The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers
Abstract
Nanotechnology enables the creation of delivery vehicles able to overcome physiologically imposed barriers, allowing new approaches for reducing the unwanted side effects of systemic delivery of drug, increasing targeting efficiency and so improving therapy efficacy. Owing to the considerable advances in material sciences and pharmaceutics, a broad range of different inorganic or organic drug nanocarriers have been developed. Furthermore, researchers have shown that the combination of inorganic and organic chemistries in one single material, named metal-organic framework (MOF), offers structural designability at the molecular level together with tunable porosity and chemical functionalisability. While the MOF size can be controlled at the nanometer scale, these features are of paramount interest in the development of the next generation of drug delivery systems. After a short state-of-the-art about MOF technology and within the drug delivery context, this paper discusses the benefits of using MOF nanoparticles compared to dendrimers and mesoporous silica nanoparticles in order to understand the challenges that must still be overcome.
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“However, the limitations of physiological instability and the cytotoxicity of MOFs from toxic metal ions have limited their drug delivery applications.124”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [124]
Citations
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Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions
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Metadata
- Authors
- Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J.
- Affiliations
- Center for NanoScience (DE)
- University of Liège (BE)
- Philipps University of Marburg (DE)
- Kavli Energy NanoScience Institute (US)
- Corresponding author
- Wuttke, Stefan
- Parak, Wolfgang J.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 123
- Pages
- 172-183
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2580236852
- Cited by
- 286
- References
- 196
- Citations by year
- 2026: 13 · 2025: 30 · 2024: 15 · 2023: 24 · 2022: 22 · 2021: 31 · 2020: 32 · 2019: 50 · 2018: 54 · 2017: 15
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Deutsche Forschungsgemeinschaft (WU 622/4-1)
- University of Liège, Belgium (CRA2015)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Organic Frameworks: Synthesis and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Keywords
- metal-organic frameworks, drug delivery, mesoporous silica nanoparticles, dendrimers, drug nanocarriers, nanoparticle drug delivery, tunable porosity, chemical functionalization, targeted drug delivery
- MeSH terms
- Metal-Organic Frameworks, Diffusion, Particle Size, Silicon Dioxide, Porosity, Dendrimers, Nanocapsules, Nanopores, Absorption, Physicochemical
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