Environment-dependent adhesive behaviors of mussel-inspired coordinate-crosslinked bioadhesives
Abstract
Mussel‐inspired, coordinate‐crosslinked gels have attracted extensive attention but their adhesive behaviors are still not fully understood. Herein, four mussel‐inspired molecules with different molecular characteristics are synthesized to study their adhesive behaviors. It is demonstrated that their adhesive behaviors are dependent on the environments. For these mussel‐inspired molecules, physiological environment containing relatively low Fe3+ contents is appropriate for achieving high adhesive strength. In addition, the mussel‐inspired molecules with positive charge, high molecular weight, or high catechol substitute ratio benefited for improving adhesive strength, however, only in the appropriate environment. In the inappropriate environments (physiological pH, high Fe3+ contents), the adhesives show similar low adhesive strength. These environment‐dependent adhesive behaviors are due to the poor interfacial adhesive capacity of the adhesives formed in the inappropriate environments. The study uncovers the adhesive behaviors of mussel‐inspired coordinate‐crosslinked gels and thus may further provide valuable evidences in the design of metal‐crosslinked bioadhesives.
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Since the catechol group can chelate with Fe3+ under weakly alkaline conditions, coordination crosslinking is often used in the design of multiple crosslinked hydrogels.
“Since the catechol group can chelate with Fe3+ under weakly alkaline conditions [100], coordination crosslinking is often used in the design of multiple crosslinked hydrogels.”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [100]
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Self-citation
- Authors
- Li, S., Chen, N., Li, Y., Zhao, J., Hou, X., & Yuan, X.
- Affiliations
- Tianjin University (CN)
- Corresponding author
- Zhao, Jin
- Venue
- Macromolecular Materials and Engineering
- Publisher
- Wiley
- Published
- 2019-12-04
- Volume
- 305
- Issue
- 1
- ISSN
- 1438-7492 (ISSN-L)
- 1439-2054
- OpenAlex
- W2994567836
- Cited by
- 17
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Materials and Engineering (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (51673144, 51103095))
- Natural Science Foundation of Tianjin Municipality (17JCYBJC17500))
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- adhesion strength, catechol, environmental dependence, interfacial adhesion, positive charge, molecular weight, pH
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