Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Towards MR-navigable nanorobotic carriers for drug delivery into the brain

Tabatabaei, S. N., Duchemin, S., Girouard, H., & Martel, S. M. (2012) · Proceedings - IEEE International Conference on Robotics and Automation/Proceedings · doi:10.1109/icra.2012.6225041 · Cited by 44

Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating

Mei, L., Zhang, Q., Yang, Y., He, Q., & Gao, H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.08.020 · Cited by 44

Brain-Targeted Delivery of Trans-Activating Transcriptor-Conjugated Magnetic PLGA/Lipid Nanoparticles

Wen, X., Wang, K., Zhao, Z., Zhang, Y., Sun, T., Zhang, F., Wu, J. H., Fu, Y., Du, Y., Zhang, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106652 · Cited by 44

Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus

Yazdan-Shahmorad, A., Tian, N., Kharazia, V., Samaranch, L., Kells, A. P., Bringas, J., He, J.-W., Bankiewicz, K. S., & Sabes, P. N. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.10.009 · Cited by 44

Scavenger receptor class B type I expression in murine brain and regulation by estrogen and dietary cholesterol

Srivastava, R. A. K. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00006-6 · Cited by 43

The effects of natalizumab on the innate and adaptive immune system in the central nervous system

Stüve, O. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.03.022 · Cited by 43

Novel chemotherapeutic agents for the treatment of glioblastoma multiforme

Jendrossek, V., Belka, C., & Bamberg, M. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.12.1899 · Cited by 43

From the Cover: Comparative Proteomics Reveals Silver Nanoparticles Alter Fatty Acid Metabolism and Amyloid Beta Clearance for Neuronal Apoptosis in a Triple Cell Coculture Model of the Blood–Brain Barrier

Lin, H.-C., Ho, M., Tsen, C.-M., Huang, C.-C., Wu, C.-C., Huang, Y.-J., Hsiao, I., & Chuang, C. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx079 · Cited by 43

Targeting microbubbles-carrying TGFβ1 inhibitor combined with ultrasound sonication induce BBB/BTB disruption to enhance nanomedicine treatment for brain tumors

Chen, Y., Chiang, C., Wu, S., Chen, L., Hsieh, W., & Lin, W.-L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.288 · Cited by 42

P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models

Liu, Q., Hou, J., Chen, X., Liu, G.-T., Zhang, D., Sun, H., & Zhang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102442 · Cited by 41

Low-intensity focused ultrasound for the treatment of brain diseases: safety and feasibility

Toccaceli, G., Barbagallo, G. M. V., & Peschillo, S. (2019) · Theranostics · doi:10.7150/thno.31765 · Cited by 41

The identification of leptin-derived peptides that are taken up by the brain

Barrett, G. L., Trieu, J., & Naim, T. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.02.008 · Cited by 40

Toxicological effect of joint cadmium selenium quantum dots and copper ion exposure on zebrafish

Zhang, W., Sun, X., Chen, L., Lin, K., Dong, Q., Huang, C., Fu, R., & Zhu, J. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.1918 · Cited by 39

Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-α and IL-6 Release by Blockading NF-κB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187

Lu, Y., Jeong, Y. T., Li, X., Kim, M. J., Park, P., Hwang, S., Son, J. K., & Chang, H. W. (2013) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2013.068 · Cited by 38

Synergistic Combination of Doxorubicin and Paclitaxel Delivered by Blood Brain Barrier and Glioma Cells Dual Targeting Liposomes for Chemotherapy of Brain Glioma

Chen, X., Yuan, M., Zhang, Q., Yang, Y. T., Gao, H., & He, Q. (2016) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201017666160401144440 · Cited by 36

Dual Role of the Metalloprotease FtsH in Biogenesis of the DrrAB Drug Transporter

Li, W., Rao, D. K., & Kaur, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.441915 · Cited by 35

Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome c Nanoparticles in Tumor Cells

Morales‐Cruz, M., Cruz‐Montañez, A., Figueroa, C. M., González-Robles, T. J., Davila, J., Inyushin, M. Y., Loza-Rosas, S. A., Molina, A. M., Muñoz-Perez, L., Kucheryavykh, L. Y., et al. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00461 · Cited by 35

Targeted delivery of large fusion protein into hippocampal neurons by systemic administration

Xiang, L., Zhou, R., Fu, A., Xu, X., Huang, Y., & Hu, C. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.523788 · Cited by 32

A review of the clinical pharmacokinetics of opioids, benzodiazepines, and antimigraine drugs delivered intranasally

Veldhorst-Janssen, N. M. L., Fiddelers, A. A. A., van der Kuy, P. H. M., Neef, C., & Marcus, M. A. E. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.12.015 · Cited by 31

Intranasal and intravenous administration of octa-arginine modified poly(lactic-co-glycolic acid) nanoparticles facilitates central nervous system delivery of loperamide

O'Donnell, A., Moollan, A., Baneham, S., Önal, M. Ö., Pabari, R. M., Cox, D. M., Kirby, B. P., & Ramtoola, Z. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12347 · Cited by 29

Identification and characterization of interleukin-13 receptor in human medulloblastoma and targeting these receptors with interleukin-13-pseudomonas exotoxin fusion protein.

Joshi, B. H., Leland, P., & Puri, R. K. (2003) · PubMed · Cited by 27

Both Water Intoxication and Osmotic BBB Disruption Increase Brain Water Content in Rats

Kozler, P., RILJAK, V., & Pokorny, J. (2013) · Physiological Research · doi:10.33549/physiolres.932566 · Cited by 27

Combined Local Blood–Brain Barrier Opening and Systemic Methotrexate for the Treatment of Brain Tumors

Cooper, I., Last, D., Guez, D., Sharabi, S., Goldman, S. E., Lubitz, I., Daniels, D., Salomon, S., Tamar, G., Tamir, T., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.6 · Cited by 26

Self-organized nanoparticles based on chitosan-folic acid and dextran succinate-doxorubicin conjugates for drug targeting

Lee, K. D., Choi, S.-H., Kim, D., Lee, H., & Choi, K. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0489-z · Cited by 24

Superior Therapeutic Efficacy of Nanoparticle Albumin Bound Paclitaxel Over Cremophor-Bound Paclitaxel in Experimental Esophageal Adenocarcinoma

Hassan, S., Awasthi, N., Li, J., Williams, F., Schwarz, M. A., Schwarz, R. E., & von Holzen, U. W. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.01.022 · Cited by 24

From naturally-occurring neurotoxic agents to CNS shuttles for drug delivery

Soddu, E., Rassu, G., Giunchedi, P., Sarmento, B. F. C. C., & Gavini, E. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.04.005 · Cited by 21

Local administration of chitosan microspheres after traumatic brain injury in rats: a new challenge for cyclosporine – a delivery

Türkoğlu, Ö. F., Eroğlu, H., Gürcan, O., Bodur, E., Sargon, M. F., Öner, L., & Beşkonaklı, E. (2010) · British Journal of Neurosurgery · doi:10.3109/02688697.2010.487126 · Cited by 20

Getting cancer drugs into the brain

Bender, E. (2018) · Nature · doi:10.1038/d41586-018-06707-4 · Cited by 19

Effect of Functional Magnetic Particles on Radiofrequency Capacitive Heating

Shinkai, M., Ueda, K., Ohtsu, S., Honda, H., Kohri, K., & Kobayashi, T. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00803.x · Cited by 15

Effect of methylprednisolone on the axonal impairment accompanying cellular brain oedema induced by water intoxication in rats.

Kozler, P., & Pokorny, J. (2012) · PubMed · Cited by 15

Getting to the brain

Baratta, M. G. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0182-3 · Cited by 15

A Method for Evaluating Nanoparticle Transport Through the Blood–Brain Barrier In Vitro

Guarnieri, D., Muscetti, O., & Netti, P. A. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0363-4_12 · Cited by 13

Metastatic brain tumors: current therapeutic options and historical perspective.

Rivkin, M. A., & Kanoff, R. B. (2013) · PubMed · Cited by 12

Targeted Delivery and Tolerability of MRI-Guided CED Infusion into the Cerebellum of Nonhuman Primates

Salegio, E. A., Campagna, M. V., Allen, P. C., Stockinger, D. E., Song, Y., & Hwa, G. G. C. (2018) · Human Gene Therapy Methods · doi:10.1089/hgtb.2018.049 · Cited by 4

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Strategies for delivering therapeutics across the blood–brain barrier

Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi, M., Chehelgerdi, M., Allela, O. Q. B., Pecho, R. D. C., Narayanan, J., Rao, D. P., Thamaraikani, T., Vasanthan, M., Viktor, P., Lakshmaiya, N., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01865-0 · Cited by 1,132

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Montoto, S. S., Muraca, G., & Ruiz, M. E. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.587997 · Cited by 695

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Wang, B., Hu, S., Teng, Y., Chen, J., Wang, H., Xu, Y., Wang, K., Xu, J., Cheng, Y., & Gao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01889-y · Cited by 641

Advances in CNS drug delivery strategies to cross the blood-brain barrier

Li, G., Li, Z., Sun, Y., Bu, T., Chen, S., Yang, L., Li, Z., Mao, W., & Jia, Y. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111524 · Cited by 10

Harnessing nanotechnology for improved drug delivery across the blood-brain barrier and enhanced neural repair

Xu, M., Wang, H., Wang, C., Wang, C., Hu, S., & Weng, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126221 · Cited by 2

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708

The Route of Nanomaterials Entering Brain

Liu, Y., & He, Q. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804598-5.00002-7 · Cited by 14

Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review

Kulkarni, M., Patel, K., Patel, A. K., Patel, S., Desai, J. L., Patel, M. M., Shah, U., Patel, A. D., & Solanki, N. D. (2023) · ADMET & DMPK · doi:10.5599/admet.2043 · Cited by 46