The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Drug delivery to the central nervous system
Open accessAbstract
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug development remains challenging, with high costs, long pathways to clinical use and high failure rates. The CNS is highly protected by physiological barriers, in particular, the blood–brain barrier and the blood–cerebrospinal fluid barrier, which limit access of most drugs. Biomaterials can be designed to bypass or traverse these barriers, enabling the controlled delivery of drugs into the CNS. In this Review, we first examine the effects of normal and diseased CNS physiology on drug delivery to the brain and spinal cord. We then discuss CNS drug delivery designs and materials that are administered systemically, directly to the CNS, intranasally or peripherally through intramuscular injections. Finally, we highlight important challenges and opportunities for materials design for drug delivery to the CNS and the anticipated clinical impact of CNS drug delivery. The central nervous system is protected by tightly regulated physiological barriers, which make drug delivery into the brain and spinal cord very challenging. This Review discusses the pathophysiological changes that complicate drug delivery into the central nervous system and examines materials-based strategies to bypass or overcome these barriers for drug delivery.
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Cited by
Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system
Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., et al. (2025) · Nature Materials · doi:10.1038/s41563-024-02114-5 · Cited by 171
Kim, M., Shin, M., Zhao, Y., Ghosh, M., & Son, Y. (2024) · Small Science · doi:10.1002/smsc.202400280 · Cited by 97
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“distribution of NPs Since BBB is a major challenge for brain drug delivery, BBB penetration is one of the pivotal indices of nanodrugs in clinical AD therapy [65,66].”
BackgroundJiao, Y., Yang, L., Wang, R., Song, G., Fu, J., Wang, J., Gao, N., & Wang, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121611 · Cited by 63
Metadata
- Authors
- Nance, E., Pun, S. H., Saigal, R., & Sellers, D. L.
- Venue
- Nature Reviews Materials
- Published
- 2021-12-03
- Volume
- 7
- Issue
- 4
- Pages
- 314-331
- ISSN
- 2058-8437 (ISSN-L)
- OpenAlex
- W4205567487
- Cited by
- 414
- References
- 40
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Nance, E., Pun, S. H., Saigal, R., & Sellers, D. L. (2021). Drug delivery to the central nervous system. Nature Reviews Materials. https://doi.org/10.1038/s41578-021-00394-w
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