New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works

Pathogenesis of NIDDM. A balanced overview.

DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596 · see citing works

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians

Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322 · see citing works

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311 · see citing works

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300 · see citing works

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267 · see citing works

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents

Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-12-909 · Cited by 1,038 · see citing works

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252625599 · Cited by 1,036 · see citing works

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works

Life without white fat: a transgenic mousePreprint

Moitra, J., Mason, M. M., Olive, M., Krylov, D. Y., Gavrilova, O., Marcus‐Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 776 · see citing works

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737 · see citing works

Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication

Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., & Attardi, G. M. (1999) · Science · doi:10.1126/science.286.5440.774 · Cited by 725 · see citing works

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects

Perseghin, G., Price, T. B., Petersen, K. F., Roden, M., Cline, G. W., Gerow, K., Rothman, D. L., & Shulman, G. I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351804 · Cited by 699 · see citing works

Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo

Szczepaniak, L. S., Babcock, E. E., Schick, F., Dobbins, R. L., Garg, A., Burns, D. K., McGarry, J. D., & Stein, D. T. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e977 · Cited by 688 · see citing works

Regulation of mitochondrial biogenesis in skeletal muscle by CaMK

Wu, H., Kanatous, S. B., Thurmond, F. A., Gallardo, T., Isotani, E., Bassel-Duby, R., & Williams, R. S. (2002) · Science · doi:10.1126/science.1071163 · Cited by 684 · see citing works

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, O., Marcus-Samuels, B., Graham, D., Kim, J. K., Shulman, G. I., Castle, A. L., Vinson, C., Eckhaus, M., & Reitman, M. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7901 · Cited by 676 · see citing works

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675 · see citing works

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

Mayerson, A. B., Hundal, R. S., Dufour, S., Lebon, V., Befroy, D., Cline, G. W., Enocksson, S., Inzucchi, S. E., Shulman, G. I., & Petersen, K. F. (2002) · Diabetes · doi:10.2337/diabetes.51.3.797 · Cited by 647 · see citing works

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

Hundal, R. S., Petersen, K. F., Mayerson, A. B., Randhawa, P. S., Inzucchi, S. E., Shoelson, S. E., & Shulman, G. I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14955 · Cited by 623 · see citing works

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · cited 2× · see citing works

Impaired Glucose Tolerance as a Disorder of Insulin Action

Lillioja, S., Mott, D. M., Howard, B. V., Bennett, P. H., Yki-Järvinen, H., Freymond, D., Nyomba, B. L., Zurlo, F., Swinburn, B., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181901 · Cited by 578 · see citing works

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

Hundal, R. S., Petersen, K. F., Mayerson, A. B., Randhawa, P. S., Inzucchi, S., Shoelson, S. E., & Shulman, G. I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214955 · Cited by 557 · see citing works

Muscle-specific Pparg deletion causes insulin resistance

Hevener, A. L., He, W., Barak, Y., Le, J., Bandyopadhyay, G. K., Olson, P., Wilkes, J. J., Evans, R. M., & Olefsky, J. M. (2003) · Nature Medicine · doi:10.1038/nm956 · Cited by 492 · see citing works

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443 · see citing works

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

Rothman, D. L., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115686 · Cited by 328 · see citing works

Decreased Muscle Glucose-Transport Phosphorylation Is an Early Defect in the Pathogenesis of Non-Insulin-Dependent Diabetes-Mellitus

Rothman, D. L., Magnusson, I., Cline, G., Gerard, D., Kahn, C. R., Shulman, R. G., & Shulman, G. I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.983 · Cited by 325 · see citing works

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.006 · Cited by 261 · see citing works

Glycemic Effects of Intensive Caloric Restriction and Isocaloric Refeeding in Noninsulin-Dependent Diabetes Mellitus*

HENRY, R. R., SCHEAFFER, L., & OLEFSKY, J. M. (1985) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem-61-5-917 · Cited by 245 · see citing works

Sexual differentiation; Factor determining forms of obesity.

Vague, J. (1947) · PubMed · Cited by 218 · see citing works

TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.

Azen, S., Peters, R., Berkowitz, K., Kjos, S., Xiang, A., & Buchanan, T. (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(97)00151-7 · Cited by 164 · see citing works

13C/31P NMR studies on the mechanism of insulin resistance in obesity.

Petersen, K. F., Hendler, R., Price, T. B., Perseghin, G., Rothman, D. L., Held, N., Amatruda, J. M., & Shulman, G. I. (1998) · Diabetes · doi:10.2337/diabetes.47.3.381 · Cited by 109 · see citing works

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Fillmore, J. J., Gavrilova, O., Chao, L. C., Higashimori, T., Choi, H., Kim, H., Yu, C., Chen, Y., Qu, X., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1311 · Cited by 88 · see citing works

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

Newsholme, P., Haber, E. P., Hirabara, S. M., Rebelato, E. L. O., Procopio, J., Morgan, D., Oliveira‐Emilio, H. C., Carpinelli, A. R., & Curi, R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135871 · Cited by 684 · see citing works

Metabolic Mechanisms in Heart Failure

Ashrafian, H., Frenneaux, M. P., & Opie, L. H. (2007) · Circulation · doi:10.1161/circulationaha.107.702795 · Cited by 517 · see citing works

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436 · see citing works

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPK Pathways

Gao, D., Nong, S., Huang, X., Lu, Y., Zhao, H., Lin, Y., Man, Y., Wang, S., Yang, J., & Li, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128694 · Cited by 325 · see citing works

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

Mulvihill, E. E., Assini, J. M., Lee, J. K., Allister, E. M., Sutherland, B. G., Koppes, J. B., Sawyez, C. G., Edwards, J. Y., Telford, D. E., Charbonneau, A., et al. (2011) · Diabetes · doi:10.2337/db10-0589 · Cited by 202 · see citing works

Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle

Clark, M. G. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90477.2008 · Cited by 188 · see citing works

Insulin resistance and body composition in cancer patients

Dev, R., Bruera, E. D., & Dalal, S. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx815 · Cited by 167 · see citing works

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.029 · Cited by 141 · see citing works

Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?

Muoio, D. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.11.007 · Cited by 137 · see citing works

The Role of Nutritional Support for Cancer Patients in Palliative Care

Cotogni, P., Stragliotto, S., Ossola, M., Collo, A., Riso, S., & on behalf of the Intersociety Italian Working Group for Nutritional Support in Cancer (2021) · Nutrients · doi:10.3390/nu13020306 · Cited by 142 · see citing works

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1

DeAngelis, A. M., Heinrich, G., Dai, T., Bowman, T. A., Patel, P. R., Lee, S. J., Hong, E., Jung, D. Y., Aßmann, A., Kulkarni, R. N., et al. (2008) · Diabetes · doi:10.2337/db08-0379 · Cited by 105 · see citing works

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus

Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104 · see citing works

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

Tamrakar, A. K., Schertzer, J. D., Chiu, T. T., Foley, K. P., Bilan, P. J., Philpott, D. J., & Klip, A. (2010) · Endocrinology · doi:10.1210/en.2010-0437 · Cited by 102 · see citing works

Mechanisms by which diabetes increases cardiovascular disease

Gleissner, C. A., Galkina, E., Nadler, J. L., & Ley, K. F. (2007) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2007.12.005 · Cited by 97 · see citing works

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

Lee, Y., Berglund, E. D., Yu, X., Wang, M.-Y., Evans, M. R., Scherer, P. E., Holland, W. L., Charron, M. J., Roth, M. G., & Unger, R. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409638111 · Cited by 96 · see citing works

Reduction of Plasma NEFA Concentration by Nicotinic Acid Enhances the Response to Insulin in Feed-Restricted Holstein Cows

Pires, J., Pescara, J. B., & Grummer, R. R. (2007) · Journal of Dairy Science · doi:10.3168/jds.2007-0146 · Cited by 84 · see citing works

Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate

Costa, M. J. D. C., So, A. Y., Kaasik, K., Krueger, K. C., Pillsbury, M. L., Fu, Y., Ptáček, L. J., Yamamoto, K. R., & Feldman, B. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164558 · Cited by 83 · see citing works

miR-200s Contribute to Interleukin-6 (IL-6)-induced Insulin Resistance in Hepatocytes

Dou, L., Zhao, T., Wang, L., Huang, X., Jiao, J., Gao, D., Zhang, H., Shen, T., Man, Y., Wang, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.423145 · Cited by 67 · see citing works

Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells

Tamrakar, A. K., Jaiswal, N., Yadav, P. P., Maurya, R., & Srivastava, A. K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.03.023 · Cited by 65 · see citing works

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

Lee, B. Y., Al-Waili, N., Stubbs, D., Wendell, K., Butler, G. J., Al-Waili, T. N., & Al-Waili, A. N. (2010) · International Journal of Medical Sciences · doi:10.7150/ijms.7.29 · Cited by 58 · see citing works

MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells

Wen, F., Yang, Y., Jin, D., Sun, J., Yu, X., & Yang, Z. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.034 · Cited by 56 · see citing works

The Use of Nicotinic Acid to Induce Sustained Low Plasma Nonesterified Fatty Acids in Feed-Restricted Holstein Cows

Pires, J., & Grummer, R. R. (2007) · Journal of Dairy Science · doi:10.3168/jds.2006-904 · Cited by 54 · see citing works

4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells

Maurya, C. K., Singh, R. M., Jaiswal, N., Venkateswarlu, K., Narender, T., & Tamrakar, A. K. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.07.018 · Cited by 52 · see citing works

From a glucocentric to a lipocentric approach towards metabolic syndrome

Mittra, S., Bansal, V. S., & Bhatnagar, P. K. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.01.006 · Cited by 48 · see citing works

Fructose-induced ROS generation impairs glucose utilization in L6 skeletal muscle cells

Jaiswal, N., Maurya, C. K., Pandey, J., Rai, A. K., & Tamrakar, A. K. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1031662 · Cited by 47 · see citing works

Reduced oocyte and embryo quality in response to elevated non-esterified fatty acid concentrations: A possible pathway to subfertility?

Hoeck, V. V., Bols, P. E. J., Binelli, M., & Leroy, J. (2014) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2014.07.015 · Cited by 45 · see citing works

Effect of berberine on the HPA-axis pathway and skeletal muscle GLUT4 in type 2 diabetes mellitus rats

Mi, J. D., He, W., Lv, J., Zhuang, K., Huang, H., & Quan, S. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s211188 · Cited by 45 · see citing works

The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis

Graus-Nunes, F., & Souza-Mello, V. (2019) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2018.10.191 · Cited by 43 · see citing works

Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase

Wang, F., Yan, J., Niu, Y., Li, Y., Lin, H., Liu, X., Liu, J., & Li, L. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.814691 · Cited by 42 · see citing works

MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression

Dou, L., Wang, S., Sui, X., Meng, X., Shen, T., Huang, X., Guo, J., Fang, W., Man, Y., Xi, J., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373962 · Cited by 37 · see citing works

Jinlida reduces insulin resistance and ameliorates liver oxidative stress in high-fat fed rats

Liu, Y., Song, A., Zang, S., Wang, C., Song, G., Li, X., Zhu, Y., Yu, X., Li, L., Wang, Y., et al. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.12.040 · Cited by 37 · see citing works

Egr2 enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway in HepG2 cells treated with palmitate

Lü, L., Ye, X., Yao, Q., Lu, A., Zhao, Z., Ding, Y., Meng, C., Yu, W., Du, Y., & Cheng, J. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.08.023 · Cited by 37 · see citing works

Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus

Cheng, F.-R., Cui, H., Fang, J.-L., Yuan, K., & Guo, Y. (2019) · Molecules · doi:10.3390/molecules24081454 · Cited by 37 · see citing works

Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner

Jaiswal, N., Yadav, P. P., Maurya, R., Srivastava, A. K., & Tamrakar, A. K. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.049 · Cited by 37 · see citing works

Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment,

Chevalier, S., & Farsijani, S. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0369 · Cited by 34 · see citing works

RabGAPs in skeletal muscle function and exercise

Espelage, L., Al‐Hasani, H., & Chadt, A. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0143 · Cited by 33 · see citing works

Chemical constituents of Kigelia pinnata twigs and their GLUT4 translocation modulatory effect in skeletal muscle cells

Khan, M. F., Dixit, P., Jaiswal, N., Tamrakar, A. K., Srivastava, A. K., & Maurya, R. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.10.002 · Cited by 32 · see citing works

Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle

Cao, Y., Chang, S., Dong, J., Zhu, S., Zheng, X., Li, J., Long, R., Zhou, Y., Cui, J., & Zhang, Y. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.049 · Cited by 31 · see citing works

Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance

Zhao, H., Huang, X., Jiao, J., Zhang, H., Liu, J., Qin, W., Meng, X., Shen, T., Lin, Y., Chu, J., et al. (2015) · Scientific Reports · doi:10.1038/srep18093 · Cited by 30 · see citing works

Small-Molecule Compounds that Modulate Lipolysis in Adipose Tissue: Targeting Strategies and Molecular Classes

Wang, M., & Fotsch, C. H. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.010 · Cited by 30 · see citing works

Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo

Arha, D., Pandeti, S., Mishra, A., Srivastava, S. P., Srivastava, A. K., Narender, T., & Tamrakar, A. K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.055 · Cited by 29 · see citing works

JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes

Vijayvargia, R., Mann, K., Weiss, H. R., Pownall, H. J., & Ruan, H. (2010) · Obesity · doi:10.1038/oby.2009.501 · Cited by 25 · see citing works

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Arha, D., Ramakrishna, E., Gupta, A. P., Rai, A. K., Sharma, A., Ahmad, I., Riyazuddin, M., Gayen, J. R., Maurya, R., & Tamrakar, A. K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.015 · Cited by 25 · see citing works

MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1

Luan, B.-G., & Sun, C. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.05.001 · Cited by 23 · see citing works

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Wei, X., Tao, J., Shen, Y., Xiao, S., Jiang, S., Shang, E., Zhu, Z., Qian, D., & Duan, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00955 · Cited by 23 · see citing works

The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells

Yang, Q., Zhu, Z. H., Wang, L., Xia, H., Mao, J., Wu, J., Kato, K., Li, H., Zhang, J., Yamanaka, K., et al. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.04.001 · Cited by 21 · see citing works

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Xu, X., Saadeldeen, F. S. A., Xu, L., Zhao, Y., Wei, J., Wang, H., Liu, Z., & Kang, W. (2019) · BioMed Research International · doi:10.1155/2019/3176483 · Cited by 21 · see citing works

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Olive, J. L., Ballard, K. D., Miller, J. J., & Milliner, B. A. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.028 · Cited by 21 · see citing works

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Scholl, J. (2012) · Cholesterol · doi:10.1155/2012/367898 · Cited by 20 · see citing works

Antidiabetic property of A erva lanata ( L .) J uss. ex S chult. is mediated by inhibition of alpha glucosidase, protein glycation and stimulation of adipogenesis 软毛白花苋(L.)的降糖特性是通过对α葡萄糖甙酶与蛋白质糖基化的抑制以及脂肪生成的刺激达成的

Riya, M. P., Antu, K. A., Pal, S., Chandrakanth, K. C., Anilkumar, K. S., Tamrakar, A. K., Srivastava, A. K., & Raghu, K. G. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12216 · Cited by 20 · see citing works

3-Deoxyglucosone induces insulin resistance by impairing insulin signaling in HepG2 cells

Liang, G., Wang, F., Song, X., Zhang, L., Qian, Z. Y., & Jiang, G. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5081 · Cited by 19 · see citing works

KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes

Wang, S., Zhao, Y., Xia, N., Zhang, W., Tang, Z., Wang, C., Zhu, X., & Cui, S. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0440-x · Cited by 19 · see citing works

Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance

Venojärvi, M., Aunola, S., Puhke, R., Marniemi, J., Hämäläinen, H., Halonen, J.-P., Lindström, J., Rastas, M., Hällsten, K., Nuutila, P., et al. (2008) · BMC Endocrine Disorders · doi:10.1186/1472-6823-8-3 · Cited by 19 · see citing works

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Pandey, J., Maurya, R., Raykhera, R., Srivastava, M. N., Yadav, P. P., & Tamrakar, A. K. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6555 · Cited by 19 · see citing works

MicroRNA-191, acting via the IRS-1/Akt signaling pathway, is involved in the hepatic insulin resistance induced by cigarette smoke extract

Yang, Q., Cui, Y., Luo, F., Liu, X., Wang, Q., Bai, J., Dong, F., Sun, Q., Lu, L., Xu, H., et al. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0277-7 · Cited by 18 · see citing works

Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes

He, S., Peng, W.-B., & Zhou, H. (2018) · Marine Drugs · doi:10.3390/md16020048 · Cited by 18 · see citing works

Annona stenophylla aqueous extract stimulate glucose uptake in established C2Cl2 muscle cell lines

Taderera, T., Chagonda, L. S., Gomo, E., Katerere, D. R., & Shai, L. J. (2019) · African Health Sciences · doi:10.4314/ahs.v19i2.47 · Cited by 18 · see citing works

Creatine Kinase Equilibration and ΔGATP over an Extended Range of Physiological Conditions: Implications for Cellular Energetics, Signaling, and Muscle Performance

Wiseman, R. W., Brown, C. M., Beck, T. W., Brault, J. J., Reinoso, T. R., Shi, Y., & Chase, P. B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713244 · Cited by 14 · see citing works

Hypoglycemic Effect of the N‐Butanol Fraction of Torreya grandis Leaves on Type 2 Diabetes Mellitus in Rats through the Amelioration of Oxidative Stress and Enhancement of β‐Cell Function

Li, X., Jia, S., Yuan, K., & Jin, S. (2022) · BioMed Research International · doi:10.1155/2022/5648896 · Cited by 16 · see citing works

In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis

Xu, H., Wang, Q., Sun, Q., Qin, Y., Han, A., Cao, Y., Yang, Q., Yang, P., Lü, J., Liu, Q., et al. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-1337-3 · Cited by 16 · see citing works

Autoregulation of Free Radicals via Uncoupling Protein Control in Pancreatic β-Cell Mitochondria

Heuett, W. J., & Periwal, V. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.10.012 · Cited by 15 · see citing works

Assessment of Lipid and Metabolite Changes in Obese Calf Muscle Using Multi-Echo Echo-planar Correlated Spectroscopic Imaging

Nagarajan, R., Carpenter, C., Lee, C. C., Michael, N., Sarma, M., Souza, R., Xu, E., Velan, S., Hahn, T. J., Go, V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17529-1 · Cited by 13 · see citing works

P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways

Geng, S., Zhu, W., Wang, S., Xie, C., Li, X., Wu, J., Li, Y., Chen, Y., Wang, X., Meng, Y., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.085 · Cited by 13 · see citing works

Atmospheric PM2.5 aspiration causes tauopathy by disturbing the insulin signaling pathway

Wei, W., Chen, M., Li, G., & Sang, N. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.001 · Cited by 13 · see citing works

Uptake of 18F-Labeled 6-Fluoro-6-Deoxy-d-Glucose by Skeletal Muscle Is Responsive to Insulin Stimulation

Spring-Robinson, C. L., Chandramouli, V., Schumann, W. C., Faulhaber, P., Wang, Y., Wu, C., Ismail‐Beigi, F., & Muzic, R. F. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.062687 · Cited by 13 · see citing works

Adipokines promote lipotoxicity in human skeletal muscle cells

Taube, A., Lambernd, S., van Echten‐Deckert, G., Eckardt, K., & Eckel, J. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.688751 · Cited by 13 · see citing works

Metabolic syndrome among Puerto Ricans and other Hispanic populations.

Marcial, J. M., Altieri, P. I., Banchs, H. L., Escobales, N., & Crespo, M. J. (2011) · PubMed · Cited by 12 · see citing works

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Ramakrishna, K. K. G., Thakur, R. K., Pasam, V. R., Pandey, J., Mahar, R., Shukla, S. K., Tamrakar, A. K., & Tripathi, R. P. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.11.074 · Cited by 11 · see citing works

β-Sitosterol-D-Glucopyranoside Mimics Estrogenic Properties and Stimulates Glucose Utilization in Skeletal Muscle Cells

Pandey, J., Dev, K., Chattopadhyay, S., Kadan, S., Sharma, T., Maurya, R., Sanyal, S., Siddiqi, M. I., Zaid, H., & Tamrakar, A. K. (2021) · Molecules · doi:10.3390/molecules26113129 · Cited by 11 · see citing works

Effects of niacin supplementation on the insulin resistance in Holstein cows during early lactation

Hristovska, T., Cincović, M., Belić, B., Stojanović, D., Jezdimirović, M., Djoković, R., & Toholj, B. (2017) · Acta Veterinaria Brno · doi:10.2754/avb201786030231 · Cited by 10 · see citing works

Fas‐Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway

Sun, B., Zhou, J., Gao, Y., He, F., Xu, H., Chen, X., Zhang, W., & Chen, L. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3756925 · Cited by 7 · see citing works

Gaining metabolic insight in older men undergoing androgen deprivation therapy for prostate cancer (the ADT & Metabolism Study): Protocol of a longitudinal, observational, cohort study

Braga‐Basaria, M., Travison, T. G., Taplin, M., Lin, A. P., Dufour, A. B., Habtemariam, D. A., Nguyen, P. L., Kibel, A. S., Ravi, P. K., Bearup, R., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281508 · Cited by 6 · see citing works

Microwave-assisted efficient synthesis of pyrazole-fibrate derivatives as stimulators of glucose uptake in skeletal muscle cells

Gupta, S., Rai, A. K., Pandey, S., Singh, L., Kant, R., Tamrakar, A. K., & Sashidhara, K. V. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127760 · Cited by 6 · see citing works

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Ploug, T., & Vinten, J. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00817b.2006 · Cited by 5 · see citing works

Different roles of zinc plus arachidonic acid on insulin sensitivity between high fructose- and high fat-fed rats

Hwang, I.-K., Yoon, T., Kim, C., Cho, B.-M., Lee, S.-I., & Song, M. K. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.12.007 · Cited by 4 · see citing works

MR Spectroscopy and Spectroscopic Imaging for Evaluation of Skeletal Muscle Metabolism: Basics and Applications in Metabolic Diseases

Boesch, C. (2013) · Medical radiology · doi:10.1007/174_2013_847 · Cited by 2 · see citing works

Eicosapentanoic and Docosahexanoic Acids, (EPA;DHA), Increase Insulin Sensitivity in Growing Steers.

Cartiff, S. (2010) · NCSU Libraries Repository (North Carolina State University Libraries) · Cited by 2 · see citing works

Effects of Zinc Plus Arachidonic Acid on Insulin Resistance in High Fructose-Fed Rats

Choi, C.-S., Kim, Y.-W., Lee, H.-S., Yoon, T., Cho, B.-M., Lee, S.-I., Kim, S., & Hwang, I.-K. (2009) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2009.38.4.415 · Cited by 1 · see citing works

Efeitos da suplementação com óleo de peixe sobre a resistência à insulina e a função mitocondrial no músculo esquelético de camundongos alimentados com dieta hiperlipídica.

Martins, A. R. (2014) · doi:10.11606/t.87.2014.tde-05012015-152951

A lipoperoxidação plasmática como preditor de esteatohepatite não alcoólica em obesos mórbidos com doença hepática gordurosa não alcoólica

Maggioni, L. (2014) · Americanae (AECID Library)

Molecular mechanisms of development of cellular insulin resistance

Raksha, N., Savchuk, О., & Остапченко, Л. І. (2011) · Biopolymers and Cell · doi:10.7124/bc.000106

Efeitos da suplementação com óleo de peixe sobre a resistência à insulina e a função mitocondrial no músculo esquelético de camundongos alimentados com dieta hiperlipídica

Paulo, S., & Hirabara, M. (2014)

Hip circumference correlates negatively with insulin resistance in type 2 diabetic patients

Wali, N., Mukhtar, I. G., & Ibrahim, S. (2020) · Sahel Medical Journal · doi:10.4103/smj.smj_14_19

Current World Literature

(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282c3a898

Role of phenolic compounds from brazilian native fruits on obesity-induced insulin resistance in skeletal muscle

Pessoa, É. V. M. (2021) · doi:10.11606/d.9.2021.tde-23022022-142148

Mitochondrial adaptations in insulin resistant muscle

Broek, N. N. (2010) · TU/e Research Portal · doi:10.6100/ir684831

Unraveling the Cellular Mechanism of Insulin Resistance in Humans: New Insights from Magnetic Resonance Spectroscopy

Shulman, G. I. (2004) · Physiology · doi:10.1152/physiol.00007.2004 · Cited by 147 · see citing works

Magnetic resonance spectroscopy and the effects of free fatty acids on ectopic fat accumulation and insulin resistance in type 2 diabetes

Begovatz, P., Trautwein, C., & Shah, N. J. (2017) · RWTH Publications (RWTH Aachen)

Etiology of Insulin Resistance

Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.01.009 · Cited by 825 · see citing works

An MR Spectroscopy-Based Approach to Lean Versus Obese Diabetic Patients ∗

Bietenbeck, M., & Yılmaz, A. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.04.041 · Cited by 1 · see citing works

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works