The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Fracture healing: mechanisms and interventions
Open accessAbstract
Fractures are the most common large-organ, traumatic injuries to humans. The repair of bone fractures is a postnatal regenerative process that recapitulates many of the ontological events of embryonic skeletal development. Although fracture repair usually restores the damaged skeletal organ to its pre-injury cellular composition, structure and biomechanical function, about 10% of fractures will not heal normally. This article reviews the developmental progression of fracture healing at the tissue, cellular and molecular levels. Innate and adaptive immune processes are discussed as a component of the injury response, as are environmental factors, such as the extent of injury to the bone and surrounding tissue, fixation and the contribution of vascular tissues. We also present strategies for fracture treatment that have been tested in animal models and in clinical trials or case series. The biophysical and biological basis of the molecular actions of various therapeutic approaches, including recombinant human bone morphogenetic proteins and parathyroid hormone therapy, are also discussed.
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Cites
WNT signaling in bone homeostasis and disease: From human mutations to treatments
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High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
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Romosozumab in Postmenopausal Women with Low Bone Mineral Density
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Self-citationAspenberg, P., Genant, H. K., Johansson, T., Nino, A. J., See, K., Krohn, K., García-Hernández, P. A., Recknor, C. P., Einhorn, T. A., Dalsky, G. P., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090731 · Cited by 513
Self-citationOverview of the fracture healing cascade
Phillips, A. M. (2005) · Injury · doi:10.1016/j.injury.2005.07.027 · Cited by 311
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Cited by
Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. W., Luyten, F. P., & Picart, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.017 · Cited by 961
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Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
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Current Advances in Immunomodulatory Biomaterials for Bone Regeneration
Lee, J., Byun, H., Madhurakkat Perikamana, S. K., Lee, S., & Shin, H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801106 · Cited by 452
Metadata
- Authors
- Einhorn, T. A., & Gerstenfeld, L. C.
- Venue
- Nature Reviews Rheumatology
- Published
- 2014-09-30
- Volume
- 11
- Issue
- 1
- Pages
- 45-54
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W1996361385
- Cited by
- 1,807
- References
- 7
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
