Biological activity of lycopene metabolites: implications for cancer prevention: Nutrition Reviews©, Vol. 66, No. 12

A decade of molecular biology of retinoic acid receptors

Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 1× · see citing works

Lycopene as the most efficient biological carotenoid singlet oxygen quencher

Mascio, P. D., Kaiser, S., & Sies, H. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90467-0 · Cited by 2,238 · see citing works

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

Chan, J. M., Stampfer, M. J., Giovannucci, E. L., Gann, P. H., Ma, J., Wilkinson, P., Hennekens, C. H., & Pollak, M. (1998) · Science · doi:10.1126/science.279.5350.563 · Cited by 1,992 · see citing works

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B. J., ROSNER, B. A., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,822 · see citing works

Tomatoes, Tomato-Based Products, Lycopene, and Cancer: Review of the Epidemiologic Literature

Giovannucci, E. L. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.4.317 · Cited by 1,471 · see citing works

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

Yu, H. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.18.1472 · Cited by 1,433 · see citing works

Carotenoid actions and their relation to health and disease

Krinsky, N. I., & Johnson, E. J. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.10.001 · Cited by 1,426 · see citing works

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Xu, C., Li, C. Y.-T., & Kong, A. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,272 · see citing works

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.620 · Cited by 1,118 · see citing works

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102 · see citing works

Antioxidant activities of carotenes and xanthophylls

Miller, N. J., Sampson, J., Candeias, L. P., Bramley, P. M., & Rice-Evans, C. A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00323-7 · Cited by 1,030 · see citing works

The promise of retinoids to fight against cancer

Altucci, L., & Gronemeyer, H. (2001) · Nature Reviews Cancer · doi:10.1038/35106036 · Cited by 773 · see citing works

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

Muto, Y., Moriwaki, H., Ninomiya, M., Adachi, S., Saito, A. M., Takasaki, K., Tanaka, T., Tsurumi, K., Okuno, M., Tomita, E., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199606133342402 · Cited by 667 · see citing works

Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum

Khachik, F., Spangler, C. J., Smith, J. C., Canfield, L. M., Steck, A., & Pfander, H. (1997) · Analytical Chemistry · doi:10.1021/ac961085i · Cited by 535 · see citing works

Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action

Zhang, L., Cooney, R. V., & Bertram, J. S. (1991) · Carcinogenesis · doi:10.1093/carcin/12.11.2109 · Cited by 513 · see citing works

Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene

Levy, J., Bosin, E., Feldman, B., Giat, Y., Miinster, A., Danilenko, M., & Sharoni, Y. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514415 · Cited by 507 · see citing works

Chemistry, Distribution, and Metabolism of Tomato Carotenoids and Their Impact on Human Health

Khachik, F., Carvalho, L. S., Bernstein, P. S., Muir, G. J., Zhao, D.-Y., & Katz, N. B. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701002 · Cited by 473 · see citing works

Carotenoids Affect Proliferation of Human Prostate Cancer Cells

Kotake‐Nara, E., Miyashita, K., Nagao, A., Kushiro, M., Zhang, H., & Sugawara, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.12.3303 · Cited by 465 · see citing works

Identification and Characterization of a Mammalian Enzyme Catalyzing the Asymmetric Oxidative Cleavage of Provitamin A

Kiefer, C., Hessel, S., Lampert, J. M., Vogt, K., Lederer, M. O., Breithaupt, D. E., & Lintig, J. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011510200 · Cited by 453 · see citing works

Filling the Gap in Vitamin A Research

von Lintig, J., & Vogt, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11915 · Cited by 449 · see citing works

cis-trans lycopene isomers, carotenoids, and retinol in the human prostate.

Clinton, S. K., Emenhiser, C., Schwartz, S. J., Bostwick, D. G., Williams, A. W., Moore, B. J., & Erdman, J. W. (1996) · PubMed · Cited by 437 · see citing works

Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

Holmes, M. D., Pollak, M., Willett, W. C., & Hankinson, S. E. (2002) · PubMed · Cited by 435 · see citing works

Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study

Agarwal, S., & Rao, A. V. (1998) · Lipids · doi:10.1007/s11745-998-0295-6 · Cited by 430 · see citing works

Chemoprotection against cancer by induction of Phase 2 enzymes

Talalay, P. (2000) · BioFactors · doi:10.1002/biof.5520120102 · Cited by 421 · see citing works

Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention

Chen, L., Stacewicz‐Sapuntzakis, M., Duncan, C. A., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.24.1872 · Cited by 416 · see citing works

Retinaldehyde represses adipogenesis and diet-induced obesity

Ziouzenkova, O., Orasanu, G., Sharlach, M., Akiyama, T. E., Berger, J. P., Viereck, J. C., Hamilton, J. A., Tang, G., Dolnikowski, G. G., Vogel, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1587 · Cited by 380 · see citing works

A Review of Epidemiologic Studies of Tomatoes, Lycopene, and Prostate Cancer

Giovannucci, E. L. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701003 · Cited by 375 · see citing works

The singlet oxygen and carotenoid interaction

Conn, P. F., Schalch, W., & Truscott, T. G. (1991) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(91)80266-k · Cited by 373 · see citing works

Prostate Carcinogenesis in N-methyl-N-nitrosourea (NMU)-Testosterone-Treated Rats Fed Tomato Powder, Lycopene, or Energy-Restricted Diets

Boileau, T. W.-M. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg081 · Cited by 363 · see citing works

Retinoid Signaling and Activator Protein-1 Expression in Ferrets Given -Carotene Supplements and Exposed to Tobacco Smoke

Wang, X.-D., Liu, C., Bronson, R. T., Smith, D. E., Krinsky, N. I., & Russell, R. M. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.60 · Cited by 356 · see citing works

The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine.

Olson, J. A., & Hayaishi, O. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.5.1364 · Cited by 342 · see citing works

Lycopene Interferes With Cell Cycle Progression and Insulin-Like Growth Factor I Signaling in Mammary Cancer Cells

Karas, M., Amir, H., Fishman, D., Danilenko, M., Segal, S., Nahum, A., Koifmann, A., Giat, Y., Levy, J., & Sharoni, Y. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc3601_14 · Cited by 331 · see citing works

Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties.

Zhang, L., Cooney, R. V., & Bertram, J. S. (1992) · PubMed · Cited by 329 · see citing works

Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer

Khachik, F., Beecher, G. R., & Smith, J. C. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590830 · Cited by 325 · see citing works

Carotenoids activate the antioxidant response element transcription system

Ben-Dor, A., Steiner, M., Gheber, L., Danilenko, M., Dubi, N., Linnewiel‐Hermoni, K., Zick, A., Sharoni, Y., & Levy, J. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.177.4.1 · Cited by 319 · see citing works

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

Muto, Y., Moriwaki, H., & Shiratori, Y. (1998) · Digestion · doi:10.1159/000051435 · Cited by 316 · see citing works

Retinoids in cancer therapy and chemoprevention: Promise meets resistance

Freemantle, S. J., Spinella, M. J., & Dmitrovsky, E. (2003) · Oncogene · doi:10.1038/sj.onc.1206936 · Cited by 312 · see citing works

Cis-Lycopene Is More Bioavailable Than Trans-Lycopene In Vitro and In Vivo in Lymph-Cannulated Ferrets

Boileau, A. C., Merchen, N. R., Wasson, K., Atkinson, C., & Erdman, J. W. (1999) · Journal of Nutrition · doi:10.1093/jn/129.6.1176 · Cited by 306 · see citing works

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova‐Kostova, A. T., & Holtzclaw, W. D. (2003) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(02)00038-9 · Cited by 289 · see citing works

Separation and identification of carotenoids and their oxidation products in the extracts of human plasma

Khachik, F., Beecher, G. R., Goli, M. B., et al. (1992) · Analytical Chemistry · doi:10.1021/ac00042a016 · Cited by 287 · see citing works

Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase

Redmond, T. M., Gentleman, S., Duncan, T. E., Yu, S., Wiggert, B. O., Gantt, E., & Cunningham, F. X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009030200 · Cited by 279 · see citing works

Biosynthesis of Vitamin A with Rat Intestinal Enzymes

Goodman, D. S., & Huang, H. S. (1965) · Science · doi:10.1126/science.149.3686.879 · Cited by 263 · see citing works

The Structure of a Retinal-Forming Carotenoid Oxygenase

Kloer, D. P., Ruch, S., Al‐Babili, S., Beyer, P., & Schulz, G. E. (2005) · Science · doi:10.1126/science.1108965 · Cited by 261 · see citing works

CMO1 Deficiency Abolishes Vitamin A Production from β-Carotene and Alters Lipid Metabolism in Mice

Hessel, S., Eichinger, A., Isken, A., Amengual, J., Hunzelmann, S., Hoeller, U., Elste, V., Hunziker, W., Goralczyk, R., Oberhauser, V., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706763200 · Cited by 259 · see citing works

Diverse carotenoids protect against chemically induced neoplastic transformation

Bertram, J. S., Pung, A., Churley, M., Kappock, T. J., Wilkins, L. R., & Cooney, R. V. (1991) · Carcinogenesis · doi:10.1093/carcin/12.4.671 · Cited by 252 · see citing works

Biochemical Properties of Purified Recombinant Human β-Carotene 15,15′-Monooxygenase

Lindqvist, A., & Andersson, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202756200 · Cited by 239 · see citing works

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

Nahum, A., Hirsch, K., Danilenko, M., Watts, C. K. W., Prall, O. W. J., Levy, J., & Sharoni, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204452 · Cited by 236 · see citing works

Activation of the Nrf2–ARE signaling pathway: a promising strategy in cancer prevention

Giudice, A., & Montella, M. (2006) · BioEssays · doi:10.1002/bies.20359 · Cited by 232 · see citing works

Enzymatic conversion of β-carotene into β-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues

Wang, X., Tang, G., Fox, J. G., Krinsky, N. I., & Russell, R. M. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90322-a · Cited by 229 · see citing works

Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?

Riso, P., Pinder, A. C., Santangelo, A., & Porrini, M. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.4.712 · Cited by 223 · see citing works

Cloning and Expression of β,β-Carotene 15,15′-Dioxygenase

Wyss, A., Wirtz, G., Woggon, W. ‐., Brugger, R., Wyss, M., Friedlein, A., Bachmann, H., & Hunziker, W. H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2619 · Cited by 217 · see citing works

The Biochemical Characterization of Ferret Carotene-9′, 10′-Monooxygenase Catalyzing Cleavage of Carotenoids in Vitro and in Vivo

Hu, K., Liu, C., Ernst, H., Krinsky, N. I., Russell, R. M., & Wang, X.-D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512095200 · Cited by 212 · see citing works

Tomato Sauce Supplementation and Prostate Cancer: Lycopene Accumulation and Modulation of Biomarkers of Carcinogenesis

Bowen, P. E., Chen, L., Stacewicz‐Sapuntzakis, M., Duncan, C., Sharifi, R., Ghosh, L., Kim, H.-S., Christov-Tzelkov, K., & van Breemen, R. B. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701008 · Cited by 208 · see citing works

Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR–RXR complex

Ziouzenkova, O., & Plutzky, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.081 · Cited by 202 · see citing works

Moderate Intervention with Carotenoid-Rich Vegetable Products Reduces Lipid Peroxidation in Men

Bub, A., Watzl, B., Delincée, H., Adam, S., Wever, J., Müller, H., Rechkemmer, G., & Abrahamse, L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2200 · Cited by 200 · see citing works

Insulin-Like Growth Factor-I and Binding Protein-3 and Risk of Cancer

Giovannucci, E. L. (1999) · Hormone Research in Paediatrics · doi:10.1159/000053160 · Cited by 195 · see citing works

Lymphocyte Lycopene Concentration and DNA Protection from Oxidative Damage Is Increased in Women after a Short Period of Tomato Consumption

Porrini, M., & Riso, P. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.189 · Cited by 194 · see citing works

Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat

Breinholt, V. M., Lauridsen, S. T., Daneshvar, B., et al. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00401-8 · Cited by 179 · see citing works

Lycopene and Vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model

Siler, U., Barella, L., Spitzer, V., Schnorr, J., Lein, M., Góralczyk, R., & Wertz, K. (2004) · The FASEB Journal · doi:10.1096/fj.03-1116fje · Cited by 177 · see citing works

Lycopene Inhibits Proliferation and Enhances Gap-Junction Communication of KB-1 Human Oral Tumor Cells

Livny, O., Reifen, R. M., Madar, Z., et al. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3754 · Cited by 177 · see citing works

A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (2000) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(00)90013-3 · Cited by 175 · see citing works

Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas

Canene‐Adams, K., Lindshield, B., Wang, S., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3462 · Cited by 175 · see citing works

Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets.

Liu, C., Lian, F., Smith, D. E., Russell, R. M., & Wang, X. (2003) · PubMed · Cited by 170 · see citing works

Enzymatic metabolites of lycopene induce Nrf2‐mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

Lian, F., & Wang, X. (2008) · International Journal of Cancer · doi:10.1002/ijc.23696 · Cited by 165 · see citing works

Stimulation of Gap Junctional Communication: Comparison of acyclo-Retinoic Acid and Lycopene

Stahl, W., von Laar, J., Martin, H., Emmerich, T., & Sies, H. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1510 · Cited by 162 · see citing works

Biogenesis of retinoic acid from beta-carotene. Differences between the metabolism of beta-carotene and retinal.

Napoli, J. L., & Race, K. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77845-4 · Cited by 157 · see citing works

Lycopene oxidation product enhances gap junctional communication

Aust, O., Ale‐Agha, N., Zhang, L., Wollersen, H., Sies, H., & Stahl, W. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(03)00148-0 · Cited by 156 · see citing works

Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation

Hossain, M. Z., Wilkens, L. R., Mehta, P. P., et al. (1989) · Carcinogenesis · doi:10.1093/carcin/10.9.1743 · Cited by 153 · see citing works

Cloning and Characterization of a Human β,β-Carotene-15, 15′-Dioxygenase That Is Highly Expressed in the Retinal Pigment Epithelium

Yan, W., Jang, G.-F., Haeseleer, F., Esumi, N., Chang, J. T., Kerrigan, M., Campochiaro, M., Campochiaro, P. A., Palczewski, K., & Zack, D. J. (2001) · Genomics · doi:10.1006/geno.2000.6476 · Cited by 152 · see citing works

Expression and Characterization of a Murine Enzyme Able to Cleave β-Carotene

Paik, J., During, A., Harrison, E. H., Mendelsohn, C. L., Lai, K., & Blaner, W. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010086200 · Cited by 150 · see citing works

Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets

Liu, C. (2000) · Carcinogenesis · doi:10.1093/carcin/21.12.2245 · Cited by 150 · see citing works

Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat

Gradelet, S., Astorg, P. O., Leclerc, J., Chevalier, J., Vernevaut, M. F., & Siess, M. H. (1996) · Xenobiotica · doi:10.3109/00498259609046688 · Cited by 142 · see citing works

Asymmetric Cleavage of β-Carotene Yields a Transcriptional Repressor of Retinoid X Receptor and Peroxisome Proliferator-Activated Receptor Responses

Ziouzenkova, O., Orasanu, G., Sukhova, G. K., Lau, E., Berger, J. P., Tang, G., Krinsky, N. I., Dolnikowski, G. G., & Plutzky, J. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0225 · Cited by 132 · see citing works

Lycopene Inhibits the Growth of Normal Human Prostate Epithelial Cells in Vitro

Obermüller-Jevic, U. C., Olano-Martin, E., Corbacho, A. M., van der Vliet, A., Valacchi, G., Cross, C. E., Eiserich, J. P., & Packer, L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3356 · Cited by 131 · see citing works

Physiologically Attainable Concentrations of Lycopene Induce Mitochondrial Apoptosis in LNCaP Human Prostate Cancer Cells

Hantz, H. L., Young, L. F., & Martin, K. R. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000303 · Cited by 124 · see citing works

Cell Type-specific Expression of β-Carotene 9', 10'-Monooxygenase in Human Tissues

Lindqvist, A., He, Y.-G., & Andersson, S. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6705.2005 · Cited by 124 · see citing works

Tomatoes, Lycopene, and Prostate Cancer

Giovannucci, E. L., & Clinton, S. K. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-218-44277 · Cited by 124 · see citing works

Expression pattern and localization of β,β-carotene 15,15′-dioxygenase in different tissues

Wyss, A., Wirtz, G., Woggon, W., BRUGGER, R., Wyss, M., Friedlein, A., Riss, G., Bachmann, H., & Hunziker, W. H. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540521 · Cited by 122 · see citing works

Lycopenoids: Are lycopene metabolites bioactive?

Lindshield, B., Canene‐Adams, K., & Erdman, J. W. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.09.012 · Cited by 122 · see citing works

Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.

Suzui, M., Masuda, M., Lim, J. T. E., Albanese, C., Pestell, R. G., & Weinstein, I. B. (2002) · PubMed · Cited by 122 · see citing works

Are dietary influences on the risk of prostate cancer mediated through the insulin‐like growth factor system?

Mucci, L. A., Tamimi, R. M., Λάγιου, Π., Trichopoulou, A., Benetou, V., Spanos, E., & Trichopoulos, D. (2001) · British Journal of Urology · doi:10.1046/j.1464-410x.2001.02191.x · Cited by 121 · see citing works

β-Carotene Absorption and Cleavage in Rats Is Affected by the Vitamin A Concentration of the Diet

van Vliet, T., van Vlissingen, M. F., van Schaik, F., & van den Berg, H. (1996) · Journal of Nutrition · doi:10.1093/jn/126.2.499 · Cited by 120 · see citing works

Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo

Lian, F., Smith, D. E., Ernst, H., Russell, R. M., & Wang, X. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm076 · Cited by 119 · see citing works

Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication

Trosko, J. E., Chang, C., Upham, B. L., & Wilson, M. R. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00288-4 · Cited by 117 · see citing works

Enzymatic formation of 9‐ cis , 13‐ cis , and all‐trans retinals from isomers of β‐carotene

Nagao, A., & Olson, J. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.12.8088462 · Cited by 116 · see citing works

Connexins as targets for cancer chemoprevention and chemotherapy

King, T. J., & Bertram, J. S. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.08.012 · Cited by 114 · see citing works

Biosynthesis of 9-cis-Retinoic Acid from 9-cis-β-Carotene in Human Intestinal Mucosa in Vitro

Wang, X. D., Krinsky, N. I., Benotti, P. N., & Russell, R. M. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1371 · Cited by 108 · see citing works

Cleavage Products of Lycopene Produced by in Vitro Oxidations: Characterization and Mechanisms of Formation

Caris, C., Schmid, A., Carail, M., & Boehm, V. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034735+ · Cited by 108 · see citing works

Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

Bhuvaneswari, V., Velmurugan, B., Balasenthil, S., et al. (2001) · Fitoterapia · doi:10.1016/s0367-326x(01)00321-5 · Cited by 104 · see citing works

β-Oxidation in Rabbit Liver in Vitro and in the Perfused Ferret Liver Contributes to Retinoic Acid Biosynthesis from β-Apocarotenoic Acids

Wang, X., Russell, R. M., Liu, C., Stickel, F., Smith, D. E., & Krinsky, N. I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26490 · Cited by 104 · see citing works

Cell Cycle Arrest and Induction of Apoptosis by Lycopene in LNCaP Human Prostate Cancer Cells

Hwang, E., & Bowen, P. E. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.284 · Cited by 103 · see citing works

Acyclic Carotenoids and Their Oxidation Mixtures Inhibit the Growth of HL-60 Human Promyelocytic Leukemia Cells

Nara, E., Hayashi, H., Kotake, M., Miyashita, K., & Nagao, A. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc392_18 · Cited by 100 · see citing works

Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1

Nahum, A., Zeller, L., Danilenko, M., Prall, O. W. J., Watts, C. K. W., Sutherland, R. L., Levy, J., & Sharoni, Y. (2006) · European Journal of Nutrition · doi:10.1007/s00394-006-0595-x · Cited by 99 · see citing works

Identification of beta‐carotene 15,15′‐monooxygenase as a peroxisome proliferator‐activated receptor target gene

Boulanger, A., McLemore, P., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Yu, S., Gentleman, S., & Redmond, T. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0690fje · Cited by 99 · see citing works

Retinoid‐enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein

Rogers, M., Berestecky, J. M., Hossain, M. Z., Guo, H., Kadle, R., Nicholson, B. J., & Bertram, J. S. (1990) · Molecular Carcinogenesis · doi:10.1002/mc.2940030605 · Cited by 99 · see citing works

Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions.

Jerome, L., Shiry, L., & Leyland-Jones, B. R. (2003) · Endocrine Related Cancer · doi:10.1677/erc.0.0100561 · Cited by 98 · see citing works

Lycopene Inhibits Experimental Metastasis of Human Hepatoma SK-Hep-1 Cells in Athymic Nude Mice

Huang, C., Liao, J., & Hu, M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.538 · Cited by 96 · see citing works

Retinoid Agonist Activities of Synthetic Geranyl Geranoic Acid Derivatives

Araki, H., Shidoji, Y., Yamada, Y., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1471 · Cited by 95 · see citing works

Apo-8′-Lycopenal and Apo-12′-Lycopenal Are Metabolic Products of Lycopene in Rat Liver

Gajic, M., Zaripheh, S., Sun, F.-R., & Erdman, J. W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1552 · Cited by 93 · see citing works

Lycopene affects proliferation and apoptosis of four malignant cell lines

Salman, H., Bergman, M., Djaldetti, M., & Bessler, H. (2007) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2007.02.015 · Cited by 89 · see citing works

Formation of cleavage products by autoxidation of lycopene

Kim, S., Nara, E., Kobayashi, H., et al. (2001) · Lipids · doi:10.1007/s11745-001-0706-8 · Cited by 87 · see citing works

Feedback Regulation of β,β-Carotene 15,15′-Monooxygenase by Retinoic Acid in Rats and Chickens

Bachmann, H., Desbarats, A., Pattison, P., Sedgewick, M., Riss, G., Wyss, A., Góralczyk, R., Cardinault, N., Duszka, C., & Grolier, P. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3616 · Cited by 85 · see citing works

Effects of acyclo-Retinoic Acid and Lycopene on Activation of the Retinoic Acid Receptor and Proliferation of Mammary Cancer Cells

Ben-Dor, A., Nahum, A., Danilenko, M., Giat, Y., Stahl, W., Martin, H.-D., Emmerich, T., Noy, N., Levy, J., & Sharoni, Y. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2412 · Cited by 85 · see citing works

Modulation of Metabolic Enzymes by Dietary Phytochemicals: A Review of Mechanisms Underlying Beneficial Versus Unfavorable Effects

Mandlekar, S., Hong, J., & Kong, A. T. (2006) · Current Drug Metabolism · doi:10.2174/138920006778017795 · Cited by 84 · see citing works

Key Role of Conserved Histidines in Recombinant Mouse β-Carotene 15,15′-Monooxygenase-1 Activity

Poliakov, E., Gentleman, S., Cunningham, F. X., Miller‐Ihli, N. J., & Redmond, T. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500409200 · Cited by 82 · see citing works

Lycopene Supplementation Prevents Smoke-Induced Changes in p53, p53 Phosphorylation, Cell Proliferation, and Apoptosis in the Gastric Mucosa of Ferrets

Liu, C., Russell, R. M., & Wang, X. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.106 · Cited by 80 · see citing works

Role of insulin-like growth factor binding proteins in the control of IGF actions

Clemmons, D. R., Busby, W. H., Arai, T., Nam, T., Clarke, J. B., Jones, J. I., & Ankrapp, D. K. (1995) · Progress in Growth Factor Research · doi:10.1016/0955-2235(95)00013-5 · Cited by 79 · see citing works

Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse

Guttenplan, J. B., Chen, M. J., Kosinska, W., Thompson, S., Zhao, Z., & Cohen, L. A. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00705-9 · Cited by 79 · see citing works

Expression pattern and localization of β,β-carotene 15,15′-dioxygenase in different tissues

Wyss, A., WIRTZ, G. M., Woggon, W., et al. (2001) · Biochemical Journal · doi:10.1042/bj3540521 · Cited by 79 · see citing works

Characterization of .beta.-apo-13-carotenone and .beta.-apo-14'-carotenal as enzymic products of the excentric cleavage of .beta.-carotene

Tang, G., Wang, X. D., Russell, R. M., & Krinsky, N. I. (1991) · Biochemistry · doi:10.1021/bi00105a003 · Cited by 78 · see citing works

Intestinal uptake and lymphatic absorption of beta-carotene in ferrets: a model for human beta-carotene metabolism

Wang, X. D., Krinsky, N. I., Marini, R. P., et al. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.263.4.g480 · Cited by 77 · see citing works

β-Carotene Conversion into Vitamin A in Human Retinal Pigment Epithelial Cells

Chichili, G. R., Nöhr, D., ̈ffer, M. S., Lintig, J. V., & Biesalski, H. K. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0089 · Cited by 72 · see citing works

β‐Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non‐small‐cell lung cancer cells and up‐regulates retinoic acid receptor β expression

Lian, F., Hu, K., Russell, R. M., & Wang, X. (2006) · International Journal of Cancer · doi:10.1002/ijc.22111 · Cited by 72 · see citing works

A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells

Zhang, H., Kotake-Nara, E., Ono, H., & Nagao, A. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.09.019 · Cited by 70 · see citing works

[18] Separation and quantification of carotenoids in human plasma

Khachik, F., Beecher, G. R., Goli, M. B., et al. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)13122-e · Cited by 67 · see citing works

Membrane-associated Insulin-like Growth Factor-binding Protein-3 Inhibits Insulin-like Growth Factor-I-induced Insulin-like Growth Factor-I Receptor Signaling in Ishikawa Endometrial Cancer Cells

Karas, M., Danilenko, M., Fishman, D., LeRoith, D., Levy, J., & Sharoni, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16514 · Cited by 63 · see citing works

Lycopene supplementation elevates circulating insulin-like growth factor–binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer

Vrieling, A., Voskuil, D. W., Bonfrèr, J. M. G., Korse, C. M., van Doorn, J., Cats, A., Depla, A. C. T. M., Timmer, R., Witteman, B. J. M., van Leeuwen, F. E., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1456 · Cited by 63 · see citing works

Dietary Lycopene Downregulates Carotenoid 15,15′-Monooxygenase and PPAR-γ in Selected Rat Tissues

Zaripheh, S., Nara, T., Nakamura, M., & Erdman, J. W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.932 · Cited by 62 · see citing works

Variations in Plasma Lycopene and Specific Isomers over Time in a Cohort of U.S. Men

Wu, K., Schwartz, S. J., Platz, E. A., et al. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1930 · Cited by 58 · see citing works

High Dose Lycopene Supplementation Increases Hepatic Cytochrome P4502E1 Protein and Inflammation in Alcohol-Fed Rats

Veeramachaneni, S., Ausman, L. M., Choi, S., Russell, R. M., & Wang, X. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1329 · Cited by 58 · see citing works

Partial Synthesis and Structural Elucidation of the Oxidative Metabolites of Lycopene Identified in Tomato Paste, Tomato Juice, and Human Serum

Khachik, F., Steck, A., Niggli, U. A., et al. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980322a · Cited by 57 · see citing works

Enzymatic and oxidative metabolites of lycopene

Ferreira, A. L. A., Yeum, K., Russell, R. M., Krinsky, N. I., & Tang, G. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00107-4 · Cited by 57 · see citing works

In vitro binding affinity of novel synthetic polyprenoids (polyprenoic acids) to cellular retinoid-binding proteins.

Muto, Y., Moriwaki, H., & Omori, M. (1981) · PubMed · Cited by 57 · see citing works

Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad

Palozza, P., Sheriff, A., Serini, S., et al. (2005) · APOPTOSIS · doi:10.1007/s10495-005-1393-2 · Cited by 56 · see citing works

Participation of Lycopene and Beta-Carotene in Carcinogenesis: Defenders, Aggressors, or Passive Bystanders?

Arab, L., Steck‐Scott, S., & Bowen, P. E. (2001) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a000803 · Cited by 54 · see citing works

Carotenoids and Retinoids

(2005) · AOCS Publishing eBooks · doi:10.1201/9781439822371 · Cited by 51 · see citing works

Enzymatic and oxidative metabolites of lycopene

Ferreira, A. L. A., Yeum, K., Russell, R. M., Krinsky, N. I., & Tang, G. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.02.007 · Cited by 50 · see citing works

Nutritional Status Affects Intestinal Carotene Cleavage Activity and Carotene Conversion to Vitamin A in Rats

Parvin, S., & Sivakumar, B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.3.573 · Cited by 48 · see citing works

Proposed Mechanisms for the Formation of Synthetic and Naturally Occurring Metabolites of Lycopene in Tomato Products and Human Serum

Khachik, F., Pfander, H., & Traber, B. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9803233 · Cited by 46 · see citing works

β-Carotene and β-Apo-14′-Carotenoic Acid Prevent the Reduction of Retinoic Acid Receptor β in Benzo[a]pyrene-Treated Normal Human Bronchial Epithelial Cells

Prakash, P., Liu, C., Hu, K., Russell, R. M., Wang, X., & Krinsky, N. I. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.667 · Cited by 46 · see citing works

Acyclo-retinoic acid induces apoptosis in human prostate cancer cells.

Kotake‐Nara, E., Kim, S., Kobori, M., et al. (2002) · PubMed · Cited by 44 · see citing works

Cooperation between MEF2 and PPARγ in human intestinal β,β-carotene 15,15'-monooxygenase gene expression

Gong, X., Tsai, S., Yan, B., & Rubin, L. P. (2006) · BMC Molecular Biology · doi:10.1186/1471-2199-7-7 · Cited by 42 · see citing works

Carotenoid Oxidative/Degradative Products and Their Biological Activities

Wang, X. (2004) · Oxidative stress and disease · doi:10.1201/9780203026649.ch14 · Cited by 33 · see citing works

Performance of isoelectric focusing in uncoated and commercially available coated capillaries

Mazzeo, J. R., Martineau, J. A., & Krull, I. S. (1992) · Methods · doi:10.1016/1046-2023(92)90035-7 · Cited by 27 · see citing works

In Vitro Binding Affinity of Novel Synthetic Polyprenoids (Polyprenoic Acids) to Cellular Retinoid-Binding Proteins

武藤, 泰., 森脇, 久., & 大森, 正. (1981) · 癌 · Cited by 23 · see citing works

Novel Lycopene Metabolites Are Detectable in Plasma of Preruminant Calves after Lycopene Supplementation

Sicilia, T., Bub, A., Rechkemmer, G., et al. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2616 · Cited by 23 · see citing works

Induction of connexin 43 by carotenoids: functional consequences

Bertram, J. S. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.02.037 · Cited by 20 · see citing works

Can Smoke-Exposed Ferrets Be Utilized to Unravel the Mechanisms of Action of Lycopene?

Wang, X. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.2053s · Cited by 18 · see citing works

Retinoids and Carotenoids as Cancer Chemopreventive Agents

Hix, L. M., Vine, A. L., Lockwood, S. F., et al. (2005) · AOCS Publishing eBooks · doi:10.1201/9781439822371.ch11 · Cited by 3 · see citing works

Antioxidant and pro-oxidant activities of carotenoids and their oxidation products

Ribeiro, D., Freitas, M., Silva, A. M. S., Carvalho, F., & Fernandes, E. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.07.060 · Cited by 280 · see citing works

Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids

Moran, N. E., Mohn, E. S., Hason, N., Erdman, J. W., & Johnson, E. J. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy025 · Cited by 205 · see citing works

The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes

Ascenso, A., Pedrosa, T., Pinho, S., Pinho, F., Oliveira, J. M. P. F. D., Cabral Marques, H., Oliveira, H., Simões, S., & Santos, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8214631 · Cited by 57 · see citing works

Propiedades químicas, biológicas y valor nutritivo del licopeno

Periago, M. J., Martínez‐Valverde, I., Ros, G., et al. (2001) · Anales de Veterinaria de Murcia · Cited by 7 · see citing works

DETERMINATION OF CAROTENOIDS IN TOMATO PRODUCTS USING VIS/NIR SPECTROSCOPY

Saad, A. M., Pék, Z., Szuvandzsiev, P., et al. (2017) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.15414/jmbfs.2017.7.1.27-31 · Cited by 20 · see citing works

Analysis of carotenoids and lycopene in tomato (Lycopersicon esculentum Mill.) and their retention in tomato juice

Mendelová, A., Andrejiová, A., Lí­šková, M., et al. (2012) · Potravinarstvo Slovak Journal of Food Sciences · doi:10.5219/195 · Cited by 7 · see citing works

Antioxidative properties of lycopene and other carotenoids from tomatoes: Synergistic effects

Shi, J., Kakuda, Y., & Yeung, D. L. (2004) · BioFactors · doi:10.1002/biof.552210141 · Cited by 94 · see citing works

Carotenoid Changes of Intact Watermelons after Storage

Perkins-Veazie, P. M., & Collins, J. K. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0532664 · Cited by 59 · see citing works