Lycopene affects proliferation and apoptosis of four malignant cell lines
Abstract
The beneficial effect of lycopene from tomatoes on a variety of chronic diseases and particularly its association with decreased incidence of prostate and breast cancer seems to be well established. The aim of the study was to examine its anti-proliferative and apoptotic effect on other malignant cell lines. Cells of the following lines were incubated with 1.0, 2.0, and 4.0microM of lycopene: human colon carcinoma (HuCC), B chronic lymphocytic leukemia (EHEB), human erythroleukemia (K562) and Raji, a prototype of Burkitt lymphoma cell line. The results showed that lycopene exerted a significant dose-dependent effect on the proliferation capacity of K562, Raji and HuCC lines, whereas this effect was observed in EHEB cells only with the highest dose used in the study. Increased apoptotic rate was found after incubation of HuCC cells with 2.0 and 4.0microM of lycopene and in Raji cells following incubation with 2.0microM. The findings point out that the anti-proliferative effect of lycopene on tumor cells and its effect on the apoptotic rate depends on its dosage and on the type of the malignant cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lycopene has been shown to inhibit proliferation of several types of cancer cells through different mechanisms in in vitro systems.
“In fact, lycopene has been shown to inhibit proliferation of several types of cancer cells through different mechanisms in in vitro systems [10, 11].”
From The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes (2016) · cites this paper as [10]
Cites
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574 · see citing works
Tomato lycopene and its role in human health and chronic diseases.
Agarwal, S., & Rao, A. V. (2000) · Europe PMC (PubMed Central) · Cited by 738 · see citing works
Overview of Mechanisms of Action of Lycopene
Heber, D., & Lu, Q. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701013 · Cited by 478 · see citing works
Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials
Basu, A., & Imrhan, V. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602510 · Cited by 279 · see citing works
Rao, A. V., Ray, M. R., & RAO, L. G. S. (2006) · Advances in food and nutrition research · doi:10.1016/s1043-4526(06)51002-2 · Cited by 225 · see citing works
A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer
Kirsh, V. A., Mayne, S. T., Peters, U., Chatterjee, N., Leitzmann, M. F., Dixon, L. B., Urban, D. A., Crawford, E. D., & Hayes, R. B. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0563 · Cited by 180 · see citing works
Inverse associations between plasma lycopene and other carotenoids and prostate cancer.
Lu, Q., Hung, J. C., Heber, D., Go, V. L. W., Reuter, V. E., Cordon‐Cardo, C., Scher, H. I., Marshall, J., & Zhang, Z. (2001) · PubMed · Cited by 174 · see citing works
Sato, R., Helzlsouer, K. J., Alberg, A. J., Hoffman, S. C., Norkus, E. P., & Comstock, G. W. (2002) · PubMed · Cited by 160 · see citing works
Lycopene: A Review of Its Potential as an Anticancer Agent
Bhuvaneswari, V., & Nagini, S. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/156801105774574667 · Cited by 152 · see citing works
Hantz, H. L., Young, L. F., & Martin, K. R. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000303 · Cited by 124 · see citing works
Limpens, J., Schröder, F. H., de Ridder, C. M., Bolder, C. A., Wildhagen, M. F., Obermüller-Jevic, U. C., Krämer, K., & van Weerden, W. M. (2006) · Journal of Nutrition · doi:10.1093/jn/136.5.1287 · Cited by 107 · see citing works
Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1
Nahum, A., Zeller, L., Danilenko, M., Prall, O. W. J., Watts, C. K. W., Sutherland, R. L., Levy, J., & Sharoni, Y. (2006) · European Journal of Nutrition · doi:10.1007/s00394-006-0595-x · Cited by 99 · see citing works
Hirsch, K., Atzmon, A., Danilenko, M., Levy, J., & Sharoni, Y. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9405-7 · Cited by 93 · see citing works
Dietary and Plasma Lycopene and the Risk of Breast Cancer
Sesso, H. D., Buring, J. E., Zhang, S. M., Norkus, E. P., & Gaziano, J. M. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0683 · Cited by 80 · see citing works
A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells
Zhang, H., Kotake-Nara, E., Ono, H., & Nagao, A. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.09.019 · Cited by 70 · see citing works
Kanagaraj, P., Vijayababu, M. R., Ravisankar, B., Jaganathan, A., Aruldhas, M. M., & Arunakaran, J. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0177-6 · Cited by 67 · see citing works
Carotenoids Induce Apoptosis in the T-lymphoblast Cell Line Jurkat E6.1
Müller, K. H., Carpenter, K. L. H., Challis, I. R., Skepper, J. N., & Arends, M. J. (2002) · Free Radical Research · doi:10.1080/10715760290032539 · Cited by 65 · see citing works
Processed Tomato Products as a Source of Dietary Lycopene:Bioavailability and Antioxidant Properties
Rao, A. V. (2004) · Canadian Journal of Dietetic Practice and Research · doi:10.3148/65.4.2004.161 · Cited by 58 · see citing works
Ellinger, S., Ellinger, J., & Stehle, P. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000247470.64532.34 · Cited by 58 · see citing works
Gene Signature of Breast Cancer Cell Lines Treated with Lycopene
Chalabi, N., Delort, L., Corre, L. L., Satih, S., Bignon, Y., & Bernard-Gallon, D. J. (2006) · Pharmacogenomics · doi:10.2217/14622416.7.5.663 · Cited by 57 · see citing works
Hwang, E., & Bowen, P. E. (2005) · BioFactors · doi:10.1002/biof.5520230205 · Cited by 56 · see citing works
Lycopene, tomatoes, and coronary heart disease
Das, S., Otani, H., Maulik, N., & Das, D. K. (2005) · Free Radical Research · doi:10.1080/10715760500053685 · Cited by 47 · see citing works
Hwang, E., & Bowen, P. E. (2005) · BioFactors · doi:10.1002/biof.5520230203 · Cited by 38 · see citing works
Prostate cells exposed to lycopene in vitro liberate lycopene‐enriched exosomes
Goyal, A. K., Delves, G., Chopra, M., Lwaleed, B. A., & Cooper, A. J. (2006) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06434.x · Cited by 21 · see citing works
Ansari, M., & Ansari, S. (2005) · Future Oncology · doi:10.1517/14796694.1.3.425 · Cited by 16 · see citing works
Did Columbus Also Open the Exploration of the Modern Diet?
Mariani-Costantini, A., & Ligabue, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1992.tb07717.x · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bioactivities of phytochemicals present in tomato
Chaudhary, P., Sharma, A., Singh, B., & Nagpal, A. K. (2018) · Journal of Food Science and Technology · doi:10.1007/s13197-018-3221-z · Cited by 353 · see citing works
Revealing the Power of the Natural Red Pigment Lycopene
Kong, K. W., Khoo, H. E., Prasad, K. N., Ismail, A., Tan, C. P., & Rajab, N. F. (2010) · Molecules · doi:10.3390/molecules15020959 · Cited by 281 · see citing works
Hyun, K., Koo, S. Y., & Lee, D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802111x · Cited by 245 · see citing works
Saffron and natural carotenoids: Biochemical activities and anti-tumor effects
Bolhassani, A., Khavari, A., & Bathaie, S. Z. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.11.001 · Cited by 228 · see citing works
Antioxidant and anti-proliferative properties of lycopene
Kelkel, M., Schumacher, M. M., Dicato, M. A., & Diederich, M. F. (2011) · Free Radical Research · doi:10.3109/10715762.2011.564168 · Cited by 227 · see citing works
Lycopene – a bioactive carotenoid offering multiple health benefits: a review
Przybylska, S. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14260 · Cited by 230 · see citing works
Multitargeted therapy of cancer by lycopene
van Breemen, R. B., & Pajkovic, N. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.016 · Cited by 215 · see citing works
Sources, stability, encapsulation and application of natural pigments in foods
Jurić, S., Jurić, M., Król-Kilińska, Ż., Vlahoviček‐Kahlina, K., Vinceković, M., Dragović‐Uzelac, V., & Donsı̀, F. (2020) · Food Reviews International · doi:10.1080/87559129.2020.1837862 · Cited by 210 · see citing works
Viuda‐Martos, M., Sanchez-Zapata, E., Sayas‐Barberá, E., Sendra, E., Pérez‐Álvarez, J. Á., & Fernández‐López, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.623799 · Cited by 204 · see citing works
Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines.
Gloria, N. F., Soares, N. D. C. P., Brand, C., de Oliveira, F. L., Borojević, R., & Teodoro, A. J. (2014) · PubMed · Cited by 194 · see citing works
Mein, J. R., Lian, F., & Wang, X.-D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00120.x · Cited by 191 · see citing works
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds
Li, Y., Wicha, M. S., Schwartz, S. J., & Sun, D. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.11.001 · Cited by 179 · see citing works
Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
Pratheeshkumar, P., Sreekala, C., Zhang, Z., Budhraja, A., Ding, S., Son, Y., Wang, X., Hitron, J. A., Hyun-Jung, K., Wang, L., et al. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833035 · Cited by 178 · see citing works
Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines
Teodoro, A. J., de Oliveira, F. L., Martins, N., Maia, G. D. A., Martucci, R. B., & Borojević, R. (2012) · Cancer Cell International · doi:10.1186/1475-2867-12-36 · Cited by 154 · see citing works
Palozza, P., Colangelo, M., Simone, R. E., Catalano, A., Boninsegna, A., Lanza, P., Monego, G., & Ranelletti, F. O. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq157 · Cited by 153 · see citing works
Watermelon lycopene and allied health claims
Naz, A., Butt, M. S., Sultan, M. T., Qayyum, M. M. N., & Niaz, R. S. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-6561 · Cited by 118 · see citing works
Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies
Palozza, P., Simone, R. E., Catalano, A., & Mele, M. C. (2011) · Cancers · doi:10.3390/cancers3022333 · Cited by 114 · see citing works
Anticancer activity of C arica papaya: A review
Nguyen, T. T. T., Shaw, P. N., Parat, M., & Hewavitharana, A. K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200388 · Cited by 113 · see citing works
Jeong, Y., Lim, J. W., & Kim, H. (2019) · Nutrients · doi:10.3390/nu11040762 · Cited by 110 · see citing works
Molecular Targets of Natural Compounds with Anti-Cancer Properties
Kubczak, M., Szustka, A., & Rogalińska, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413659 · Cited by 103 · see citing works
Tomato waste: Carotenoids content, antioxidant and cell growth activities
Stajčić, S., Ćetković, G., Čanadanović‐Brunet, J. M., Djilas, S., Mandić, A., & Četojević‐Simin, D. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.09.069 · Cited by 94 · see citing works
Choi, H., & Lee, D. G. (2015) · Biochimie · doi:10.1016/j.biochi.2015.05.009 · Cited by 88 · see citing works
Khuda‐Bukhsh, A. R., Das, S., & Saha, S. K. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2014.864420 · Cited by 87 · see citing works
A mechanistic updated overview on lycopene as potential anticancer agent
Özkan, G., Günal‐Köroğlu, D., Karadağ, A., Çapanoğlu, E., Cardoso, S. M., Al‐Omari, B., Călina, D. C., Sharifi‐Rad, J., & Cho, W. C. S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114428 · Cited by 84 · see citing works
Skin Protection by Carotenoid Pigments
Flieger, J., Raszewska-Famielec, M., Radzikowska-Büchner, E., & Flieger, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031431 · Cited by 75 · see citing works
Anticancer Effect of Lycopene in Gastric Carcinogenesis
Kim, M. J., & Kim, H. (2015) · Journal of Cancer Prevention · doi:10.15430/jcp.2015.20.2.92 · Cited by 70 · see citing works
The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes
Ascenso, A., Pedrosa, T., Pinho, S., Pinho, F., Oliveira, J. M. P. F. D., Cabral Marques, H., Oliveira, H., Simões, S., & Santos, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8214631 · Cited by 57 · see citing works
Yang, C., Huang, S., Liu, C., & Hu, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204451n · Cited by 55 · see citing works
Burgess, L. C., Rice, E., Fischer, T., Seekins, J. R., Burgess, T. P., Sticka, S. J., & Klatt, K. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.03.001 · Cited by 55 · see citing works
Park, B., Lim, J. W., & Kim, H. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.07.010 · Cited by 51 · see citing works
Lycopene inhibits angiogenesis in human umbilical vein endothelial cells and rat aortic rings
Elgass, S., Cooper, A., & Chopra, M. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005800 · Cited by 38 · see citing works
Gupta, P., Bansal, M. P., & Koul, A. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.099 · Cited by 37 · see citing works
Phytochemicals and cancer chemoprevention
Dave, A., Parande, F., Park, E., & Pezzuto, J. M. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.106 · Cited by 36 · see citing works
Complementary and Alternative Medicine and Breast Cancer
Subramani, R., & Lakshmanaswamy, R. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.07.008 · Cited by 35 · see citing works
Momordica cochinchinensis Aril Extract Induced Apoptosis in Human MCF-7 Breast Cancer Cells
Petchsak, P., & Sripanidkulchai, B. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.13.5507 · Cited by 34 · see citing works
Czarnik-Kwaśniak, J., Kwaśniak, K., Kwasek, P., Świerzowska, E., Strojewska, A., & Tabarkiewicz, J. (2019) · Nutrients · doi:10.3390/nu12010096 · Cited by 33 · see citing works
Moccia, S., Russo, M., Durante, M., Lenucci, M. S., Mita, G., & Russo, G. L. (2020) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2020.05.001 · Cited by 30 · see citing works
Natural compounds as inducers of cell death
Diederich, M. F., & Noworyta, K. (2012) · Springer eBooks · doi:10.1007/978-94-007-4575-9 · Cited by 30 · see citing works
Rotelli, M. T., Bocale, D., Fazio, M. D., Ancona, P., Scalera, I., Memeo, R., Travaglio, E., Zbar, A. P., & Altomare, D. F. (2015) · Surgical Oncology · doi:10.1016/j.suronc.2015.08.001 · Cited by 29 · see citing works
Wang, J., Liu, X.-J., Liu, R.-S., Li, H., & Ya-jie Tang, A. (2011) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-011-0628-6 · Cited by 28 · see citing works
Sahin, M. A., Şahın, E., & Gümüşlü, S. (2011) · Acta Histochemica · doi:10.1016/j.acthis.2011.03.004 · Cited by 27 · see citing works
Cancer prevention – review paper
Lewandowska, A., Lewandowski, T., Rudzki, M., Rudzki, S., & Laskowska, B. (2020) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/116906 · Cited by 26 · see citing works
Lycopene Inhibits Proliferation, Invasion and Migration of Human Breast Cancer Cells
Koh, M.-S., Hwang, J. S., & Moon, A. (2010) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2010.18.1.092 · Cited by 26 · see citing works
Ettorre, A., Frosali, S., Andreassi, M. G., & Stefano, A. D. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009386 · Cited by 25 · see citing works
Effects of lycopene on proliferation and death of canine osteosarcoma cells
Wakshlag, J. J., & Balkman, C. E. (2010) · American Journal of Veterinary Research · doi:10.2460/ajvr.71.11.1362 · Cited by 25 · see citing works
Analysis of fouling and juice quality in crossflow ultrafiltration of watermelon juice
Bhattacharjee, C., Saxena, . K., & Dutta, S. (2017) · Food Science and Technology · doi:10.1590/1678-457x.15217 · Cited by 24 · see citing works
Anticancer activity of lycopene in HT-29 colon cancer cell line
Ataseven, D., Öztürk, A., Özkaraca, M., & Joha, Z. (2023) · Medical Oncology · doi:10.1007/s12032-023-02001-0 · Cited by 23 · see citing works
Fernández‐Bedmar, Z., Anter, J., & Moraga, Á. A. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22185 · Cited by 21 · see citing works
Mosqueda-Martínez, E., Chiquete‐Félix, N., Castañeda-Támez, P., Ricardez-García, C., Gutiérrez‐Aguilar, M., Uribe‐Carvajal, S., & Méndez-Romero, O. A. (2024) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2024.1378590 · Cited by 19 · see citing works
Gharib, A., & Faezizadeh, Z. (2014) · Pharmacognosy Magazine · doi:10.4103/0973-1296.127368 · Cited by 17 · see citing works
Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress
Ou, S., Fang, Y., Tang, H., Wu, T., Chen, L., Jiang, M. H., Zhou, L., Xu, J., & Guo, K. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15419 · Cited by 16 · see citing works
Nemzer, B. V., Yashin, A. Y., Vedenin, A. N., Yashin, Y. I., Yashunsky, D. V., Nifantiev, N. E., & Kalita, D. (2019) · Journal of Food Research · doi:10.5539/jfr.v8n1p60 · Cited by 17 · see citing works
Marlow, G., Han, D. Y., Triggs, C. M., & Ferguson, L. R. (2015) · Lifestyle Genomics · doi:10.1159/000435783 · Cited by 14 · see citing works
Lycopene in the Prevention of Radiation-Induced Esophagitis
Coskun, H., Andiç, F., Dağlıoğlu, Y. K., Doran, F., Şahin, K., Tunali, C., & Küçük, Ö. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1265133 · Cited by 13 · see citing works
Park, M. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115906 · Cited by 13 · see citing works
Carotenoides en quimioprevención: Licopeno
Vitale, A. A., Bernatené, E. A., & Pomilio, A. B. (2010) · Acta bioquímica clínica latinoamericana/Acta bioquímica clínica latinoamericana · Cited by 12 · see citing works
Evidence and Prospects of Lycopene as Powerful Red Superfood: Modern Approach to Food Science
Gupta, E., Mishra, P., Singh, P., & Mishra, N. (2023) · Current Traditional Medicine · doi:10.2174/2215083810666230417093938 · Cited by 11 · see citing works
Palomo, I. F., Moore‐Carrasco, R., Carrasco, G. A., Villalobos, P., & Guzmán, L. (2010) · Idesia · doi:10.4067/s0718-34292010000300016 · Cited by 10 · see citing works
Mennati, A., Rostamizadeh, K., Manjili, H. K., Mousavi, M. A., Zhiani, M., Sabouri, I., Attari, E., Fathi, M., & Danafar, H. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102806 · Cited by 9 · see citing works
Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line
Dourado, G. K. Z. S., Stanilka, J. M., Percival, S. S., & Cesar, T. B. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.15.6491 · Cited by 9 · see citing works
Properties of lycopene and utilizing it to produce functional foods
Siepko, N., Chwastowska-Siwiecka, I., & Kondratowicz, J. (2015) · Zywnosc-nauka Technologia Jakosc · doi:10.15193/zntj/2015/103/084 · Cited by 9 · see citing works
Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review
Verrillo, M., Pantina, V. D., Venezia, V., Modica, C., Iacono, M. L., Bianca, P., Bozzari, G., Angeloro, F., Cozzolino, V., Stassi, G., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107740 · Cited by 8 · see citing works
Review article: WATERMELON LYCOPENE AND ALLIED HEALTH CLAIMS
Naz, A., Butt, M. S., Sultan, M. T., Qayyum, M. M. N., & Niaz, R. S. (2014) · Cited by 8 · see citing works
Resveratrol and Lycopene in the Diet and Cancer Prevention
Arora, V. K., Sachdeva, A. K., Singh, P., Baveja, A., Chopra, K., & Kuhad, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405205-5.00012-x · Cited by 7 · see citing works
de Farias, B. S., Rizzi, F. Z., da Silva, P. P., Ribeiro, E. S., Diaz, P. S., Cadaval, T. R. S., & Pinto, L. A. D. A. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117099 · Cited by 6 · see citing works
Natural compounds as a potential modifier of stem cells renewal: Comparative analysis
Mishra, A., Pathak, Y., Mishra, S. K., Prakash, H., & Tripathi, V. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175412 · Cited by 6 · see citing works
Likopen – występowanie, właściwości oraz potencjalne zastosowanie
Belter, A., Giel-Pietraszuk, M., Oziewicz, S., Chomczyński, P., & Barciszewski, J. (2011) · Postępy Biochemii · Cited by 5 · see citing works
Dutta, D., & Dutta, D. (2022) · doi:10.1002/9781119746843.ch11 · Cited by 5 · see citing works
Rodeiro, I., Magariño, Y., López-Ocejo, O., Garrido, G., & Delgado, R. (2008) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 4 · see citing works
Karagil, S., Szczesnowska, A., Haddad, N. F., Gamaethige, S. M., Coakley, E., Dawood, N., Rama., V., Barker, J., Langat, M. K., Morgan, H., et al. (2025) · Therapeutics · doi:10.3390/therapeutics2010005 · Cited by 3 · see citing works
Ko, H.-J., Su, Y., Loh, J., & Tsai, C. Y. (2024) · Formosan Journal of Surgery · doi:10.1097/fs9.0000000000000123 · Cited by 3 · see citing works
Şahin, K., & Küçük, Ö. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_164 · Cited by 3 · see citing works
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
Nguyen, T. T. (2016) · The University of Queensland · doi:10.14264/uql.2016.283 · Cited by 3 · see citing works
Cancer Stem Cells: Novel Target Using Dietary Components for Prevention and Treatment
Dhar, A., Fogt, L., Subramaniam, D., & Anant, S. (2011) · Springer eBooks · doi:10.1007/978-94-007-2630-7_2 · Cited by 2 · see citing works
Tommonaro, G., Piscitelli, C., Lavorgna, M., Isidori, M., Russo, C., Prisco, R. D., Abbamondi, G. R., & Iodice, C. (2017) · JOURNAL OF ADVANCES IN BIOLOGY · doi:10.24297/jab.v10i2.6187 · Cited by 2 · see citing works
Ali, M. S., Dongsar, T. S., Haldar, N., Gajbhiye, V., Aqil, M., & Kesharwani, P. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2026.2614975 · Cited by 1 · see citing works
The Garden Pharmacy: Pot Marigold: An Herbal Florin for Health
Duke, J. A. (2008) · Alternative and Complementary Therapies · doi:10.1089/act.2008.14303 · Cited by 1 · see citing works
Induction of Apoptosis by Polyphenolic Compounds in Cancer Cells
Coşan, D. T., & Soyocak, A. (2012) · Springer eBooks · doi:10.1007/978-94-007-4575-9_8 · Cited by 1 · see citing works
Antioxidants: Potential Inducers of Gene Expression through CAMP Dependent Pathway
Tandon, S. (2013) · Journal of Blood Disorders & Transfusion · doi:10.4172/2155-9864.s3-006 · Cited by 1 · see citing works
Rodeiro, I., Magariño, Y., López-Ocejo, O., Garrido, G., & Delgado, R. (2008)
Phytocomplexity: The Key to Rational Chemoprevention
Gundala, S. R., Robinson, M. H., & Aneja, R. (2015) · Springer eBooks · doi:10.1007/978-3-319-21461-0_4
Gold nanoparticle mediated membrane permeabilization of phytochemicals into breast cancer cells
Chen, F. (2014) · ProQuest Demo Repository
Nguyen, T. T. N., Khoa, T. A., Vu, T. H. Q., Chinh, V. N., & Phung, L. T. K. (2017) · AIP conference proceedings · doi:10.1063/1.5000206
Wpływ wybranych składników żywności na profilaktykę chorób nowotworowych
Swora-Cwynar, E., Dymkowska-Malesa, M., Grzymislawski, M. B., & Dobrowolska, A. (2018) · Kosmos · doi:10.36921/kos.2018_2397
Implication of phytochemicals for cancer “immunotherapy”
Lahane, S., Chainani, L., & Majumdar, A. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34084-0.00008-x
Liu, X., Jiang, Q., Xie, B., Zhang, Z., Zhou, J., Zhou, T., & Wang, H. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864261483986
Kumar, A., Parashar, N. C., Parashar, G., Rani, I., Kaur, D., Sharma, S., Tuli, H. S., Bhatia, G. K., Sarwar, T., & Rahmani, A. H. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101214
- Authors
- Salman, H., Bergman, M., Djaldetti, M., & Bessler, H.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Djaldetti, M.
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 61
- Issue
- 6
- Pages
- 366-369
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2166507545
- Cited by
- 89
- References
- 26
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- lycopene, antiproliferative activity, apoptosis, malignant cell lines, colon cancer, chronic lymphocytic leukemia, erythroleukemia, Burkitt lymphoma, dose-dependent effects, tomato
- MeSH terms
- Lycopene, Burkitt Lymphoma, Carotenoids, Colonic Neoplasms, Dose-Response Relationship, Drug, Leukemia, Erythroblastic, Acute, Humans, Neoplasms, Leukemia, B-Cell, Apoptosis, K562 Cells, Cell Line, Tumor, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
