The DOI matches its Crossref record; 326 of the 326 references it cites were found in a registry or an index.
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds
Open accessAbstract
Bone-tissue defects affect millions of people worldwide. Despite being common treatment approaches, autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect. This has prompted researchers to explore novel bone-regeneration methods. In recent decades, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field. As researchers have provided deep insights into bone physiology and the bone-healing mechanism, various biomimicking and bioinspired BTE scaffolds have been reported. Now it is necessary to review the progress of natural bone physiology and bone healing mechanism, which will provide more valuable enlightenments for researchers in this field. This work details the physiological microenvironment of the natural bone tissue, bone-healing process, and various biomolecules involved therein. Next, according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism, it elaborates the biomimetic design of a scaffold, highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration.
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1 retracted
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Cited by
Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds
Koushik, T. M., Miller, C. M., & Antunes, E. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202766 · Cited by 359
Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration
Yuan, X., Zhu, W., Yang, Z., He, N., Chen, F., Han, X., & Zhou, K. (2024) · Advanced Materials · doi:10.1002/adma.202403641 · Cited by 339
Recent advances in regenerative biomaterials
Cao, D., & Ding, J. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac098 · Cited by 259
Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review
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Wu, M., Wang, Y., Liu, H., Chen, F., Zhang, Y., Wu, P., Deng, Z., & Cai, L. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111705 · Cited by 28
Self-citation
Metadata
- Authors
- Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 6
- Issue
- 11
- Pages
- 4110-4140
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W3159439354
- Cited by
- 494
- References
- 326
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z. (2021). Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2021.03.043
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