Neurotrophic and anti-neuroinflammatory constituents from the aerial parts of Coriandrum sativum
Abstract
In the course of our continuing search for biologically active compounds from medicinal sources, we investigated the MeOH extract of the aerial parts of Coriandrum sativum Linn. An extended phytochemical investigation of the aerial parts of C. sativum led to the isolation and identification of seven compounds (1-7) including two new isocoumarin glycosides (1-2) and a new phenolic glycoside (5). The chemical structures of the new compounds (1, 2, and 5) were elucidated by analysis of 1D and 2D NMR (1 H and 13 C NMR, COSY, HSQC, and HMBC) and HRESIMS data as well as by using chemical methods. All the isolates were evaluated not only for their potential neurotrophic activity by means of induction of nerve growth factor (NGF) in C6 glioma cells but also for production of nitric oxide (NO) levels in lipopolysaccharide (LPS)-activated murine microglia BV-2 cells to assess their anti-neuroinflammatory activity. Compounds 1-3 and 7 were stimulants of NGF release, with levels of NGF stimulated at 127.23 ± 1.89%, 128.22 ± 5.45%, 121.23 ± 6.66%, and 120.94 ± 3.97%, respectively. Furthermore, the aglycones of 1 and 2 (1a and 2a) showed more potent NGF secretion activity and anti-neuroinflammatory effect than did their glycosides (1a : 130.81 ± 5.45% and 2a : 134.44 ± 5.45%).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Coriandrum sativum has anti-neuroinflammatory activity.
“Anti-neuroinflammatory”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [171]
Coriandrum sativum has potent NGF secretion activity.
“potent NGF”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [171]
Cites
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Production of tumor necrosis factor-alpha by microglia and astrocytes in culture
Sawada, M., Kondo, N., Suzumura, A., & Marunouchi, T. (1989) · Brain Research · doi:10.1016/0006-8993(89)90078-4 · Cited by 631 · see citing works
The role of carbohydrates in biologically active natural products
Weymouth‐Wilson, A. C. (1997) · Natural Product Reports · doi:10.1039/np9971400099 · Cited by 556 · see citing works
Hara, S., Okabe, H., & Mihashi, K. (1987) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.35.501 · Cited by 545 · see citing works
Implications of glial nitric oxide in neurodegenerative diseases
Yuste, J. E., Tarragon, E., Campuzano, C. M., & Ros-Bernal, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00322 · Cited by 356 · see citing works
Subedi, L., Lee, J. H., Yumnam, S., Ji, E., & Kim, S. Y. (2019) · Cells · doi:10.3390/cells8020194 · Cited by 274 · see citing works
Self-citationStudies on the glycosides of Epimedium grandiflorum MORR. var. thunbergianum (Miq.) NAKAI.. III.
Miyase, T., Ueno, A., Takizawa, N., Kobayashi, H., & OGUCHI, H. (1988) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.36.2475 · Cited by 267 · see citing works
Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum
Matasyoh, J. C., Maiyo, Z. C., Ngure, R. M., & Chepkorir, R. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.07.097 · Cited by 263 · see citing works
Samojlik, I., Lakić, N., Mimica–Dukić, N., Daković-Svajcer, K., & Božin, B. N. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101645n · Cited by 237 · see citing works
Spuch, C., & Navarro, C. (2011) · Journal of Drug Delivery · doi:10.1155/2011/469679 · Cited by 177 · see citing works
Coriander ( Coriandrum sativum ): A promising functional food toward the well-being
Prachayasittikul, V., Prachayasittikul, S., Ruchirawat, S., & Prachayasittikul, V. (2017) · Food Research International · doi:10.1016/j.foodres.2017.11.019 · Cited by 154 · see citing works
Studies on the glycosides of Epimedium grandiflorum MORR. var. thunbergianum (MIQ.) NAKAI. I.
Miyase, T., Ueno, A., Takizawa, N., Kobayashi, H., & Karasawa, H. (1987) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.35.1109 · Cited by 153 · see citing works
Krohn, K., Bahramsari, R., Flörke, Ü., Ludewig, K., Kliche-Spory, C., Michel, A., Aust, H.-J., Draeger, S., Schulz, B., & Antus, S. (1997) · Phytochemistry · doi:10.1016/s0031-9422(96)00854-0 · Cited by 150 · see citing works
Phytochemical and bioactive profile of Coriandrum sativum L.
Wei, J., Liu, Z., Zhao, Y.-P., Zhao, L., Xue, T.-K., & Lan, Q. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.171 · Cited by 91 · see citing works
Coriander Genomics Database: a genomic, transcriptomic, and metabolic database for coriander
Song, X., Nie, F., Chen, W., Ma, X., Gong, K. Q., Yang, Q., Wang, J., Li, N., Sun, P., Pei, Q., et al. (2020) · Horticulture Research · doi:10.1038/s41438-020-0261-0 · Cited by 63 · see citing works
Unsicker, K., Vey, J., Hofmann, H., Müller, T. H., & Wilson, A. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.2242 · Cited by 60 · see citing works
Phytotoxins of Botryosphaeria obtusa
Venkatasubbaiah, P., & Chilton, W. S. (1990) · Journal of Natural Products · doi:10.1021/np50072a044 · Cited by 60 · see citing works
Salicin derivatives from Salix glandulosa and their biological activities
Kim, C. S., Subedi, L., Park, K.-J., Kim, S. Y., Choi, S. U., Kim, K. H., & Lee, K. R. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.08.013 · Cited by 58 · see citing works
Self-citationIridoid and phenolic diglycosides from Canthium berberidifolium
Kanchanapoom, T., Kasai, R., & Yamasaki, K. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00140-1 · Cited by 58 · see citing works
Flavonoids and other phenolics from Artemisia hispanica
Marco, J. A., Barberá, Ó., Rodríguez, S., Domingo, C., & Adell, J. (1988) · Phytochemistry · doi:10.1016/0031-9422(88)80018-9 · Cited by 58 · see citing works
Constituents from the bark of Tabebuia impetiginosa
Warashina, T., Nagatani, Y., & Noro, T. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.06.012 · Cited by 53 · see citing works
Coriandrin, a novel highly photoactive compound isolated from Coriandrum sativum
Ceska, O., Chaudhary, S. K., Warrington, P. J., Ashwood-Smith, M. J., Bushnell, G. W., & Poultont, G. A. (1988) · Phytochemistry · doi:10.1016/0031-9422(88)80101-8 · Cited by 49 · see citing works
Anti-Neurodegenerative Biflavonoid Glycosides from Impatiens balsamina
Kim, C. S., Bae, M., Oh, J., Subedi, L., Suh, W. S., Choi, S. Z., Son, M. W., Kim, S. Y., Choi, S. U., Oh, D., et al. (2017) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00981 · Cited by 49 · see citing works
Self-citationThree isocoumarins from Coriandrum sativum
Taniguchi, M., Yanai, M., Xiao, Y. Q., Kido, T.-I., & Baba, K. (1996) · Phytochemistry · doi:10.1016/0031-9422(95)00930-2 · Cited by 48 · see citing works
Phenylbutan-2-one β-d-glucosides from raspberry fruit
Pabst, A., Barron, D., Adda, J., & Schreier, P. H. (1990) · Phytochemistry · doi:10.1016/0031-9422(90)85346-h · Cited by 40 · see citing works
Evaluation of coriander spice as a functional food by using in vitro bioassays
Zhang, C., Dissanayake, A. A., Kevseroğlu, K., & Nair, M. G. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.120 · Cited by 35 · see citing works
Bringmann, G., Münchbach, M., Messer, K., Koppler, D., Michel, M., Schupp, O., Wenzel, M., & Louis, A. M. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00080-1 · Cited by 33 · see citing works
Chemical constituents of the roots of Rheum officinale
Gao, L.-L., Xu, X., & Yang, J. (2013) · Chemistry of Natural Compounds · doi:10.1007/s10600-013-0689-7 · Cited by 33 · see citing works
A New Coumarin Glucoside from Daphne arisanensis.
Niwa, M., Sugino, H., TAKASHIMA, S., Sakai, T., Wu, Y., Tian-Sheng, W. U., & Chan-Sheng, K. U. O. H. (1991) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.39.2422 · Cited by 30 · see citing works
The Role of PPARδ Signaling in the Cardiovascular System
Ding, Y., Yang, K. D., & Yang, Q. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00014-4 · Cited by 23 · see citing works
Limodissimin A: A New Dimeric Coumarin from Limonia acidissima
Kim, K. H. (2009) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2009.30.9.2135 · Cited by 20 · see citing works
Schlingmann, G., & Roll, D. M. (2005) · Chirality · doi:10.1002/chir.20105 · Cited by 18 · see citing works
Suh, W. S., Kwon, O. K., Lee, T. H., Subedi, L., Kim, S. Y., & Lee, K. R. (2017) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c17-00720 · Cited by 18 · see citing works
Self-citationPhenolic constituents from the twigs of Betula schmidtii collected in Goesan, Korea
Park, K.-J., Cha, J. M., Subedi, L., Kim, S. Y., & Lee, K. R. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.112085 · Cited by 16 · see citing works
Self-citationPhytochemical study of acetone solvent extract of Coriander sativum
Nathenial, S., Fatima, A., Fatima, R., Ijaz, N., Saeed, N., Shafqat, A., & Leghari, L. (2019) · Journal of Pharmacognosy and Phytochemistry · Cited by 8 · see citing works
Inhibitory effect of coumarins on nitric oxide production in LPS-activated murine macrophages
TaeCheol, R., HeeCheol, C., Kim, B.-Y., Kim, Y. H., Jong-Seog, A., YoungKook, K., & Lee, H.-S. (1999) · 생약학회지 · Cited by 3 · see citing works
Inhibitory effect of coumarins on nitric oxide production in LPS-activated murine macrophages
Rho, T. C., Choi, H. C., Kim, B. Y., Kim, Y. H., Ahn, J. S., Kim, Y. K., & Lee, H. S. (1999) · KRIBB Repository · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits
Mahleyuddin, N. N., Moshawih, S., Ming, L. C., Zulkifly, H. H., Kifli, N., Loy, M. J., Sarker, M. M. R., Al-Worafi, Y. M., Goh, B. H., Thuraisingam, S., et al. (2021) · Molecules · doi:10.3390/molecules27010209 · Cited by 405 · see citing works
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
Nan, Z., Shang, Y., Zhu, Y., Zhang, H., Sun, R.-R., Tian, J., Jiang, Z., Ma, X.-L., & Bai, C. (2025) · Phytochemistry · doi:10.1016/j.phytochem.2025.114480 · Cited by 41 · see citing works
Hong, W., Liu, D., Zhao, P., Qin, S.-Y., Xi, Y.-F., Guo, R., Huang, X., Song, S., & Li, D. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105521 · Cited by 14 · see citing works
Munni, Y. A., Dash, R., Mitra, S., Dash, N., Shima, M., & Moon, I. S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116165 · Cited by 12 · see citing works
Fukuyama, Y., Kubo, M., & Harada, K. (2024) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-031-42422-9_1 · Cited by 7 · see citing works
Jin, Y., Guo, Z., Zhu, H., Zhang, Z., Jiang, X., Yang, Y., Liu, P., Yang, Y. Z., Wang, M., & Gao, H. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107301 · Cited by 7 · see citing works
Agarwal, U., Kanupriya, K., Tonk, R. K., & Verma, S. K. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10142-5 · Cited by 6 · see citing works
Sharma, D., Rajbongshi, B., Isphak, T., Basumatary, S., Dutta, K., Rudrapal, M., & Goswami, A. K. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500038 · Cited by 5 · see citing works
Gutiérrez, R. M. P., & Gómez, J. T. (2022) · Current Nutrition & Food Science · doi:10.2174/1573401318666221005124312 · Cited by 4 · see citing works
Targu, M., Pun, B., Arora, M., Joshi, S. R., & Kumaria, S. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.08.049 · Cited by 3 · see citing works
Ismail, F., Ismail, W. U., Muhammad, G., Hussain, M. A., & Zulfiqar, Z. (2025) · Natural Product Communications · doi:10.1177/1934578x241312791 · Cited by 2 · see citing works
He, W., Hu, D., Guo, M., Nie, B., Zhang, G., Jia, Y., Hou, Z., Shu, S., Shao, Y., Simonsen, H. T., et al. (2025) · The Plant Journal · doi:10.1111/tpj.70311
Vu, T. N., Chu, H. T. T., Thủy, Đ. T. T., Tien, T. Q., Do, P. T., Tran, K. Q., & Setzer, W. N. (2026) · Horticulture Environment and Biotechnology · doi:10.1007/s13580-025-00794-9
- Authors
- Cha, J. M., Yoon, D., Kim, S. Y., Kim, C. S., & Lee, K. R.
- Affiliations
- Sungkyunkwan University (KR)
- Gachon University (KR)
- Corresponding author
- Lee, Kang Ro
- Venue
- Bioorganic Chemistry
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 105
- Pages
- 104443
- ISSN
- 0045-2068 (ISSN-L)
- OpenAlex
- W3096936548
- Cited by
- 14
- References
- 37
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- coriander, phenolic glycosides, neurotrophic activity, anti-neuroinflammatory activity, nerve growth factor, nitric oxide, microglia, C6 glioma cells, natural product isolation, structure elucidation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Glycosides, Humans, Lipopolysaccharides, Macrophages, Nitric Oxide, Phenols, Plant Extracts, Neuroprotective Agents, Nerve Growth Factor, Coriandrum, Plant Components, Aerial, Isocoumarins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review