The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives
Open accessAbstract
Summary Bone fractures are the most common traumatic injuries in humans. The repair of bone fractures is a regenerative process that recapitulates many of the biological events of embryonic skeletal development. Most of the time it leads to successful healing and the recovery of the damaged bone. Unfortunately, about 5-10% of fractures will lead to delayed healing or non-union, more so in the case of co-morbidities such as diabetes. In this article, we review the different strategies to heal bone defects using synthetic bone graft substitutes and biologically active substances or stem cells. Our review is different from previous reviews, which focus on strategies that are still at the early stages of development and use mostly in vitro experiments with cell lines or stem cells. Here, we focus on what is already implemented in the clinics, what is currently in clinical trials, and what has been tested in animal models. Treatment approaches can be classified in three major categories: i) synthetic bone graft substitutes (BGS) whose architecture and surface can be optimized; ii) BGS combined with bioactive molecules such as growth factors, peptides or small molecules targeting bone precursor cells, bone formation and metabolism; iii) cell-based strategies with progenitor cells combined or not with active molecules that can be injected or seeded on BGS for improved delivery. We review the major types of adult stromal cells (bone marrow, adipose and periosteum derived) that have been used and compare their properties. Finally, we discuss the remaining challenges that need to be addressed to significantly improve the healing of bone defects.
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Cited by
Normal Bone Anatomy and Physiology
Clarke, B. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04151206 · Cited by 2,192
The application of hyaluronic acid in bone regeneration
Zhai, P., Peng, X., Li, B., Liu, Y., Sun, H., & Li, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.169 · Cited by 438
Wang, W., Zhang, B., Li, M., Li, J., Zhang, C., Han, Y., Wang, L., Wang, K., Zhou, C., Liu, L., et al. (2021) · Composites Part B: Engineering · doi:10.1016/j.compositesb.2021.109192 · Cited by 369
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Mesenchymal stem cells: Amazing remedies for bone and cartilage defects
Kangari, P., Talaei-Khozani, T., Razeghian-Jahromi, I., & Razmkhah, M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02001-1 · Cited by 286
Metadata
- Authors
- Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. W., Luyten, F. P., & Picart, C.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 180
- Pages
- 143-162
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2859280788
- Cited by
- 961
- References
- 161
- FWCI
- 29.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. W., Luyten, F. P., & Picart, C. (2018). Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. Biomaterials. https://doi.org/10.1016/j.biomaterials.2018.07.017
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