The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Mesenchymal stem cell-macrophage crosstalk and bone healing
Open accessAbstract
Recent research has brought about a clear understanding that successful fracture healing is based on carefully coordinated cross-talk between inflammatory and bone forming cells. In particular, the key role that macrophages play in the recruitment and regulation of the differentiation of mesenchymal stem cells (MSCs) during bone regeneration has been brought to focus. Indeed, animal studies have comprehensively demonstrated that fractures do not heal without the direct involvement of macrophages. Yet the exact mechanisms by which macrophages contribute to bone regeneration remain to be elucidated. Macrophage–derived paracrine signaling molecules such as Oncostatin M, Prostaglandin E2 (PGE2), and Bone Morphogenetic Protein-2 (BMP2) have been shown to play critical roles; however the relative importance of inflammatory (M1) and tissue regenerative (M2) macrophages in guiding MSC differentiation along the osteogenic pathway remains poorly understood. In this review, we summarize the current understanding of the interaction of macrophages and MSCs during bone regeneration, with the emphasis on the role of macrophages in regulating bone formation. The potential implications of aging to this cellular cross-talk are reviewed. Emerging treatment options to improve facture healing by utilizing or targeting MSC-macrophage crosstalk are also discussed.
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Cites
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BackgroundThe chemokine system in diverse forms of macrophage activation and polarization
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Cited by
Modulation of the Inflammatory Response and Bone Healing
Maruyama, M., Rhee, C., Utsunomiya, T., Zhang, N., Ueno, M., Yao, Z., & Goodman, S. B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00386 · Cited by 541
Self-citationLin, H., Sohn, J., Shen, H., Langhans, M. T., & Tuan, R. S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.026 · Cited by 445
Schlundt, C., Fischer, H., Bucher, C. H., Rendenbach, C., Duda, G. N., & Schmidt-Bleek, K. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.052 · Cited by 415
Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing
Mao, J., Chen, L., Cai, Z., Qian, S., Liu, Z., Zhao, B., Zhang, Y., Sun, X., & Cui, W. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202111003 · Cited by 253
Niu, Y., Wang, Z., Shi, Y., Dong, L., & Wang, C. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.012 · Cited by 213
Metadata
- Authors
- Pajarinen, J., Lin, T., Gibon, E., Kohno, Y., Maruyama, M., Nathan, K., Lu, L., Yao, Z., & Goodman, S. B.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 196
- Pages
- 80-89
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2782456302
- Cited by
- 999
- References
- 15
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- green
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