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Cited by 313

The DOI matches its Crossref record; 186 of the 186 references it cites were found in a registry or an index.

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

Open access
Newman, Hunter, Shih, Yuru Vernon, Varghese, Shyni·2021·Biomaterials
DOI 10.1016/j.biomaterials.2021.121114
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Abstract

Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant economic and clinical impact. While an inflammatory response upon injury is necessary to facilitate healing, its resolution is critical for bone tissue repair as elevated acute or chronic inflammation is associated with impaired healing in patients and animal models. This process is governed by important crosstalk between immune cells through mediators that contribute to resolution of inflammation in the local healing environment. Approaches modulating the initial inflammatory phase followed by its resolution leads to a pro-regenerative environment for bone regeneration. In this review, we discuss the role of inflammation in bone repair, the negative impact of dysregulated inflammation on bone tissue regeneration, and how timely resolution of inflammation is necessary to achieve normal healing. We will discuss applications of biomaterials to treat large bone defects with a specific focus on resolution of inflammation to modulate the immune environment following bone injury, and their observed functional benefits. We conclude the review by discussing future strategies that could lead to the realization of anti-inflammatory therapeutics for bone tissue repair.

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Metadata

Authors
Newman, H., Shih, Y. V., & Varghese, S.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2021-10
Volume
277
Pages
121114
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2021.121114
OpenAlex
W3198340505
Cited by
313
References
186
FWCI
10.92
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Resolution of inflammation in bone regeneration: From understandings to therapeutic applications. https://app.cochat.ai/papers/10.1016/j.biomaterials.2021.121114
The paper
Newman, H., Shih, Y. V., & Varghese, S. (2021). Resolution of inflammation in bone regeneration: From understandings to therapeutic applications. Biomaterials. https://doi.org/10.1016/j.biomaterials.2021.121114

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.