Cited by 14Plant chemical constituents analysisPhytochemistry and Biological ActivitiesMedicinal Plants and Neuroprotection

Neurotrophic and anti-neuroinflammatory constituents from the aerial parts of Coriandrum sativum

Cha, Joon Min, Yoon, DaHye, Kim, Sun Yeou, Kim, Chung Sub, Lee, Kang Ro·2020·Bioorganic Chemistry

Abstract

In the course of our continuing search for biologically active compounds from medicinal sources, we investigated the MeOH extract of the aerial parts of Coriandrum sativum Linn. An extended phytochemical investigation of the aerial parts of C. sativum led to the isolation and identification of seven compounds (1-7) including two new isocoumarin glycosides (1-2) and a new phenolic glycoside (5). The chemical structures of the new compounds (1, 2, and 5) were elucidated by analysis of 1D and 2D NMR (1 H and 13 C NMR, COSY, HSQC, and HMBC) and HRESIMS data as well as by using chemical methods. All the isolates were evaluated not only for their potential neurotrophic activity by means of induction of nerve growth factor (NGF) in C6 glioma cells but also for production of nitric oxide (NO) levels in lipopolysaccharide (LPS)-activated murine microglia BV-2 cells to assess their anti-neuroinflammatory activity. Compounds 1-3 and 7 were stimulants of NGF release, with levels of NGF stimulated at 127.23 ± 1.89%, 128.22 ± 5.45%, 121.23 ± 6.66%, and 120.94 ± 3.97%, respectively. Furthermore, the aglycones of 1 and 2 (1a and 2a) showed more potent NGF secretion activity and anti-neuroinflammatory effect than did their glycosides (1a : 130.81 ± 5.45% and 2a : 134.44 ± 5.45%).

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Crossref · 10.1016/j.bioorg.2020.104443

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Authors
Cha, J. M., Yoon, D., Kim, S. Y., Kim, C. S., & Lee, K. R.
Affiliations
  • Sungkyunkwan University (KR)
  • Gachon University (KR)
Corresponding author
Lee, Kang Ro
Venue
Bioorganic Chemistry
Publisher
Elsevier BV
Published
2020-12
Volume
105
Pages
104443
ISSN
0045-2068 (ISSN-L)
OpenAlex
W3096936548
Cited by
14
References
37
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2
FWCI
0.81
Type
journal article
Language
en
Open access
closed
Locations
  • Bioorganic Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
coriander, phenolic glycosides, neurotrophic activity, anti-neuroinflammatory activity, nerve growth factor, nitric oxide, microglia, C6 glioma cells, natural product isolation, structure elucidation
MeSH terms
Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Glycosides, Humans, Lipopolysaccharides, Macrophages, Nitric Oxide, Phenols, Plant Extracts, Neuroprotective Agents, Nerve Growth Factor, Coriandrum, Plant Components, Aerial, Isocoumarins, Mice

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