Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration
Abstract
In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assi…
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After encapsulation of exosomes, AD/CS/RSF hydrogels recruit migration and proliferation of BMSCs and promote their differentiation into chondrocytes, accelerating healing of cartilage defects in rat knee joints.
“The hydrogels, after encapsulated exosomes, showed the ability to recruit the migration and inflation of bone marrow stem cells (BMSCs). They also promoted the proliferation and differentiation of BMSCs into chondrocytes, thereby effectively accelerating the healing of cartilage defects in rat knee joints [140].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [140]
AD/CS/RSF hydrogels have exceptional adhesion strength on wet surfaces.
“Zhang and coworkers developed mussel-inspired AD/CS/RSF hydrogels with exceptional adhesion strength on wet surfaces.”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [140]
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Polydopamine-Modified functional materials promote bone regeneration
Wang, J., Cui, Y., Zhang, B., Sun, S., Xu, H., Yao, M., Wu, D., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112655 · Cited by 56 · see citing works
Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“They also promoted the proliferation and differentiation of BMSCs into chondrocytes, thereby effectively accelerating the healing of cartilage defects in rat knee joints [140].”
BackgroundEngineering exosomes for bone defect repair
Ma, S., Zhang, Y., Li, S., Li, A., Li, Y., & Pei, D. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1091360 · Cited by 38 · see citing works
Self-citation
- Authors
- Zhang, F.-X., Liu, P., Ding, W., Meng, Q.-B., Su, D.-H., Zhang, Q.-C., Lian, R.-X., Yu, B.-Q., Zhao, M.-D., Dong, J., Li, Y.-L., & Jiang, L.-B.
- Affiliations
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Fudan University (CN)
- Corresponding author
- Zhao, Ming-Dong
- Dong, Jian
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 278
- Pages
- 121169
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3203808254
- Cited by
- 328
- References
- 0
- Citations by year
- 2026: 44 · 2025: 78 · 2024: 89 · 2023: 75 · 2022: 42
- FWCI
- 16.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- injectable hydrogel, exosomes, osteoarthritis, bone marrow mesenchymal stem cells, chondroitin sulfate, regenerated silk fibroin, chemokine signaling, extracellular matrix remodeling, arthroscopic treatment
- MeSH terms
- Adhesives, Animals, Cartilage, Regeneration, Hydrogels, Tissue Engineering, Rats, Tissue Scaffolds, Exosomes
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