Cited by 301Luminescence Properties of Advanced MaterialsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery

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Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery

Xu, Huan, Cheng, Liang, Wang, Chao, Ma, Xinxing, Li, Yonggang, Liu, Zhuang·2011·Biomaterials

DOI 10.1016/j.biomaterials.2011.08.053

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Abstract

Multimodal imaging and imaging-guided therapies have become a new trend in the current development of cancer theranostics. In this work, we encapsulate hydrophobic upconversion nanoparticles (UCNPs) together with iron oxide nanoparticles (IONPs) by using an amphiphilic block copolymer, poly (styrene-block-allyl alcohol) (PS(16)-b-PAA(10)), via a microemulsion method, obtaining an UC-IO@Polymer multi-functional nanocomposite system. Fluorescent dye and anti-cancer drug molecules can be further loaded inside the UC-IO@Polymer nanocomposite for additional functionalities. Utilizing the Squaraine (SQ) dye loaded nanocomposite (UC-IO@Polymer-SQ), triple-modal upconversion luminescence (UCL)/down-conversion fluorescence (FL)/magnetic resonance (MR) imaging is demonstrated in vitro and in vivo, and also applied for in vivo cancer cell tracking in mice. On the other hand, a chemotherapy drug, doxorubicin, is also loaded into the nanocomposite, forming an UC-IO@Polymer-DOX complex, which enables novel imaging-guided and magnetic targeted drug delivery. Our work provides a method to fabricate a nanocomposite system with highly integrated functionalities for multimodal biomedical imaging and cancer therapy.

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Authors: Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z.
Affiliations: Soochow University (CN)
First Affiliated Hospital of Soochow University (CN)
Corresponding author: Li, Yonggang
Liu, Zhuang
ORCID: Cheng, Liang
Wang, Chao
Ma, Xinxing
Liu, Zhuang
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2011-12
Volume: 32
Issue: 35
Pages: 9364-9373
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2011.08.053
OpenAlex: W1964991943
Cited by: 301
References: 33
Citations by year: 2026: 5 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 13 · 2019: 18 · 2018: 24 · 2017: 30 · 2016: 21 · 2015: 27 · 2014: 28 · 2013: 34 · 2012: 32
FWCI: 14.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
Soochow University
Specialized Research Fund for the Doctoral Program of Higher Education of China
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: upconversion nanoparticles, iron oxide nanoparticles, polymer nanocomposites, amphiphilic block copolymers, microemulsion polymerization, multimodal imaging, upconversion luminescence, magnetic resonance imaging, squaraine dyes, doxorubicin, cancer theranostics, tumor cell tracking, image-guided therapy
MeSH terms: Animals, Doxorubicin, Ferric Compounds, Fluorescence, Humans, Injections, Intravenous, Magnetic Resonance Spectroscopy, Polymers, Drug Delivery Systems, Imaging, Three-Dimensional, Cell Line, Tumor, Mice, Nanoparticles, Nanocomposites

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Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery

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