Cited by 141Tissue Engineering and Regenerative MedicineBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

Open access
Dziki, Jenna L., Huleihel, Luai, Scarritt, Michelle E., Badylak, Stephen F.·2017·Tissue Engineering Part A

Abstract

Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.

Integrity signals

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Crossref · 10.1089/ten.tea.2016.0538

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94 of 94 references verified0 citation errors · 0 not checkable

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  • ECM bioscaffolds deliver immunomodulatory signals through retained bioactive molecules and native-like architecture that influence immune cell activation, polarization, and effector function.

    “As described in the previous section, ECM bioscaffolds deliver immunomodulatory signals through retained bioactive molecules and native-like architecture that influence immune cell activation, polarization, and effector function [48,80].”

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Authors
Dziki, J. L., Huleihel, L., Scarritt, M. E., & Badylak, S. F.
Affiliations
University of Pittsburgh (US)
Corresponding author
Badylak, Stephen F.
Venue
Tissue Engineering Part A
Published
2017-10
Volume
23
Issue
19-20
Pages
1152-1159
ISSN
  • 1937-3341 (ISSN-L)
  • 1937-335X
OpenAlex
W2607766702
Cited by
141
References
94
Citations by year
2026: 9 · 2025: 13 · 2024: 14 · 2023: 17 · 2022: 21 · 2021: 28 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 6
FWCI
10.93
Type
journal article
Language
en
Open access
Locations
  • Tissue Engineering Part A (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Biomedical Imaging and Bioengineering (R21EB017184)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
immunomodulation, immune response, tissue engineering, organ transplantation
MeSH terms
Animals, Biocompatible Materials, Extracellular Matrix, Humans, Immunologic Factors, Immunosuppression Therapy, Organ Transplantation, Tissue Scaffolds

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