Pro-resolving lipid mediators are leads for resolution physiology

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Resolution of inflammation: the beginning programs the end

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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

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The Human Serum Metabolome

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Resolvins

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Lipid mediator class switching during acute inflammation: signals in resolution

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Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

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Resolvin E1 and protectin D1 activate inflammation-resolution programmes

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Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

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Resolvins and protectins in inflammation resolution

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Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

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A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

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Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

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Why US adults use dietary supplements

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Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins

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Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

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Infection regulates pro-resolving mediators that lower antibiotic requirements

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Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

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Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

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Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

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Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

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Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

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Resolvin E1 Regulates Inflammation at the Cellular and Tissue Level and Restores Tissue Homeostasis In Vivo

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The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

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Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

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RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis

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Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

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Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

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Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

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Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

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Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression

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Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

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Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness

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Resolution phase lipid mediators of inflammation: agonists of resolution

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Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

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Resolution of Acute Inflammation in the Lung

Levy, B. D., & Serhan, C. N. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170408 · Cited by 302 · see citing works

Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses

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Resolution of inflammation is altered in Alzheimer's disease

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Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

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Transcriptomic analyses of murine resolution-phase macrophages

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Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

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The novel 13 <i>S</i> ,14 <i>S</i> ‐epoxy‐maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A ₄ hydrolase (LTA ₄ H), and shifts macrophage phenotype

Dalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., & Serhan, C. N. (2013) · The FASEB Journal · doi:10.1096/fj.13-227728 · Cited by 283 · see citing works

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

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Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

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Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation

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Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

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The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

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Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

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Lipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation

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Resolving TRPV1- and TNF-α-Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

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Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

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Lipoxins: resolutionary road

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Peripheral gating of pain signals by endogenous lipid mediators

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Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

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Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

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A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

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Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS

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The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats

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Lipoxin A4Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease

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Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

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Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

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The resolution of inflammation: the devil in the flask and in the details

Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-0502ufm · Cited by 195 · see citing works

Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production

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Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing

Svensson, C. I., Zattoni, M., & Serhan, C. N. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061826 · Cited by 175 · see citing works

Augmentation of Myocardial Production of 15-Epi-Lipoxin-A 4 by Pioglitazone and Atorvastatin in the Rat

Birnbaum, Y., Ye, Y., Lin, Y., Freeberg, S. Y., Nishi, S. P. E., Martinez, J. D., Huang, M.-H., Uretsky, B. F., & Perez-Polo, J. R. (2006) · Circulation · doi:10.1161/circulationaha.106.629907 · Cited by 173 · see citing works

Novel Proresolving Aspirin-Triggered DHA Pathway

Serhan, C. N., Fredman, G., Yang, R., Karamnov, S., Belayev, L., Bazan, N. G., Zhu, M., Winkler, J. W., & Petasis, N. A. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.06.008 · Cited by 164 · see citing works

Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment

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Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field

Samuelsson, B. O. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.x112.351437 · Cited by 157 · see citing works

17(R)‐resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

Bang, S., Yoo, S., Yang, T., Cho, H., & Hwang, S. W. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01568.x · Cited by 148 · see citing works

Aspirin‐triggered resolvin D1 prevents surgery‐induced cognitive decline

Terrando, N., Gómez‐Galán, M., Yang, T., Carlström, M., Gustavsson, D., Harding, R. E., Lindskog, M., & Eriksson, L. I. (2013) · The FASEB Journal · doi:10.1096/fj.13-230276 · Cited by 147 · see citing works

Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells

Ramon, S., Gao, F., Serhan, C. N., & Phipps, R. P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103483 · Cited by 145 · see citing works

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

Yamada, T., Tani, Y., Nakanishi, H., Taguchi, R., Arita, M., & Arai, H. (2010) · The FASEB Journal · doi:10.1096/fj.10-170027 · Cited by 143 · see citing works

Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

Bazan, N. G., Calandria, J. M., & Serhan, C. N. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r001131 · Cited by 140 · see citing works

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

Rajasagi, N. K., Reddy, P. B. J., Suryawanshi, A. S., Mulik, S., Gjorstrup, P., & Rouse, B. T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1003456 · Cited by 139 · see citing works

Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators

Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121887 · Cited by 139 · see citing works

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

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Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection

Cilloniz, C., Pantin-Jackwood, M. J., Ni, C., Goodman, A. G., Peng, X., Proll, S. C., Carter, V. S., Rosenzweig, E. R., Szretter, K. J., Katz, J. M., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00553-10 · Cited by 136 · see citing works

1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients

Mizwicki, M. T., Liu, G., Fiala, M., Magpantay, L. I., Sayre, J. W., Siani, A., Mahanian, M., Weitzman, R. E., Hayden, E. Y., Rosenthal, M. J., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121735 · Cited by 135 · see citing works

Efficacy and safety of 15(R/S)-methyl-lipoxin A 4 in topical treatment of infantile eczema

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Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

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D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury

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