The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing
Abstract
Lack of oxygen, reduced vascularization, elevated oxidative stress, and infection are critical clinical hallmarks of non-healing chronic diabetic wounds. Therefore, delivering oxygen, inducing angiogenesis, and management of oxidative stress and infection may provide newer and improved therapeutic avenues for better clinical outcomes in diabetic wound healing. Here, we report the development and evaluation of an exosome laden oxygen releasing antioxidant wound dressing OxOBand to promote wound closure and skin regeneration in diabetic wounds. OxOBand is composed of antioxidant polyurethane (PUAO), as highly porous cryogels with sustained oxygen releasing properties and supplemented with adipose-derived stem cells (ADSCs) exosomes. Exosomes engulfed by the cells enhanced the migration of human keratinocytes and fibroblasts and increased the survival of human neuroblastoma cells under hyperglycemic conditions. OxOBand facilitated faster wound closure, enhanced collagen deposition, faster re-epithelialization, increased neo-vascularization, and decreased oxidative stress within two weeks as compared to untreated diabetic control wounds. The dressing promoted the development of mature epithelial structures with hair follicles and epidermal morphology similar to that of healthy skin. In clinically challenging infected diabetic wounds, these dressings prevented infection and ulceration, improved wound healing with increased collagen deposition, and re-epithelialization. Altogether, OxOBand is a remarkably newer treatment strategy for enhanced diabetic wound healing and may lead to novel therapeutic interventions for the treatment of diabetic ulcers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, Shiekh et al. have shown that an antioxidant wound dressing, consisting of antioxidant polyurethane combined with ADSCs extracted exosomes, could shorten the diabetic wound healing time [105].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [105]
Citations
Cites
IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040
Ogurtsova, K., Fernandes, J. D. D. R., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., Cavan, D. A., Shaw, J. E., & Makaroff, L. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.024 · Cited by 7,138
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Wound healing and its impairment in the diabetic foot
Falanga, V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67700-8 · Cited by 2,715
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468
Fibroblasts and myofibroblasts in wound healing
Desmouliere, A., Darby, I. A., Laverdet, B., & Bonté, F. (2014) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s50046 · Cited by 1,039
Oxidative stress in normal and impaired wound repair
SCHAFER, M., & WERNER, S. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.004 · Cited by 902
Galiano, R. D., Tepper, O. M., Pelo, C. R., Bhatt, K. A., Callaghan, M. J., Bastidas, N., Bunting, S., Steinmetz, H., & Gurtner, G. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63754-6 · Cited by 812
Wound healing essentials: Let there be oxygen
Sen, C. K. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00436.x · Cited by 738
Hu, L., Wang, J., Zhou, X., Xiong, Z., Zhao, J., Yu, R., Huang, F., Zhang, H., & Chen, L. (2016) · Scientific Reports · doi:10.1038/srep32993 · Cited by 693
Concise Review: Adipose‐Derived Stem Cells as a Novel Tool for Future Regenerative Medicine
Mizuno, H., Tobita, M., & Uysal, Ç. A. (2012) · Stem Cells · doi:10.1002/stem.1076 · Cited by 668
Lower extremity amputations - a review of global variability in incidence
Moxey, P. W., Gogălniceanu, P., Hinchliffe, R. J., Loftus, I. M., Jones, K., THOMPSON, M. M., & Holt, P. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03279.x · Cited by 590
Nunan, R., Harding, K. G., & Martin, P. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.016782 · Cited by 542
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
Botusan, I. R., Sunkari, V. G., Savu, O., Catrina, A. I., Grünler, J., Lindberg, S., Pereira, T., Ylä-Herttuala, S., Poellinger, L., Brismar, K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805230105 · Cited by 533
Li, X., Xie, X., Lian, W., Shi, R., Han, S., Zhang, H., Lu, L., & Li, M. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0058-5 · Cited by 472
Smiell, J. M., Wieman, T. J., Steed, D. L., Perry, B. H., Sampson, A. R., & Schwab, B. H. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00335.x · Cited by 454
The Role of Oxygen in Wound Healing
RODRIGUEZ, P. G., FELIX, F. N., Woodley, D. T., & SHIM, E. K. (2008) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2008.34254.x · Cited by 408
Dynamics of exosome internalization and trafficking
Tian, T., Zhu, Y., Hu, F., Wang, Y., Huang, N., & Xiao, Z. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24304 · Cited by 351
Obara, K., Ishihara, M., Ishizuka, T., Fujita, M., Ozeki, Y., Maehara, T., Saito, Y., Yura, H., Matsui, T., Hattori, H., et al. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00220-5 · Cited by 316
Effect of Hyperoxia on Vascular Endothelial Growth Factor Levels in a Wound Model
Sheikh, A. Y. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.11.1293 · Cited by 306
The Exosome ‐ A Naturally Secreted Nanoparticle and its Application to Wound Healing
Rani, S., & Ritter, T. (2015) · Advanced Materials · doi:10.1002/adma.201504009 · Cited by 295
Oxygen, Oxidants, and Antioxidants in Wound Healing
Sen, C. K., Khanna, S., Gordillo, G. M., Bagchi, D., Bagchi, M., & Roy, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02920.x · Cited by 280
Concise Review: Clinical Translation of Wound Healing Therapies Based on Mesenchymal Stem Cells
Jackson, W. M., Nesti, L. J., & Tuan, R. S. (2011) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0024 · Cited by 276
Human Epidermal Growth Factor Enhances Healing of Diabetic Foot Ulcers
Tsang, M. W., Wong, W. K., Hung, C. S., Lai, K.-M., Tang, W., Cheung, E. Y. N., Kam, G. Y. W., Leung, L., Chan, C. W., Chu, C. M., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1856 · Cited by 271
Oxygen: Implications for Wound Healing
Castilla, D. M., Liu, Z., & Velazquez, O. C. (2012) · Advances in Wound Care · doi:10.1089/wound.2011.0319 · Cited by 261
Oxygen in Wound Healing and Infection
Gottrup, F. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7398-5 · Cited by 249
Glucose Effects on Skin Keratinocytes
Spravchikov, N., Sizyakov, G., Gartsbein, M., Accili, D., Tennenbaum, T., & Wertheimer, E. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1627 · Cited by 243
Lan, C.-C. E., Wu, C., Huang, S., Wu, I.-H., & Chen, G. (2013) · Diabetes · doi:10.2337/db12-1714 · Cited by 215
Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization
Xiao, Y., Reis, L. A., Feric, N. T., Knee, E. J., Gu, J., Cao, S., Laschinger, C. A., Londoño, C., Antolovich, J., McGuigan, A. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612277113 · Cited by 172
Enhanced susceptibility to infections in a diabetic wound healing model
Hirsch, T., Spielmann, M., Zuhaili, B., Koehler, T., Fossum, M., Steinau, H., Yao, F., Steinstraesser, L., Onderdonk, A. B., & Eriksson, E. K. (2008) · BMC Surgery · doi:10.1186/1471-2482-8-5 · Cited by 166
Xuan, Y., Huang, B., Tian, H. S., Li, S., Duan, Y. M., Wang, X., Zhu, Z. X., Cai, W. H., Zhu, Y. T., Wei, T. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108182 · Cited by 165
Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes
Zhu, Y., Cankova, Z., Iwanaszko, M., Lichtor, S., Mrksich, M., & Ameer, G. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804262115 · Cited by 165
Recombinant Human Epidermal Growth Factor (EGF) to Enhance Healing for Diabetic Foot Ulcers
Hong, J. P., Jung, H. D., & Kim, Y. W. (2006) · Annals of Plastic Surgery · doi:10.1097/01.sap.0000198731.12407.0c · Cited by 160
New insights in diabetic foot infection
Richard, J.-L. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i2.24 · Cited by 155
Shin, L., & Peterson, D. A. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0041 · Cited by 147
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Henriques-Antunes, H., Cardoso, R. M. S., Zonari, A. A. C., Simões‐Correia, J., Leal, E. C., Jiménez‐Balsa, A., Lino, M. M., Barradas, A. M. C., Kostić, I., Gomes, C. M. F., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00376 · Cited by 147
An accurate, precise method for general labeling of extracellular vesicles
Gray, W. D., Mitchell, A. J., & Searles, C. D. (2015) · MethodsX · doi:10.1016/j.mex.2015.08.002 · Cited by 146
Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers
Stojadinovic, O., Pastar, I., Vukelic, S., Mahoney, M. G., Brennan, D., Krzyzanowska, A., Golinko, M., Brem, H., & Tomic‐Canic, M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00321.x · Cited by 145
Zhu, Y., Hoshi, R. A., Chen, S., Yi, J., Duan, C., Galiano, R. D., Zhang, H. F., & Ameer, G. A. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.043 · Cited by 142
Evidence of oxidative stress in chronic venous ulcers
James, T. J., Hughes, M. A., Cherry, G. W., & Taylor, R. P. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2003.11304.x · Cited by 134
In diabetic foot infections antibiotics are to treat infection, not to heal wounds
Abbas, M., Uçkay, İ., & Lipsky, B. A. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1021780 · Cited by 134
Shiekh, P. A., Singh, A., & Kumar, A. (2018) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.8b01736 · Cited by 134
Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing
Kaisang, L., Wang, S., Fan, L.-J., Daoyan, P., Xian, C. J., & Shen, J. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.04.032 · Cited by 119
Philp, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A. L., & Kleinman, H. K. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2003.11105.x · Cited by 115
Savini, I., Rossi, A., Duranti, G., Avigliano, L., Catani, M. V., & Melino, G. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01624.x · Cited by 91
Guo, J., Hu, H., Gorecka, J., Bai, H., He, H., Assi, R., Isaji, T., Wang, T., Setia, O., Lopes, L. L. N. M., et al. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00120.2018 · Cited by 91
Shiekh, P. A., Singh, A., & Kumar, A. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14777 · Cited by 82
Irons, R. F., Cahill, K. W., Rattigan, D. A., Marcotte, J. H., Fromer, M. W., Chang, S., Zhang, P., Behling, E. M., Behling, K. C., & Caputo, F. J. (2018) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2018.01.065 · Cited by 70
Bonomo, S. R. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.10.1148 · Cited by 63
Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose
Suwanjang, W., Prachayasittikul, S., & Prachayasittikul, V. (2016) · PeerJ · doi:10.7717/peerj.2389 · Cited by 37
Cao, M., Jiang, J., Du, Y., & Yan, P. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.746 · Cited by 35
Transcutaneous oxygen measurements predict healing of leg wounds with hyperbaric therapy
Smith, B. M., Desvigne, L. D., Slade, J. B., Dooley, J., & Warren, D. C. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40209.x · Cited by 35
Fibronectin Matrix Mimetics Promote Full-Thickness Wound Repair in Diabetic Mice
Roy, D. C., Mooney, N. A., Raeman, C. H., Dalecki, D., & Hocking, D. C. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0024 · Cited by 29
Shiekh, P. A., Singh, A., & Kumar, A. (2020) · Data in Brief · doi:10.1016/j.dib.2020.105671 · Cited by 25
Cited by
Sorted by citations
Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 967
Guan, Y., Niu, H. M., Liu, Z., Dang, Y., Shen, J., Zayed, M. A., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 654
Tu, C., Lu, H., Zhou, T., Zhang, W., Deng, L., Cao, W., Yang, Z., Wang, Z., Wu, X., Ding, J., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121597 · Cited by 611
The Immune Functions of Keratinocytes in Skin Wound Healing
Piipponen, M., Li, D., & Xu, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228790 · Cited by 550
Pranantyo, D., Yeo, C. K., Wu, Y., Fan, C., Xu, X., Yip, Y. S., Vos, M. I. G., Mahadevegowda, S. H., Lim, P. L. K., Yang, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44968-y · Cited by 408
Metadata
- Authors
- Shiekh, P. A., Singh, A., & Kumar, A.
- Affiliations
- Indian Institute of Technology Kanpur (IN)
- Corresponding author
- Kumar, Ashok
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 249
- Pages
- 120020
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3015385912
- Cited by
- 443
- References
- 53
- Citations by year
- 2026: 53 · 2025: 75 · 2024: 82 · 2023: 97 · 2022: 82 · 2021: 40 · 2020: 14
- FWCI
- 32.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Human Resource Development (2019/P612/SL)
- Impacting Research Innovation and Technology (MHRD_6714)
- Indian Institute of Technology Kanpur
- Department of Science and Technology, Ministry of Science and Technology, India
- Department of Biotechnology, Ministry of Science and Technology, India (DST/INT/SWD/P-11/2016, DBT/IN/SWEDEN/08/AK/2017-1, MHRD_IITK_006, SPARC/2018\u20132019/P612/SL)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- diabetic wound healing, infected diabetic wounds, exosomes, adipose-derived stem cells, angiogenesis, oxidative stress, re-epithelialization, collagen deposition, keratinocyte migration, fibroblast survival, skin regeneration, wound closure
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Bandages, Diabetes Mellitus, Humans, Oxygen, Wound Healing, Exosomes, Cryogels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
