Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella‐Branger, D., Cavenee, W. K., Ohgaki, H., Wiestler, O. D., Kleihues, P., & Ellison, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1545-1 · Cited by 15,703

The 2007 WHO Classification of Tumours of the Central Nervous System

Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146315 · Cited by 1,625

Convection-enhanced delivery of macromolecules in the brain.

Bobo, R. H., Laske, D. W., Akbaşak, A., Morrison, P. F., Dedrick, R. L., & Oldfield, E. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2076 · Cited by 1,442

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060

Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 1,040

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,038

Cloning by functional expression of a member of the glutamate receptor family

Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W., & Heinemann, S. F. (1989) · Nature · doi:10.1038/342643a0 · Cited by 1,016

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

Aarts, M. M., Liu, Y., Liu, L., Besshoh, S., Arundine, M., Gurd, J. W., Wang, Y.-T., Salter, M. W., & Tymianski, M. (2002) · Science · doi:10.1126/science.1072873 · Cited by 998

Size and shape effects in the biodistribution of intravascularly injected particles

Decuzzi, P., Godin, B., Tanaka, T., Lee, S., Chiappini, C., Liu, X., & Mauro Ferrari, B. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.014 · Cited by 981

Current Strategies for Brain Drug Delivery

Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954

The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance, and Biocompatibility in Vivo

Huang, X., Li, L., Liu, T., Hao, N., Liu, H., Chen, D., & Tang, F. (2011) · ACS Nano · doi:10.1021/nn200365a · Cited by 945

Cell‐penetrating peptides: 20 years later, where do we stand?

Bechara, C., & Sagan, S. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.031 · Cited by 906

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

Uchida, Y., Ohtsuki, S., Katsukura, Y., Ikeda, C., Suzuki, T., Kamiie, J., & Terasaki, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07208.x · Cited by 881

Cell-penetrating peptides: classes, origin, and current landscape

Milletti, F. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.002 · Cited by 849

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Gabathuler, R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.028 · Cited by 829

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Yu, Y. J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y., Atwal, J., Elliott, J. M., Prabhu, S., Watts, R. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002230 · Cited by 794

Neurovascular mechanisms of Alzheimer's neurodegeneration

Zlokovic, B. V. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.02.001 · Cited by 770

Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability

Lockman, P. R., Koziara, J. M., Mumper, R. J., & Allen, D. D. (2004) · Journal of drug targeting · doi:10.1080/10611860400015936 · Cited by 742

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

Kolhar, P., Anselmo, A. C., Gupta, V., Pant, K., Prabhakarpandian, B., Ruoslahti, E. I., & Mitragotri, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308345110 · Cited by 648

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

Shen, Z., Liu, T., Li, Y., Lau, J., Yáng, Z., Fan, W., Zhou, Z., Shi, C., Ke, C., Bregadze, V. I., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b06201 · Cited by 639

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

Niewoehner, J., Bohrmann, B., Collin, L., Urich, E., Sade, H., Maier, P., Rueger, P., Stracke, J. O., Lau, W., Tissot, A. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.061 · Cited by 622

Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics

Tang, W., Fan, W., Lau, J., Deng, L., Shen, Z., & Chen, X. S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00805a · Cited by 610

Polymeric nanoparticles for drug delivery to the central nervous system

Patel, T., Zhou, J., Piepmeier, J. M., & Saltzman, W. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.006 · Cited by 592

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572

Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in Alzheimer's Disease

Sengillo, J. D., Winkler, E. A., Walker, C. T., Sullivan, J. S., Johnson, M., & Zlokovic, B. V. (2013) · Brain Pathology · doi:10.1111/bpa.12004 · Cited by 553

RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

Donahue, J. E., Flaherty, S. L., Johanson, C. E., Duncan, J. A., Silverberg, G. D., Miller, M. C., Tavares, R., Yang, W., Wu, Q., Sabo, E., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0115-3 · Cited by 519

Delivery of peptides and proteins through the blood–brain barrier

Bickel, U., Yoshikawa, T., & Pardridge, W. M. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00139-3 · Cited by 490

Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma

Kunwar, S., Chang, S. M., Westphal, M., Vogelbaum, M. A., Sampson, J. H., Barnett, G. H., Shaffrey, M. E., Ram, Z., Piepmeier, J., Prados, M. D., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/nop054 · Cited by 484

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

Pardeshi, C. V., & Belgamwar, V. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.790887 · Cited by 482 · cited 2×

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

Cabezas, R., Ávila, M. F., González, J., El-Bachá, R. D. S., Báez-Jurado, E., García‐Segura, L. M., Jurado-Coronel, J. C., Capani, F., Cardona‐Gómez, G. P., & Barreto, G. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00211 · Cited by 481

Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke

Khatri, R., McKinney, A. M., Swenson, B., & Janardhan, V. (2012) · Neurology · doi:10.1212/wnl.0b013e3182697e70 · Cited by 478

Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation

Abbott, N. J. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1374-y · Cited by 471

Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles

Kreuter, J., Ramge, P., Petrov, V. E., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R. N., von Briesen, H., & Begley, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1022604120952 · Cited by 469

Current concepts and management of glioblastoma

Preusser, M., de Ribaupierre, S., Wöehrer, A., Erridge, S., Hegi, M. E., Weller, M., & Stupp, R. (2011) · Annals of Neurology · doi:10.1002/ana.22425 · Cited by 468

Kojic acid applications in cosmetic and pharmaceutical preparations

Saeedi, M., Eslamifar, M., & Khezri, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.006 · Cited by 423

Specific role of tight junction proteins claudin-5, occludin and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult

Jiao, H., Wang, Z., Liu, Y., Wang, P., & Xue, Y. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9496-4 · Cited by 411

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409

Human Blood—Brain Barrier Insulin Receptor

Pardridge, W. M., Eisenberg, J., & Yang, J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07167.x · Cited by 399

AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study

Immonen, A., Vapalahti, M. P., Tyynelä, K., Hurskainen, H., Sandmair, A.-M., Vanninen, R. L., Langford, G. A., Murray, N., & Ylä‐Herttuala, S. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.002 · Cited by 390

Lactoferrin-conjugated PEG–PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations

Hu, K., Li, J., Shen, Y., Lü, W., Gao, X., Zhang, Q., & Jiang, X. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.016 · Cited by 354

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

Cecchelli, R., Aday, S., Sevin, E., Almeida, C., Culot, M., Dehouck, L., Coisne, C., Engelhardt, B., Dehouck, M.-P., & Ferreira, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099733 · Cited by 349

Quantitative analysis of drug delivery to the brain via nasal route

Kozlovskaya, L., Abou-Kaoud, M., & Stepensky, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.053 · Cited by 345

Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier

Qiao, R., Jia, Q., Hüwel, S., Xia, R., Liu, T., Gao, F., Galla, H., & Gao, M. (2012) · ACS Nano · doi:10.1021/nn300240p · Cited by 333

Cell-mediated drug delivery

Batrakova, E. V., Gendelman, H. E., & Kabanov, A. V. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.559457 · Cited by 325

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

van Assema, D. M. E., Lubberink, M., Bauer, M., van der Flier, W. M., Schuit, R. C., Windhorst, A. D., Comans, E. F. I., Hoetjes, N. J., Tolboom, N., Langer, O., et al. (2012) · Brain · doi:10.1093/brain/awr298 · Cited by 318

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

Yeste, A., Nadeau, M., Burns, E. J., Weiner, H. L., & Quintana, F. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120611109 · Cited by 307

The Effect of Nanoparticle Size on the Ability to Cross the Blood–Brain Barrier: An In Vivo Study

Betzer, O., Shilo, M., Opochinsky, R., Barnoy, E. A., Motiei, M., Okun, E., Yadid, G., & Popovtzer, R. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0022 · Cited by 302

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Anraku, Y., Kuwahara, H., Fukusato, Y., Mizoguchi, A., Ishii, T., Nitta, K., Matsumoto, Y., Toh, K., Miyata, K., Uchida, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00952-3 · Cited by 301

Thymidine Kinase Gene Therapy for Human Malignant Glioma, Using Replication-Deficient Retroviruses or Adenoviruses

Sandmair, A.-M., Loimas, S., Puranen, P., Immonen, A., Kossila, M., Puranen, M. I., Hurskainen, H., Tyynelä, K., Turunen, M., Vanninen, R., et al. (2000) · Human Gene Therapy · doi:10.1089/104303400750035726 · Cited by 300

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

Wolak, D. J., & Thorne, R. G. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300495e · Cited by 299

Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides

Li, J., Feng, L., Fan, L., Zha, Y., Guo, L., Zhang, Q., Chen, J., Pang, Z., Wang, Y., Jiang, X., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.031 · Cited by 298

Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T 1 -Weighted Magnetic Resonance Imaging and Chemotherapy

Shen, Z., Chen, T., Ma, X., Ren, W., Zhou, Z., Zhu, G., Zhang, A., Liu, Y., Song, J., Li, Z., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04924 · Cited by 298

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

Clark, A. J., & Davis, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517048112 · Cited by 284

Synthesis and Cellular Uptake of Folic Acid-Conjugated Cellulose Nanocrystals for Cancer Targeting

Dong, S., Cho, H. J., Lee, Y. W., & Roman, M. (2014) · Biomacromolecules · doi:10.1021/bm401593n · Cited by 283

Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles

Gao, H., Qian, J., Cao, S., Yang, Z. H., Pang, Z., Pan, S., Fan, L., Xi, Z., Jiang, X., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.058 · Cited by 280

Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links

Vijayan, M., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160527 · Cited by 275

Anatomical and Histological Factors Affecting Intranasal Drug and Vaccine Delivery

Gizurarson, S. S. (2012) · Current Drug Delivery · doi:10.2174/156720112803529828 · Cited by 273

Brain-Penetrating Nanoparticles Improve Paclitaxel Efficacy in Malignant Glioma Following Local Administration

Nance, E. A., Zhang, C., Shih, T.-Y., Xu, Q., Schuster, B. S., & Hanes, J. S. (2014) · ACS Nano · doi:10.1021/nn504210g · Cited by 272

Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice

Zhang, C., Xu, W., Zheng, X., Shao, X., Liu, Q., Zhang, Q., & Qian, Y. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.063 · Cited by 266

Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood–brain barrier

Wong, D. K., Dorovini‐Zis, K., & Vincent, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.008 · Cited by 264

Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood–tumor and blood–brain barriers improve outcomes in a rat glioma model

Aryal, M., Vykhodtseva, N. I., Zhang, Y., Park, J., & McDannold, N. J. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.007 · Cited by 261

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Knobloch, T., & Kreuter, J. (2011) · Journal of Drug Targeting · doi:10.3109/10611861003734001 · Cited by 259

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

Eugenín, E. A., Clements, J. E., Zink, M. C., & Berman, J. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1460-11.2011 · Cited by 253

A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery

Chai, Z., Hu, X., Wei, X., Zhan, C., Lu, L., Jiang, K., Su, B., Ruan, H., Ran, D., Fang, R. H., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.027 · Cited by 253

Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration

Yokel, R. A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-102-309 · Cited by 246

The Role of Drug Transporters at the Blood-Brain Barrier

de Boer, A. G., van der Sandt, I. C. J., & Gaillard, P. J. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140204 · Cited by 244

Poly(ethylene glycol)-Coated Hexadecylcyanoacrylate Nanospheres Display a Combined Effect for Brain Tumor Targeting

Brigger, I., Morizet, J., Aubert, G., Chacun, H., Terrier‐Lacombe, M., Couvreur, P., & Vassal, G. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039669 · Cited by 239

The function of scavenger receptorsexpressed by macrophages and their rolein the regulation of inflammation

Peiser, L., & Gordon, S. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(00)01362-9 · Cited by 232

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, G., Syvänen, S., Fang, X. T., Lannfelt, L., & Sehlin, D. (2017) · Theranostics · doi:10.7150/thno.17155 · Cited by 224

Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease.

Faucheux, B. A., Nillesse, N., Damier, P., Spik, G., Prigent, A., Pierce, A., Leveugle, B., Kubis, N., Hauw, J., & Agid, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9603 · Cited by 217

Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood–Brain Barrier Endothelial Cells In Vitro

Georgieva, J. V., Kalicharan, D., Couraud, P., Romero, I. A., Weksler, B. B., Hoekstra, D., & Zuhorn, I. S. (2010) · Molecular Therapy · doi:10.1038/mt.2010.236 · Cited by 215

Chemotherapeutic Drugs Released from Polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the Rat Brain

Fung, L. K., Shin, M., Tyler, B., Brem, H., & Saltzman, W. M. (1996) · Pharmaceutical Research · doi:10.1023/a:1016083113123 · Cited by 213

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

Vazana, U., Veksler, R., Pell, G. S., Prager, O., Fassler, M., Chassidim, Y., Roth, Y., Shahar, H., Zangen, A., Raccah, R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-16.2016 · Cited by 205

Polymeric implants for cancer chemotherapy

Fung, L. K., & Saltzman, W. M. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00036-7 · Cited by 203

Microemulsion-Based Soft Bacteria-Driven Microswimmers for Active Cargo Delivery

Singh, A. V., Hosseinidoust, Z., Park, B.-W., Yaşa, Ö., & Sitti, M. (2017) · ACS Nano · doi:10.1021/acsnano.7b02082 · Cited by 199

Nanotechnology—novel therapeutics for CNS disorders

Srikanth, M., & Kessler, J. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.76 · Cited by 198

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors

Sampson, J. H., Akabani, G., Archer, G. E., Berger, M. S., Coleman, R. E., Friedman, A. H., Friedman, H. S., Greer, K. L., Herndon, J. E., Kunwar, S., et al. (2008) · Neuro-Oncology · doi:10.1215/15228517-2008-012 · Cited by 196

Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology

Cho, H., Seo, J. H., Wong, K. H. K., Terasaki, Y., Park, J., Bong, K., Arai, K., Lo, E. H., & Irimia, D. (2015) · Scientific Reports · doi:10.1038/srep15222 · Cited by 196

Transport of nanoparticles through the blood–brain barrier for imaging and therapeutic applications

Shilo, M., Motiei, M., Hana, P., & Popovtzer, R. (2013) · Nanoscale · doi:10.1039/c3nr04878k · Cited by 195

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

Gaillard, P. J., Appeldoorn, C. C. M., Rip, J., Dorland, R., van der Pol, S. M. A., Kooij, G., de Vries, H. E., & Reijerkerk, A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.06.022 · Cited by 191

Phase I Study of GRN1005 in Recurrent Malignant Glioma

Drappatz, J., Brenner, A., Wong, E. T., Eichler, A., Schiff, D., Groves, M. D., Mikkelsen, T., Rosenfeld, S., Sarantopoulos, J., Meyers, C. A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2481 · Cited by 190

Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma

Tsai, Y.-C., Vijayaraghavan, P., Chiang, W., Chen, H., Liu, T., Shen, M., Omoto, A., Kamimura, M., Soga, K., & Chiu, H. (2018) · Theranostics · doi:10.7150/thno.22482 · Cited by 183

A D ‐Peptide Ligand of Nicotine Acetylcholine Receptors for Brain‐Targeted Drug Delivery

Wei, X., Zhan, C., Shen, Q., Fu, W., Xie, C., Gao, J., Peng, C., Zheng, P., & Lu, W. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201411226 · Cited by 181

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Sharma, M., Sharma, R., & Jain, D. K. (2016) · Scientifica · doi:10.1155/2016/8525679 · Cited by 180

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

Zhang, N., Yan, F., Liang, X., Wu, M., Shen, Y., Chen, M., Xu, Y., Zou, G., Jiang, P., Tang, C., et al. (2018) · Theranostics · doi:10.7150/thno.23734 · Cited by 180

A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery

Liu, Y., Li, J., Shao, K., Huang, R., Ye, L., Lou, J., & Jiang, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.011 · Cited by 172

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

Xiao, G., & Gan, L.-S. L. (2013) · International Journal of Cell Biology · doi:10.1155/2013/703545 · Cited by 171

Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma

Boockvar, J. A., Tsiouris, A. J., Hofstetter, C. P., Kovanlikaya, I., Fralin, S. R., Kesavabhotla, K., Seedial, S. M., Pannullo, S. C., Schwartz, T. H., Stieg, P. E., et al. (2010) · Journal of neurosurgery · doi:10.3171/2010.9.jns101223 · Cited by 170

Restricted transport of anti‐transferrin receptor antibody (OX26) through the blood–brain barrier in the rat

Moos, T., & Morgan, E. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00541.x · Cited by 169

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

Aday, S., Cecchelli, R., Hallier-Vanuxeem, D., Dehouck, M. P., & Ferreira, L. (2016) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.01.001 · Cited by 169

Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors

Kurzrock, R., Gabrail, N., Chandhasin, C., Moulder, S., Smith, C., Brenner, A., Sankhala, K., Mita, A., Elian, K., Bouchard, D., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0566 · Cited by 168

Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System

Gao, H., Pang, Z., & Jiang, X. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1122-4 · Cited by 167

Overcoming the Blood–Brain Barrier for Delivering Drugs into the Brain by Using Adenosine Receptor Nanoagonist

Gao, X., Qian, J., Zheng, S., Changyi, Y., Zhang, J., Ju, S., Zhu, J., & Li, C. (2014) · ACS Nano · doi:10.1021/nn5003375 · Cited by 167

The blood–brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting

Correale, J., & Villa, A. (2007) · Autoimmunity · doi:10.1080/08916930601183522 · Cited by 167

Pharmacokinetics and brain uptake of lactoferrin in rats

Ji, B., Maeda, J., Higuchi, M., Inoue, K., Akita, H., Harashima, H., & Suhara, T. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.085 · Cited by 166

Regulation of cerebral vasculature in normal and ischemic brain

Kulik, T. B., Kusano, Y., Aronhime, S., Sandler, A. L., & Winn, H. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.017 · Cited by 165

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

Staquicini, F. I., Ozawa, M. G., Moya, C. A., Driessen, W. H. P., Barbu, E. M., Nishimori, H., Soghomonyan, S., Flores, L. G., Liang, X., Paolillo, V., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44798 · Cited by 163

Targeting Anti—Transferrin Receptor Antibody (OX26) and OX26-Conjugated Liposomes to Brain Capillary Endothelial Cells Using In Situ Perfusion

Gosk, S., Vermehren, C., Storm, G., & Moos, T. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000135592.28823.47 · Cited by 163

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T., & Andresen, T. L. (2018) · Theranostics · doi:10.7150/thno.25228 · Cited by 161

Synergistic Dual-Ligand Doxorubicin Liposomes Improve Targeting and Therapeutic Efficacy of Brain Glioma in Animals

Zong, T., Mei, L., Gao, H., Cai, W., Zhu, P., Shi, K., Chen, J., Wang, Y., Gao, F., & He, Q. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500057n · Cited by 160

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease

Pisani, V., Stefani, A., Pierantozzi, M., Natoli, S., Stanzione, P., Franciotta, D., & Pisani, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-188 · Cited by 158

Glucose-Coated Gold Nanoparticles Transfer across Human Brain Endothelium and Enter Astrocytes In Vitro

Gromnicova, R., Davies, H. A., Sreekanthreddy, P., Romero, I. A., Lund, T., Roitt, I. M., Phillips, J. B., & Male, D. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081043 · Cited by 157

Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation

Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201401199 · Cited by 156

Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics

Bose, R. J., Paulmurugan, R., Moon, J. J., Lee, S., & Park, H. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.02.001 · Cited by 156

Micelle‐Based Brain‐Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand

Zhan, C., Li, B., Hu, L., Wei, X., Feng, L., Fu, W., & Lu, W. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100875 · Cited by 153

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Ahire, E. D., Thakkar, S., Darshanwad, M., & Misra, M. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.07.011 · Cited by 153

Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

Pardridge, W. M. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.952627 · Cited by 152

Nanotechnology Solutions for Alzheimer's Disease: Advances in Research Tools, Diagnostic Methods and Therapeutic Agents

Nazem, A., & Mansoori, G. A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13210 · Cited by 150

Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats

Rip, J., Chen, L., Hartman, R., van den Heuvel, A., Reijerkerk, A., van Kregten, J., van der Boom, B. G., Appeldoorn, C. C. M., de Boer, M., Maussang, D., et al. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.888070 · Cited by 149

In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer

Alibolandi, M., Ramezani, M., Abnous, K., Sadeghi, F., Atyabi, F., Asouri, M., Ahmadi, A. A., & Hadizadeh, F. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.04.026 · Cited by 147

Blood–brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons

Rite, I., Machado, A., Cano, J., & Venero, J. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04567.x · Cited by 147

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

Huang, R., Ma, H., Guo, Y., Liu, S., Kuang, Y., Shao, K., Li, J., Liu, Y., Han, L., Huang, S., et al. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1005-8 · Cited by 146

Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals

Qin, Y., Chen, H., Zhang, Q., Wang, X., Yuan, W., Kuai, R., Tang, J., Zhang, L., Zhang, Z., Zhang, Q., et al. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.09.008 · Cited by 144

A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease

Reddy, P. H., Tonk, S., Kumar, S., Vijayan, M., Kandimalla, R., Kuruva, C. S., & Reddy, A. P. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.067 · Cited by 143

Endothelial Vesicles in the Blood–Brain Barrier: Are They Related to Permeability?

Stewart, P. A. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1007026504843 · Cited by 142

Dissociation of Metabolic and Neurovascular Responses to Levodopa in the Treatment of Parkinson's Disease

Hirano, S., Asanuma, K., Ma, Y., Tang, C., Feigin, A., DHAWAN, V. M., Carbon, M., & Eidelberg, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0582-08.2008 · Cited by 142

ABC efflux transporters in brain vasculature of Alzheimer's subjects

Wijesuriya, H. C., Bullock, J. Y., Faull, R. L. M., Hladky, S. B., & Barrand, M. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.034 · Cited by 141

Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy

Desai Bradaric, B., Patel, A., Schneider, J. A., Carvey, P. M., & Hendey, B. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0684-8 · Cited by 139

Influence of surface charge and inner composition of porous nanoparticles to cross blood–brain barrier in vitro

Jallouli, Y., Paillard, A., Chang, J., Sevin, E., & Betbeder, D. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.023 · Cited by 139

Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening

Jones, R. M., Deng, L., Leung, K., McMahon, D., O’Reilly, M. A., & Hynynen, K. (2018) · Theranostics · doi:10.7150/thno.24911 · Cited by 135

Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

Iv, M., Telischak, N., Feng, D., Holdsworth, S. J., Yeom, K. W., & Daldrup-Link, H. E. (2015) · Nanomedicine · doi:10.2217/nnm.14.203 · Cited by 134

Brain tumor-targeted therapy by systemic delivery of siRNA with Transferrin receptor-mediated core-shell nanoparticles

Wei, L., Guo, X., Yang, T., Yu, M., Chen, D., & Wang, J. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.127 · Cited by 133

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

Owen, J. B., Rukhsana Sultana, A., Aluise, C. D., Erickson, M. A., Price, T. O., Bu, G., Banks, W. A., & Butterfield, D. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.013 · Cited by 132

Efficacy of interleukin-13 receptor–targeted liposomal doxorubicin in the intracranial brain tumor model

Madhankumar, A. B., Slagle‐Webb, B., Wang, X., Yang, Q. X., Antonetti, D. A., Miller, P. A., Sheehan, J. M., & Connor, J. R. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0853 · Cited by 124

Imaging Approach to Mechanistic Study of Nanoparticle Interactions with the Blood–Brain Barrier

Bramini, M., Dong, Y., Hallerbach, A., Raghnaill, M. N., Salvati, A. L., Åberg, C., & Dawson, K. A. (2014) · ACS Nano · doi:10.1021/nn5018523 · Cited by 123

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.76 · Cited by 122

Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases

Leveugle, B., Faucheux, B. A., Bouras, C., Nillesse, N., Spik, G., Hirsch, É. C., Agid, Y., & Hof, P. R. (1996) · Acta Neuropathologica · doi:10.1007/s004010050468 · Cited by 120

Changes in vascularization in substantia nigra pars compacta of monkeys rendered parkinsonian

Barcia, C., Bautista‐Hernández, V., Sánchez-Bahíllo, A., Fernández‐Villalba, E., Faucheux, B. A., Poza, M., Barreiro, A. F., Hirsch, É. C., & Herrero, M. T. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0256-2 · Cited by 120

dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

Lim, S., Kim, W., Kim, Y.-H., Lee, S., Koo, J., Lee, J.-A., Yoon, H., Kim, D.-H., Park, H.-J., Kim, H.-M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9244 · Cited by 119

Surface engineered nanostructured lipid carriers for efficient nose to brain delivery of ondansetron HCl using Delonix regia gum as a natural mucoadhesive polymer

Devkar, T. B., Tekade, A. R., & Khandelwal, K. R. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.06.037 · Cited by 118

Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors

Sawyer, A. J., Saucier-Sawyer, J. K., Booth, C. J., Liu, J., Patel, T., Piepmeier, J. M., & Saltzman, W. M. (2010) · Drug Delivery and Translational Research · doi:10.1007/s13346-010-0001-3 · Cited by 118

Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system

Chen, M. Y., Hoffer, A., Morrison, P. F., Hamilton, J. F., Hughes, J. A., Schlageter, K. S., Lee, J., Kelly, B. R., & Oldfield, E. H. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.103.2.0311 · Cited by 118

New methods for direct delivery of chemotherapy for treating brain tumors.

Sawyer, A. J., Piepmeier, J. M., & Saltzman, W. M. (2006) · PubMed Central · Cited by 116

A review on animal models of stroke: An update

Kumar, A., Aakriti, & Gupta, V. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.02.016 · Cited by 115

Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities

Curley, C. T., Sheybani, N., Bullock, T. N. J., & Price, R. J. (2017) · Theranostics · doi:10.7150/thno.21225 · Cited by 111

Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability

Jin, Q., Cai, Y. C., Li, S., Liu, H., Zhou, X., Lu, C., Gao, X., Qian, J., Zhang, J., Ju, S., et al. (2017) · Theranostics · doi:10.7150/thno.18219 · Cited by 110

Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles

Neeves, K. B., Sawyer, A. J., Foley, C. P., Saltzman, W. M., & Olbricht, W. L. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.050 · Cited by 99

Self-Assembly of Gold Nanoparticles Shows Microenvironment-Mediated Dynamic Switching and Enhanced Brain Tumor Targeting

Feng, Q., Shen, Y., Fu, Y., Muroski, M. E., Zhang, P., Wang, Q., Xu, C., Lesniak, M. S., Li, G., & Cheng, Y. (2017) · Theranostics · doi:10.7150/thno.18985 · Cited by 99

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Khan, Z. A., & Bagad, M. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s80706 · Cited by 98

Intra-arterial delivery of AAV vectors to the mouse brain after mannitol mediated blood brain barrier disruption

Foley, C. P., Rubin, D. G., Santillán, A., Sondhi, D., Dyke, J. P., Gobin, Y. P., Crystal, R. G., & Ballon, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.09.018 · Cited by 97

The Ligand Nanoparticle Conjugation Approach for Targeted Cancer Therapy

Karra, N., & Benita, S. (2011) · Current Drug Metabolism · doi:10.2174/138920012798356899 · Cited by 97

Updates in the medical management of Parkinson disease

Fernandez, H. H. (2012) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.78gr.11005 · Cited by 96

Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1

Bertrand, Y., Currie, J.-C., Poirier, J., Demeule, M., Abulrob, A., Fatehi, D., Stanimirovic, D., Sartelet, H., Castaigne, J.-P., & Béliveau, R. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.427 · Cited by 94

MiniAp‐4: A Venom‐Inspired Peptidomimetic for Brain Delivery

Oller‐Salvia, B., Sánchez‐Navarro, M., Ciudad, S., Guiu, M., Arranz‐Gibert, P., Garcia, C., Gomis, R. R., Cecchelli, R., García, J., Giralt, E., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201508445 · Cited by 92

Enhanced chemotherapy delivery by intraarterial infusion and blood‐brain barrier disruption in the treatment of cerebral metastasis

Fortin, D., Gendron, C., Boudrias, M., & Lapointe‐Garant, M. (2007) · Cancer · doi:10.1002/cncr.22450 · Cited by 91

Blood-Brain Barrier P-Glycoprotein Function in Neurodegenerative Disease

Bartels, A. L. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797440122 · Cited by 91

Delivery of nanoparticles to the brain detected by fluorescence microscopy

Reimold, I., Domke, D., Bender, J., Seyfried, C. A., Radunz, H.-E., & Fricker, G. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.05.007 · Cited by 89

Enhanced Glioma Targeting and Penetration by Dual-Targeting Liposome Co-modified with T7 and TAT

Zong, T., Mei, L., Gao, H., Shi, K., Chen, J., Wang, Y., Zhang, Q., Yang, Y., & He, Q. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24186 · Cited by 89

Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood–Brain Barrier

Cabezón, I., Manich, G., Martín-Venegas, R., Camins, A., Pelegrı́, C., & Vilaplana, J. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00597 · Cited by 89

SiO2 nanoparticles change colour preference and cause Parkinson's-like behaviour in zebrafish

Li, X., Лю, Б., Li, X.-L., Li, Y.-X., Sun, M., Chen, D.-Y., Zhao, X. J., & Feng, X. (2014) · Scientific Reports · doi:10.1038/srep03810 · Cited by 88

Influence of Short-Chain Cell-Penetrating Peptides on Transport of Doxorubicin Encapsulating Receptor-Targeted Liposomes Across Brain Endothelial Barrier

Sharma, G., Modgil, A., Zhong, T., Sun, C., & Singh, J. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1242-x · Cited by 87

Conjugation of Functionalized SPIONs with Transferrin for Targeting and Imaging Brain Glial Tumors in Rat Model

Jiang, W., Xie, H., Ghoorah, D., Shang, Y., Shi, H., Liu, F., Yang, X., & Xu, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037376 · Cited by 86

Self-Assembled Polymersomes Conjugated with Lactoferrin as Novel Drug Carrier for Brain Delivery

Yu, Y., Pang, Z., Lü, W., Yin, Q., Gao, H., & Jiang, X. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0513-7 · Cited by 86

Smart Nanodevice Combined Tumor-Specific Vector with Cellular Microenvironment-Triggered Property for Highly Effective Antiglioma Therapy

Shao, K., Ding, N., Huang, S., Ren, S., Zhang, Y. X., Kuang, Y., Guo, Y., Ma, H., An, S., Li, Y., et al. (2014) · ACS Nano · doi:10.1021/nn406285x · Cited by 86

Folic Acid-Conjugated MnO Nanoparticles as a T 1 Contrast Agent for Magnetic Resonance Imaging of Tiny Brain Gliomas

Chen, N., Shao, C., Qu, Y., Li, S., Gu, W., Zheng, T., Ye, L., & Yu, C. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am505223t · Cited by 81

Nanotherapeutic systems for local treatment of brain tumors

Chakroun, R. W., Zhang, P., Lin, R., Schiapparelli, P. V., Quiñones‐Hinojosa, A., & Cui, H. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1479 · Cited by 80

Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression

Jangula, A., & Murphy, E. J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.058 · Cited by 79

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

Serralheiro, A., Alves, G., Fortuna, A. C., & Falcão, A. C. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.05.021 · Cited by 77

Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via interleukin 13 receptor α2-mediated endocytosis

Wang, B., Lv, L., Wang, Z., Zhao, Y., Wu, L. H., Fang, X., Xu, Q., & Xin, H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.068 · Cited by 77

Nanotechnology for the Detection and Therapy of Stroke

Kyle, S., & Saha, S. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400009 · Cited by 76

Nanoparticle Enabled Drug Delivery Across the Blood Brain Barrier: in vivo and in vitro Models, Opportunities and Challenges

Gidwani, M., & Singh, A. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140508122558 · Cited by 73

Targeted Delivery of Proteins into the Central Nervous System Mediated by Rabies Virus Glycoprotein-Derived Peptide

Fu, A., Wang, Y., Zhan, L., & Zhou, R. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0667-y · Cited by 73

Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo

Huang, R., Ke, W., Han, L., Liu, Y., Shao, K., Jiang, C., & Pei, Y. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.12.008 · Cited by 69

Use of PEGylated Immunoliposomes to Deliver Dopamine Across the Blood–Brain Barrier in a Rat Model of Parkinson's Disease

Kang, Y., Jung, H., Oh, J., & Song, D. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12580 · Cited by 68

Nanoparticle-Based Targeted Therapeutics in Head-And-Neck Cancer

Wu, T., & Zhou, S. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.10083 · Cited by 67

The DrrAB Efflux System of Streptomyces peucetius Is a Multidrug Transporter of Broad Substrate Specificity

Li, W., Sharma, M., & Kaur, P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536136 · Cited by 66

Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood–brain barrier

Sun, Z., Worden, M., Wroczynskyj, Y., Yathindranath, V., van Lierop, J., Hegmann, T., & Miller, D. W. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s62260 · Cited by 63

Enhanced stability of horseradish peroxidase encapsulated in acetalated dextran microparticles stored outside cold chain conditions

Kanthamneni, N., Sharma, S., Meenach, S. A., Billet, B., Zhao, J., Bachelder, E. M., & Ainslie, K. M. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.04.043 · Cited by 63

Improved anti-glioblastoma efficacy by IL-13Rα2 mediated copolymer nanoparticles loaded with paclitaxel

Wang, B., Lv, L., Wang, Z., Jiang, Y., Lv, W., Liu, X., Wang, Z., Zhao, Y., Xin, H., & Xu, Q. (2015) · Scientific Reports · doi:10.1038/srep16589 · Cited by 63

Transferrin and cell-penetrating peptide dual-functioned liposome for targeted drug delivery to glioma.

Zheng, C.-Y., Ma, C., Bai, E., Yang, K., & Xu, R. (2015) · PubMed Central · Cited by 60

Polymersomes conjugated to 83-14 monoclonal antibodies: Invitro targeting of brain capillary endothelial cells

Dieu, L., Wu, D., Palivan, C. G., Balasubramanian, V., & Huwyler, J. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.05.021 · Cited by 59

Developmental origins of brain tumors

Liu, C., & Zong, H. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.04.012 · Cited by 59

Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue – Evaluations on Monocyte-Based Delivery System for the Central Nervous System

Tong, H.-I., Kang, W., Davy, P. M. C., Shi, Y., Sun, S., Allsopp, R., & Lu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154022 · Cited by 59

Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood–brain barrier model

Srimanee, A., Regberg, J., Hällbrink, M., Vajragupta, O., & Langel, Ü. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.014 · Cited by 58

Convection-Enhanced Delivery of a Virus-Like Nanotherapeutic Agent with Dual-Modal Imaging for Besiegement and Eradication of Brain Tumors

Pang, H., Chen, P., Wei, K., Huang, C., Shiue, Y., Huang, C.-Y., & Yang, H. (2019) · Theranostics · doi:10.7150/thno.30977 · Cited by 58

Endocytosis of Nanomedicines: The Case of Glycopeptide Engineered PLGA Nanoparticles

Vilella, A., Ruozi, B., Belletti, D., Pederzoli, F., Galliani, M., Semeghini, V., Forni, F., Zoli, M., Vandelli, M. A., & Tosi, G. (2015) · Pharmaceutics · doi:10.3390/pharmaceutics7020074 · Cited by 57

A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-cancerous cells

Shen, Z., Wu, H., Yang, S., Ma, X., Li, Z., Tan, M., & Wu, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.022 · Cited by 56

Biology of brain metastases and novel targeted therapies: Time to translate the research

Fokas, E., Steinbach, J., & Rödel, C. M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.10.005 · Cited by 56

Mucoadhesive Amphiphilic Methacrylic Copolymer-Functionalized Poly(ε-caprolactone) Nanocapsules for Nose-to-Brain Delivery of Olanzapine

da Fonseca, F. N., Betti, A. H., Carvalho, F. C., Gremião, M. P. D., Dimer, F. A., Guterres, S. S., Tebaldi, M. L., Rates, S. M. K., & Pohlmann, A. R. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2015.2078 · Cited by 56

Increasing the oscillation frequency of strong magnetic fields above 101 kHz significantly raises peripheral nerve excitation thresholds

Weinberg, I. N., Stepanov, P. Y., Fricke, S. T., Probst, R., Urdaneta, M., Warnow, D. M., Sanders, H. D., Glidden, S. C., McMillan, A. B., Starewicz, P. M., et al. (2012) · Medical Physics · doi:10.1118/1.3702775 · Cited by 55

From venoms to BBB shuttles: Synthesis and blood–brain barrier transport assessment of apamin and a nontoxic analog

Oller‐Salvia, B., Teixidò, M., & Giralt, E. (2013) · Biopolymers · doi:10.1002/bip.22257 · Cited by 54

Local Delivery of Poly Lactic-co-glycolic Acid Microspheres Containing Imatinib Mesylate Inhibits Intracranial Xenograft Glioma Growth

Benny, O., Menon, L. G., Ariel, G., Goren, E., Kim, S., Stewman, C., Black, P. M., Carroll, R. S., & Machluf, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1316 · Cited by 53

Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound

Alkins, R. D., Brodersen, P. M., Sodhi, R. N. S., & Hynynen, K. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not052 · Cited by 53

Toxins and derivatives in molecular pharmaceutics: Drug delivery and targeted therapy

Zhan, C., Li, C., Wei, X., Lu, W., & Lu, W. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.025 · Cited by 51

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti‐Intracranial Infection Applications

Shao, K., Zhang, Y. X., Ding, N., Huang, S., Wu, J., Li, J., Yang, C., Leng, Q., Ye, L., Lou, J., et al. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400214 · Cited by 51

Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats

Obermeyer, J. M., Tuladhar, A., Payne, S. L., Ho, E., Morshead, C. M., & Shoichet, M. S. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0215 · Cited by 51

Considerations for the Development and Practice of Cascade Impaction Testing, Including a Mass Balance Failure Investigation Tree

Christopher, D., Curry, P., Doub, B., Furnkranz, K., Lavery, M., Lin, K. K., Lyapustina, S., Mitchell, J. P., Rogers, B., Strickland, H., et al. (2003) · Journal of Aerosol Medicine · doi:10.1089/089426803769017604 · Cited by 50

Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure

Asquier, N., Bouchoux, G., Canney, M. S., Martin, C., Law-Ye, B., Leclercq, D., Chapelon, J., Lafon, C., Idbaïh, A., & Carpentier, A. C. (2019) · Journal of neurosurgery · doi:10.3171/2018.9.jns182001 · Cited by 50

A Novel Blood-Brain Barrier Co-Culture System for Drug Targeting of Alzheimer’s Disease: Establishment by Using Acitretin as a Model Drug

Freese, C., Reinhardt, S., Hefner, G., Unger, R. E., Kirkpatrick, C. J., & Endres, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091003 · Cited by 49

Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery

Chen, Y., Zhang, M., Jin, H., Li, D., Xu, F., Wu, A., Wang, J., & Huang, Y. (2017) · Theranostics · doi:10.7150/thno.20578 · Cited by 49

Receptor-Targeted Glial Brain Tumor Therapies

Sharma, P., & Debinski, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113326 · Cited by 49

Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis

Lee, D.-H., Rötger, C., Appeldoorn, C. C. M., Reijerkerk, A., Gladdines, W., Gaillard, P. J., & Linker, R. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.025 · Cited by 48

Transporter-Based Delivery of Anticancer Drugs to the Brain: Improving Brain Penetration by Minimizing Drug Efflux at the Blood-Brain Barrier

On, N. H., & Miller, D. W. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990458 · Cited by 47

Convection-Enhanced Delivery of Polymeric Nanoparticles Encapsulating Chemotherapy in Canines with Spontaneous Supratentorial Tumors

Young, J. S., Bernal, G. M., Polster, S. P., Núñez, L., Larsen, G. F., Mansour, N. M., Podell, M., & Yamini, B. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.06.114 · Cited by 47

Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an in vitro blood brain barrier model

Ivask, A., Pilkington, E. H., Blin, T., Käkinen, A., Vija, H., Visnapuu, M., Quinn, J. F., Whittaker, M. R., Qiao, R., Davis, T. P., et al. (2017) · Biomaterials Science · doi:10.1039/c7bm01012e · Cited by 46

Quantitative analysis of the brain-targeted delivery of drugs and model compounds using nano-delivery systems

Kozlovskaya, L., & Stepensky, D. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.06.028 · Cited by 45

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Strategies for delivering therapeutics across the blood–brain barrier

Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi, M., Chehelgerdi, M., Allela, O. Q. B., Pecho, R. D. C., Narayanan, J., Rao, D. P., Thamaraikani, T., Vasanthan, M., Viktor, P., Lakshmaiya, N., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01865-0 · Cited by 1,132

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Montoto, S. S., Muraca, G., & Ruiz, M. E. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.587997 · Cited by 695

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Wang, B., Hu, S., Teng, Y., Chen, J., Wang, H., Xu, Y., Wang, K., Xu, J., Cheng, Y., & Gao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01889-y · Cited by 641

Advances in CNS drug delivery strategies to cross the blood-brain barrier

Li, G., Li, Z., Sun, Y., Bu, T., Chen, S., Yang, L., Li, Z., Mao, W., & Jia, Y. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111524 · Cited by 10

Harnessing nanotechnology for improved drug delivery across the blood-brain barrier and enhanced neural repair

Xu, M., Wang, H., Wang, C., Wang, C., Hu, S., & Weng, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126221 · Cited by 2

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708

The Route of Nanomaterials Entering Brain

Liu, Y., & He, Q. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804598-5.00002-7 · Cited by 14

Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review

Kulkarni, M., Patel, K., Patel, A. K., Patel, S., Desai, J. L., Patel, M. M., Shah, U., Patel, A. D., & Solanki, N. D. (2023) · ADMET & DMPK · doi:10.5599/admet.2043 · Cited by 46