Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials
Open accessAbstract
Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.
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ECM bioscaffolds deliver immunomodulatory signals through retained bioactive molecules and native-like architecture that influence immune cell activation, polarization, and effector function.
“As described in the previous section, ECM bioscaffolds deliver immunomodulatory signals through retained bioactive molecules and native-like architecture that influence immune cell activation, polarization, and effector function [48,80].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [80]
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Extracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works
Self-citationWound Healing: From Passive to Smart Dressings
Farahani, M., & Shafiee, A. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100477 · Cited by 822 · see citing works
Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing
Kharaziha, M., Baidya, A., & Annabi, N. (2021) · Advanced Materials · doi:10.1002/adma.202100176 · Cited by 732 · see citing works
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680 · see citing works
Articular fibrocartilage - Why does hyaline cartilage fail to repair?
Armiento, A. R., Alini, M., & Stoddart, M. J. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.015 · Cited by 413 · see citing works
Extracellular matrix-derived biomaterials in engineering cell function
Xing, H., Lee, H., Luo, L., & Kyriakides, T. R. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107421 · Cited by 302 · see citing works
Macrophage Related Chronic Inflammation in Non-Healing Wounds
Li, M.-R., Hou, Q., Zhong, L.-Z., Zhao, Y.-L., & Fu, X.-B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 289 · see citing works
Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior
Cramer, M. C., & Badylak, S. F. (2020) · Annals of Biomedical Engineering · doi:10.1007/s10439-019-02408-9 · Cited by 196 · see citing works
Self-citationExtracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering
Rowley, A. T., Nagalla, R. R., Wang, S., & Liu, W. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801578 · Cited by 193 · see citing works
Biomaterials to enhance stem cell transplantation
Kharbikar, B. N., Mohindra, P., & Desai, T. A. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.04.002 · Cited by 183 · see citing works
Hauck, S., Zager, P., Halfter, N., Wandel, E., Torregrossa, M., Kakpenova, A., Rother, S., Ordieres, M., Räthel, S., Berg, A., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.04.026 · Cited by 135 · see citing works
The inflammasome in host response to biomaterials: Bridging inflammation and tissue regeneration
Vasconcelos, D. P., Águas, A. P., Barbosa, M. A., Pelegrı́n, P., & Barbosa, J. N. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.056 · Cited by 134 · see citing works
Regulation of decellularized matrix mediated immune response
Chakraborty, J., Roy, S., & Ghosh, S. (2020) · Biomaterials Science · doi:10.1039/c9bm01780a · Cited by 130 · see citing works
Scaffold strategies for modulating immune microenvironment during bone regeneration
He, J., Chen, G., Liu, M., Xu, Z., Chen, H., Yang, L., & Lv, Y. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110411 · Cited by 127 · see citing works
Cunniffe, G. M., Díaz‐Payno, P. J., Sheehy, E. J., Critchley, S. E., de Almeida, H. V., Pitacco, P., Carroll, S. F., Mahon, O. R., Dunne, A., Levingstone, T. J., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.044 · Cited by 124 · see citing works
Decellularized Extracellular Matrix for Remodeling Bioengineering Organoid's Microenvironment
Zhu, L., Yuhan, J., Yu, H., Zhang, B., Huang, K., & Zhu, L. (2023) · Small · doi:10.1002/smll.202207752 · Cited by 123 · see citing works
Thompson, R. E., Pardieck, J., Smith, L. J., Kenny, P., Crawford, L., Shoichet, M. S., & Sakiyama‐Elbert, S. E. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.013 · Cited by 101 · see citing works
Urbani, L., Camilli, C., Phylactopoulos, D.-E., Crowley, C., Natarajan, D., Scottoni, F., Maghsoudlou, P., McCann, C. J., Pellegata, A. F., Urciuolo, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06385-w · Cited by 101 · see citing works
Duisit, J., Amiel, H., Wüthrich, T., Taddeo, A., Dedriche, A., Destoop, V., Pardoen, T., Bouzin, C., Joris, V., Magee, D., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.009 · Cited by 99 · see citing works
Antmen, E., Vrana, N. E., & Hasırcı, V. (2021) · Biomaterials Science · doi:10.1039/d1bm00840d · Cited by 89 · see citing works
Acellular human lung scaffolds to model lung disease and tissue regeneration
Gilpin, S. E., & Wagner, D. E. (2018) · European Respiratory Review · doi:10.1183/16000617.0021-2018 · Cited by 81 · see citing works
Bioinspired electrospun dECM scaffolds guide cell growth and control the formation of myotubes
Smoak, M. M., Hogan, K. J., Grande-Allen, K. J., & Mikos, A. G. (2021) · Science Advances · doi:10.1126/sciadv.abg4123 · Cited by 80 · see citing works
Tissue engineering: current status and future perspectives
Chandra, P., Soker, S., & Atala, A. (2020) · Principles of Tissue Engineering · doi:10.1016/b978-0-12-818422-6.00004-6 · Cited by 38 · see citing works
van der Merwe, Y., Faust, A. E., Sakalli, E. T., Westrick, C. C., Hussey, G. S., Chan, K. C., Conner, I. P., Fu, V. L. N., Badylak, S. F., & Steketee, M. B. (2019) · Scientific Reports · doi:10.1038/s41598-019-39861-4 · Cited by 70 · see citing works
Self-citationExtracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
Hussey, G. S., Cramer, M. C., & Badylak, S. F. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.09.004 · Cited by 69 · see citing works
Self-citationExtracellular matrix-inspired biomaterials for wound healing
Hosty, L., Heatherington, T., Quondamatteo, F., & Browne, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09750-9 · Cited by 63 · see citing works
Porous biomaterial scaffolds for skeletal muscle tissue engineering
Kozan, N. G., Joshi, M., Sicherer, S. T., & Grasman, J. M. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1245897 · Cited by 62 · see citing works
Guimarães, C. F., Marques, A. P., & Reis, R. L. (2022) · Advanced Materials · doi:10.1002/adma.202105645 · Cited by 60 · see citing works
3D Bioprinted Patient‐Specific Extracellular Matrix Scaffolds for Soft Tissue Defects
Behre, A., Tashman, J. W., Dikyol, C., Shiwarski, D. J., Crum, R. J., Johnson, S. A., Kommeri, R., Hussey, G. S., Badylak, S. F., & Feinberg, A. W. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200866 · Cited by 57 · see citing works
Self-citationLiguori, G. R., Liguori, T. T. A., de Moraes, S. R., Sinkunas, V., Terlizzi, V., van Dongen, J. A., Sharma, P. K., Moreira, L. F. P., & Harmsen, M. C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00520 · Cited by 55 · see citing works
Applications of Biomaterials for Immunosuppression in Tissue Repair and Regeneration
Shen, P. F., Chen, Y., Luo, S., Fan, Z., Wang, J., Chang, J., & Deng, J. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.019 · Cited by 54 · see citing works
Recent advances in strategies to target the behavior of macrophages in wound healing
Zheng, H., Cheng, X., Lü, J., Shan, S., Yang, J., & Zhou, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115199 · Cited by 53 · see citing works
Crum, R. J., Hall, K., Molina, C. P., Hussey, G. S., Graham, E., Li, H., & Badylak, S. F. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00208-9 · Cited by 50 · see citing works
Self-citationFeng, Y., Xiao, K., Chen, J., Lin, J., He, Y., He, X., Cheng, F., Li, Z., Li, J., Luo, F., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121238 · Cited by 50 · see citing works
Cell-specific aptamers as potential drugs in therapeutic applications: A review of current progress
Yuhan, J., Zhu, L., Zhu, L., Huang, K., He, X., & Xu, W. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.04.039 · Cited by 47 · see citing works
Mazloomnejad, R., Babajani, A., Kasravi, M., Ahmadi, A., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1103727 · Cited by 46 · see citing works
Wu, R., He, X., Zhu, J., Yin, Y., Li, X., Liu, X., & Chen, F. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.03.107 · Cited by 45 · see citing works
Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
García-García, A., & Martin, I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02256 · Cited by 43 · see citing works
Selection of Implantation Sites for Transplantation of Encapsulated Pancreatic Islets
Zhu, H., Li, W., Liu, Z.-W., Li, W.-L., Chen, N., Lu, L., Zhang, W., Wang, Z., Wang, B., Pan, K., et al. (2017) · Tissue engineering. Part B, Reviews · doi:10.1089/ten.teb.2017.0311 · Cited by 37 · see citing works
Milan, P. B., Masoumi, F., Biazar, E., Jalise, S. Z., & Mehrabi, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400322 · Cited by 41 · see citing works
Duran, P., Sesillo, F. B., Cook, M. S., Burnett, L. A., Menefee, S. A., Do, E., French, S., Zazueta‐Damian, G., Dzieciątkowska, M., Saviola, A. J., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abj3138 · Cited by 38 · see citing works
Development of vascularized nerve scaffold using perfusion-decellularization and recellularization
Wüthrich, T. M., Leşe, I., Haberthür, D., Zubler, C., Hlushchuk, R., Hewer, E., Maistriaux, L., Gianello, P., Lengelé, B., Rieben, R., et al. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111311 · Cited by 38 · see citing works
Tavakoli, S., Kisiel, M., Biedermann, T., & Klar, A. S. (2022) · Biomedicines · doi:10.3390/biomedicines10010118 · Cited by 35 · see citing works
Ren, T., Faust, A. E., van der Merwe, Y., Xiao, B., Johnson, S. A., Kandakatla, A., Gorantla, V. S., Badylak, S. F., Washington, K. M., & Steketee, M. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-22628-8 · Cited by 33 · see citing works
Self-citationRedenski, I., Guo, S., Machour, M., Szklanny, A. A., Landau, S., Kaplan, B., Lock, R. I., Gabet, Y., Egozi, D., Vunjak‐Novakovic, G., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008687 · Cited by 32 · see citing works
Tavakoli, S., Kisiel, M. A., Biedermann, T., & Klar, A. S. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-213624 · Cited by 31 · see citing works
Padma, A. M., Alshaikh, A. B., Song, M. J., Akouri, R., Oltean, M., Brännström, M., & Hellström, M. (2021) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3217 · Cited by 30 · see citing works
Current Advances in Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering
Kim, B., Pradhan, L., Hernández, A., Yenurkar, D., Nethi, S. K., & Mukherjee, S. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300002 · Cited by 28 · see citing works
Ostadi, Y., Khanali, J., Tehrani, F. A., Yazdanpanah, G., Bahrami, S., Niazi, F., & Niknejad, H. (2024) · Biomaterials Research · doi:10.34133/bmr.0071 · Cited by 30 · see citing works
Cao, T., & Warren, C. R. (2025) · Cells · doi:10.3390/cells14120882 · Cited by 28 · see citing works
Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview
Hassan, N., Krieg, T. M., Kopp, A., Bach, A. D., & Kröger, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116242 · Cited by 29 · see citing works
Regenerative Potential of A Bovine ECM-Derived Hydrogel for Biomedical Applications
Francesco, D. D., Bertani, F., Fusaro, L., Clemente, N., Carton, F., Talmon, M., Fresu, L. G., & Boccafoschi, F. (2022) · Biomolecules · doi:10.3390/biom12091222 · Cited by 28 · see citing works
Primavera, R., Razavi, M., Kevadiya, B. D., Wang, J., Vykunta, A., Mascolo, D. D., Decuzzi, P., & Thakor, A. S. (2021) · Biofabrication · doi:10.1088/1758-5090/abdcac · Cited by 26 · see citing works
Despeyroux, A., Duret, C., Gondeau, C., Pérez-Gracia, E., Chuttoo, L., de Boussac, H., Briolotti, P., Bony, C., Noël, D., Jørgensen, C., et al. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2607 · Cited by 25 · see citing works
Research Progress on the Immunogenicity and Regeneration of Acellular Adipose Matrix: A Mini Review
Liu, K., He, Y., & Lu, F. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.881523 · Cited by 24 · see citing works
Chen, S., Chu, C., Wang, C., Yang, Y., Xu, Z.-Y., Qu, Y., & Man, Y. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122685 · Cited by 23 · see citing works
The impact of sterilization upon extracellular matrix hydrogel structure and function
White, L. J., Keane, T. J., Smoulder, A. L., Zhang, L., Castleton, A. A., Reing, J. E., Turner, N. J., Dearth, C. L., & Badylak, S. F. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.04.001 · Cited by 23 · see citing works
Self-citationJo, Y., Hwang, S. H., & Jang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179367 · Cited by 23 · see citing works
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Steketee, M. B., van der Merwe, Y., & Faust, A. E. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217324 · Cited by 20 · see citing works
Bioengineered Lungs: A Challenge and An Opportunity
Farré, R., Otero, J., Almendros, I., & Navajas, D. (2017) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2017.09.010 · Cited by 20 · see citing works
Hogan, K. J., Smoak, M. M., Koons, G. L., Perez, M. R., Bedell, M. L., Jiang, E. Y., Young, S. W., & Mikos, A. G. (2022) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37355 · Cited by 19 · see citing works
Immunology in Osseointegration After Implantation
Liu, Y., Gao, M., Yan, Y., Wang, X., Dong, Z., Cheng, L., & Xu, Y. (2025) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35566 · Cited by 20 · see citing works
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity
García‐García, A., Pigeot, S., & Martín, I. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.12.017 · Cited by 18 · see citing works
Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
Karkanitsa, M. L., Fathi, P., Ngo, T. B., & Sadtler, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.730938 · Cited by 18 · see citing works
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Halfter, N., Espinosa‐Cano, E., Pontes-Quero, G. M., Ramírez-Jiménez, R. A., Heinemann, C., Möller, S., Schnabelrauch, M., Wiesmann, H., Hintze, V., & Aguilar, M. R. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14030160 · Cited by 16 · see citing works
Liu, C., Chen, X., Liu, Y., Sun, L. J., Yu, Z., Ren, Y., Zeng, C., & Li, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301112 · Cited by 16 · see citing works
Akbaba, S., Atila, D., Keskin, D. S., Tezcaner, T., & Tezcaner, A. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118066 · Cited by 16 · see citing works
Biomimetic matrix fabricated by LMP-1 gene-transduced MC3T3-E1 cells for bone regeneration
Ma, J., Guo, W., Gao, M., Huang, B., Qi, Q., Ling, Z., Chen, Y., Hu, H., Zhou, H., Yu, F., et al. (2017) · Biofabrication · doi:10.1088/1758-5090/aa8dd1 · Cited by 15 · see citing works
Strategies for advanced particulate bone substitutes regulating the osteo-immune microenvironment
Yang, Y., Chu, C., Xiao, W., Liu, L., Man, Y., Lin, J., & Qu, Y. (2022) · Biomedical Materials · doi:10.1088/1748-605x/ac5572 · Cited by 13 · see citing works
Kim, H., Kim, Y., Fendereski, M., Hwang, N. S.-Y., & Hwang, Y. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0947-2_9 · Cited by 15 · see citing works
Xing, Y., Varghese, B., Ling, Z., Kar, A. S., Jacome, E. R., & Ren, X. (2021) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-021-00210-5 · Cited by 14 · see citing works
Sharma, S., Rajani, S., Hui, J., Chen, A., Bivalacqua, T. J., & Singh, A. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c06865 · Cited by 14 · see citing works
Francesco, D. D., Varsavia, C. D., Casarella, S., Donetti, E., Manfredi, M., Mantovani, D., & Boccafoschi, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020740 · Cited by 12 · see citing works
Francesco, D. D., Marcello, E., Casarella, S., Copes, F., Chevallier, P., Carmagnola, I., Mantovani, D., & Boccafoschi, F. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1452965 · Cited by 14 · see citing works
Dziki, J. L., & Badylak, S. F. (2019) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-019-00106-5 · Cited by 13 · see citing works
Self-citationHoll, J., Pawlukianiec, C., Corton Ruiz, J., Groth, D., Grubczak, K., Hady, H. R., Dadan, J., Reszec, J., Czaban, S., Kowalewski, C., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122164 · Cited by 12 · see citing works
Penolazzi, L., Chierici, A., Notarangelo, M. P., Dallan, B., Lisignoli, G., Lambertini, E., Greco, P., Piva, R., & Nastruzzi, C. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37683 · Cited by 11 · see citing works
Biomaterials for Topical and Transdermal Drug Delivery in Reconstructive Transplantation
Dhayani, A., Kalita, S., Mahato, M., Srinath, P., & Vemula, P. K. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0137 · Cited by 11 · see citing works
Ji, H., Sukarto, A., Deegan, D. B., & Fan, F. (2021) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000003420 · Cited by 11 · see citing works
Clickable Biomaterials for Modulating Neuroinflammation
Cornelison, R. C., & Fadel, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158496 · Cited by 10 · see citing works
Construction of novel antimicrobial peptide-modified extracellular matrix biologic scaffold material
Liang, C., Chen, J., Zhang, Y., Wei, F., Ling, Y., & Li, X. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.002 · Cited by 10 · see citing works
Cytokine networks in immune-mediated muscle regeneration
Dziki, J. L., Velayutham, M., Hussey, G. S., & Turnquist, H. R. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.03.001 · Cited by 9 · see citing works
Self-citationPeripheral Nerve Matrix Hydrogel Promotes Recovery after Nerve Transection and Repair
Bernard, M., McOnie, R. C., Tomlinson, J. E., Blum, E., Prest, T. A., Sledziona, M., Willand, M., Gordon, T., Borschel, G. H., Soletti, L., et al. (2023) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000010261 · Cited by 9 · see citing works
Ovarian scaffolds promoted mouse ovary recovery from cyclophosphamide damage
Ma, H., Wang, Y., Liu, G., Hu, Q., Zhu, J., & Dai, Y. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.103950 · Cited by 9 · see citing works
Eps, J. L. V., Boada, C., Scherba, J. C., Zavlin, D., Arrighetti, N., Shi, A., Wang, X., Tasciotti, E., Buell, J. F., Ellsworth, W. A., et al. (2021) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3255 · Cited by 9 · see citing works
Safari, Z., Sadeghizadeh, M., Asgaritarghi, G., Bardania, H., Sadeghizadeh, D., & Soudi, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108654 · Cited by 9 · see citing works
Nguyen, H.-Q.-D., Kao, C., Chiang, C., Hung, Y.-H., & Lo, C. (2022) · Gels · doi:10.3390/gels8030187 · Cited by 8 · see citing works
Fadeeva, I. S., Teterina, A. Y., Minaychev, V. V., Сенотов, А. С., Смирнов, И. В., Фадеев, Р. С., Smirnova, P. V., Menukhov, V. O., Lomovskaya, Y. V., Акатов, В. С., et al. (2023) · Biomimetics · doi:10.3390/biomimetics8010091 · Cited by 8 · see citing works
Ledwon, J. K., Applebaum, S. A., Progri, B., Vignesh, O., Gutowski, K. S., Chang, A. B., Tepole, A. B., & Gosain, A. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113091 · Cited by 7 · see citing works
Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review
Romero, D. J., Hussey, G., & Capella-Monsonís, H. (2025) · Biologics · doi:10.3390/biologics5030028 · Cited by 7 · see citing works
“As described in the previous section, ECM bioscaffolds deliver immunomodulatory signals through retained bioactive molecules and native-like architecture that influence immune cell activation, polarization, and effector function [48,80].”
Biomaterial Strategies of Macrophage Behaviour in Bone Regeneration
Chocholata, P. K., Dvořáková, J., Babuška, V., & Čedíková, M. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00443-8 · Cited by 6 · see citing works
Advancing standard techniques for treatment of perianal fistula; when tissue engineering meets seton
Nazari, H., Soltani, Z. E., Asbagh, R. A., Sharifi, A., Badripour, A., Heirani‐Tabasi, A., Warkiani, M. E., Keramati, M. R., Behboodi, B., Fazeli, M. S., et al. (2022) · Health Sciences Review · doi:10.1016/j.hsr.2022.100026 · Cited by 6 · see citing works
Lin, Q., Zhang, X., Yang, D., Liu, C.-H., Huleihel, L., Remlinger, N. T., Gilbert, T. W., & Di, Y. P. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01090 · Cited by 6 · see citing works
Self-citationDuran, P., Sesillo, F. B., Burnett, L. A., Menefee, S. A., Cook, M. S., Zazueta‐Damian, G., Dzieciątkowska, M., Do, E., French, S., Shah, M. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.28.446170 · Cited by 6 · see citing works
Macrophage response to biomaterials
Barbosa, J. N., & Vasconcelos, D. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102967-1.00003-7 · Cited by 5 · see citing works
Preclinical evaluation of a novel antibiotic-eluting BioEnvelope for CIED infection prevention
Garrigos, Z. E., Catanzaro, J. N., Deegan, D. F., Ji, Z., & Sohail, M. R. (2024) · Frontiers in Drug Delivery · doi:10.3389/fddev.2024.1441956 · Cited by 5 · see citing works
Iwasaki, N., Roldo, M., Karali, A., & Blunn, G. W. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213873 · Cited by 4 · see citing works
Tissue-engineered cardiovascular products
Taylor, D. A., Hochman‐Mendez, C., Huelsmann, J., Elgalad, A., & Sampaio, L. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00084-8 · Cited by 4 · see citing works
- Authors
- Dziki, J. L., Huleihel, L., Scarritt, M. E., & Badylak, S. F.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Badylak, Stephen F.
- ORCID
- Badylak, Stephen F.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2017-10
- Volume
- 23
- Issue
- 19-20
- Pages
- 1152-1159
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- PMC
- PMC6112165
- OpenAlex
- W2607766702
- Cited by
- 141
- References
- 94
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 17 · 2022: 21 · 2021: 28 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 6
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Tissue Engineering Part A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R21EB017184)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- immunomodulation, immune response, tissue engineering, organ transplantation
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Immunologic Factors, Immunosuppression Therapy, Organ Transplantation, Tissue Scaffolds
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