Free radical-decellularized tissue promotes enhanced antioxidant and anti-inflammatory macrophage response
Open accessAbstract
Oxidative stress leads to the progression of many diseases including chronic wounds, atherosclerosis, stroke and cancer. The modification of biomolecules with reactive nitrogen or oxygen species has been shown to trigger oxidative stress pathways that are beneficial for healing. Extracellular matrix scaffolds have been used successfully in reconstructive applications due to the beneficial host response they induce. To tailor extracellular matrix scaffolds to enhance antioxidant response, ECM were prepared using reactive nitrogen or oxygen species. These scaffolds were shown to be effectively decellularized and possess oxidative or nitroxidative protein modifications. Macrophage responses in vitro and in an in vivo muscle injury model were shown to have enhanced antioxidant phenotypes without impairment of long-term remodeling. These observations suggest that ECM decellularized with reactive oxygen or nitrogen species could provide better outcomes for the treatment of ischemic diseases.
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Acids such as PAA, HCl, and acetic acid, via proton donation and covalent interactions, are capable of disrupting ECM components and structure.
“Acids such as PAA, HCl, and acetic acid, via proton donation and covalent interactions, are capable of disrupting ECM components and structure.”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [76]
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Bhattacharya, T., Kundu, M., Patil, P. D., Bhattacharya, I., Sibi, N. P., Sahu, A., Sarkar, S., Sreedhar, R., & Arumugam, S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107618
Wu, S., Xu, W., 姚佳倩, Li, R., Yang, Y., Jin, J., Peng, X., Liu, W., Xu, Z., Mi, A., et al. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05106-1
- Authors
- LoPresti, S. T., Popovic, B., Kulkarni, M., Skillen, C. D., & Brown, B. N.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Brown, B.N.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 222
- Pages
- 119376
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2962963522
- Cited by
- 24
- References
- 73
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 3
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomaterials (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Science Foundation
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- extracellular matrix scaffolds, decellularization, reactive oxygen species, reactive nitrogen species, oxidative stress, macrophage response, antioxidant response, anti-inflammatory response, muscle damage, tissue remodeling, ischemic diseases, chronic wounds
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Cells, Cultured, Extracellular Matrix, Free Radicals, Immunohistochemistry, Macrophages, Mice, Inbred C57BL, Phagocytosis, Swine, Urea, Reactive Oxygen Species, Fluorescent Antibody Technique, Indirect, Reactive Nitrogen Species, Tissue Scaffolds
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