Using Rare Earth Ion Doped NaYF 4 Nanocrystals
Kumar, R., Nyk, M., Ohulchanskyy, T. Y., Flask, C. A., & Prasad, P. N. (2009) · Advanced Functional Materials · doi:10.1002/adfm.200800765 · Cited by 624
Mesoporous‐Silica‐Coated Up‐Conversion Fluorescent Nanoparticles for Photodynamic Therapy
Qian, H., Guo, H., Ho, P. C., Mahendran, R., & Zhang, Y. (2009) · Small · doi:10.1002/smll.200900692 · Cited by 620
Small Upconverting Fluorescent Nanoparticles for Biomedical Applications
Chatterjee, D. K., Gnanasammandhan, M. K., & Zhang, Y. (2010) · Small · doi:10.1002/smll.201000418 · Cited by 540
Upconversion nanoparticles: synthesis, surface modification and biological applications
Wang, M., Abbineni, G., Clevenger, A. L., Mao, C., & Xu, S. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.02.013 · Cited by 529
Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals
Rufaihah, A. J., & Zhang, Y. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.012 · Cited by 509
PET/NIRF/MRI triple functional iron oxide nanoparticles
Xie, J., Chen, K., Huang, J., Lee, S., Wang, J., Gao, J., Li, X., & Chen, X. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.010 · Cited by 492
Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging
Mader, H. S., Kele, P., Saleh, S. M., & Wolfbeis, O. S. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.08.014 · Cited by 446
Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging
Zhou, J., Yu, M., Sun, Y., Zhang, X., Zhu, X., Wu, Z., Wu, D., & Li, F. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.071 · Cited by 411
X‐ray scatter correction algorithm for cone beam CT imaging
Ning, R., Tang, X., & Conover, D. L. (2004) · Medical Physics · doi:10.1118/1.1711475 · Cited by 323
Highly-sensitive multiplexed in vivo imaging using pegylated upconversion nanoparticles
Cheng, L., Yang, K., Zhang, S., Shao, M., Lee, S., & Liu, Z. (2010) · Nano Research · doi:10.1007/s12274-010-0036-2 · Cited by 303
Xiong, L., Chen, Z., Yu, M.-X., Li, F., Liu, C., & Huang, C.-H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.015 · Cited by 303
Squaraine-Derived Rotaxanes: Sterically Protected Fluorescent Near-IR Dyes
Arunkumar, E., Forbes, C. C., Noll, B. C., & Smith, B. D. (2005) · Journal of the American Chemical Society · doi:10.1021/ja042404n · Cited by 300
18F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly
Liu, Q., Sun, Y., Li, C., Zhou, J., Li, C., Yang, T., Zhang, X., Yi, T., Wu, D., & Li, F. (2011) · ACS Nano · doi:10.1021/nn200298y · Cited by 297
Hu, S., & Gao, X. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102489q · Cited by 291
Guo, H., Qian, H., Idris, N. M., & Zhang, Y. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.11.004 · Cited by 226
Molecular imaging with targeted contrast ultrasound
Kaufmann, B. A., & Lindner, J. R. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.01.004 · Cited by 197
Cheng, L., Yang, K., Shao, M., Lee, S., & Liu, Z. (2011) · The Journal of Physical Chemistry C · doi:10.1021/jp111006z · Cited by 174
Fan, H., Olivo, M., Shuter, B., Yi, J., Ramaswamy, B., Tan, H., Xing, G., Ng, C.-T., Liu, L., Lucky, S. S., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja103738t · Cited by 143
Ryu, J. Y., Park, H., Kim, K., Kim, H., Yoo, J. H., Kang, M., Im, K., Grailhe, R., & Song, R. (2010) · The Journal of Physical Chemistry C · doi:10.1021/jp107725r · Cited by 122
Patel, D., Kell, A. J., Simard, B., Xiang, B., Lin, H. Y., & Tian, G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.013 · Cited by 93
Facile Preparation of a Hybrid Nanoprobe for Triple‐Modality Optical/PET/MR Imaging
Park, J. C., Yu, M. K., An, G. I., Park, S., Oh, J., Kim, H. J., Kim, J., Wang, E. K., Hong, I., Ha, Y. S., et al. (2010) · Small · doi:10.1002/smll.201001418 · Cited by 81
High-performance nanostructured MR contrast probes
Hu, F., Joshi, H. M., Dravid, V. P., & Meade, T. J. (2010) · Nanoscale · doi:10.1039/c0nr00173b · Cited by 67
Patel, D., Kell, A. J., Simard, B., Deng, J., Xiang, B., Lin, H., Gruwel, M. L. H., & Tian, G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.025 · Cited by 61
Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging
Lim, E., Yang, J., Dinney, C. P., Suh, J., Huh, Y., & Haam, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.081 · Cited by 60
Flagged first, then by citations
Cited by
Sorted by citations
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,746
Controlling upconversion nanocrystals for emerging applications
Zhou, B., Shi, B., Jin, D., & Liu, X. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.251 · Cited by 1,507
Gai, S., Li, C., Yang, P., & Lin, J. (2013) · Chemical Reviews · doi:10.1021/cr4001594 · Cited by 1,464
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy
Dong, H., Du, S., Zheng, X.-Y., Lyu, G.-M., Sun, L., Li, L.-D., Zhang, P., Zhang, C., & Yan, C. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00091 · Cited by 1,133
Metadata
- Authors
- Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z.
- Affiliations
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Li, Yonggang
- Liu, Zhuang
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 32
- Issue
- 35
- Pages
- 9364-9373
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1964991943
- Cited by
- 301
- References
- 33
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 13 · 2019: 18 · 2018: 24 · 2017: 30 · 2016: 21 · 2015: 27 · 2014: 28 · 2013: 34 · 2012: 32
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Soochow University
- Specialized Research Fund for the Doctoral Program of Higher Education of China
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- upconversion nanoparticles, iron oxide nanoparticles, polymer nanocomposites, amphiphilic block copolymers, microemulsion polymerization, multimodal imaging, upconversion luminescence, magnetic resonance imaging, squaraine dyes, doxorubicin, cancer theranostics, tumor cell tracking, image-guided therapy
- MeSH terms
- Animals, Doxorubicin, Ferric Compounds, Fluorescence, Humans, Injections, Intravenous, Magnetic Resonance Spectroscopy, Polymers, Drug Delivery Systems, Imaging, Three-Dimensional, Cell Line, Tumor, Mice, Nanoparticles, Nanocomposites
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
