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Cited by 422Surgical Sutures and AdhesivesHydrogels: synthesis, properties, applicationsPolymer Surface Interaction Studies

Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure

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Mehdizadeh, Mohammadreza, Weng, Hong, Gyawali, Dipendra, Tang, Liping, Yang, Jian·2012·Biomaterials
DOI 10.1016/j.biomaterials.2012.07.055PMC PMC3432175
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Abstract

The existing surgical adhesives are not ideal for wet tissue adhesion required in many surgeries such as those for internal organs. Developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility has been a significant challenge. Herein, learning from nature, we report a one-step synthesis of a family of injectable citrate-based mussel-inspired bioadhesives (iCMBAs) for surgical use. Within the formulations investigated, iCMBAs showed 2.5-8.0 folds stronger wet tissue adhesion strength over the clinically used fibrin glue, demonstrated controlled degradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility both in vitro and in vivo. iCMBAs were able to stop bleeding instantly and suturelessly, and close wounds (2 cm long×0.5 cm deep) created on the back of Sprague-Dawley rats, which is impossible when using existing gold standard, fibrin glue, due to its weak wet tissue adhesion strength. Equally important, the new bioadhesives facilitate wound healing, and are completely degraded and absorbed without eliciting significant inflammatory response. Our results support that iCMBA technology is highly translational and could have broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.

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  • These hydrogels are mainly designed as tissue adhesives, hemostatic sealants, nanocomposite gels, drug carriers, hydrogel bioelectrodes, and anti-adhesion gel coatings.

    “These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelectrodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [87]

  • Mehdizadeh and coworkers developed an injectable citrate-based mussel-inspired hydrogel bioadhesive (iCMBA) by oxidation-induced crosslinking; the optimized iCMBA bioadhesive showed a strong adhesive strength of about 123 kPa in lap shear tests, about eight times that of commercial fibrin glue; in wound healing experiments, iCMBA hydrogel bioadhesive effectively sealed wounds on the backs of rats

    “For example, Mehdizadeh and coworkers developed an injectable citrate-based mussel-inspired hydrogel bioadhesive (iCMBA) by oxidation-induced crosslinking. The optimized iCMBA bioadhesive showed a strong adhesive strength of about 123 kPa in lap shear tests. Its adhesive strength was about eight times that of commercial fibrin glue. In wound healing experiments, iCMBA hydrogel bioadhesive”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [87]

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Research works printed but not linked: 38

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Cited by

Sorted by citations

Authors
Mehdizadeh, M., Weng, H., Gyawali, D., Tang, L., & Yang, J.
Affiliations
  • The University of Texas at Arlington (US)
  • Pennsylvania State University (US)
Corresponding author
Yang, Jian
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2012-11
Volume
33
Issue
32
Pages
7972-7983
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2012.07.055
PMC
PMC3432175
OpenAlex
W2074861758
Cited by
422
References
0
Citations by year
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FWCI
18.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Biomedical Imaging and Bioengineering
  • National Science Foundation (0954109)
Topics
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
wet tissue adhesion, sutureless wound closure, hemostatic agents, fibrin glue, biocompatibility, wound healing, surgical sealants
MeSH terms
Animals, Cell Survival, Cross-Linking Reagents, Injections, Polymers, Tensile Strength, Tissue Adhesives, Wound Healing, Rats, Sprague-Dawley, Citric Acid, NIH 3T3 Cells, Cell Proliferation, Bivalvia, Mice, Rats

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