Macrophages in Tissue Repair, Regeneration, and Fibrosis
Open accessAbstract
Inflammatory monocytes and resident tissue macrophages are key regulators of tissue repair, regeneration, and fibrosis. Following tissue injury, monocytes and macrophages undergo marked phenotypic and functional changes to play critical roles during the initiation, maintenance, and resolution phases of tissue repair. Disturbances in macrophage function can lead to aberrant repair, with uncontrolled inflammatory mediator and growth factor production, deficient generation of anti-inflammatory macrophages, or failed communication between macrophages and epithelial cells, endothelial cells, fibroblasts, and stem or tissue progenitor cells all contributing to a state of persistent injury, which may lead to the development of pathological fibrosis. In this review, we discuss the mechanisms that instruct macrophages to adopt pro-inflammatory, pro-wound healing, pro-fibrotic, anti-inflammatory, anti-fibrotic, pro-resolving, and tissue regenerating phenotypes following injury, and highlight how some of these mechanisms and macrophage activation states could be exploited therapeutically.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
M1 and M2 macrophages play coordinating roles in the wound healing process by secreting cytokines such as IL-6, TGF-β, TNF-α, and IL-8 to mobilize peripheral or systemic monocytes and lymphocytes to gather around the wound surface.
“M1 and M2 macrophages also play coordinating roles in the wound healing process by secreting cytokines, such as IL-6, transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and IL-8, to mobilize peripheral or systemic monocytes and lymphocytes to gather around the wound surface (Snyder et al., 2016;Wynn and Vannella, 2016).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
The Introduction (page unavailable) says macrophages of different phenotypes regulate stages of wound repair and produce inflammatory mediators; it also identifies TGF-β1 as a product of wound-healing macrophages. The Tissue Regeneration section (page unavailable) describes TNF-α-producing inflammatory macrophages, but says CCL2 from neighboring hair follicles recruits them. These passages do not support the specific claim that macrophage-secreted IL-6, TGF-β, TNF-α, and IL-8 mobilize monocytes and lymphocytes to the wound surface. (LLM, conf=0.85)
Experimental — accuracy not yet measuredM1 macrophages secrete numerous proteolytic enzymes to degrade extracellular matrix (ECM), including collagens, elastin, and fibronectin.
“M1 macrophages secrete numerous proteolytic enzymes to degrade extracellular matrix (ECM), including collagens, elastin, and fibronectin.”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
The Introduction says macrophages produce matrix metalloproteinases, and “Regulation and function of pro-fibrotic macrophages” says these enzymes degrade ECM proteins and identifies a macrophage-secreted elastase. The paper does not assign this activity specifically to M1 macrophages or explicitly identify collagen and fibronectin as substrates. (LLM, conf=0.85)
Experimental — accuracy not yet measuredM2 macrophages secrete ECM cross-linking enzymes, such as glutaminyl transferase and osteopontin, which promote ECM and cell adhesion.
“M2 macrophages secrete ECM cross-linking enzymes, such as glutaminyl transferase and osteopontin, which promote ECM and cell adhesion”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
The section “Regulation and function of pro-fibrotic macrophages” (page unavailable) says M(IL-4) macrophages regulate collagen fibril assembly and that loss of IL-4Rα signaling diminishes induction of lysyl hydroxylase 2, an enzyme involved in collagen cross-links. It does not say these macrophages secrete glutaminyl transferase or osteopontin, or that those substances promote ECM and cell adhesion. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBoth M1 and M2 macrophages play important roles in collagen deposition.
“suggesting that both macrophages play important roles in collagen deposition (Wynn and Vannella, 2016;Hesketh et al., 2017;Liu et al., 2021).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Wynn and Vannella, 2016
In “Regulation and function of pro-fibrotic macrophages” (page not available), the review says collagen fibril assembly during skin repair depends on M(IL-4) macrophages, broadly corresponding to M2. It also says inflammatory monocytes can promote fibrosis, but does not establish that M1 macrophages play an important role in collagen deposition specifically. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMacrophage polarization is instructed by biomechanical properties of the fibrotic microenvironment, including matrix stiffness, fluid shear stress, and intercellular tension, through integrin/FAK, Piezo1/TRPV4, YAP/TAZ, NF-kB, and ROCK signaling.
“Beyond biochemical cues, the biomechanical properties of the fibrotic microenvironment-notably increased matrix stiffness, fluid shear stress, and intercellular tension-are now recognized as active instructors of macrophage polarization (6,74,75).”
From The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives (2025) · cites this paper as [74]
Pro-fibrotic macrophages commonly coordinate scar formation via interactions with fibroblasts, the major cellular source of pathological extracellular matrix deposition during fibrosis.
“pro-fibrotic macrophages commonly coordinate scar formation via a range of interactions with fibroblasts, the major cellular source of pathological extracellular matrix deposition during fibrosis18,27,74–78.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [76]
M2 macrophages promote fibroproliferation and uncontrolled repair.
“M1 macrophages suppress, and M2 macrophages promote, fibroproliferation and uncontrolled repair (17).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [17]
M1 macrophages suppress fibroproliferation and uncontrolled repair.
“M1 macrophages suppress, and M2 macrophages promote, fibroproliferation and uncontrolled repair (17).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Stutchfield, B., Antoine, D., Mackinnon, A. C., Gow, D. J., Bain, C., Hawley, C. A., Hughes, M. J., Francis, B., Wojtacha, D., Man, T. Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.053 · Cited by 175 · see citing works
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works
Self-citationMacrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Self-citationMacrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · see citing works
Self-citationCellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495 · see citing works
Self-citationCirculating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works
Self-citationThe regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,185 · see citing works
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096 · see citing works
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,788 · see citing works
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765 · see citing works
Self-citationSelective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494 · see citing works
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
Wynn, T. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31487 · Cited by 1,451 · see citing works
Self-citationJenkins, S., Ruckerl, D., Cook, P., Jones, L., Finkelman, F., van Rooijen, N., MacDonald, A., & Allen, J. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,427 · see citing works
Macrophages: master regulators of inflammation and fibrosis
Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392 · see citing works
Self-citationNeutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works
Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping
Rappolee, D. A., Mark, D., Banda, M. J., & Werb, Z. (1988) · Science · doi:10.1126/science.3041594 · Cited by 1,101 · see citing works
Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055 · see citing works
Self-citationRamachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works
Berse, B., Brown, L. F., Water, L. V. D., Dvorak, H. F., & Senger, D. R. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.2.211 · Cited by 897 · see citing works
Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
Cattin, A., Burden, J., Emmenis, L. V., Mackenzie, F., Hoving, J. J., Calavia, N. G., Guo, Y.-P., McLaughlin, M., Rosenberg, L. H., Quereda, V., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.021 · Cited by 886 · see citing works
Macrophages are required for adult salamander limb regeneration
Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300290110 · Cited by 829 · see citing works
Macrophages are required for neonatal heart regeneration
Aurora, A. B., Porrello, E. R., Tan, W. H., Mahmoud, A. I., Hill, J. A., Bassel‐Duby, R., Sadek, H. A., & Olson, E. N. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72181 · Cited by 823 · see citing works
Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration
Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell · doi:10.1016/j.cell.2013.02.053 · Cited by 818 · see citing works
Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406508111 · Cited by 818 · see citing works
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816 · see citing works
Self-citationPonomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
Hume, D. A., & MacDonald, K. P. A. (2011) · Blood · doi:10.1182/blood-2011-09-379214 · Cited by 757 · see citing works
Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2667 · Cited by 747 · see citing works
Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration
Das, A., Sinha, M., Datta, S., Abas, M., Chaffee, S. M., Sen, C. K., & Roy, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.001 · Cited by 747 · see citing works
Lemos, D. R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S. T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S. A., & Rossi, F. M. V. (2015) · Nature Medicine · doi:10.1038/nm.3869 · Cited by 740 · see citing works
Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727 · see citing works
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
Shimokado, K., Raines, E. W., Madtes, D. K., Barrett, T. B., Benditt, E. P., & Ross, R. (1985) · Cell · doi:10.1016/0092-8674(85)90033-9 · Cited by 715 · see citing works
Macrophages and cancer: from mechanisms to therapeutic implications
Ostuni, R., Kratochvill, F., Murray, P. J., & Natoli, G. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.004 · Cited by 685 · see citing works
Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., Kim, K.-W., Klein, E., Kalchenko, V., Bendel, P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.012 · Cited by 683 · see citing works
Jay, T. R., Miller, C. M., Cheng, P. J., Graham, L. C., Bemiller, S., Broihier, M. L., Xu, G., Margevicius, D., Karlo, J. C., Sousa, G. L., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142322 · Cited by 682 · see citing works
Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655 · see citing works
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A., & Davis, R. J. (2012) · Science · doi:10.1126/science.1227568 · Cited by 635 · see citing works
Host Responses in Tissue Repair and Fibrosis
Duffield, J. S., Lupher, M., Thannickal, V. J., & Wynn, T. A. (2012) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163930 · Cited by 624 · see citing works
Self-citationPradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology · doi:10.1002/hep.26429 · Cited by 613 · see citing works
Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10
Lang, R., Patel, D. H., Morris, J. J., Rutschman, R. L., & Murray, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2253 · Cited by 613 · see citing works
Baeck, C., Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-300304 · Cited by 609 · see citing works
Shouval, D. S., Biswas, A., Goettel, J. A., McCann, K. J., Conaway, E. A., Redhu, N. S., Mascanfroni, I. D., Adham, Z. A., Lavoie, S., Ibourk, M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.011 · Cited by 581 · see citing works
Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis
Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F.-T., Hughes, J., & Sethi, T. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070726 · Cited by 562 · see citing works
Zigmond, E., Bernshtein, B., Friedlander, G., Walker, C., Yona, S., Kim, K.-W., Brenner, O. J., Krauthgamer, R., Varol, C., Müller, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.012 · Cited by 560 · see citing works
Cho, D. I., Kim, M. R., Jeong, H. Y., Jeong, H. C., Jeong, M. H., Yoon, S. H., Kim, Y. S., & Ahn, Y. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.135 · Cited by 543 · see citing works
Scavenger receptors in innate immunity
Peiser, L., Mukhopadhyay, S., & Gordon, S. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00307-7 · Cited by 536 · see citing works
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Willenborg, S., Lucas, T., van Loo, G., Knipper, J. A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., et al. (2012) · Blood · doi:10.1182/blood-2012-01-403386 · Cited by 534 · see citing works
MacDonald, K. P. A., Palmer, J. S., Cronau, S. L., Seppanen, E. J., Olver, S. D., Raffelt, N. C., Kuns, R. D., Pettit, A. R., Clouston, A. D., Wainwright, B. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-266296 · Cited by 507 · see citing works
Khalil, N., Bereznay, O., Sporn, M., & Greenberg, A. H. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.3.727 · Cited by 505 · see citing works
Said, E. A., Dupuy, F. P., Trautmann, L., Zhang, Y., Shi, Y., Far, M. E., Hill, B. J., Noto, A., Ancuța, P., Peretz, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2106 · Cited by 474 · see citing works
IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration
Deng, B., Wehling-Henricks, M., Villalta, S. A., Wang, Y., & Tidball, J. G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103180 · Cited by 472 · see citing works
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471 · see citing works
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis
Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1719oc · Cited by 466 · see citing works
Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, K., Foretz, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.017 · Cited by 464 · see citing works
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity
Westphalen, K., Gusarova, G. A., Islam, M. N., Subramanian, M., Cohen, T. S., Prince, A. S., & Bhattacharya, J. (2014) · Nature · doi:10.1038/nature12902 · Cited by 463 · see citing works
Nardo, D. D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2784 · Cited by 463 · see citing works
Dal-Secco, D., Wang, J., Zeng, Z., Kołaczkowska, E., Wong, C. H. Y., Petri, B., Ransohoff, R. M., Charo, I. F., Jenne, C. N., & Kubes, P. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141539 · Cited by 453 · see citing works
Chen, F., Liu, Z., Wu, W., Rozo, C. T., Bowdridge, S. A. A., Millman, A., van Rooijen, N., Urban, J. F., Wynn, T. A., & Gause, W. C. (2012) · Nature Medicine · doi:10.1038/nm.2628 · Cited by 451 · see citing works
Self-citationXu, H., Zhu, J., Smith, S. M., Foldi, J., Zhao, B., Chung, A. Y., Outtz, H. H., Kitajewski, J., Shi, C., Weber, S., et al. (2012) · Nature Immunology · doi:10.1038/ni.2304 · Cited by 438 · see citing works
Lech, M., & Anders, H. (2013) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2012.12.001 · Cited by 424 · see citing works
Saclier, M., Yacoub‐Youssef, H., Mackey, A. L., Arnold, L., Ardjoune, H., Magnan, M., Sailhan, F., Chelly, J., Pavlath, G. K., Mounier, R., et al. (2012) · Stem Cells · doi:10.1002/stem.1288 · Cited by 421 · see citing works
Negash, A. A., Ramos, H. J., Crochet, N., Lau, D., Doehle, B., Papić, N., Delker, D. A., Jo, J., Bertoletti, A., Hagedorn, C. H., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003330 · Cited by 416 · see citing works
Jenkins, S. J., Rückerl, D., Thomas, G. D., Hewitson, J. P., Duncan, S., Brombacher, F., Maizels, R. M., Hume, D. A., & Allen, J. E. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121999 · Cited by 396 · see citing works
Recurrent turnover of senescent cells during regeneration of a complex structure
Yun, M. H., Davaapil, H., & Brockes, J. P. (2015) · eLife · doi:10.7554/elife.05505 · Cited by 385 · see citing works
Gundra, U. M., Girgis, N. M., Ruckerl, D., Jenkins, S., Ward, L. N., Kurtz, Z. D., Wiens, K. E., Tang, M. S., Basu-Roy, U., Mansukhani, A., et al. (2014) · Blood · doi:10.1182/blood-2013-08-520619 · Cited by 371 · see citing works
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent
Kaviratne, M., Hesse, M., Leusink, M., Cheever, A. W., Davies, S. J., McKerrow, J. H., Wakefield, L. M., Letterio, J. J., & Wynn, T. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4020 · Cited by 370 · see citing works
Self-citationModulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair
Harel-Adar, T., Ben-Mordechai, T., Amsalem, Y., Feinberg, M. S., Leor, J., & Cohen, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015623108 · Cited by 363 · see citing works
TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
Murray, L. A., Chen, Q., Kramer, M. S., Hesson, D. P., Argentieri, R. L., Peng, X., Gulati, M., Homer, R. J., Russell, T., van Rooijen, N., et al. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.10.013 · Cited by 362 · see citing works
Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology · doi:10.1002/hep.24315 · Cited by 346 · see citing works
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
Pesce, J. T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27727 · Cited by 340 · see citing works
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
Soroosh, P., Doherty, T. A., Duan, W., Mehta, A. K., Choi, H., Adams, Y. F., Mikulski, Z., Khorram, N., Rosenthal, P., Broide, D. H., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121849 · Cited by 340 · see citing works
Tonkin, J. N., Temmerman, L., Sampson, R. D., Gallego-Colón, E., Barberi, L., Bilbao, D., Schneider, M. D., Musarò, A., & Rosenthal, N. A. (2015) · Molecular Therapy · doi:10.1038/mt.2015.66 · Cited by 320 · see citing works
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
Knipper, J., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Munitz, A., Rothenberg, M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.005 · Cited by 313 · see citing works
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Xiao, X., Gaffar, I. M., Guo, P., Wiersch, J. C., Fischbach, S., Peirish, L., Song, Z., El‐Gohary, Y., Prasadan, K. L., Shiota, C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321347111 · Cited by 313 · see citing works
CSF-1 signaling mediates recovery from acute kidney injury
Zhang, M.-Z., Yao, B., Yang, S., Li, J., Wang, S., Fan, X., Yin, H., Wong, K., Miyazawa, T., Chen, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60363 · Cited by 312 · see citing works
Pulmonary macrophage transplantation therapy
Suzuki, T., Arumugam, P. I., Sakagami, T., Lachmann, N., Chalk, C., Sallese, A., Abe, S., Trapnell, C., Carey, B. C., Moritz, T., et al. (2014) · Nature · doi:10.1038/nature13807 · Cited by 308 · see citing works
Mitchell, S., Thomas, G., Harvey, K., Cottell, D., Reville, K., Berlasconi, G., Petasis, N. A., Erwig, L., Rees, A. J., Savill, J., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000032417.73640.72 · Cited by 287 · see citing works
Antoniades, C. G., Quaglia, A., Taams, L. S., Mitry, R. R., Hussain, M. J., Abeles, R. D., Possamai, L. A., Bruce, M., McPhail, M. J. W., Starling, C., et al. (2012) · Hepatology · doi:10.1002/hep.25657 · Cited by 281 · see citing works
Eosinophils secrete IL-4 to facilitate liver regeneration
Goh, Y. P. S., Henderson, N. C., Heredia, J. E., Eagle, A. R., Odegaard, J. I., Lehwald, N., Nguyen, K. D., Sheppard, D., Mukundan, L., Locksley, R. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304046110 · Cited by 281 · see citing works
TNF Counterbalances the Emergence of M2 Tumor Macrophages
Kratochvill, F., Neale, G. A. M., Haverkamp, J. M., de Velde, L.-A. V., Smith, A. M., Kawauchi, D., McEvoy, J. D., Roussel, M. F., Dyer, M. A., Qualls, J. E., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.033 · Cited by 278 · see citing works
IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis
Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V. W., Zheng, G., Tan, T. K., Ince, J., Alexander, S. I., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060592 · Cited by 278 · see citing works
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
Ehling, J., Bartneck, M., Wei, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306294 · Cited by 273 · see citing works
Baeck, C., Wei, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., et al. (2014) · Hepatology · doi:10.1002/hep.26783 · Cited by 270 · see citing works
Macrophage Subpopulations Are Essential for Infarct Repair With and Without Stem Cell Therapy
Ben-Mordechai, T., Holbová, R., Landa‐Rouben, N., Harel-Adar, T., Feinberg, M. S., Elrahman, I. A., Blum, G., Epstein, F. H., Silman, Z., Cohen, S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.057 · Cited by 266 · see citing works
CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease
Alexander, K. A., Flynn, R. P., Lineburg, K. E., Kuns, R. D., Teal, B. E., Olver, S. D., Lor, M., Raffelt, N. C., Koyama, M., Leveque, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75935 · Cited by 257 · see citing works
Macrophages modulate the viability and growth of human mesenchymal stem cells
Freytes, D. O., Kang, J. W., Marcos‐Campos, I., & Vunjak‐Novakovic, G. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24357 · Cited by 255 · see citing works
Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., Chen, J., Liao, J.-Y., Cui, X., Zeng, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms9523 · Cited by 253 · see citing works
Utay, N. S., Mentink‐Kane, M. M., Cheever, A. W., & Wynn, T. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3655 · Cited by 249 · see citing works
Self-citationLocal Arginase 1 Activity Is Required for Cutaneous Wound Healing
Campbell, L., Saville, C. R., Murray, P. J., Cruickshank, S. M., & Hardman, M. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.164 · Cited by 246 · see citing works
Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations
Chen, C., Wang, L., Plikus, M. V., Jiang, T. X., Murray, P. J., Ramos, R., Guerrero‐Juarez, C. F., Hughes, M. W., Lee, O. K., Shi, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.016 · Cited by 245 · see citing works
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
Xu, J., Chi, F., Guo, T., Punj, V., Lee, W. N. P., French, S. W., & Tsukamoto, H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76468 · Cited by 241 · see citing works
Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
Korf‐Klingebiel, M., Reboll, M. R., Klede, S., Brod, T., Pich, A., Polten, F., Napp, L. C., Bauersachs, J. K., Ganser, A., Brinkmann, E., et al. (2015) · Nature Medicine · doi:10.1038/nm.3778 · Cited by 229 · see citing works
London, A., Itskovich, E., Benhar, I., Kalchenko, V., Mack, M., Jung, S., & Schwartz, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101202 · Cited by 213 · see citing works
Evans, T. A., Barkauskas, D. S., Myers, J., Hare, E. G., You, J., Ransohoff, R. M., Huang, A. Y.-C., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.013 · Cited by 209 · see citing works
Macrophage activation and skeletal muscle healing following traumatic injury
Novak, M. L., Weinheimer-Haus, E. M., & Koh, T. J. (2013) · The Journal of Pathology · doi:10.1002/path.4301 · Cited by 208 · see citing works
Bourdonnay, E., Zasłona, Z., Penke, L. R. K., Speth, J. M., Schneider, D. J., Przybranowski, S. A., Swanson, J. A., Mancuso, P., Freeman, C. M., Curtis, J. L., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141675 · Cited by 206 · see citing works
Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H. L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., Denis, R. G. P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3829 · Cited by 205 · see citing works
Pellicoro, A., Aucott, R. L., Ramachandran, P., Robson, A. J., Fallowfield, J. A., Snowdon, V., Hartland, S. N., Vernon, M. A., Duffield, J. S., Benyon, C. R., et al. (2011) · Hepatology · doi:10.1002/hep.25567 · Cited by 190 · see citing works
Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
Mitchell, C., Couton, D., Couty, J., Anson, M., Crain‐Denoyelle, A., Bizet, V., Rénia, L., Pol, S., Mallet, V. O., & Gilgenkrantz, H. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080632 · Cited by 189 · see citing works
Heymann, F., Hammerich, L., Storch, D., Bartneck, M., Huss, S., Rüsseler, V., Gaßler, N., Lira, S. A., Luedde, T., Trautwein, C., et al. (2011) · Hepatology · doi:10.1002/hep.24764 · Cited by 178 · see citing works
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart
Lörchner, H., Pöling, J., Gajawada, P., Hou, Y., Polyakova, V., Sawa Kostin, D., Adrian-Segarra, J. M., Boettger, T., Wietelmann, A., Warnecke, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3816 · Cited by 177 · see citing works
Madala, S. K., Pesce, J. T., Ramalingam, T. R., Wilson, M. S., Minnicozzi, S. C., Cheever, A. W., Thompson, R. W., Mentink‐Kane, M. M., & Wynn, T. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903008 · Cited by 162 · see citing works
Self-citationBusch, S. A., Hamilton, J. A., Horn, K. P., Cuascut, F. X., Cutrone, R., Lehman, N., Deans, R., Ting, A. E., Mays, R. W., & Silver, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3566-10.2011 · Cited by 145 · see citing works
Ueno, M., Maeno, T., Nomura, M., Aoyagi, K., Matsui, H., Hara, K., Tanaka, T., Iso, T., Suga, T., & Kurabayashi, M. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2010 · Cited by 140 · see citing works
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease
Chen, L., Zhou, X., Fan, L. X., Yao, Y., Swenson-Fields, K. I., Gadjeva, M. G., Wallace, D. P., Peters, D. J. M., Yu, A. S. L., Grantham, J. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80467 · Cited by 139 · see citing works
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis
Borthwick, L. A., Barron, L., Hart, K. M., Vannella, K. M., Thompson, R. W., Oland, S., Cheever, A., Sciurba, J., Ramalingam, T. R., Fisher, A. J., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2015.34 · Cited by 138 · see citing works
Self-citationYuk, J., Kim, T. S., Kim, S. Y., Lee, H., Han, J., Dufour, C. R., Kim, J. K., Jin, H. S., Yang, C., Park, K.-S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.003 · Cited by 134 · see citing works
Hesse, M., Cheever, A., Jankovic, D., & Wynn, T. (2000) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64607-x · Cited by 133 · see citing works
Self-citationResolution of Liver Fibrosis: Basic Mechanisms and Clinical Relevance
Ramachandran, P., Iredale, J., & Fallowfield, J. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1550057 · Cited by 129 · see citing works
Chen, G., Chen, H., Wang, C., Peng, Y., Sun, L., Liu, H., & Liu, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033626 · Cited by 129 · see citing works
Shaked, I., Hanna, R. N., Shaked, H., Chodaczek, G., Nowyhed, H. N., Tweet, G., Tacke, R., Basat, A. B., Mikulski, Z., Togher, S., et al. (2015) · Nature Immunology · doi:10.1038/ni.3321 · Cited by 126 · see citing works
Perdiguero, E. G., Klapproth, K., Schulz, C., Busch, K., Bruijn, M. F. T. R. D., Rodewald, H.-R., & Geissmann, F. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.022 · Cited by 122 · see citing works
Boehler, R. M., Kuo, R., Shin, S., Goodman, A. G., Pilecki, M. A., Leonard, J. N., & Shea, L. D. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.25175 · Cited by 116 · see citing works
Vannella, K., Barron, L., Borthwick, L., Kindrachuk, K. N., Narasimhan, P., Hart, K. M., Thompson, R. W., White, S., Cheever, A., Ramalingam, T., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004372 · Cited by 108 · see citing works
Self-citationMurray, P. J., Rathmell, J. C., & Pearce, E. J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.014 · Cited by 99 · see citing works
Chujo, S., Shirasaki, F., Kondo‐Miyazaki, M., Ikawa, Y., & Takehara, K. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21750 · Cited by 84 · see citing works
Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus
Zheng, D., Wang, Y., Cao, Q., Lee, V. W., Zheng, G., Sun, Y., Tan, T. K., Wang, Y., Alexander, S. I., & Harris, D. C. H. (2011) · Nephron Experimental Nephrology · doi:10.1159/000321034 · Cited by 82 · see citing works
IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease
Cao, Q., Wang, C., Dong, Z., Wang, Y., Lee, V. W., Wang, Y. M., Zheng, G., Tan, T. K., Yu, D., Alexander, S. I., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010070693 · Cited by 82 · see citing works
Wehr, A., Baeck, C., Ulmer, T. F., Gaßler, N., Hittatiya, K., Luedde, T., Neumann, U. P., Trautwein, C., & Tacke, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112327 · Cited by 79 · see citing works
Ueno, M., Maeno, T., Nishimura, S., Ogata, F., Masubuchi, H., Hara, K., Yamaguchi, K., Aoki, F., Suga, T., Nagai, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms7332 · Cited by 70 · see citing works
IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages
Hos, D., Bucher, F., Regenfuß, B., Dreisow, M.-L., Bock, F., Heindl, L. M., Eming, S. A., & Cursiefen, C. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.012 · Cited by 70 · see citing works
Macrophages decide between regeneration and fibrosis in muscle
Muñoz‐Cánoves, P., & Serrano, A. L. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.005 · Cited by 67 · see citing works
Pro-resolution properties of macrophages in renal injury
Kluth, D. (2007) · Kidney International · doi:10.1038/sj.ki.5002332 · Cited by 28 · see citing works
Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation
Knuever, J., Willenborg, S., Ding, X.-L., Akyüz, M., Partridge, L., Niessen, C., Brüning, J., & Eming, S. (2015) · Journal of Immunology · doi:10.4049/jimmunol.1501237 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981 · see citing works
Macrophages in immunoregulation and therapeutics
Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,348 · see citing works
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Self-citationInflammation and metabolism in tissue repair and regeneration
Eming, S. A., Wynn, T. A., & Martin, P. (2017) · Science · doi:10.1126/science.aam7928 · Cited by 1,369 · see citing works
Self-citationTransforming growth factor–β in tissue fibrosis
Frangogiannis, N. G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190103 · Cited by 1,308 · see citing works
The Neutrophil's Role During Health and Disease.
Liew, P., & Kubes, P. (2019) · Physiological Reviews · doi:10.1152/physrev.00012.2018 · Cited by 1,032 · see citing works
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162152 · Cited by 1,133 · see citing works
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055 · see citing works
Self-citationBui, T. M., Wiesolek, H. L., & Sumagin, R. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mr0220-549r · Cited by 966 · see citing works
Phagocytosis: An Immunobiologic Process
Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902 · see citing works
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900 · see citing works
M2b macrophage polarization and its roles in diseases
Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 889 · see citing works
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
Frangogiannis, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.07.001 · Cited by 855 · see citing works
Liu, L., Wei, Q., Lin, Q., Fang, J., Wang, H., Kwok, H., Tang, H., Nishiura, K., Peng, J., Tan, Z., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123158 · Cited by 830 · see citing works
Design of biodegradable, implantable devices towards clinical translation
Li, C., Guo, C., Fitzpatrick, V., Ibrahim, A. G. A., Zwierstra, M. J., Hanna, P. C., Lechtig, A., Nazarian, A., Lin, S. J., & Kaplan, D. L. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0150-z · Cited by 819 · see citing works
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J. R., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.014 · Cited by 799 · see citing works
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift
Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799 · see citing works
Iddir, M., Alex Brito, O., Dingeo, G., Sosa, S., Samouda, H., Frano, M. R. L., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 795 · see citing works
Zhao, J., Li, X., Hu, J., Chen, F., Qiao, S., Sun, X., Gao, L., Xie, J., & Xu, B. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz040 · Cited by 769 · see citing works
Promoting tissue regeneration by modulating the immune system
Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766 · see citing works
Macrophages in inflammation, repair and regeneration
Oishi, Y., & Manabe, I. (2018) · International Immunology · doi:10.1093/intimm/dxy054 · Cited by 645 · see citing works
Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing
Kharaziha, M., Baidya, A., & Annabi, N. (2021) · Advanced Materials · doi:10.1002/adma.202100176 · Cited by 732 · see citing works
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706 · see citing works
Skin Acute Wound Healing: A Comprehensive Review
Cañedo‐Dorantes, L., & Cañedo-Ayala, M. (2019) · International Journal of Inflammation · doi:10.1155/2019/3706315 · Cited by 712 · see citing works
Mechanisms of Organ Injury and Repair by Macrophages
Vannella, K. M., & Wynn, T. A. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034356 · Cited by 656 · see citing works
Self-citationShared and distinct mechanisms of fibrosis
Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 645 · see citing works
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Di, X., Gao, X., Peng, L., Ai, J., Jin, X., Qi, S., Li, H., Wang, K., & Luo, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01501-9 · Cited by 660 · see citing works
Tissue macrophages: heterogeneity and functions
Gordon, S., & Plüddemann, A. (2017) · BMC Biology · doi:10.1186/s12915-017-0392-4 · Cited by 601 · see citing works
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597 · see citing works
Macrophages as a therapeutic target to promote diabetic wound healing
Sharifiaghdam, M., Shaabani, E., Majidi, R. F., Smedt, S. C. D., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.016 · Cited by 596 · see citing works
Jiang, Y., Trotsyuk, A. A., Niu, S., Henn, D., Chen, K., Shih, C., Larson, M. R., Mermin-Bunnell, A. M., Mittal, S., Lai, J., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01528-3 · Cited by 570 · see citing works
Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564 · see citing works
Sicco, C. L., Reverberi, D., Balbi, C., Ulivi, V., Principi, E., Pascucci, L., Becherini, P., Bosco, M. C., Varesio, L., Franzin, C., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0363 · Cited by 560 · see citing works
An acute immune response underlies the benefit of cardiac stem cell therapy
Vagnozzi, R. J., Maillet, M., Sargent, M. A., Khalil, H., Johansen, A. K. Z., Schwanekamp, J. A., York, A. J., Huang, V. H., Nahrendorf, M., Sadayappan, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1802-2 · Cited by 547 · see citing works
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression
Kortlever, R. M., Sodir, N. M., Wilson, C. H., Burkhart, D. L., Pellegrinet, L., Brown Swigart, L., Littlewood, T. D., & Evan, G. I. (2017) · Cell · doi:10.1016/j.cell.2017.11.013 · Cited by 553 · see citing works
Physiology and diseases of tissue-resident macrophages
Lazarov, T., Juarez-Carreño, S., Cox, N., & Geissmann, F. (2023) · Nature · doi:10.1038/s41586-023-06002-x · Cited by 540 · see citing works
Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Dehkordi, A. N., Mirahmadi, F., Chehelgerdi, M., & Dehkordi, S. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 547 · see citing works
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I. L., Mittermaier, M., Mache, C., Chua, R. L., Knoll, R., Timm, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.033 · Cited by 528 · see citing works
Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.001 · Cited by 525 · see citing works
Abandoning M1/M2 for a Network Model of Macrophage Function
Nahrendorf, M., & Swirski, F. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.309194 · Cited by 525 · see citing works
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Shook, B. A., Wasko, R. R., Rivera-Gonzalez, G. C., Salazar-Gatzimas, E., López-Giráldez, F., Dash, B. C., Muñoz-Rojas, A. R., Aultman, K. D., Zwick, R. K., Lei, V., et al. (2018) · Science · doi:10.1126/science.aar2971 · Cited by 519 · see citing works
The extracellular matrix and the immune system: A mutually dependent relationship
Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519 · see citing works
Macrophages and the maintenance of homeostasis
Mosser, D. M., Hamidzadeh, K., & Gonçalves, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00541-3 · Cited by 509 · see citing works
Establishment and Maintenance of the Macrophage Niche
Guilliams, M., Thierry, G. R., Bonnardel, J., & Bajenoff, M. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.015 · Cited by 512 · see citing works
Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?
Parisi, L., Gini, E., Baci, D., Tremolati, M., Fanuli, M., Bassani, B., Farronato, G., Bruno, A., & Mortara, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/8917804 · Cited by 508 · see citing works
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Wang, M., Yuan, Q., & Xie, L. (2018) · Stem Cells International · doi:10.1155/2018/3057624 · Cited by 506 · see citing works
Tissue-specific contribution of macrophages to wound healing
Minutti, C. M., Knipper, J. A., Allen, J. E., & Zaiss, D. M. W. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.006 · Cited by 472 · see citing works
Single cell transcriptomic landscape of diabetic foot ulcers
Theocharidis, G., Thomas, B. E., Sarkar, D., Mumme, H., Pilcher, W., Dwivedi, B., Sandoval-Schaefer, T., Sîrbulescu, R. F., Kafanas, A., Mezghani, I., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27801-8 · Cited by 483 · see citing works
Irizarry-Caro, R. A., McDaniel, M. M., Overcast, G. R., Jain, V. G., Troutman, T. D., & Pasare, C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009778117 · Cited by 465 · see citing works
TGF-β1 – A truly transforming growth factor in fibrosis and immunity
Lodyga, M., & Hinz, B. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.010 · Cited by 462 · see citing works
Astrocytes and microglia: In sickness and in health
Vainchtein, I. D., & Molofsky, A. V. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.003 · Cited by 450 · see citing works
Macrophages in Lung Injury, Repair, and Fibrosis
Cheng, P., Li, S., & Chen, H. (2021) · Cells · doi:10.3390/cells10020436 · Cited by 443 · see citing works
Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
Chen, G., Yu, Y., Wu, X., Wang, G., Ren, J., & Zhao, Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801386 · Cited by 435 · see citing works
The Formation and Function of Granulomas
Pagán, A. J., & Ramakrishnan, L. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100022 · Cited by 431 · see citing works
Tu, Z., Chen, M., Wang, M., Shao, Z., Jiang, X., Wang, K., Yao, Z., Yang, S., Zhang, X., Gao, W., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100924 · Cited by 426 · see citing works
Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease
Prame Kumar, K., Nicholls, A. J., & Wong, C. H. Y. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2753-2 · Cited by 417 · see citing works
Role of Inflammation and the Immune System in the Progression of Osteoarthritis
Woodell‐May, J., & Sommerfeld, S. D. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24457 · Cited by 410 · see citing works
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works
Tailoring Materials for Modulation of Macrophage Fate
Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 402 · see citing works
Fetal monocytes and the origins of tissue-resident macrophages
Hoeffel, G., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.001 · Cited by 393 · see citing works
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
Lu, Y., Nayer, B., Singh, S. K., Alshoubaki, Y. K., Yuan, E., Park, A. J., Maruyama, K., Akira, S., & Martino, M. M. (2024) · Nature · doi:10.1038/s41586-024-07237-y · Cited by 394 · see citing works
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393 · see citing works
Biological responses to physicochemical properties of biomaterial surface
Rahmati, M., Silva, E. A., Reseland, J. E., Heyward, C. A., & Haugen, H. J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00103a · Cited by 403 · see citing works
Macrophage Polarization and Osteoporosis: A Review
Muñoz, J., Akhavan, N. S., Mullins, A. P., & Arjmandi, B. H. (2020) · Nutrients · doi:10.3390/nu12102999 · Cited by 389 · see citing works
Type 2 immunity in allergic diseases
Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Ardıçlı, S., Li, M., D’Avino, P., Beha, C., Babayev, H., Zhao, B., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01261-2 · Cited by 413 · see citing works
Macrophages in Renal Injury and Repair
Huen, S. C., & Cantley, L. G. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034219 · Cited by 377 · see citing works
Li, L., Yu, R., Cai, T., Chen, Z., Lan, M., Zou, T., Wang, B., Wang, Q., Zhao, Y., & Cai, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106939 · Cited by 381 · see citing works
The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics
Prakash, J., & Shaked, Y. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0002 · Cited by 391 · see citing works
Agarwal, H., Nakara, A., & Shanmugam, V. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.116 · Cited by 380 · see citing works
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Zhang, L., Wang, Y., Wu, G., Xiong, W., Gu, W., & Wang, C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0864-2 · Cited by 368 · see citing works
Cui, H., Xie, N., Banerjee, S., Ge, J., Jiang, D., Dey, T., Matthews, Q. L., Liu, R.-M., & Liu, G. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0360oc · Cited by 373 · see citing works
Martin, K. E., & Garcı́a, A. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.038 · Cited by 375 · see citing works
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Macrophage polarization and meta-inflammation
Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 369 · see citing works
Macrophage plasticity: signaling pathways, tissue repair, and regeneration
Yan, L., Wang, J., Cai, X., Liou, Y., Shen, H., Hao, J., Huang, C., Luo, G., & He, W. (2024) · MedComm · doi:10.1002/mco2.658 · Cited by 396 · see citing works
Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370 · see citing works
Macrophage biology in the peripheral nervous system after injury
Zigmond, R. E., & Echevarría, F. D. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.001 · Cited by 369 · see citing works
Silvin, A., Uderhardt, S., Piot, C., Da Mesquita, S., Yang, K., Geirsdottir, L., Mulder, K., Eyal, D., Liu, Z., Bridlance, C., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.07.004 · Cited by 368 · see citing works
Bochenek, M. A., Veiseh, O., Vegas, A. J., McGarrigle, J. J., Qi, M., Marchese, E., Omami, M., Doloff, J. C., Mendoza-Elias, J., Nourmohammadzadeh, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0275-1 · Cited by 367 · see citing works
The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review
Ma, W., Gao, F., Gu, K., & Chen, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01140 · Cited by 360 · see citing works
Macrophage polarization and metabolism in atherosclerosis
Hou, P., Fang, J., Liu, Z., Shi, Y., Agostini, M., Bernassola, F., Bove, P., Candi, E., Rovella, V., Sica, G. S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06206-z · Cited by 360 · see citing works
Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
Sawaya, A., Stone, R. C., Brooks, S., Pastar, I., Jozic, I., Hasneen, K., O’Neill, K., Mehdizadeh, S., Head, C., Strbo, N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18276-0 · Cited by 320 · see citing works
Advances of hydrogel dressings in diabetic wounds
Wang, H., Xu, Z., Meng, Z., Liu, G., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01747g · Cited by 359 · see citing works
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
Fabre, T., Barron, A. M. S., Christensen, S. M., Asano, S., Bound, K., Lech, M. P., Wadsworth, M. H., Chen, X., Wang, C., Wang, J., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add8945 · Cited by 355 · see citing works
Self-citationHe, L., Jhong, J.-H., Chen, Q., Huang, K.-Y., Strittmatter, K., Kreuzer, J., DeRan, M., Wu, X., Lee, T.-Y., Slavov, N., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109955 · Cited by 354 · see citing works
Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works
Scarless wound healing programmed by core-shell microneedles
Zhang, Y., Yang, Y., Yang, Y., Zhao, S., You, J., Wang, J., Cai, J., Wang, J., Wang, J., Zhang, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39129-6 · Cited by 360 · see citing works
Interactions between mesenchymal stem cells and the immune system
Li, N., & Hua, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2473-5 · Cited by 338 · see citing works
Hoeft, K., Schaefer, G. J. L., Kim, H., Schumacher, D., Bleckwehl, T., Long, Q., Klinkhammer, B. M., Peisker, F., Koch, L., Nagai, J. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112131 · Cited by 323 · see citing works
Key players in the immune response to biomaterial scaffolds for regenerative medicine
Chung, L., Maestas, D. R., Housseau, F., & Elisseeff, J. H. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.006 · Cited by 328 · see citing works
YAP-mediated mechanotransduction tunes the macrophage inflammatory response
Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8471 · Cited by 329 · see citing works
Saleh, B., Dhaliwal, H. K., Lara, R. P., Sani, E. S., Abdi, R., Amiji, M. M., & Annabi, N. (2019) · Small · doi:10.1002/smll.201902232 · Cited by 323 · see citing works
Interaction of tumor-associated macrophages and cancer chemotherapy
Larionova, I., Cherdyntseva, N., Liu, T., Patysheva, M., Rakina, M., & Kzhyshkowska, J. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1596004 · Cited by 322 · see citing works
Lei, F., Cui, N., Zhou, C., Chodosh, J., Vavvas, D. G., & Paschalis, E. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922788117 · Cited by 322 · see citing works
The interaction of innate immune and adaptive immune system
Wang, R., Lan, C., Benlagha, K., Câmara, N. O. S., Miller, H. E., Kubo, M., Heegaard, S., Lee, P. P. W., Yang, L., Forsman, H. F., et al. (2024) · MedComm · doi:10.1002/mco2.714 · Cited by 355 · see citing works
Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., Hong, J., Qu, Z., Chen, J., Liu, A., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01778-6 · Cited by 318 · see citing works
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications
Newman, H., Shih, Y.-R. V., & Varghese, S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121114 · Cited by 318 · see citing works
The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis
Desai, O., Winkler, J., Minasyan, M., & Herzog, E. L. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00043 · Cited by 314 · see citing works
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis
Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 327 · see citing works
- Authors
- Wynn, T. A., & Vannella, K. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wynn, Thomas A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 44
- Issue
- 3
- Pages
- 450-462
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4794754
- OpenAlex
- W2301044272
- Semantic Scholar
- 3e7cc72db53c49f88a543c99b71749931fb6c7b0
- Cited by
- 4,481
- References
- 129
- Citations by year
- 2026: 673 · 2025: 638 · 2024: 564 · 2023: 511 · 2022: 504 · 2021: 475 · 2020: 399 · 2019: 299 · 2018: 228 · 2017: 136 · 2016: 35 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 29.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (Z01AI001019, Z01AI000829)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophages, tissue repair, tissue regeneration, fibrosis, inflammatory monocytes, macrophage polarization, wound healing, inflammation resolution, macrophage-targeted therapy
- MeSH terms
- Animals, Cell Communication, Cell Differentiation, Fibrosis, Humans, Macrophage Activation, Macrophages, Phenotype, Regeneration, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
