Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728 · see citing works

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.200 · Cited by 1,930 · see citing works

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,771 · see citing works

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Karikó, K., Muramatsu, H., Ludwig, J., & Weissman, D. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr695 · Cited by 898 · see citing works

Development and Function of Dendritic Cell Subsets

Mildner, A., & Jung, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.016 · Cited by 762 · see citing works

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Kormann, M. S. D., Hasenpusch, G., Aneja, M. K., Nica, G., Flemmer, A. W., Herber-Jonat, S., Huppmann, M., Mays, L. E., Illenyi, M., Schams, A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1733 · Cited by 733 · see citing works

N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Andries, O., Mc Cafferty, S., De Smedt, S. C., Weiss, R., Sanders, N. N., & Kitada, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.051 · Cited by 701 · see citing works

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Anderson, B. R., Muramatsu, H., Nallagatla, S. R., Bevilacqua, P. C., Sansing, L. H., Weissman, D., & Karikó, K. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq347 · Cited by 682 · see citing works

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2682 · Cited by 646 · see citing works

Type I Interferon in the Pathogenesis of Lupus

Crow, M. K. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1002795 · Cited by 565 · see citing works

Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

Midoux, P., & Monsigny, M. L. P. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801070 · Cited by 503 · see citing works

Faithful activation of an extra‐bright red fluorescent protein in “knock‐in” Cre‐reporter mice ideally suited for lineage tracing studies

Luche, H., Weber, O., Nageswara Rao, T., Blum, C., & Fehling, H. J. (2007) · European Journal of Immunology · doi:10.1002/eji.200636745 · Cited by 482 · see citing works

Colorimetric determination of neutral sugars by a resorcinol sulfuric acid micromethod

Monsigny, M. L. P., Petit, C., & Roche, A. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90578-7 · Cited by 370 · see citing works

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

Anderson, B. R., Muramatsu, H., Jha, B. K., Silverman, R. H., Weissman, D., & Kariko, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr586 · Cited by 356 · see citing works

Polyfunctional responses by human T cells result from sequential release of cytokines

Han, Q., Bagheri, N., Bradshaw, E. M., Hafler, D. A., Lauffenburger, D. A., & Love, J. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117194109 · Cited by 329 · see citing works

Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma

Wilgenhof, S., Corthals, J., Heirman, C., van Baren, N., Lucas, S., Kvistborg, P., Thielemans, K., & Neyns, B. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.4121 · Cited by 312 · see citing works

Systemic delivery of factor IX messenger RNA for protein replacement therapy

Ramaswamy, S., Tonnu, N., Tachikawa, K., Limphong, P., Vega, J. B., Karmali, P. P., Chivukula, P., & Verma, I. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619653114 · Cited by 301 · see citing works

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Stadler, C. R., Bähr-Mahmud, H., Celik, L., Hebich, B., Roth, A. S., Roth, R. P., Karikó, K., Türeci, Ö., & Sahin, U. (2017) · Nature Medicine · doi:10.1038/nm.4356 · Cited by 290 · see citing works

Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin

Karikó, K., Muramatsu, H., Keller, J. M., & Weissman, D. (2012) · Molecular Therapy · doi:10.1038/mt.2012.7 · Cited by 282 · see citing works

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Svitkin, Y. V., Cheng, Y. M., Chakraborty, T., Presnyak, V., John, M., & Sonenberg, N. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx135 · Cited by 278 · see citing works

Nanotoxicity: A Key Obstacle to Clinical Translation of siRNA-Based Nanomedicine

Xue, H. Y., Liu, S., & Wong, H. L. (2014) · Nanomedicine · doi:10.2217/nnm.13.204 · Cited by 251 · see citing works

Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-β In Vivo

Lienenklaus, S., Cornitescu, M., Ziętara, N., Łyszkiewicz, M., Gekara, N. O., Jabłońska, J., Edenhofer, F., Rajewsky, K., Bruder, D., Hafner, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804277 · Cited by 238 · see citing works

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

Perche, F., Benvegnu, T. J., Berchel, M., Lebegue, L., Pichon, C., Jaffrès, P., & Midoux, P. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.12.010 · Cited by 219 · see citing works

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

Lint, S. V., Goyvaerts, C., Maenhout, S. K., Goethals, L., Disy, A., Benteyn, D., Pen, J. J., Bonehill, A., Heirman, C., Breckpot, K., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2957 · Cited by 210 · see citing works

Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems

Rezaee, M., Oskuee, R. K., Nassirli, H., & Malaekeh-Nikouei, B. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.023 · Cited by 200 · see citing works

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

ZHANG, J., LIU, F., & Huang, L. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.004 · Cited by 195 · see citing works

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

Kauffman, K. J., Mir, F. F., Jhunjhunwala, S., Kaczmarek, J. C., Hurtado, J. E., Yang, J. H., Webber, M. J., Kowalski, P. S., Heartlein, M. W., DeRosa, F., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.006 · Cited by 191 · see citing works

Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.

Wang, Y.-H., Su, H.-H., Yang, Y., Hu, Y.-X., Zhang, L., Blancafort, P., & Huang, L. (2013) · Molecular Therapy · doi:10.1038/mt.2012.250 · Cited by 189 · see citing works

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

Bonehill, A., Tuyaerts, S., Nuffel, A. M. T. V., Heirman, C., Bos, T. J., Fostier, K., Neyns, B., & Thielemans, K. (2008) · Molecular Therapy · doi:10.1038/mt.2008.77 · Cited by 185 · see citing works

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

Donovan, J., Dufner, M., & Korennykh, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218528110 · Cited by 163 · see citing works

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

Zatsepin (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s106625 · Cited by 162 · see citing works

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

Mockey, M., Bourseau, E., Voshavar, C., Chaudhuri, A., Lafosse, S., Cam, É. L., Quesniaux, V. F. J., Ryffel, B., Pichon, C., & Midoux, P. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701072 · Cited by 161 · see citing works

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Broos, K., Van der Jeught, K., Puttemans, J., Goyvaerts, C., Heirman, C., Dewitte, H., Verbeke, R., Lentacker, I., Thielemans, K., & Breckpot, K. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.38 · Cited by 121 · see citing works

Optimizing Cardiac Delivery of Modified mRNA

Sultana, N., Magadum, A., Hadas, Y., Kondrat, J., Singh, N., Youssef, E., Calderon, D., Chepurko, E., Dubois, N. C., Hajjar, R. J., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.016 · Cited by 114 · see citing works

Recent advances on the immunomodulatory effects of IFN-α: Implications for cancer immunotherapy and autoimmunity

Rizza, P., Moretti, F., & Belardelli, F. (2010) · Autoimmunity · doi:10.3109/08916930903510880 · Cited by 108 · see citing works

Synthesis and Transfection Activity of New Cationic Phosphoramidate Lipids: High Efficiency of an Imidazolium Derivative

Mével, M., Breuzard, G., Yaouanc, J., Clément, J., Lehn, P., Pichon, C., Jaffrès, P., & Midoux, P. (2008) · ChemBioChem · doi:10.1002/cbic.200700727 · Cited by 90 · see citing works

Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula

Lint, S. V., Wilgenhof, S., Heirman, C., Corthals, J., Breckpot, K., Bonehill, A., Neyns, B., & Thielemans, K. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1558-3 · Cited by 89 · see citing works

Cross-dressed CD8α + /CD103 + dendritic cells prime CD8 + T cells following vaccination

Li, L., Kim, S., Herndon, J. M., Goedegebuure, P. S., Belt, B. A., Satpathy, A. T., Fleming, T. P., Hansen, T. H., MURPHY, K. M. M., & Gillanders, W. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203468109 · Cited by 79 · see citing works

Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

Bialkowski, L., van Weijnen, A., der Jeught, K. V., Renmans, D., Daszkiewicz, L., Heirman, C., Stangé, G. M., Breckpot, K., Aerts, J. L., & Thielemans, K. (2016) · Scientific Reports · doi:10.1038/srep22509 · Cited by 79 · see citing works

Type I and III Interferon in the Gut: Tight Balance between Host Protection and Immunopathology

Pott, J., & Stockinger, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00258 · Cited by 58 · see citing works

Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection

Gonçalves, C., Berchel, M., Gosselin, M.-P., Malard, V., Cheradame, H., Jaffrès, P., Guégan, P., Pichon, C., & Midoux, P. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.005 · Cited by 51 · see citing works

Antigen Specific In Vivo Killing Assay using CFSE Labeled Target Cells

Durward, M., Harms, J. S., & Splitter, G. A. (2010) · Journal of Visualized Experiments · doi:10.3791/2250 · Cited by 39 · see citing works

Toll like receptor mediated immune stimulation can be visualized in vivo by [ 18 F]FDG-PET

Pektor, S., Bausbacher, N., Otto, G., Lawaczeck, L., Grabbe, S., Schreckenberger, M., & Miederer, M. (2016) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2016.07.004 · Cited by 14 · see citing works

Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

Barbeau, J., Lemiègre, L., Quelen, A., Malard, V., Gao, H., Gonçalves, C., Berchel, M., Jaffrès, P., Pichon, C., Midoux, P., et al. (2016) · Carbohydrate Research · doi:10.1016/j.carres.2016.10.003 · Cited by 14 · see citing works

Adjuvant-Enhanced mRNA Vaccines

Bialkowski, L., der Jeught, K. V., Renmans, D., van Weijnen, A., Heirman, C., Keyaerts, M., Breckpot, K., & Thielemans, K. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6481-9_11 · Cited by 11 · see citing works

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works

mRNA-based therapeutics: powerful and versatile tools to combat diseases

Qin, S., Tang, X., Chen, Y., Chen, K., Fan, N., Xiao, W., Zheng, Q., Li, G., Teng, Y., Wu, M., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01007-w · Cited by 801 · see citing works

Recent advancements in liposome technology

Filipczak, N., Pan, J., Yalamarty, S. S. K., & Torchilin, V. P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.022 · Cited by 604 · see citing works

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Lee, Y., Jeong, M., Park, J., Jung, H., & Lee, H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01086-x · Cited by 477 · see citing works

The challenge and prospect of mRNA therapeutics landscape

Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., & Huang, Y. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107534 · Cited by 417 · see citing works

RNA modifications: importance in immune cell biology and related diseases

Cui, L., Ma, R., Cai, J., Guo, C., Chen, Z., Yao, L., Wang, Y., Fan, R., Wang, X., & Shi, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01175-9 · Cited by 423 · see citing works

mRNA therapeutics in cancer immunotherapy

Beck, J. D., Reidenbach, D., Salomon, N., Sahin, U., Türeci, Ö., Vormehr, M., & Kranz, L. M. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01348-0 · Cited by 385 · see citing works

Three decades of messenger RNA vaccine development

Verbeke, R., Lentacker, I., De Smedt, S. C., & Dewitte, H. (2019) · Nano Today · doi:10.1016/j.nantod.2019.100766 · Cited by 342 · see citing works

Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy

Guevara, M. L., Persano, F., & Persano, S. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.589959 · Cited by 257 · see citing works

Recent Advances in Lipid Nanoparticles and Their Safety Concerns for mRNA Delivery

Wang, J., Ding, Y., Chong, K. C., Cui, M., Cao, Z., Tang, C., Tian, Z., Hu, Y., Zhao, Y., & Jiang, S. (2024) · Vaccines · doi:10.3390/vaccines12101148 · Cited by 246 · see citing works

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Gu, Z., Silva, C. G. D., van der Maaden, K., OSSENDORP, F. A., & Cruz, L. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111054 · Cited by 177 · see citing works

Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity

Mai, Y., Guo, J., Zhao, Y., Ma, S., Hou, Y., & Yang, J. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104143 · Cited by 163 · see citing works

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Bevers, S., Kooijmans, S. A. A., van de Velde, E., Evers, M. J. W., Seghers, S., Gitz-Francois, J. J., van Kronenburg, N. C. H., Fens, M. H. A. M., Mastrobattista, E., Hassler, L., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.007 · Cited by 146 · see citing works

The use of RNA-based treatments in the field of cancer immunotherapy

Chehelgerdi, M., & Chehelgerdi, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01807-w · Cited by 146 · see citing works

Nanomedicine-Based Approaches for mRNA Delivery

Uchida, S., Perche, F., Pichon, C., & Cabral, H. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00618 · Cited by 139 · see citing works

Nanoplatforms for mRNA Therapeutics

Meng, C., Chen, Z., Li, G., Welte, T., & Shen, H. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000099 · Cited by 130 · see citing works

The roles of polymers in mRNA delivery

Huang, P., Deng, H., Zhou, Y., & Chen, X. S. (2022) · Matter · doi:10.1016/j.matt.2022.03.006 · Cited by 129 · see citing works

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines

Nakamura, T., Sato, Y., Yamada, Y., Abd Elwakil, M. M., Kimura, S., Younis, M. A., & Harashima, H. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114417 · Cited by 121 · see citing works

Hybrid Nanomaterials for Cancer Immunotherapy

Li, J., Lu, W., Yang, Y., Xiang, R., Ling, Y., Yu, C., & Zhou, Y. (2022) · Advanced Science · doi:10.1002/advs.202204932 · Cited by 120 · see citing works

From structural design to delivery: mRNA therapeutics for cancer immunotherapy

Zhou, F., Huang, L., Li, S., Yang, W., Chen, F., Cai, Z., Liu, X., Xu, W., Lehto, V., Lächelt, U., et al. (2023) · Exploration · doi:10.1002/exp.20210146 · Cited by 115 · see citing works

mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond

Sentí, M. E., del Valle, L. G., & Schiffelers, R. M. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115190 · Cited by 116 · see citing works

Neo-Antigen mRNA Vaccines

Esprit, A., de Mey, W., Shahi, R. B., Thielemans, K., Franceschini, L., & Breckpot, K. (2020) · Vaccines · doi:10.3390/vaccines8040776 · Cited by 105 · see citing works

Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants

Fan, N., Chen, K., Zhu, R., Zhang, Z., Huang, H., Qin, S., Zheng, Q., He, Z., He, X., Xiao, W., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq3500 · Cited by 102 · see citing works

An Integrated Polymeric mRNA Vaccine without Inflammation Side Effects for Cellular Immunity Mediated Cancer Therapy

Huang, P., Jiang, L., Pan, H., Ding, L., Zhou, B., Zhao, M., Zou, J., Li, B., Qi, M., Deng, H., et al. (2022) · Advanced Materials · doi:10.1002/adma.202207471 · Cited by 95 · see citing works

miRNA Delivery by Nanosystems: State of the Art and Perspectives

Moraes, F. C., Pichon, C., Letourneur, D., & Chaubet, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111901 · Cited by 93 · see citing works

Selective tumor antigen vaccine delivery to human CD169 + antigen-presenting cells using ganglioside-liposomes

Affandi, A. J., Grabowska, J. A., Olesek, K., Venegas, M. L., Barbaria, A., Rodríguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006186117 · Cited by 88 · see citing works

Nanoparticle technology for mRNA: Delivery strategy, clinical application and developmental landscape

Li, X., Qi, J., Wang, J., Hu, W., Zhou, W., Wang, Y., & Li, T. (2024) · Theranostics · doi:10.7150/thno.84291 · Cited by 96 · see citing works

Synthetic modified messenger RNA for therapeutic applications

Gao, M., Zhang, Q., Feng, X.-H., & Liu, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.020 · Cited by 89 · see citing works

Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications

Lopes, C., Cristóvão, J. S., Silvério, V., Lino, P. R., & Fonte, P. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2135502 · Cited by 85 · see citing works

Lipid nanoparticle-based mRNA vaccines in cancers: Current advances and future prospects

Huang, T., Peng, L., Han, Y., Wang, D., He, X., Wang, J., & Ou, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.922301 · Cited by 84 · see citing works

Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines

Alfagih, I. M., Aldosari, B. N., AlQuadeib, B. T., Almurshedi, A. S., & Alfagih, M. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010045 · Cited by 79 · see citing works

mRNA Cancer Vaccines: Construction and Boosting Strategies

Liu, X., Huang, P., Yang, R., & Deng, H. (2023) · ACS Nano · doi:10.1021/acsnano.3c05635 · Cited by 78 · see citing works

Nano Drug Delivery System for Tumor Immunotherapy: Next-Generation Therapeutics

Zhou, L., Zou, M., Xu, Y., Lin, P., Lei, C., & Xia, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.864301 · Cited by 76 · see citing works

Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes

Veiga, N., Diesendruck, Y., & Peer, D. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.002 · Cited by 74 · see citing works

Nanomaterials for mRNA ‐based therapeutics: Challenges and opportunities

Li, D., Liu, Q., Yang, M., Xu, H., Zhu, M., Zhang, Y., Xu, J., Tian, C., Yao, J., Wang, L., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10492 · Cited by 71 · see citing works

Mannose-Functionalized Biodegradable Nanoparticles Efficiently Deliver DNA Vaccine and Promote Anti-tumor Immunity

Sun, B. F., Zhao, X., Wu, Y., Cao, P., Movahedi, F., Liu, J., Wang, J., Xu, Z. P., & Gu, W. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01401 · Cited by 71 · see citing works

Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation

Jia, W., Wu, Y., Xie, Y., Yu, M., & Chen, Y. (2025) · Advanced Materials · doi:10.1002/adma.202413603 · Cited by 74 · see citing works

The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges

He, J., Xu, S., & Mixson, A. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080774 · Cited by 65 · see citing works

Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy

Xu, S., Ling, S., Shan, Q., Ye, Q., Zhan, Q., Jiang, G., Zhuo, J., Pan, B., Wen, X., Feng, T., et al. (2021) · Advanced Science · doi:10.1002/advs.202003042 · Cited by 61 · see citing works

Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles

Delehedde, C., Even, L., Midoux, P., Pichon, C., & Perche, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070945 · Cited by 59 · see citing works

Bacterial outer membrane vesicle-based cancer nanovaccines

Gao, X., Feng, Q., Wang, J., & Zhao, X. (2022) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0452 · Cited by 56 · see citing works

Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine

Perche, F., Clemençon, R., Schulze, K., Ebensen, T., Guzmán, C. A., & Pichon, C. (2019) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2019.07.014 · Cited by 55 · see citing works

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

Van Hoecke, L., Roose, K., Ballegeer, M., Zhong, Z., Sanders, N. N., De Koker, S., Saelens, X., & Van Lint, S. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.09.004 · Cited by 55 · see citing works

Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy

Karmacharya, P., Patil, B. R., & Kim, J. O. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00569-9 · Cited by 54 · see citing works

mRNA vaccine designs for optimal adjuvanticity and delivery

Mochida, Y., & Uchida, S. (2024) · RNA Biology · doi:10.1080/15476286.2024.2333123 · Cited by 55 · see citing works

mRNA vaccines contribute to innate and adaptive immunity to enhance immune response in vivo

Cao, Q., Fang, H., & Tian, H. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122628 · Cited by 55 · see citing works

Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy

Firdessa-Fite, R., & Creusot, R. J. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.10.015 · Cited by 53 · see citing works

Emerging Concepts of Nanobiotechnology in mRNA Delivery

Wang, Y., & Yu, C. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003545 · Cited by 52 · see citing works

Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond

Hsu, J. C., Liu, P., Song, Y., Song, W., Saladin, R. J., Peng, Y., Hu, S., Lan, X., & Cai, W. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00421c · Cited by 48 · see citing works

Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action

Maruggi, G., Ulmer, J. B., Rappuoli, R., & Yu, D. L. (2021) · Current topics in microbiology and immunology · doi:10.1007/82_2021_233 · Cited by 45 · see citing works

Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders

Chu, R., Wang, Y., Kong, J., Pan, T. S., Yang, Y., & He, J. F. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02766j · Cited by 48 · see citing works

Lipid nanoparticle-based mRNA vaccines: a new frontier in precision oncology

Jacob, E. M., Huang, J., & Chen, M. (2024) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbae017 · Cited by 46 · see citing works

Insights Into Dendritic Cells in Cancer Immunotherapy: From Bench to Clinical Applications

Salah, A., Wang, H., Li, Y., Ji, M., Ou, W., Qi, N., & Wu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.686544 · Cited by 41 · see citing works

Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

Lee, D. S., Amirthalingam, S., Lee, C., Rajendran, A. K., Ahn, Y.-H., & Hwang, N. S.-Y. (2023) · Nanoscale Advances · doi:10.1039/d3na00198a · Cited by 37 · see citing works

In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matrix loaded with BMP2/NS1 mRNAs lipopolyplexes

Wang, P., Perche, F., Midoux, P., Cabral, ‪. S. D., Malard, V., Correia, I. J., El‐Hafci, H., Petite, H., Logeart‐Avramoglou, D., & Pichon, C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.021 · Cited by 36 · see citing works

Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics

Yang, W., Cao, J., Cheng, H., Chen, L., Yu, M., Chen, Y., & Cui, X. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.014 · Cited by 36 · see citing works

Nanomedicine for advanced cancer immunotherapy

Diep, Y. N., Kim, T. J., Cho, H., & Lee, L. P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.004 · Cited by 34 · see citing works

Spleen-targeted nanosystems for immunomodulation

Wang, F., Lou, J., Gao, X., Zhang, L., Sun, F., Wang, Z., Ji, T., & Qin, Z. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101943 · Cited by 33 · see citing works

Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

Lombaerde, E. D., Chen, Y., Ye, T., Deckers, J., Mencarelli, G., Swarte, K. D., Lauwers, H., Coen, R. D., Kasmi, S., Bevers, S., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202310623 · Cited by 34 · see citing works

Advances in Cancer Vaccine Research

Liu, N., Xiao, X., Zhang, Z.-Q., Mao, C., Wan, M., & Shen, J. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01154 · Cited by 33 · see citing works

mRNA-based modalities for infectious disease management

Zhang, M., Hussain, A., Yang, H., Zhang, J., Liang, X., & Huang, Y. (2022) · Nano Research · doi:10.1007/s12274-022-4627-5 · Cited by 33 · see citing works

Path towards mRNA delivery for cancer immunotherapy from bench to bedside

Chen, W., Zhu, Y., He, J., & Sun, X. (2023) · Theranostics · doi:10.7150/thno.89247 · Cited by 31 · see citing works

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

Stoitzner, P., Romani, N., Rademacher, C., Probst, H. C., & Mahnke, K. (2022) · European Journal of Immunology · doi:10.1002/eji.202149515 · Cited by 29 · see citing works

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Joe, P. T., Christopoulou, I., Hoecke, L. V., Schepens, B., Ysenbaert, T., Heirman, C., Thielemans, K., Saelens, X., & Aerts, J. L. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1991-3 · Cited by 29 · see citing works

Nanomaterials Boost CAR‐T Therapy for Solid Tumors

Long, J., Wang, Y., Jiang, X., Ge, J., Chen, M., Zheng, B., Wang, R., Wang, M., Xu, M., Qi, K., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304615 · Cited by 28 · see citing works

Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system

Simion, V., Henriet, E., Jurić, V., Aquino, R., Loussouarn, C., Laurent, Y., Martı́n, F., Midoux, P., Garcion, E., Pichon, C., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.028 · Cited by 27 · see citing works

Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy

Neill, B., Romero, A. R., & Fenton, O. S. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00721 · Cited by 30 · see citing works

Application of stimuli responsive nanocomposites in drug delivery and theranostics to counter cancer proliferation and drug resistance

Khanna, N., Chatterji, T., Singh, S., & Pandey, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104958 · Cited by 28 · see citing works

The landscape of neoantigens and its clinical applications: From immunobiology to cancer vaccines

Chakraborty, C., Majumder, A., Bhattacharya, M., Chatterjee, S., & Lee, S. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100177 · Cited by 27 · see citing works

Antigen transfer and its effect on vaccine-induced immune amplification and tolerance

Shi, Y., Lu, Y., & You, J. (2022) · Theranostics · doi:10.7150/thno.75904 · Cited by 27 · see citing works

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 28 · see citing works

Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production

Broos, K., Lecocq, Q., Keersmaecker, B. D., Raes, G., Corthals, J., Lion, E., Thielemans, K., Devoogdt, N., Keyaerts, M., & Breckpot, K. (2019) · Vaccines · doi:10.3390/vaccines7030085 · Cited by 26 · see citing works

A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges

Youness, R. A., Mohamed, A. H., Efthimiadou, E. Κ., Mekky, R. Y., Braoudaki, M., & Fahmy, S. A. (2023) · ACS Omega · doi:10.1021/acsomega.3c04134 · Cited by 25 · see citing works

Advances in targeted delivery of mRNA into immune cells for enhanced cancer therapy

Huang, L., Huang, Z., Zhang, Y., Lin, C., Zhao, Z., Li, R., Saw, P. E., & Xu, X. (2024) · Theranostics · doi:10.7150/thno.93745 · Cited by 23 · see citing works

The effect of polar headgroups and spacer length on the DNA transfection of cholesterol-based cationic lipids

Radchatawedchakoon, W., Thongbamrer, C., Konbamrung, W., Khattawee, P., Sakee, U., Roobsoong, W., Sattabongkot, J., Opanasopit, P., & Yingyongnarongkul, B. (2020) · RSC Medicinal Chemistry · doi:10.1039/c9md00459a · Cited by 22 · see citing works

PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines

Xiao, W., Wang, F., Gu, Y., He, X., Fan, N., Zheng, Q., Qin, S., He, Z., Wei, Y., & Song, X. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108755 · Cited by 21 · see citing works

Lipid-mRNA nanoparticles landscape for cancer therapy

Li, Y., Fang, H., Zhang, T., Wang, Y., Qi, T., Li, B., & Jiao, H. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1053197 · Cited by 19 · see citing works

Advances in non-viral mRNA delivery to the spleen

Narasipura, E. A., & Fenton, O. S. (2024) · Biomaterials Science · doi:10.1039/d4bm00038b · Cited by 19 · see citing works

Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives

Oh, C., Jung, H. S., Park, J., Awad, J., Jiang, D., Dowling, D. J., & Im, H. (2025) · ACS Nano · doi:10.1021/acsnano.5c04836 · Cited by 20 · see citing works

Physical and chemical advances of synthetic delivery vehicles to enhance mRNA vaccine efficacy

Kim, H. J., Seo, S. K., & Park, H. Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.029 · Cited by 18 · see citing works

Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery

SUZUKI, M. T., Mochida, Y., Hori, M., Hayashi, A., Toh, K., Tockary, T. A., Liu, X., Marx, V., Yokoo, H., Miyata, K., et al. (2024) · Small Science · doi:10.1002/smsc.202300258 · Cited by 17 · see citing works

mRNA Lipoplexes with Cationic and Ionizable α-Amino-lipophosphonates: Membrane Fusion, Transfection, mRNA Translation and Conformation

Akhter, S., Berchel, M., Jaffrès, P., Midoux, P., & Pichon, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030581 · Cited by 17 · see citing works

N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes

Mokuda, S., Watanabe, H., Kohno, H., Ishitoku, M., Araki, K., Hirata, S., & Sugiyama, E. (2022) · Cytotechnology · doi:10.1007/s10616-022-00540-4 · Cited by 16 · see citing works

Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy

Wang, F., Zhang, M., Tian, M., Lou, J., Pan, L., Gao, X., Zhang, L., Lou, X., Zhu, L., Sheng, Y., et al. (2023) · Nano Research · doi:10.1007/s12274-023-6111-2 · Cited by 16 · see citing works

Therapeutic Vaccines for HPV-Associated Cervical Malignancies: A Systematic Review

Alouini, S., & Pichon, C. (2024) · Vaccines · doi:10.3390/vaccines12040428 · Cited by 16 · see citing works

Synthetic nanomaterials for spleen-specific mRNA delivery

Nie, S., Yang, B., Ma, R., Zha, L., Qin, Y., Ou, L., Chen, X. S., & Li, L. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122859 · Cited by 15 · see citing works

Rational design of polymer-based mRNA delivery systems for cancer treatment

Wan, Q., Sun, Y., Sun, X., & Zhou, Z. (2024) · Polymer Chemistry · doi:10.1039/d4py00206g · Cited by 14 · see citing works

Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria

Perche, F., Gall, T. L., Montier, T., Pichon, C., & Malinge, J. (2019) · Pharmaceuticals · doi:10.3390/ph12020081 · Cited by 14 · see citing works

Targeted Drug Delivery to the Spleen and Its Implications for the Prevention and Treatment of Cancer

Khalil, I. A., Faheem, A., & El‐Tanani, M. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050651 · Cited by 14 · see citing works

Dendritic cell-targeting polymer nanoparticle-based immunotherapy for cancer: A review

Hu, Y., Zhang, W. J., Chu, X., Wang, A., He, Z., Si, C., & Hu, W. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122703 · Cited by 13 · see citing works

Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneous in vivo delivery of tyrosine kinase inhibitors and kinase activity biosensors

Bofinger, R., Weitsman, G. E., Evans, R., Glaser, M., Sander, K., Allan, H., Hochhauser, D., Kalber, T. L., Årstad, E., Hailes, H. C., et al. (2021) · Nanoscale · doi:10.1039/d1nr02770k · Cited by 13 · see citing works

“Nano effects”: a review on nanoparticle-induced multifarious systemic effects on cancer theranostic applications

Ravichandran, G., Yadav, D. N., Murugappan, S., Sankaranarayanan, S. A., Revi, N., & Rengan, A. K. (2022) · Materials Advances · doi:10.1039/d2ma00784c · Cited by 13 · see citing works

Impact of net charge, targeting ligand amount and mRNA modification on the uptake, intracellular routing and the transfection efficiency of mRNA lipopolyplexes in dendritic cells

Delehedde, C., Ciganek, I., Rameix, N., Laroui, N., Gonçalves, C., Even, L., Midoux, P., & Pichon, C. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123531 · Cited by 13 · see citing works

Stability Criterion for the Assembly of Core–Shell Lipid–Polymer–Nucleic Acid Nanoparticles

Paris, J. L., Gaspar, R., Coelho, F., Beule, P. D., & Silva, B. F. B. (2023) · ACS Nano · doi:10.1021/acsnano.3c07204 · Cited by 12 · see citing works

Antibody-Conjugated Vitamin E-Derived Liposomes for Targeted Gene Transfer

Kamra, M., Maiti, B., Saha, P., Karande, A. A., & Bhattacharya, S. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00656 · Cited by 11 · see citing works

Intranasal mRNA Delivery via Customized RNA-Polyplex Nanoparticles Enhancing Gene Expression through Photochemical Mechanisms

Jeong, H., Kim, H., Kim, Y. A., Kim, K. S., & Na, K. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c12604 · Cited by 11 · see citing works

The dawn of a new Era: mRNA vaccines in colorectal cancer immunotherapy

Song, J., Zhang, Y., Zhou, C., Zhan, J., Cheng, X., Huang, H., Mao, S., & Zong, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112037 · Cited by 10 · see citing works

Efficient Induction of Antigen-Specific CD8+ T-Cell Responses by Cationic Peptide-Based mRNA Nanoparticles

D’haese, S., Laeremans, T., den Roover, S., Allard, S. D., Vanham, G. L., & Aerts, J. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071387 · Cited by 10 · see citing works

In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture

Paris, J. L., Coelho, F., Teixeira, A., Diéguez, L., Silva, B. F. B., & Abalde‐Cela, S. (2020) · Molecules · doi:10.3390/molecules25143277 · Cited by 9 · see citing works

Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

Moignic, A. L., Malard, V., Benvegnu, T. J., Lemiègre, L., Berchel, M., Jaffrès, P., Baillou, C., Guillot‐Delost, M., Macedo, R., Rochefort, J., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.03.035 · Cited by 127 · see citing works

Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination

Persano, S., Guevara, M. L., Li, Z., Mai, J., Ferrari, M., Pompa, P. P., & Shen, H. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.019 · Cited by 187 · see citing works

Abstract LB-205: A lipoplex-based mRNA nanovaccine for cancer immunotherapy

Hongxia, Z., You, X., Xiaojuan, W., Wang, Z., Feifei, X., Wu, J., & Xia, X. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-lb-205

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

Van Hoecke, L., Roose, K., Ballegeer, M., Zhong, Z., Sanders, N. N., De Koker, S., Saelens, X., & Van Lint, S. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.09.004 · Cited by 55 · see citing works

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Broos, K., Van der Jeught, K., Puttemans, J., Goyvaerts, C., Heirman, C., Dewitte, H., Verbeke, R., Lentacker, I., Thielemans, K., & Breckpot, K. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.38 · Cited by 121 · see citing works