The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing
Abstract
Lack of oxygen, reduced vascularization, elevated oxidative stress, and infection are critical clinical hallmarks of non-healing chronic diabetic wounds. Therefore, delivering oxygen, inducing angiogenesis, and management of oxidative stress and infection may provide newer and improved therapeutic avenues for better clinical outcomes in diabetic wound healing. Here, we report the development and evaluation of an exosome laden oxygen releasing antioxidant wound dressing OxOBand to promote wound closure and skin regeneration in diabetic wounds. OxOBand is composed of antioxidant polyurethane (PUAO), as highly porous cryogels with sustained oxygen releasing properties and supplemented with adipose-derived stem cells (ADSCs) exosomes. Exosomes engulfed by the cells enhanced the migration of human keratinocytes and fibroblasts and increased the survival of human neuroblastoma cells under hyperglycemic conditions. OxOBand facilitated faster wound closure, enhanced collagen deposition, faster re-epithelialization, increased neo-vascularization, and decreased oxidative stress within two weeks as compared to untreated diabetic control wounds. The dressing promoted the development of mature epithelial structures with hair follicles and epidermal morphology similar to that of healthy skin. In clinically challenging infected diabetic wounds, these dressings prevented infection and ulceration, improved wound healing with increased collagen deposition, and re-epithelialization. Altogether, OxOBand is a remarkably newer treatment strategy for enhanced diabetic wound healing and may lead to novel therapeutic interventions for the treatment of diabetic ulcers.
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“Furthermore, Shiekh et al. have shown that an antioxidant wound dressing, consisting of antioxidant polyurethane combined with ADSCs extracted exosomes, could shorten the diabetic wound healing time [105].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [105]
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Cites
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Guan, Y., Niu, H. M., Liu, Z., Dang, Y., Shen, J., Zayed, M. A., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 654
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The Immune Functions of Keratinocytes in Skin Wound Healing
Piipponen, M., Li, D., & Xu, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228790 · Cited by 550
Pranantyo, D., Yeo, C. K., Wu, Y., Fan, C., Xu, X., Yip, Y. S., Vos, M. I. G., Mahadevegowda, S. H., Lim, P. L. K., Yang, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44968-y · Cited by 408
Metadata
- Authors
- Shiekh, P. A., Singh, A., & Kumar, A.
- Affiliations
- Indian Institute of Technology Kanpur (IN)
- Corresponding author
- Kumar, Ashok
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 249
- Pages
- 120020
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3015385912
- Cited by
- 443
- References
- 53
- Citations by year
- 2026: 53 · 2025: 75 · 2024: 82 · 2023: 97 · 2022: 82 · 2021: 40 · 2020: 14
- FWCI
- 32.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Human Resource Development (2019/P612/SL)
- Impacting Research Innovation and Technology (MHRD_6714)
- Indian Institute of Technology Kanpur
- Department of Science and Technology, Ministry of Science and Technology, India
- Department of Biotechnology, Ministry of Science and Technology, India (DST/INT/SWD/P-11/2016, DBT/IN/SWEDEN/08/AK/2017-1, MHRD_IITK_006, SPARC/2018\u20132019/P612/SL)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- diabetic wound healing, infected diabetic wounds, exosomes, adipose-derived stem cells, angiogenesis, oxidative stress, re-epithelialization, collagen deposition, keratinocyte migration, fibroblast survival, skin regeneration, wound closure
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Bandages, Diabetes Mellitus, Humans, Oxygen, Wound Healing, Exosomes, Cryogels
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