The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation
Abstract
Tissue engineering is a promising strategy for the repair of large-scale bone defects, in which scaffolds and growth factors are two critical issues influencing the efficacy of bone regeneration. Unfortunately, the broad application of growth factors is limited by their poor stability in the scaffolds. In the present study, the strictly controlled expression of human bone morphogenetic protein-4 (hBMP-4) in the presence of doxycycline is achieved by adding an hBMP-4 gene fragment into a non-viral artificial restructuring plasmid vector (pSTAR) to form the pSTAR-hBMP-4 plasmid (phBMP-4). Furthermore, the controlled release of phBMP-4 is obtained with an electroactive tissue engineering scaffold, generated by combining a triblock copolymer of poly(l-lactic acid)-block-aniline pentamer-block-poly(l-lactic acid) (PLA-AP) with poly(lactic-co-glycolic acid)/hydroxyapatite (PLGA/HA). This PLGA/HA/PLA-AP/phBMP-4 composite scaffold, with controlled gene release and Dox-regulated gene expression upon electrical stimulation, operating synergistically, exhibits an improved cell proliferation ability, enhanced osteogenesis differentiation in vitro, and effective bone healing in vivo in a rabbit radial defect model. Taking these results together, the proposed smart PLGA/HA/PLA-AP/phBMP-4 scaffold lays a solid theoretical and experimental basis for future applications of such multi-functional materials in bone tissue engineering to help patients in need.
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Osteoinductive ceramics as a synthetic alternative to autologous bone grafting
Yuan, H., Fernandes, H., Habibovic, P., de Boer, J., Barradas, A. M. C., de Ruiter, A., Walsh, W. R., van Blitterswijk, C. A., & de Bruijn, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003600107 · Cited by 746
An Improved Tet-On System for Gene Expression in Neurons Delivered by a Single Lentiviral Vector
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Cited by
Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.043 · Cited by 494
Self-citationLiu, Z., Wan, X., Wang, Z. L., & Li, L. (2021) · Advanced Materials · doi:10.1002/adma.202007429 · Cited by 478
Recent advances in PLGA-based biomaterials for bone tissue regeneration
Jin, S., Xia, X., Huang, J., Yuan, C., Zuo, Y., Li, Y., & Li, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.067 · Cited by 295
Recent advances in regenerative biomaterials
Cao, D., & Ding, J. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac098 · Cited by 259
Self-citationWang, T., Ouyang, H., Luo, Y., Xue, J., Wang, E., Zhang, L., Zhou, Z., Liu, Z., Li, X., Tan, S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi6799 · Cited by 161
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Metadata
- Authors
- Cui, L., Zhang, J., Zou, J., Yang, X., Guo, H., Tian, H., Zhang, P., Wang, Y., Zhang, N., Zhuang, X., Li, Z., Ding, J., & Chen, X.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 230
- Pages
- 119617
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2983101878
- Cited by
- 228
- References
- 5
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cui, L., Zhang, J., Zou, J., Yang, X., Guo, H., Tian, H., Zhang, P., Wang, Y., Zhang, N., Zhuang, X., Li, Z., Ding, J., & Chen, X. (2020). Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation. Biomaterials. https://doi.org/10.1016/j.biomaterials.2019.119617
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