The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Macrophages with cellular backpacks for targeted drug delivery to the brain
Open accessAbstract
Most potent therapeutics are unable to cross the blood-brain barrier following systemic administration, which necessitates the development of unconventional, clinically applicable drug delivery systems. With the given challenges, biologically active vehicles are crucial to accomplishing this task. We now report a new method for drug delivery that utilizes living cells as vehicles for drug carriage across the blood brain barrier. Cellular backpacks, 7–10 µm diameter polymer patches of a few hundred nanometers in thickness, are a potentially interesting approach, because they can act as drug depots that travel with the cell-carrier, without being phagocytized. Backpacks loaded with a potent antioxidant, catalase, were attached to autologous macrophages and systemically administered into mice with brain inflammation. Using inflammatory response cells enabled targeted drug transport to the inflamed brain. Furthermore, catalase-loaded backpacks demonstrated potent therapeutic effects deactivating free radicals released by activated microglia in vitro. This approach for drug carriage and release can accelerate the development of new drug formulations for all the neurodegenerative disorders.
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Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741
Cited by
Strategies for delivering therapeutics across the blood–brain barrier
Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138
Cellular backpacks for macrophage immunotherapy
Shields, C. W., Evans, M. A., Wang, L. L.-W., Baugh, N., Iyer, S., Wu, D., Zhao, Z., Pusuluri, A., Ukidve, A., Pan, D. C., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz6579 · Cited by 414
Drug delivery to the central nervous system
Nance, E., Pun, S. H., Saigal, R., & Sellers, D. L. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00394-w · Cited by 414
Tailoring Materials for Modulation of Macrophage Fate
Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 403
Wang, J., Tang, W., Yang, M., Yin, Y., Li, H., Hu, F., Tang, L., Ma, X., Zhang, Y., & Wang, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120784 · Cited by 317
Metadata
- Authors
- Klyachko, N. L., Polak, R., Haney, M. J., Zhao, Y., Gomes Neto, R. J., Hill, M. C., Kabanov, A. V., Cohen, R. E., Rubner, M. F., & Batrakova, E. V.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 140
- Pages
- 79-87
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2626083382
- Cited by
- 176
- References
- 3
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Klyachko, N. L., Polak, R., Haney, M. J., Zhao, Y., Gomes Neto, R. J., Hill, M. C., Kabanov, A. V., Cohen, R. E., Rubner, M. F., & Batrakova, E. V. (2017). Macrophages with cellular backpacks for targeted drug delivery to the brain. Biomaterials. https://doi.org/10.1016/j.biomaterials.2017.06.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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