Delivery materials for siRNA therapeutics

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Phenotypic Heterogeneity of the Endothelium

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

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Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,

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Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

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Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

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The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

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Lipid-like materials for low-dose, in vivo gene silencing

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Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

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PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

Mishra, S., Webster, P. C., & Davis, M. E. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00363 · Cited by 733 · see citing works

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

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Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

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Stealth Me. PEG‐PLA Nanoparticles Avoid Uptake by the Mononuclear Phagocytes System

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Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

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On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

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Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

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Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

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In vivo activity of nuclease-resistant siRNAs

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Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

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Sheddable Coatings for Long-Circulating Nanoparticles

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Folate-Targeted Therapies for Cancer

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Current Protocols in Nucleic Acid Chemistry

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Current progress of siRNA/shRNA therapeutics in clinical trials

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Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

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Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

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Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

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Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

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A review of nanocarriers for the delivery of small interfering RNA

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Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery

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siRNA Conjugate Delivery Systems

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Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

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New Class of Polymers for the Delivery of Macromolecular Therapeutics

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Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

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A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

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Cyclodextrin-Modified Polyethylenimine Polymers for Gene Delivery

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Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

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The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

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ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

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Physicochemical and Biological Characterization of Targeted, Nucleic Acid-Containing Nanoparticles

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Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

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Nonbilayer phase of lipoplex–membrane mixture determines endosomal escape of genetic cargo and transfection efficiency

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An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4 + T Cell Decline in Humanized Mice

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Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer

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Development of a Nonviral Gene Delivery Vehicle for Systemic Application

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Effects of Structure of β-Cyclodextrin-Containing Polymers on Gene Delivery

Hwang, S. J., Bellocq, N. C., & Davis, M. E. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0001084 · Cited by 217 · see citing works

Polymers in Small-Interfering RNA Delivery

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Silencing or Stimulation? siRNA Delivery and the Immune System

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Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2 + Breast Cancer Growth and Metastasis

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In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(–PEG)/siRNA complexes

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Nanovector delivery of siRNA for cancer therapy

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In vivo delivery of RNAi with lipid-based nanoparticles

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Tunable pH-Sensitive Liposomes Composed of Mixtures of Cationic and Anionic Lipids

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Impact of tumor‐specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA‐containing nanoparticles

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Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules

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Elimination Pathways of Systemically Delivered siRNA

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Targeted Delivery Systems for Oligonucleotide Therapeutics

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Synthesis of Cluster Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor

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Update on the glomerular filtration barrier

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Self-Assembling Nucleic Acid Delivery Vehicles via Linear, Water-Soluble, Cyclodextrin-Containing Polymers

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Inhibition of protein kinase C by cationic amphiphiles

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Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery. 1. Carbohydrate Size and Its Distance from Charge Centers

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Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes

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Effect of PEGylation on Biodistribution and Gene Silencing of siRNA/Lipid Nanoparticle Complexes

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Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery. 3. Cyclodextrin Type and Functionalization

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Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy

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Co-Injection of a Targeted, Reversibly Masked Endosomolytic Polymer Dramatically Improves the Efficacy of Cholesterol-Conjugated Small Interfering RNAs In Vivo

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Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

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