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Cited by 183Hernia repair and managementTissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications

ECM hydrogel coating mitigates the chronic inflammatory response to polypropylene mesh

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Faulk, Denver M., Londono, Ricardo, Wolf, Matthew T., Ranallo, Christian A., Carruthers, Christopher A., Wildemann, Justin D., Dearth, Christopher L., Badylak, Stephen F.·2014·Biomaterials
DOI 10.1016/j.biomaterials.2014.06.057PMC PMC5942585
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Abstract

Polypropylene has been used as a surgical mesh material for several decades. This non-degradable synthetic polymer provides mechanical strength, a predictable host response, and its use has resulted in reduced recurrence rates for ventral hernia and pelvic organ prolapse. However, polypropylene and similar synthetic materials are associated with a chronic local tissue inflammatory response and dense fibrous tissue deposition. These outcomes have prompted variations in mesh design to minimize the surface area interface and increase integration with host tissue. In contrast, biologic scaffold materials composed of extracellular matrix (ECM) are rapidly degraded in-vivo and are associated with constructive tissue remodeling and minimal fibrosis. The objective of the present study was to assess the effects of an ECM hydrogel coating on the long-term host tissue response to polypropylene mesh in a rodent model of abdominal muscle injury. At 14 days post implantation, the ECM coated polypropylene mesh devices showed a decreased inflammatory response as characterized by the number and distribution of M1 macrophages (CD86+/CD68+) around mesh fibers when compared to the uncoated mesh devices. At 180 days the ECM coated polypropylene showed decreased density of collagen and amount of mature type I collagen deposited between mesh fibers when compared to the uncoated mesh devices. This study confirms and extends previous findings that an ECM coating mitigates the chronic inflammatory response and associated scar tissue deposition characteristic of polypropylene.

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  • ECM degradation peptides promote M2-like phenotypes in vitro and in vivo.

    “promotion of M2-like phenotypes in vitro [40,44,153] and in vivo [152,154,155].”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [155]

    The Discussion describes ECM scaffolds as modulating the host response toward an M2-Th2 phenotype, and Results §3.3 reports fewer M1 macrophages around ECM-coated mesh after implantation. But the paper does not establish that ECM degradation peptides themselves promote M2-like phenotypes; it lists peptide release and immune modulation as distinct potential mechanisms. The cited in vivo finding therefore supports only the broader ECM-related part of the claim. (LLM, conf=0.82)

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Research works printed but not linked: 45

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Cited by

Sorted by citations

Authors
Faulk, D. M., Londono, R., Wolf, M. T., Ranallo, C. A., Carruthers, C. A., Wildemann, J. D., Dearth, C. L., & Badylak, S. F.
Affiliations
University of Pittsburgh (US)
Corresponding author
Badylak, Stephen F.
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2014-10
Volume
35
Issue
30
Pages
8585-8595
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2014.06.057
PMC
PMC5942585
OpenAlex
W1963795951
Cited by
183
References
0
Citations by year
2026: 13 · 2025: 11 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 18 · 2020: 9 · 2019: 16 · 2018: 22 · 2017: 21 · 2016: 12 · 2015: 19 · 2014: 1 · 2013: 1
FWCI
17.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (NIH 1F31AA021324-01)
  • National Science Foundation Graduate Research Fellowship
  • ARCS foundation
  • NIH-NHLBI (T32-HL76124-6)
  • CR Bard, Inc
Topics
  • Health Sciences › Medicine › Surgery › Hernia repair and management
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
polypropylene mesh, chronic inflammation, M1 macrophages, collagen deposition, type I collagen, fibrosis, ventral hernia repair, biological scaffolds, host tissue response, mesh implantation
MeSH terms
Animals, Biomechanical Phenomena, Chronic Disease, Collagen, Extracellular Matrix, Fluorescent Antibody Technique, Inflammation, Macrophages, Phenotype, Polypropylenes, Surgical Mesh, Implants, Experimental, Coated Materials, Biocompatible, Hydrogel, Polyethylene Glycol Dimethacrylate, Sus scrofa, Rats

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