The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis
Open accessAbstract
Local renin-angiotensin system (RAS) in the pancreas is linked to the modulation of glucose-stimulated insulin secretion (GSIS) in beta cells and insulin sensitivity in target tissues, emerging as a promising tool in the prevention and/or treatment of obesity, diabetes, and systemic arterial hypertension. Insulin resistance alters pancreatic islet cell distribution and morphology and hypertrophied islets exhibit upregulated angiotensin II type 1 receptor, which drives oxidative stress, apoptosis, and fibrosis, configuring beta cell dysfunction and diminishing islet lifespan. Pharmacological modulation of RAS has shown beneficial effects in diet-induced obesity model, mainly related to the translational potential that angiotensin receptor blockers and ECA2/ANG (1-7)/MAS receptor axis modulation have when it comes to islet preservation and type 2 diabetes prevention and/or treatment. This review describes the existing evidence for different approaches to blocking RAS elements in the management of insulin resistance and diabetes and focuses on islet remodeling and GSIS in rodents and humans.
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Relatively independent RAS exists in almost all organs and tissues and can play a local role through paracrine/autocrine.
“Later, it was gradually discovered that relatively independent RAS in almost all organs and tissues can play a local role in many organs and tissues through paracrine/autocrine [15–21].”
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Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats
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Renin Angiotensin System, Gut-Lung Cross Talk and Microbiota. Lessons from SARS-CoV Infections
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- Authors
- Graus-Nunes, F., & Souza-Mello, V.
- ORCID
- Souza-Mello, Vanessa
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 109
- Pages
- 639-645
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2898669007
- Cited by
- 43
- References
- 75
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 10 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 7 · 2018: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- renin-angiotensin system, endocrine pancreas, beta-cell function, glucose-stimulated insulin secretion, insulin resistance, type 2 diabetes, angiotensin II type 1 receptor, angiotensin-(1-7), Mas receptor, angiotensin receptor blockers, islet fibrosis, oxidative stress, beta-cell apoptosis, obesity
- MeSH terms
- Angiotensin I, Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Homeostasis, Humans, Insulin Resistance, Islets of Langerhans, Peptide Fragments, Renin-Angiotensin System, Drug Delivery Systems
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