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Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
Open accessAbstract
mRNA-based vaccines have the benefit of triggering robust anti-cancer immunity without the potential danger of genome integration from DNA vaccines or the limitation of antigen selection from peptide vaccines. Yet, a conventional mRNA vaccine comprising of condensed mRNA molecules in a positively charged protein core structure is not effectively internalized by the antigen-presenting cells. It cannot offer sufficient protection for mRNA molecules from degradation by plasma and tissue enzymes either. Here, we have developed a lipopolyplex mRNA vaccine that consists of a poly-(β-amino ester) polymer mRNA core encapsulated into a 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine/1,2-dioleoyl-sn-glycero-3-phosphatidyl-ethanolamine/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000 (EDOPC/DOPE/DSPE-PEG) lipid shell. This core-shell structured mRNA vaccine enters dendritic cells through macropinocytosis. It displayed intrinsic adjuvant activity by potently stimulating interferon-β and interleukin-12 expression in dendritic cells through Toll-like receptor 7/8 signaling. Dendritic cells treated with the mRNA vaccine displayed enhanced antigen presentation capability. Mice bearing lung metastatic B16-OVA tumors expressing the ovalbumin antigen were treated with the lipopolyplex mRNA, and over 90% reduction of tumor nodules was observed. Collectively, this core-shell structure offers a promising platform for mRNA vaccine development.
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“The findings of this study revealed that, compared with naked PbAE-mRNA, cellular transfection efficiency was greatly improved when LPP-coated PbAE-mRNA was used.”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [326]
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“Moreover, this LPP-based mRNA vaccine exhibited intrinsic adjuvant activity, which stimulates dendritic cells (DCs) to secrete cytokines and inhibit tumor growth by activating the TLR7/8 signaling pathway, resulting in a significant antitumor activity.”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [326]
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Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,496
Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
Kantoff, P. W., Higano, C. S., Shore, N. D., Berger, E. R., Small, E. J., Penson, D. F., Redfern, C. H., Ferrari, A. C., Dreicer, R., Sims, R. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001294 · Cited by 5,572
Neoantigens in cancer immunotherapy
Schumacher, T. N., & Schreiber, R. D. (2015) · Science · doi:10.1126/science.aaa4971 · Cited by 4,783
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,819
A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
Carreno, B. M., Magrini, V., Becker-Hapak, M., Kaabinejadian, S., Hundal, J., Petti, A. A., Ly, A., Lie, W.-R., Hildebrand, W. H., Mardis, E. R., et al. (2015) · Science · doi:10.1126/science.aaa3828 · Cited by 1,285
CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO
Trombetta, E. S., & Mellman, I. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104538 · Cited by 1,226
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
Yadav, M., Jhunjhunwala, S., Phung, Q. T., Lupardus, P., Tanguay, J., Bumbaca, S., Franci, C., Cheung, T. K., Fritsche, J., Weinschenk, T., et al. (2014) · Nature · doi:10.1038/nature14001 · Cited by 1,186
gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma
Schwartzentruber, D. J., Lawson, D. H., Richards, J. M., Conry, R. M., Miller, D. M., Treisman, J. S., Gailani, F., Riley, L. B., Conlon, K. C., Pockaj, B. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1012863 · Cited by 935
Research works printed but not linked: 1
- Fotin-Mleczek, 2011, Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity, J. Immunother. (Hagerstown, Md 1997), 34, 1
Cited by
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Items 101–187 of 187
Huang, L., Zhao, F., He, M., Fang, Y., Ma, X., Lu, S., Li, E., Xiao, H. Q., Zhu, H., Wang, X., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.002 · Cited by 23
Self-citationZhang, S.-W., Wang, H., Ding, X., Xiao, Y.-L., Shao, Z.-M., You, C., Gu, Y., & Jiang, Y. (2022) · Fundamental Research · doi:10.1016/j.fmre.2022.03.009 · Cited by 23
Nanoparticles for immunotherapy
Anfray, C., Mainini, F., & Andón, F. T. (2020) · Frontiers of nanoscience · doi:10.1016/b978-0-08-102828-5.00011-5 · Cited by 21
The main battlefield of mRNA vaccine – Tumor immune microenvironment
Li, X., Ma, S., Gao, T., Mai, Y., Song, Z., & Yang, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109367 · Cited by 22
DNA-based nanostructures for RNA delivery
Wu, Y., Luo, L., Hao, Z., & Liu, D. (2024) · Medical Review · doi:10.1515/mr-2023-0069 · Cited by 23
Virus‐Mimic mRNA Vaccine for Cancer Treatment
Meng, C., Chen, Z., Mai, J., Shi, Q., Tian, S., Hinkle, L. E., Li, J., Zhang, Z., Ramirez, M., Zhang, L., et al. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100144 · Cited by 21
Self-citationEmerging lipid–polymer hybrid nanoparticles for genome editing
Gameiro, M. D., Mano, J. F., & Gaspar, V. M. (2024) · Polymer Chemistry · doi:10.1039/d4py00298a · Cited by 22
Hou, Y., Tang, Z., Farheen, J., Saeed, M., Luo, L., Ren, W., Luo, D., Mushtaq, A., Zhao, R., Ge, J., et al. (2023) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.11.024 · Cited by 18
mRNA therapeutics for disease therapy: principles, delivery, and clinical translation
Zhou, D., Wang, K., Zhang, Y., Ma, K., Yang, X., Li, Z.-Y., Yu, S., Chen, K., & Qiao, S. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02782h · Cited by 18
Self-citationmRNA delivery systems 2.0: Engineering extrahepatic delivery for non-vaccine therapeutics
Dalabehera, M., Ghosh, A., Mohanty, S., Chellappan, D. K., Chaudhari, S., Ale, Y., Poonia, N., Subudhi, R. N., Khanna, M., & Lim, H. G. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102584 · Cited by 22
mRNA-based personalized cancer vaccines: opportunities, challenges and outcomes
Ibragimova, A. A., Fedorov, A. A., Kirilenko, K. M., Чойнзонов, Е. Л., Denisov, E. V., & Patysheva, M. R. (2025) · Acta Naturae · doi:10.32607/actanaturae.27707 · Cited by 14
Recent Advances in Messenger Ribonucleic Acid (mRNA) Vaccines and Their Delivery Systems: A Review
Belay, W. Y., Nibret, G., & Aschale, Y. (2023) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s418314 · Cited by 16
Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
Du, P., Huang, L., Fang, Y., Zhao, F., Li, Q., Ma, X., Li, R., Chen, Q., Shen, H., Wang, Q., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012116 · Cited by 13
Self-citationShi, J., Yin, H., Sun, Q., Teng, R., Zhu, Y., & Du, J. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.4c00219 · Cited by 14
Rational design of polymer-based mRNA delivery systems for cancer treatment
Wan, Q., Sun, Y., Sun, X., & Zhou, Z. (2024) · Polymer Chemistry · doi:10.1039/d4py00206g · Cited by 15
Advances in Development of mRNA-Based Therapeutics
Huang, L., Zhang, L., Li, W., Li, S., Wen, J., Li, H., & Liu, Z. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_222 · Cited by 16
Toudeshkchouei, M. G., Tavakoli, A., Mohammadghasemi, H., Karimi, A., Ai, J., Rabiee, M., & Rabiee, N. (2022) · Future Medicinal Chemistry · doi:10.4155/fmc-2022-0027 · Cited by 15
Perche, F., Gall, T. L., Montier, T., Pichon, C., & Malinge, J. (2019) · Pharmaceuticals · doi:10.3390/ph12020081 · Cited by 14
Mimicking Pathogens to Augment the Potency of Liposomal Cancer Vaccines
Twilhaar, M. K. N., Czentner, L., van Nostrum, C. F., Storm, G., & den Haan, J. M. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070954 · Cited by 13
Instigation of the epoch of nanovaccines in cancer immunotherapy
Shah, S., Famta, P., Tiwari, V. K., Kotha, A. K., Kashikar, R., Chougule, M. B., Chung, Y. H., Steinmetz, N. F., Uddin, M. N., Singh, S. B., et al. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1870 · Cited by 14
Stability Criterion for the Assembly of Core–Shell Lipid–Polymer–Nucleic Acid Nanoparticles
Paris, J. L., Gaspar, R., Coelho, F., Beule, P. D., & Silva, B. F. B. (2023) · ACS Nano · doi:10.1021/acsnano.3c07204 · Cited by 13
Wang, B., Peng, X.-B., Li, J., Wang, Y.-R., Chen, L.-P., Wu, M.-H., Zhang, Y.-Y., Wang, W., Feng, D., Tang, S.-H., et al. (2024) · American Journal of Cancer Research · doi:10.62347/nvfb3780 · Cited by 12
CAR T Cell Nanosymbionts: Revealing the Boundless Potential of a New Dyad
Baena, J. C., Pérez, L. M., Toro-Pedroza, A., Kitawaki, T., & Loukanov, A. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313157 · Cited by 13
Lu, T., Xu, R., Wang, C., Zhao, J., Peng, B., Wang, J., & Zhang, L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.853113 · Cited by 12
Piperazine-derived ionizable lipids for enhanced mRNA delivery and cancer immunotherapy
Xu, K. J., Xu, Y., Sun, J., Cheng, X., Lu, C., Chen, W., He, B., & Jiang, T. (2024) · Nano Research · doi:10.1007/s12274-024-6575-8 · Cited by 11
Pharmaceutical strategies for optimized mRNA expression
Shi, Y., Mao, J., Wang, S., Ma, S., Luo, L., & You, J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122853 · Cited by 11
An mRNA vaccine induces antimycobacterial immunity by activating DNA damage repair and autophagy
Chen, D., Huang, W., Shen, L., Zhang, J., Pan, Z., Zhang, C., Tang, Y., Zhou, Z., Tao, J., Luo, G., et al. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102402 · Cited by 10
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Lu, H., Xiao, J., Song, J., Song, Y., Li, H., Ren, H., Li, J., Cong, R., Li, H., Fang, Y., et al. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70201 · Cited by 9
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Gabelmann, A., Mansouri-Ghahnavieh, E., Koch, M., Shinde, P. V., Guzmán, C. A., Loretz, B., & Lehr, C. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113875 · Cited by 9
Paris, J. L., Coelho, F., Teixeira, A., Diéguez, L., Silva, B. F. B., & Abalde‐Cela, S. (2020) · Molecules · doi:10.3390/molecules25143277 · Cited by 10
Developing Vaccines in Pancreatic Adenocarcinoma: Trials and Tribulations
Phan, T. X., Fan, D., & Melstrom, L. G. (2024) · Current Oncology · doi:10.3390/curroncol31090361 · Cited by 9
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Liu, X., Li, Y., Liu, X., Huang, Y., Wang, F., Li, J., Guo, Y., Zhu, X., Zhu, L., & Zhang, C. (2025) · Small Methods · doi:10.1002/smtd.202401286 · Cited by 8
Zhang, Y., Li, J., Wang, Z., Kuang, Y., Li, S., & Wang, X. (2025) · Animal Diseases · doi:10.1186/s44149-025-00186-7 · Cited by 9
Poly(beta-amino esters): applications in immunology
Bayraktutan, H., Kopiasz, R. J., Elsherbeny, A., Gurnani, P., & Alexander, C. (2025) · Chemical Science · doi:10.1039/d5sc05951h · Cited by 9
Cellular functions and biomedical applications of circular RNAs
Zhang, Z., & Wang, Z. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024241 · Cited by 9
Willemen, Y., Versteven, M., Peeters, M., Berneman, Z. N., & Smits, E. (2020) · Cancers · doi:10.3390/cancers12020299 · Cited by 8
Challenges and opportunities of nanotechnology in cancer immunotherapy
Lee, D., Huntoon, K. M., Jiang, W., & Kim, B. Y. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90949-5.00024-3 · Cited by 8
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Zhao, M., Zhou, L., Zhai, Y., Sun, A., Shao, G., & Lin, Q. (2025) · Biomolecules · doi:10.3390/biom15070936 · Cited by 8
Current status of vaccine immunotherapy for gastrointestinal cancers
Suzuki, N., Shindo, Y., Nakajima, M., Tsunedomi, R., & Nagano, H. (2023) · Surgery Today · doi:10.1007/s00595-023-02773-y · Cited by 7
Advances in Therapeutic Cancer Vaccines, Their Obstacles, and Prospects Toward Tumor Immunotherapy
Eskandari, A., Leow, T. C., Rahman, M. B. A., & Oslan, S. N. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01144-3 · Cited by 7
Multicompartmental Lipopolyplex as Vehicle for Antigens and Genes Delivery in Vaccine Formulations
Santos, I. S., Sendra, L., Moret, I., Herrero, M. J., & Aliño, S. F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020281 · Cited by 7
Engineering Delivery Technologies for Optimizing mRNA Vaccines
Gu, T., Yan, X., & Liu, S. (2025) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00032 · Cited by 7
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Li, S., Wu, J., Li, X., Chen, J., & Wang, C. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.110720 · Cited by 6
Meade, E., & Garvey, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178307 · Cited by 5
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Khan, M., Taira, O., Shi, X., Wang, H., & Cai, X. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152950 · Cited by 5
Wang, T., Han, R., Hao, Z., Cheng, X., Li, J., Zhai, C., Guo, J., Wang, D., Deng, Y., Zhang, L., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102787 · Cited by 5
Song, S., Liu, Z., Guo, L., Wang, Y., Liu, H., Yang, M., & Chen, G. (2024) · Journal of Flow Chemistry · doi:10.1007/s41981-024-00316-1 · Cited by 5
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Huang, J., Song, W., Meng, L., Shen, Y., & Zhou, R. (2022) · Nanoscale · doi:10.1039/d1nr07897f · Cited by 5
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Tabasi, H., Mollazadeh, S., Fazeli, E., Abnus, K., Taghdisi, S. M., Ramezani, M., & Alibolandi, M. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04597-5 · Cited by 5
Kruse, S., Fricke, L. T., Zottnick, S., Schlösser, A., Grabowska, A. K., Feidt, E., Uhl, P., Junglas, E., Förster, J. D., Blersch, J., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2548002 · Cited by 4
Zhai, Q., Wang, Z., Tang, H., Hu, S., Chen, M., & Ji, P. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101212 · Cited by 4
Küçük, H. B., Yaşa, H., Yıldız, T., & YUSUFOĞLU, A. S. (2017) · Synthetic Communications · doi:10.1080/00397911.2017.1364768 · Cited by 4
Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme
Wang, Y., & Yu, C. (2020) · Angewandte Chemie · doi:10.1002/ange.202003545 · Cited by 4
Roy, A. A., Jain, N., Pokale, R., Madhusoodanan, G., Mukharya, A., Farhana, S. A., Rao, B. S. S., Goda, J. S., & Mutalik, S. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126862 · Cited by 4
Ren, C., Cui, X., Wang, H., Jin, C., Gao, L., Li, Y., Wang, W., Yao, T., Zhang, D., Feng, Y., et al. (2025) · Immunology Letters · doi:10.1016/j.imlet.2025.106977 · Cited by 3
Targeting Toll-Like Receptors for the Treatment of Lung Cancer
Rawat, S., Dhaundhiyal, K., Dhramshaktu, I. S., Hussain, M. S., & Gupta, G. (2024) · Springer eBooks · doi:10.1007/978-981-99-7141-1_13 · Cited by 2
Shan, X., Han, R., Cheng, X., Bing, J., Qi, Z., Sun, S., Wang, T., Chu, Q., Deng, Y., Zhai, D., et al. (2025) · Vaccines · doi:10.3390/vaccines13010093 · Cited by 2
Nanomaterials-enabled mRNA delivery for Cancer immunotherapy
Chen, Y., Liang, S., Peng, Y., Ma, K., Yun, K., Ma, X., Hai, L., Mei, L., Wang, L., & Wang, Z. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216945 · Cited by 2
Matrices Activated with Messenger RNA
Martinez-Campelo, R., & García-Fuentes, M. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14010048 · Cited by 2
Nanoparticles for mRNA-based cancer immunotherapy
Pahwa, R., Sharma, G., Panwar, R., & Mishra, N. (2025) · Advances in immunology · doi:10.1016/bs.ai.2024.10.012 · Cited by 1
Neoantigen mRNA Cancer Vaccines: How Deep Learning Is Advancing Design and Breaking Barriers
Ismail, S., & Barakat, K. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1011567 · Cited by 1
Cancer-Immunity Cycle-Based Smart Nucleic Acid Nanodrugs for Potentiated Immunotherapy
Wu, B., Chen, J., Jiang, L., Zhao, Z., Shan, X., Ouyang, C., Jiang, P., Tong, X., Lü, Y., Zhang, J., et al. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00202 · Cited by 1
Sun, S., Deng, Y., Ren, J., Xiaotian, H., Bing, J., Wang, T., Hao, Z., Tian, H., Zhang, L., & Tan, W. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00412-9 · Cited by 1
Kaplan, Ö., Bal, K., Çeli̇k, S. K., Tosun, N. G., & Gök, M. K. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108276 · Cited by 1
Kaplan, Ö., TUNCEL, N., Bal, K., Çeli̇k, S. K., & Gök, M. K. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108438 · Cited by 1
Mao, M., Zhang, Z., Wei, H. Y., & Wang, Z. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2023-0315 · Cited by 1
Xia, Q., Jing, Q., Lu, C., Guo, X., Chen, X., Tang, C., Han, J., Wang, H., Dong, Y., Fang, P., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124350 · Cited by 1
Nanotechnology in Generation and Biomedical Application of Induced Pluripotent Stem Cells
Tang, H., Rui, M., Yu, C., Chu, T., Li, C., Zhan, Z., Cao, H., Li, H., Liu, Z., & Shen, H. (2018) · Nano LIFE · doi:10.1142/s1793984418410027 · Cited by 1
Self-citationDevelopment of biomaterial porous scaffolds for dendritic cell modulation and mRNA delivery
Chen, R. (2017) · ResearchWorks at the University of Washington (University of Washington)
Designed synthesis of silica based nanocarriers for mRNA delivery
Wang, Y. (2020) · The University of Queensland · doi:10.14264/b28d1e7
The mRNA Technology in Cancer Immunotherapy
Persano, F., Leporatti, S., Persano, S., Guevara, M. L., & Gigli, G. (2022) · Current Nanomaterials · doi:10.2174/2405461507666220131110055
Self-citationLipid Nanoparticles to Harness the Therapeutic Potential of mRNA for Cancer Treatment
Guevara, M. L., Persano, F., & Persano, S. (2022) · RNA technologies · doi:10.1007/978-3-031-08415-7_14
Self-citationMessenger RNA Nanovaccine in Cancer Immunotherapy
Li, M., & Zhang, H. (2022) · Springer eBooks · doi:10.1007/978-3-031-17831-3_9
mRNA vaccines: a promising solution for incurable diseases
Ge, H., Hei, Y., & Wu, J. (2024) · International Conference on Biological Engineering and Medical Science (ICBioMed) · doi:10.1117/12.3021657
Allen, R., & Saeui, C. T. (2023) · Vaccine Insights · doi:10.18609/vac/2023.55
Generation and Characterization of In Vitro Transcribed mRNA
Poveda, C., Chen, Y., & Strych, U. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3770-8_6
Wang, T., Han, R., Hao, Z., Cheng, X., Li, J., Zhai, C., Wang, D., Deng, Y. L., Zhang, L., & Tan, W. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5083848
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Zheng, X., Manshian, B. B., & Soenen, S. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-14064-8.00039-4
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Shen, Y.-M., Wan, F., Xu, H., Yu, L., Huang, S., Ye, D., & Dai, B. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189427
Yadava, S. K., Tripathi, A., Kabilan, M., Champion, J. A., & Cicerone, M. T. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114312 · Cited by 1
Huang, H., Yi, X., Wei, Q., Li, M., Cai, X., Lv, Y., Weng, L., Mao, Y., Fan, W., Zhao, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26566451
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Chu, T.-H., Huynh, T. L., & Phuong, L.-T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1818121
Elumalai, S., Jujjuri, L., Das, A., P, V. K., & Maji, S. (2026) · Innovation of Chemistry & Materials for Sustainability · doi:10.63654/icms.2026.03029
Wang, X., Wang, A., Huang, W., Tian, P., Cao, L., Xiao, B., Han, J., Huang, Z., & Jiang, L. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01850-5
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Nagapurkar, S., & Chatterjee, B. (2026) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266379726251115040906
Meng, H., Fu, B., Liang, M., 王俏镟, 刘星浦, Li, M., Hu, Q., Duan, Y., & Gao, C. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71571
Metadata
- Authors
- Persano, S., Guevara, M. L., Li, Z., Mai, J., Ferrari, M., Pompa, P. P., & Shen, H.
- Affiliations
- Houston Methodist (US)
- Italian Institute of Technology (IT)
- Corresponding author
- Shen, Haifa
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 125
- Pages
- 81-89
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC5378555
- OpenAlex
- W2589539207
- Cited by
- 187
- References
- 43
- Citations by year
- 2026: 10 · 2025: 26 · 2024: 30 · 2023: 28 · 2022: 26 · 2021: 18 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 4
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 296 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biomaterials (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1R01CA193880-01A1, U54CA210181)
- U.S. Department of Defense (W81XWH-12-1-0414)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- mRNA vaccines, lipopolyplexes, poly(β-amino ester), core-shell nanoparticles, dendritic cells, macropinocytosis, interferon-beta, IL-12, antigen presentation, lung metastasis, B16-OVA tumor, antitumor immunity, vaccine adjuvants, lipid shell
- MeSH terms
- Animals, Drug Synergism, Female, Liposomes, Male, Mice, Inbred C57BL, Neoplasms, Experimental, RNA, Messenger, Transfection, Treatment Outcome, Cancer Vaccines, Cell Line, Tumor, Mice
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