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Cited by 438Bone Tissue Engineering MaterialsHydrogels: synthesis, properties, applicationsDental Implant Techniques and Outcomes

The application of hyaluronic acid in bone regeneration

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Zhai, Peisong, Peng, Xiaoxing, Li, Baoquan, Liu, Yiping, Sun, Hongchen, Li, Xiangwei·2020·International Journal of Biological Macromolecules
DOI 10.1016/j.ijbiomac.2019.10.169
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Abstract

Hyaluronic acid (HA) exists naturally as an important component of the extracellular matrix (ECM) in the human body. In recent decades, HA has been widely used in bone regeneration, and is currently a popular topic, particularly in the craniofacial and dental fields. From maxilla augmentation to craniofacial bone trauma, there is now a large demand for bone regenerative therapy. Serving as a cell-seeding scaffold or a carrier for bioactive components, hyaluronic acid-incorporated scaffolds and carriers in bone regeneration can be fabricated into either rigid or colloidal forms. Since the type of material used is a critical factor in the biological properties of a scaffold, HA derivatives or HA-incorporated composite scaffolds have shown excellent potential for improving osteogenesis and mineralization. Furthermore, in order to better enhance osteogenesis, local delivery carriers based on hyaluronic acid derivatives, rather than specifically serving as scaffolds, can be established by loading different osteoinductive or osteogenetic components and acquiring different release patterns. Such osteoinductive carriers immobilized on implant surfaces are also effective in improving osseointegration. Thus, as such a competent biomaterial, hyaluronic acid should be considered a promising tool in bone regeneration.

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  • HA is one of the main components of the ECM and can be used to crosslink collagen fibrils, as it participates in mineralization.

    “It is one of the main components of the ECM and can be used to crosslink collagen fibrils, as it participates in mineralization [58].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [58]

    The Introduction identifies HA as an ECM component, and §4.1 describes its influence on mineralization in a collagen/chitosan/HA scaffold. But §4.1 attributes the scaffold’s crosslinking reaction to chitosan, not to HA crosslinking collagen fibrils; the cited paper does not establish that part of the claim. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Zhai, P., Peng, X., Li, B., Liu, Y., Sun, H., & Li, X.
Affiliations
  • Jilin University (CN)
  • Changchun University of Chinese Medicine (CN)
Corresponding author
Li, Xiangwei
ORCID
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2020-05
Volume
151
Pages
1224-1239
ISSN
0141-8130 (ISSN-L)
DOI
10.1016/j.ijbiomac.2019.10.169
OpenAlex
W2985281929
Cited by
438
References
4
Citations by year
2026: 45 · 2025: 89 · 2024: 79 · 2023: 76 · 2022: 72 · 2021: 61 · 2020: 16
FWCI
3.01
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Biological Macromolecules (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Jilin Provincial Health Department (2017J065, 2018J112, JJKH20180229KJ)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
Keywords
hyaluronic acid, bone regeneration, extracellular matrix, bone scaffolds, composite scaffolds, bone formation, mineralization, local drug delivery, osseointegration
MeSH terms
Biocompatible Materials, Bone Regeneration, Colloids, Drug Carriers, Extracellular Matrix, Humans, Hyaluronic Acid, Osteogenesis, Structure-Activity Relationship, Tissue Scaffolds

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