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Tailoring Smart Oral Nano/Micro Delivery System to Address Multifaceted Gastrointestinal Barriers for Improved Delivery of Food Bioactive Compounds

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2-Monoacylglycerol Mimetic Liposomes to Promote Intestinal Lymphatic Transport for Improving Oral Bioavailability of Dihydroartemisinin

Zheng, B., Pan, F., Shi, M., He, C., He, B., Wang, R., Ren, G., Yang, S., & Zhang, S. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s462374 · Cited by 21 · see citing works

Endoplasmic reticulum-targeted strategies for programmed cell death in cancer therapy: Approaches and prospects

Li, L., Zhu, Z., Jiang, X., Tang, Y. J., Li, J., Zhang, Z., Ding, B., Li, X., Yu, M., & Gan, Y. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114059 · Cited by 21 · see citing works

Self-Assembled Recombinant Elastin and Globular Protein Vesicles with Tunable Properties for Diverse Applications

Gray, M. A., Rodriguez-Otero, M. R., & Champion, J. A. (2024) · Accounts of Chemical Research · doi:10.1021/acs.accounts.3c00694 · Cited by 21 · see citing works

Modulating the elasticity of milk exosome-based hybrid vesicles to optimize transepithelial transport and enhance oral peptide delivery

Xiao, P., Yuan, H., Liu, H., Guo, C., Feng, Y., Zhao, W., Zhao, B., Yin, T., Zhang, Y. X., He, H., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.01.090 · Cited by 20 · see citing works

The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles

Chang, Z., Wu, Y., Hu, P., Jiang, J., Quan, G., Wu, C., Pan, X., & Huang, Z. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020286 · Cited by 20 · see citing works

Bioinspired fine-tuning of the mechanical rigidity of SNEDDS for the efficient crossing of multiple gastrointestinal barriers

Li, J., Xu, Y., Zhang, J., Li, Q., Wang, C., Wu, Z., Yang, W., Xu, M. K., Zhang, Z., Wang, L., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.044 · Cited by 19 · see citing works

Effects of nanoparticle deformability on multiscale biotransport

Gadalla, H. H., Yuan, Z., Chen, Z., Alsuwayyid, F., Das, S., Mitra, H., Ardekani, A. M., Wagner, R., & Yeo, Y. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115445 · Cited by 19 · see citing works

Microneedle‐Loaded Gene‐Editable Nanohybrids Engineer Cancer Cells by Telomere Stress Induction and Metabolic Interference for Enhanced Cuproptosis and Immunotherapy

Luan, X., Du, S., Liu, Z., He, B., Pan, Y., Yang, J. M., Li, Y., Kong, D., Han, X. H., & Song, Y. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202416285 · Cited by 19 · see citing works

Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond

Cho, H., Huh, K. M., Shim, M. S., Cho, Y., Lee, J. Y., Lee, H. S., Kwon, Y. J., & Kang, H. C. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115386 · Cited by 18 · see citing works

Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers

Tian, L., You, X., Liu, J., Li, Y., Li, S., Jin, X., Li, S., Pan, F., Yu, Z., Zhang, T., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c08256 · Cited by 18 · see citing works

Advanced Oral Delivery Systems for Nutraceuticals

Yang, X., Zhang, L., Zheng, Z., Langer, R., & Jaklenec, A. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500271 · Cited by 16 · see citing works

Nano-purpurin-Cu delivery via TPGS-induced macropinocytosis enables cuproptosis/metabolic synergy to ablate cancer stemness and Boost immunotherapy in colorectal cancer

Song, Y., Cheng, W., Tian, H., Huang, Y., Huang, C., Jia, Y., & Xu, L. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123874 · Cited by 14 · see citing works

Evaluating the binding mechanism, structural changes and stability of ternary complexes formed by the interaction of folic acid with whey protein concentrate-80 and L-ascorbyl 6-palmitate

Wang, X., Wang, Z., Zhang, K., Szeto, I. M., Yan, Y., Liu, B., Zhang, J., Evivie, S. E., Li, B., & Duan, S. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139924 · Cited by 14 · see citing works

Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics

Wang, X., Wang, K., Fang, Y., Zhang, Y., Yi, L., Li, X., Zhao, Q., Zhu, X., Cai, S., & Wan, L. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102763 · Cited by 13 · see citing works

AI-engineered multifunctional nanoplatforms: synergistically bridging precision diagnosis and intelligent therapy in next-generation oncology

Zhao, L., Liu, X., & Deng, X. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03947-1 · Cited by 11 · see citing works

Biologically responsive and structure-tunable 1H/19F MRI nanoprobes: personalizing cancer imaging and therapy

Yu, G., Yang, W., Wang, Y., Zhou, X., & Zhang, B. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216860 · Cited by 10 · see citing works

Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate

Cong, J., Zheng, Z., Fu, Y., Chang, Z., Chen, C., Wu, C., Pan, X., Huang, Z., & Quan, G. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2375385 · Cited by 10 · see citing works

Nanoparticles prepared with biotin-esterified debranched starch as an oral carrier to improve the stability and antioxidant activity of resveratrol

Wang, C.-C., Yang, B., Feng, R., Tao, H., Xu, B., & Zhang, B. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134543 · Cited by 9 · see citing works

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia

Chang, C., Lu, C., Zheng, Y., Lin, L., Chen, X., Chen, L., Chen, Z., & Chen, R. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101201 · Cited by 9 · see citing works

Functional Liposomes Improve the Oral Absorption of Lurasidone Hydrochloride by Overcoming Multiple Absorption Barriers and Eliminating Food Effect

Song, T., Wang, W., Wu, Y., Liu, C., Yuan, L., Sun, Z., Zhang, J., & Sun, Y. Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s512876 · Cited by 9 · see citing works

Optimizing anthocyanin Oral delivery: Effects of food biomacromolecule types on Nanocarrier performance for enhanced bioavailability

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Elucidating siRNA Cellular Delivery Mechanism Mediated by Quaternized Starch Nanoparticles

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Hair follicle-targeted baicalin nanocrystal delivery using microneedles for long-acting treatment of androgenetic alopecia

Xiong, S., Ying, W., Xiao, T., Liu, Z., Fu, H., Chai, G., & Xu, Y. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126675 · Cited by 8 · see citing works

Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity

Liu, Y., Song, J., Guo, Y., Li, S., Yuan, M., Tang, J., Tang, J., Li, M., Guo, Y., & Guo, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125289 · Cited by 8 · see citing works

Yolk-shell cationic liposomes overcome mucus and epithelial barriers for enhanced oral drug delivery

Qiu, Y., Zhuo, Y., Ye, Y., Li, X., Zhu, Z., Wang, B., Guo, C., Liu, Y., & Yu, M. (2023) · Giant · doi:10.1016/j.giant.2023.100221 · Cited by 8 · see citing works

Functional factors for precision nutrition interventions in starch-based delivery systems

Qin, M., Li, L., Du, J., Hong, Y., Gu, Z., Cheng, L., Li, Z., Li, C., & Ban, X. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2564213 · Cited by 7 · see citing works

Polysaccharide-based inflammatory microenvironment-responsive nanocarriers for ulcerative colitis: Advances in design, mechanisms, and therapeutic applications

Wu, S., Feng, R., Meng, R., Ji, Q.-Y., Tao, H., Xu, B., & Zhang, B. (2026) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2026.125069 · Cited by 7 · see citing works

Supramolecular protein-peptide co-assembly mediated by Ca2+ enhances curcumin penetration through intestinal barriers

Tian, L., Zhao, Y., Pan, F., Ren, W., Yang, M., Li, Y., Li, S., Yu, Y., Zhang, T., & Du, Z. (2025) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2025.111581 · Cited by 7 · see citing works

Engineered dual-antioxidant nanoplatform: Lactoferrin peptide-orientin nanoassembly orchestrates redox homeostasis for precised inflammatory bowel disease therapy

Ran, Y., Hu, J., Jin, G., Zhang, M., Zhao, J., Zeng, K., Xu, Z., & Ming, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165994 · Cited by 5 · see citing works

Nanodrug delivery materials for digestive system diseases

Yang, D., Zeng, H., Zhuang, Y., Jiang, S., & Pan, W. (2024) · APL Materials · doi:10.1063/5.0214020 · Cited by 5 · see citing works

Enteral Route Nanomedicine for Cancer Therapy

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Preparation and characterization of novel acylated chitosan/carboxymethyl konjac glucomannan nanogels for the encapsulation of polyphenols

Long, M., Wang, H., Li, Y., Chen, Z., Zeng, Z., Luo, J., Tian, Z., Zhang, F., & Xiong, L. (2025) · LWT · doi:10.1016/j.lwt.2025.117759 · Cited by 5 · see citing works

The aggregation of casein micelles induced by Ca 2+ during in vitro digestion: effects on the release of loaded anthocyanins

Ren, J., Liao, M., Li, K., Chen, F., Hu, X., Ma, L., & Ji, J. (2023) · Food & Function · doi:10.1039/d3fo03684g · Cited by 5 · see citing works

RNAi‐mediated pest control targeting the Troponin I (wupA) gene in sweet potato weevil, Cylas formicarius

Zhang, M., Zhang, X., Chen, T., Liao, Y., Yang, B., & Wang, G. (2024) · Insect Science · doi:10.1111/1744-7917.13403 · Cited by 5 · see citing works

Twisted Intramolecular Charge Transfer-Based Viscosity-Responsive Probe Reveals Lysosomal Degradation Process of Endocytosed Foreign Bodies

Li, H., Zhang, J., Li, H., Zhang, E., Kong, W., Kong, R., Zhao, Y., Qu, F., & Tan, W. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c02729 · Cited by 5 · see citing works

Protein-based self-assembled delivery systems for food nutraceuticals

Zhang, Y., Xia, Z., Wang, Y., Quan, H., Lu, Y., Wang, Y., Zhang, Y., Xue, P., Song, S., & Guo, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147661 · Cited by 4 · see citing works

Advances and challenges in research methods on oral absorption mechanisms of nano-formulations

Sun, S.-J., Liu, Y.-T., Nie, J., Hu, Z., Liu, Z.-R., Chen, H., Hua, Y.-Z., Feng, S., Yi, T., & Zhang, J. (2025) · PeerJ · doi:10.7717/peerj.20032 · Cited by 4 · see citing works

Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma

Deng, X., Liu, X., Feng, J., & Zhao, L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07508-w · Cited by 4 · see citing works

Efferocytosis-inspired nanodrug treats sepsis by alleviating inflammation and secondary immunosuppression

Guo, X., Shen, P., Shao, R., Hong, T., Liu, W., Shen, Y. X., Su, F., Wang, Q., & He, B. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acef9a · Cited by 4 · see citing works

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works

Supramolecular self-assembly of enzymatically hydrolyzed food protein polypeptides: Versatile architecture for enhancing the intestinal absorption of natural bioactive compounds

Feng, J., Liu, S., Huang, W., & Li, Y. (2025) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2025.103734 · Cited by 3 · see citing works

Boosting luteolin bioavailability via P-glycoprotein efflux inhibition: a self-microemulsifying drug delivery systems

Zheng, Y., Chen, B., Huang, X., Ai, C., Teng, H., & Chen, L. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.01.030 · Cited by 3 · see citing works

Characterization of herpetrione amorphous nanoparticles stabilized by hydroxypropylmethyl cellulose and its absorption mechanism in vitro

Wang, F., Hang, L., Dai, B., Li, F., Zhu, Y., Jia, H., Ai, Y., Wang, L., Xue, Y., & Yuan, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131744 · Cited by 3 · see citing works

Out of the box thinking: challenges and future perspectives for food-grade nutraceutical delivery systems

Zhang, Y., Wang, Y., Zhang, K., Lin, X., Xue, Y., & Zhang, Z. (2024) · Food Materials Research · doi:10.48130/fmr-0024-0022 · Cited by 2 · see citing works

Orally sequence-targeted nanoparticles equipped with egg white-derived peptides co-assembly enhanced luteolin bioavailability for obesity mitigation

Liu, J., Yang, J., Li, Y., Fang, X., Li, S., Zhang, H., Zhang, T., Liu, C., Yang, M., & Du, Z. (2025) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2025.112320 · Cited by 2 · see citing works

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Xu, Y., Wu, K., Wei, B., Song, G., Sun, C., Li, X., Liu, X., Ma, Z., Lv, M., Landman, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202522455 · Cited by 2 · see citing works

Fluorescence Imaging Analysis of PTK7 Clustering in Situ via a Programmable DNA Network for Apoptosis Induction and Drug Resistance Reversal

Nie, K., Liu, L., Chen, H., Liang, R., Zhang, Y. E. L., Cheng, F., Wu, X. Q., Zhan, L., Huang, C. Z., Liang, Q. L., et al. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c00917 · Cited by 2 · see citing works

Advances in Protein‐Based Delivery Systems: From Structural Design to Smart Responses and Intestinal Microbiome Modulation

Wang, X., Fei, S. O. N. G., Zhang, L., Jiang, L., Li, D., & Huang, Z. (2026) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70504 · Cited by 2 · see citing works

Research advances in self-assembled peptide delivery systems for fibrosis treatment

Zhang, Y., Su, D., & Wang, Y. (2025) · Precision medicine and engineering. · doi:10.1016/j.preme.2025.100043 · Cited by 1 · see citing works

Hydroxypropyl-β-cyclodextrin as a co-delivery vehicle for synergistically enhancing fucoxanthin oral bioavailability through dual regulation of SR-B1 and ABCB1 transporters

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An engineered micropatch for oral delivery of heterophyllin B in type 2 diabetes treatment

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Iridium Nanoantidotes Attenuate Jellyfish Toxin-Induced Hepatotoxicity by Inhibiting Gasdermin D Palmitoylation

Liu, L., Wang, X., Song, X., Huang, H., Geng, X., Wang, X., Yan, W., Xu, T., Chang, M., Chen, Y., et al. (2026) · ACS Nano · doi:10.1021/acsnano.5c20940 · Cited by 1 · see citing works

Self-assembly of Fu brick tea polysaccharide conjugate and chitosan quaternary ammonium salt for the synergistic stabilization of β-carotene-loaded complex emulsions with enhanced stability and bioaccessibility

Zheng, W., Gao, Y., Xu, Q., Zhang, J., Deng, W., & Chen, Y. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151476 · Cited by 1 · see citing works

Modular design for drug delivery across hierarchical gastrointestinal barriers: From materials to systems

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Breaking Down Intracellular Barriers: Advanced Nanocarriers for Cytosolic Small-Interfering RNA Delivery

He, D., Wang, Y., Ling, X., Guo, R., Li, M., & He, Q. (2026) · Pharmaceutical Fronts · doi:10.1055/a-2871-6002 · Cited by 1 · see citing works

Biointerface Structure Effects Govern the Macropinocytosis Process for Nanoclay to Enter Cells

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Solid lipid nanoparticles in improving the therapeutic effectiveness of anticancer compounds

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Nanotechnology in Cancer Drug Delivery: Innovations and Challenges

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Surface Chemistry-Based Nanomedicine Design in Oral Drug Delivery

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The Construction Strategy of Curcumin Nanomedicine Delivery System and Its Application in the Treatment of Ulcerative Colitis

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The Uric Acid Degrading Probiotics MC1 in Quercetin Nanocoatings and Bioactive Polysaccharides Microgels for Anti‐Hyperuricemia and Gut Microenvironment Modulation

Li, Z., Ma, Z., Zhao, D., Poortinga, A. T., Wang, X., Zhang, Y., Yue, Q., Wu, K., Li, M., Chen, S., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505897 · Cited by 1 · see citing works

Oral biomaterials facilitate the transplantation of therapeutic organelles

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Synergistic modification of β-casein micelles by dextran and genipin for naringenin delivery: A systematic evaluation of physicochemical stability, digestive properities, and cellular uptake

Ye, J., Wu, F., Yang, B., Zhang, Z., Wen, X., Ni, Y., & Li, M. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108686

Flammulina velutipes Polysaccharides Demonstrate an Impact on Metabolic Regulation via Gender-specific Modification of Key Gut Microbiota in Mice

Zhao, R., Gao, C., Yao, H., Du, H., Hu, Q., & Zhao, L. (2026) · Food Science and Human Wellness · doi:10.26599/fshw.2026.9251064

Nanocarriers enhance oral bioavailability: from absorption mechanisms to design strategies

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Uniform sub-10 nm crosslinked polymeric nanoparticles loaded with berberine for oral diabetes treatment

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Micellar delivery of napabucasin counteracts photothermal therapy-induced stemness in pancreatic cancer

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Oral co-delivery of quercetin and anthocyanins via dual-ligand nanoparticles alleviate obesity and associated metabolic disorders

Zhang, H., Liu, C., Yang, J., Li, S., Yang, M., Liu, J., Zhang, T., & Li, Y. (2026) · Food Research International · doi:10.1016/j.foodres.2026.119945

One-step assembly of astaxanthin-loaded probiotic-derived extracellular vesicles: a strategy for enhancing absorption and alleviating oxidative stress

Li, X., Wang, K., Huang, K., Zhong, T., Ge, P., & Tan, M. (2026) · Marine Life Science & Technology · doi:10.1007/s42995-026-00404-2

Membrane Phase Separation: An Emerging Biophysical Perspective on Food-Derived Bioactive Peptides

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Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer‐Chemotherapeutics Conjugates Based on DNA Tiling‐Mediated Structural Nanotechnology

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Evaluation of the structure and function of whey protein concentrate combined with folic acid and l ‐ascorbyl 6‐palmitate

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Speciation transformation and toxic effects of nanoscale mercury in aquatic environments

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An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis

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Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

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Highly stable hydrophobic dietary polyphenols enhance brain delivery and neuroprotection: Tunable crystallization properties in interfacial assembly

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Polymer-based in-situ gelling nanoplatforms for buccal drug delivery: a comprehensive review of advances and challenges

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Physicochemical Properties and Intestinal Mucus Mucoadhesion of Flammulina velutipes Polysaccharide Nanoliposomes: Effects of Particle Size and Sterol Composition

Wang, X., Zhang, L., Zhang, M., You, L., & Hileuskaya, K. S. (2026) · Journal of Future Foods · doi:10.1016/j.jfutfo.2026.09.014

Size and morphology optimization-driven in vivo targeting of nanomedicines: Mechanisms and characterization techniques

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Enhanced Transport of Shape and Rigidity-Tuned α-Lactalbumin Nanotubes across Intestinal Mucus and Cellular Barriers

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Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules

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Research on the fate of polymeric nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size, surface charge and pro-hydrophobics

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Overcoming multiple gastrointestinal barriers by bilayer modified hollow mesoporous silica nanocarriers

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Nanocarriers enhance oral bioavailability: from absorption mechanisms to design strategies

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