The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy
Abstract
Photothermal therapy (PTT) normally requires to maintain the temperature of tumor lesions above 50 °C, which potentially induces local inflammation and tumor metastasis. To avoid these side effects, it is vital to achieve effective antitumor efficacy at relatively low temperature (42-45 °C) during the PTT treatment. Herein, we design a polydopamine (PDA)-coated nucleic acid nanogel as a therapeutic complex for siRNA-mediated low-temperature PTT. First, siRNAs that target the heat-shock-protein 70 (Hsp70) serve as crosslinkers to guide the DNA-grafted polycaprolactone (DNA-g-PCL) assemble into nanosized hydrogel particles through nucleic acid hybridization. Thereafter, the obtained siRNA-embedded nanogels are further coated with a thin layer of polydopamine, which not only protects the nanogels against enzymatic degradation but also endows the nanogels with excellent photothermal conversion capacity under near infrared (NIR) light irradiation. After surface PEGylation, this triple shield siRNA delivery complex shows the capability of effective ablating the tumor under relatively mild condition.
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Cites
Mussel-inspired surface chemistry for multifunctional coatings
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Non-viral vectors for gene-based therapy
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Delivery materials for siRNA therapeutics
Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800
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Zeng, X., Luo, M., Liu, G., Wang, X., Tao, W., Lin, Y., Ji, X., Nie, L., & Mei, L. (2018) · Advanced Science · doi:10.1002/advs.201800510 · Cited by 598
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Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
Self-citationNanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment
Gao, G., Sun, X., & Liang, G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100738 · Cited by 359
Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine
Wu, D., Zhou, J., Creyer, M. N., Yim, W., Chen, Z., Messersmith, P. B., & Jokerst, J. V. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00908c · Cited by 317
DNA hydrogel-based gene editing and drug delivery systems
Mo, F., Jiang, K., Zhao, D., Wang, Y., Song, J., & Tan, W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.018 · Cited by 304
Self-citationBioinspired polydopamine hydrogels: Strategies and applications
Xu, Y., Hu, J., Hu, J., Cheng, Y., Chen, X., Gu, Z., & Li, Y. (2023) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2023.101740 · Cited by 285
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Metadata
- Authors
- Ding, F., Gao, X., Huang, X., Ge, H., Xie, M., Qian, J., Song, J., Li, Y., Zhu, X., & Zhang, C.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 245
- Pages
- 119976
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3010749666
- Cited by
- 273
- References
- 6
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- closed
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