Cited by 729Phytochemistry and Biological ActivitiesTannin, Tannase and Anticancer ActivitiesPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 174 of the 178 references it cites were found in a registry or an index.

Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

Open access

Bai, Jinrong, Zhang, Yunsen, Tang, Ce, Hou, Ya, Ai, Xiaopeng, Chen, Xiaorui, Zhang, Yi, Wang, Xiaobo, Meng, Xianli·2021·Biomedicine & Pharmacotherapy

DOI 10.1016/j.biopha.2020.110985

Open this paper in CoChat — free account Open PDF

Abstract

Gallic acid (GA), also known as 3,4,5-trihydroxybenzoic acid, is a natural secondary metabolite and widely isolated from various fruits, plants and nuts. In recent years, GA has received increasing attention for its powerful anti-inflammatory properties. The purpose of this review is to clearly illuminate the pharmacological activities and related molecular mechanisms of GA in inflammatory diseases. After consulting a large number of literatures, we made a comprehensive exposition on the chemical characteristics, plant origins, pharmacokinetics and toxicity of GA, especially its pharmacological activities and mechanisms of action. Although the plant source of GA is very rich, its lower extraction rate limits the application of GA in development. It is worth mentioning that GA can not only be separated from many plants, but also be produced in large quantities through biological and chemical synthesis. According to pharmacokinetic studies, the absorption and elimination of GA after oral administration are fast, while the structural optimization or dosage form adjustment of GA is beneficial to increase its bioavailability. Promisingly, toxicity studies have shown that GA scarcely has obvious toxicity or side effects in a variety of animal experiments and clinical trials. The results show that the anti-inflammatory mechanisms of GA mainly involved MAPK and NF-κB signaling pathways. It thus weakens the inflammatory response by reducing the release of inflammatory cytokines, chemokines, adhesion molecule and cell infiltration. Due to its excellent pharmacological activities, GA is expected to be a potential candidate for the treatment of various inflammation-related diseases. This paper will provide theoretical basis for the clinical application of GA and guide the future research and medicinal development of GA.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopha.2020.110985

Cites

174 of 174 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Drug-like properties and the causes of poor solubility and poor permeability
Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,776
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019
Singh, D., Agustí, A. G. N., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Criner, G. J., Frith, P. A., Halpin, D. M. G., Han, M. K., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.00164-2019 · Cited by 1,994
Research Progress on the Relationship between Atherosclerosis and Inflammation
Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., & Chen, R. (2018) · Biomolecules · doi:10.3390/biom8030080 · Cited by 900
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
Vogelmeier, C. F., Criner, G. J., Martínez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.00214-2017 · Cited by 899
Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex
Fujihara, M., Muroi, M., Tanamoto, K., Suzuki, T., Azuma, H., & Ikeda, H. (2003) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.08.003 · Cited by 580
Toll receptors, CD14, and macrophage activation and deactivation by LPS
Dobrovolskaia, M. A., & Vogel, S. N. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01613-1 · Cited by 562
Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases
Pasparakis, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2655 · Cited by 538
Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells
Kim, S.-H., Jun, C.-D., Suk, K., Choi, B.-J., Lim, H., Park, S., Lee, S. H., Shin, H.-Y., Kim, D.-K., & Shin, T.-Y. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj063 · Cited by 495
CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport
Pardridge, W. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051781.x · Cited by 460
Deep Learning for Drug-Induced Liver Injury
Xu, Y., Dai, Z., Chen, F., Gao, S., Pei, J., & Lai, L. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00238 · Cited by 405

Show all 178 references

Research works printed but not linked: 6

Schneide, 2012, Drug molecular design: from entry to master, East China University of Science and Technology Press, China, 174
Li, 2019, The anti-inflammatory effect of feiyangchangweiyan capsule and its main components on pelvic inflammatory disease in rats via the regulation of the NF-кB and BAX/BCL-2 pathway, Evid. Complement. Alternat. Med., 9585727
Lee, 2016, Antiviral effects of black raspberry (Rubus coreanus) seed and its gallic acid against influenza virus infection, Viruses, 8, 157, 10.3390/v8060157 · DOI
Zamudio-Cuevas, 2020, The enzymatic poly (gallic acid) reduces pro-inflammatory cytokines in vitro, a potential application in inflammatory diseases, Inflammation
Cheng, 2018, Gallic Acid-L-Leucine conjugate protects mice against LPS-Induced inflammation and Sepsis via correcting proinflammatory lipid mediator profiles and oxidative stress, Oxid. Med. Cell. Longev., 10.1155/2018/1081287 · DOI
Zhou, 2019, Study on the distribution of gallic acid in rat tissues, Chinese pharmacist, 22, 597

Sorted by citations

Items 601–700 of 729

Anti-inflammatory Activity of Polyphenols from Labisia pumila Leaves Extract
Hassan, S. N. S., Hasham, R., Hashim, S. H., & Hamzah, M. A. A. M. (2024) · Malaysian Journal of Fundamental and Applied Sciences · doi:10.11113/mjfas.v20n2.3369
Protective Effect of Probiotics on the Intestinal Mucosal Barrier and Expression of Zonulin, Zo-1, and Muc1 in the Intestinal Tissue of YaksPreprint
Chang, Z., Liu, R., Dong, H., Fouad, D., Nawaz, S., Zhong, L., & Wua, Q. (2024) · Research Square · doi:10.21203/rs.3.rs-5375235/v1
Sorghum Phenolic Compounds: Revisiting the Therapeutic Aspects and Processing Opportunities
Santana, Á. L., Peterson, J., Siliveru, K., & Smolensky, D. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-30037-0_14-1
Influence of Selected Natural Antioxidants on Iron-Induced Enzymatic Alterations Related to Oxidative Stress
Karaman, M., & Toraman, E. (2024) · Cumhuriyet Science Journal · doi:10.17776/csj.1425012
Anti-obesity Effects of Anti-inflammatory Polyphenols
Gezer, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-62491-9_15
Investigation of the Protective Effect of Gallic Acid on the Toxicity of Diazinon-Induced Mitochondrial Damage and Oxidative Stress in the Brain of MicePreprint
Oladzadeh, M., & Mohammadi, H. (2024) · Preprints.org · doi:10.20944/preprints202409.0040.v1
In vitro biological activities and phenolic compounds analysis by RP-HPLC-PDA of Thymus ciliatus (Desf.) Benth. ssp. coloratus extracts from Western Algeria
Saadi, F. Z., Merghache, D., Ferrah, N., Boucherit‐Otmani, Z., Haci, I. A. E., Belarbi, M., & Hassani, F. (2024) · Vegetos · doi:10.1007/s42535-024-01084-y
How Morphological Structure and Amino-Functional Group of Adsorbents Affect the Adsorption Properties for Phenolic AcidsPreprint
Zhang, T., Geng, C., Zhu, F., Quan, J., Zhou, W., Li, N., Nie, L., & Liu, H. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5094016
Qualitative and quantitative determination of the main components of Capparis cartilaginea Decne. infusion by HPLC-UV
Alsharif, B., & Boylan, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15366-2.00007-1
Chemical Constituents and Biological Activities of Vietnamese Leea indica (Burm. f.) Merr.
Diep, N. T., Tâm, N. T., Thien, D. D., & Thảo, Đ. T. (2025) · Letters in Organic Chemistry · doi:10.2174/0115701786361790250318171101
Exploring the protective effects of ethanolic extract of Chenopodium quinoa seed (quinoa) on the reproductive alterations of BPA-exposed females in vivo: a preliminary study
Jana, P. K., Sil, S., Ghosh, A., Sultana, I., & Chattopadhyay, S. (2025) · Discover Toxicology · doi:10.1007/s44339-025-00023-z
Sorghum Phenolic Compounds: Revisiting the Therapeutic Aspects and Processing Opportunities
Santana, Á. L., Peterson, J., Siliveru, K., & Smolensky, D. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-51158-5_14
Mid-infrared spectroscopic identification of the right-fermented Baiyaojian for pulmonary inflammation therapy
Qi, Y., Hu, Y., Chen, J., & Dong, L. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.126460
Phytochemical analysis of Citrus japonica enrich extract and investigation of Anti-inflammatory activity in Rat ModelPreprint
Chauhdary, Z., Akhtar, N., Afzaal, M., Tariq, M., Munir, R., & Saleem, U. (2025) · Research Square · doi:10.21203/rs.3.rs-6772850/v1
SPITTLEBUGS BIOFOAM: EXCRETORY PRODUCTS CHEMISTRY, AND ITS PESTICIDAL ACTIVITY
Madasamy, K., Kalyani, S. K., Sri Ram Muthu, T., & Sahayaraj, K. (2025) · Journal of Biopesticides · doi:10.57182/jbiopestic.18.1.36-48
Nettle & Sarsaparilla Combination (Allergy Guard)
Zdravkov, G. (2025) · Journal of Medical - Clinical Research & Reviews · doi:10.33425/2639-944x.1419
Pharmacological Aspects and Clinical Implications of Tea (Camellia Sinensis) Bioactive Compounds Against Prostate Cancer
Li, M., Nisar, M. F., Gan, Y., & Wan, C. C. (2025) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.13.special-issue-july.02
Physicochemical Characteristics and Functionality of Burdekin Plum During Fruit Maturation
Chen, G., Netzel, M. E., Cozzolino, D., & Sultanbawa, Y. F. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/8811862
Topical composite hydrogel incorporating human amniotic membrane and spidroin for the treatment of chronic wounds in diabetes mellitus
Pakpahan, S. E., Barlian, A., Wibowo, A., & Wibowo, I. (2025) · ADMET & DMPK · doi:10.5599/admet.2822
Comprehensive safety assessment of Qiwei Tiexie Pill: integrating histopathological, biochemical, and metabolomic analyses in a rat model
Zheng, Q., Liu, W., Wang, C., Kan, Z.-B., Wang, Q., Cui, L., Lin, Z., Zhou, F., Feng, X., & Wang, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1567316
Investigating the release of active compounds and cytotoxicity of thymol/gallic acid/β-cyclodextrin bio-nanocomposite: a targeted strategy with the approach of disrupting the genes involved in the quorum sensing system and biofilm formation in P. aeruginosa (PAO1)
Ashrafi, B., Heydari, R., Rezaei, F., Beiranvand, B., Pajouhi, N., Rashidipour, M., Taherikalani, M., & Soroush, S. (2025) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2025.2563676
Harnessing Justicia adhatoda-based Nanoparticles: A novel frontier in Alzheimer's disease therapy
Imath, M., Dash, A., & Ragavendran, C. (2025) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2025.103809
In Vivo Anti-Inflammatory Activity of Four Edible Cactaceae Flowers from Mexico
Pensamiento-Niño, C. A., Hernández-Fuentes, A. D., Añorve‐Morga, J., Duarte‐Sierra, A., Ramírez‐Moreno, E., Sosa-Gutierrez, C. G., & Ojeda-Ramírez, D. (2025) · Metabolites · doi:10.3390/metabo15100665
Liquid Chromatography‐Mass Spectrometry Profiling and High‐Performance Liquid Chromatography Method Validation for Quantification of Acteoside, Emodin, and Chrysophanol in a Thai Traditional Anti‐Hemorrhoidal Formulation
Monton, C., Jongcharoenkamol, J., & Suksaeree, J. (2025) · Separation Science Plus · doi:10.1002/sscp.70149
Proximate Composition, Mineral analysis and Phytochemical Characterization of an Ethnomedicinal Plant Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir
Athira, S., & Sreeranjini, S. (2024) · International Journal of Plant and Environment · doi:10.18811/ijpen.v10i03.13
Enhancing Muscle Quality in Largemouth Bass (Micropterus salmoides) through Temporary Rearing: An Inside-Out Purification Approach for Premium Yusheng
Chen, S., Wu, Y., Xia, Y., Wang, C., Hu, A., Sun, Y., Shi, L., Chen, L., Guo, X., Qiao, Y., et al. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.08.029
Unveiling the pharmacological promise of Tamarix chinensis Lour: An integrative review of phytochemical constituents, therapeutic potentials, and mechanistic pathways
Saeed, M. T., Zhao, J., Mohamed, H., Naz, T., Iqbal, B., Ramadan, A. S., Akhtar, H. M. S., Assefa, M., Khalid, H., Song, Y., et al. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100722
Unlocking the Anti-Cancer Potential of Gallic Acid - A Scientific Scoping Analysis
Elangovan, R., Fathima, L., Elgiva, M. S. P., Sindhu, R., Prabu, D., Rajmohan, M., & Dhamodhar, D. (2025) · doi:10.38124/ijisrt/25nov649
Medical nanocomposites based on hydrophilic and hydrophobic silicas and their properties
Krupska, Т. V., Borysenko, M. V., Klymenko, N. Y., Zrol, L. V., Новикова, О. А., & Turov, V. V. (2025) · Poverhnostʹ · doi:10.15407/surface.2025.17.413
Chronic Gallic Acid Treatment Attenuates Hippocampal Neurodegeneration in Aged Rats
González‐Cano, S. I., Juárez-Serrano, D., Handal‐Silva, A., Morán-Perales, J. L., Vázquez‐Roque, R. A., Galindo-Ramírez, F., Treviño, S., Guevara, J., & Díaz, A. (2025) · Synapse · doi:10.1002/syn.70036
Potential Effects and Mechanisms of Whole Grain Intake on Rheumatoid Arthritis
Liu, Z., Chang, J., Wang, X., Li, T., Yu, Y., Zhang, J., Wang, J., & Sun, B. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250885
Self-citation
Additional file 1 of Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies
Li, K., Gong, Q., Lu, B., Huang, K., Tong, Y., Emmanuel, M. T., Lin, M., Xu, Z., Lu, F., Li, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22724244
Additional file 1 of Dynamic hydrogel–metal–organic framework system promotes bone regeneration in periodontitis through controlled drug delivery
Luo, Q., Yang, Y., Ho, C., Li, Z., Chiu, W., Li, A., Dai, Y., Li, W., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26725694
Additional file 1 of Isolation and identification of active ingredients and biological activity of Dioscorea nipponica Makino
Xia, G., Zhao, G., Pei, S., Zheng, Y., Zang, H., & Li, L. (2023) · Figshare · doi:10.6084/m9.figshare.23700423
Additional file 1 of Effects of Leea indica leaf extracts and its phytoconstituents on natural killer cell-mediated cytotoxicity in human ovarian cancer
Neo, S.-Y., Siew, Y.-Y., Yew, H.-C., He, Y., Poh, K.-L., Tsai, Y.-C., Ng, S.-L., Tan, W.-X., Chong, T.-I., Lim, C. S. E.-S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22617674
HPLC analysis and anti-inflammatory, antinociceptive and antidepressant properties of the plant Cynara humilis L.
Khomsi, M. E., Doubi, M., Hmamou, A., Tahiri, N. E. H., Esserghini, H., Slaoui, M., & Hmouni, D. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100452
Protective Effects of Gallic Acid Against Chronic Restraint Stress-Induced Histological Alterations of Skin
Karip, B. Z., Polat, İ. Ö., Kırmızıkan, S., & Çikler, E. (2025) · Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi · doi:10.34087/cbusbed.1623924
Neuro-Resilience with Emblica officinalis (Amla): Targeting Oxidative Stress and Neuroinflammation
Sharma, A., Babbar, A., & Chary, K. J. S. (2026) · Springer eBooks · doi:10.1007/978-981-95-4751-7_13
Stimulation of TRPM2 Channel in Glioblastoma Tumour Cells by Gallic Acid Potentiated the Anti-Tumour and Oxidant Effects of Doxorubicin
Yazğan, Y., Yazğan, B., & Ahlatci, A. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700977
An endemic plant in turkey: antioxidant and enzyme ınhibition potential of different extracts of Asyneuma linifolium subsp. eximium
Zambak, F., Sen, İ., Zengin, G., Acioglu, L. K., Yeşilyurt, İ., Turna, E., & Çakmak, Y. S. (2026) · Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology · doi:10.1007/s44473-025-00063-8
Effects of gallic acid and essential oil supplementation on performance, health and cecal bacterial count in broilers challenged with coccidiosis
Lee, J., Song, D., Kim, H., Chang, S., Lee, B., Taechavasonyoo, A., & Cho, J. H. (2026) · Journal of Animal Science and Technology · doi:10.5187/jast.2500430
Gallic Acid Protects Against LPS‐Induced Cardiac Dysfunction by Modulating Inflammatory Responses and Notch Signaling in Zebrafish Embryo Larvae
Piyushbhai, M. K., Binesh, A., & Venkatachalam, K. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70729
Targeting Galectin-3 C-epitope oligomers associated maladaptive mechanotransductive signaling in pressure-overload induced left ventricular cardiac hypertrophyPreprint
Shinde, P. L., Kumar, V., Singh, S., Sivakumar, K. C., Abhirami, P., Mishra, A., & Mishra, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704762
Germinação de grão-de-bico e transformações bioquímicas associadas
Holanda, M. H. B. (2024) · doi:10.47749/t/unicamp.2024.1507684
Integrating traditional Chinese medicine and modern technology: A new approach to understanding Changmaxifeng granules for tic disorders
Qiu, M.-Q., yang, W.-J. O., Qiu, W.-S., & Chen, M.-M. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.v16.i3.114342
The signaling pathways of atherosclerosis regulated by Taohong Siwu Decoction
Yan, K., Gong, S., Li, Y., Shi, Z., Bao, Y., Leng, J., & Ning, K. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61103-x
Simultaneous UV-Spectrophotometric Method for Quantifying Berberine and Gallic Acid in Polyherbal Formulation and Evaluation of its Antioxidant Potential
Patil, S., Parsekar, D., Mehta, P., & Jakkannavar, A. (2026) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2026.00120
Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis
Liu, G., Wang, Z., Xu, H., Jia, J., Xue, Z., Ge, W., Ji, X., Cui, L., & Huang, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062582
Immunomodulatory and Antioxidant Potencies of γ‐irradiated Piper cubeba in Complete Freund's Adjuvant‐Induced Arthritis in Rats
Abdel‐Hamid, G. R., ElWahab, S. A. E. W. A., Elgazzar, E. M., Soude, A. L., & Anees, L. M. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503288
Danggui-Shaoyao-San ameliorates metabolic dysfunction-associated steatohepatitis via suppressing hepatic macrophage NLRP3 inflammasome
Huang, Q., Lyu, S., Xin, X., An, Z., Sun, Q., Gao, S., Yiyang, H., Gou, X., & Feng, Q. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121578
Managing dry eye disease – a review of selected traditional Chinese medicine and some of their metabolites focusing on molecular mechanisms and signaling pathways
Lu, Y., Li, Y., Zhao, Z., Liu, Y., Wang, J., & Yao, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1693198
Pseudo-cereal based yogurt alternatives with focus on processing and nutra-pharmaceutical applications
Sanasam, P., Morya, S., Ramadan, M. F., & Mugabi, R. (2026) · Discover Food · doi:10.1007/s44187-026-00949-2
Gallic Acid Provides Effective Protection Against Sodium Benzoate-induced Facilitation of the Contraction of Duodenal Visceral Smooth Muscle in Rat
Dey, C., Sarkar, K., Dutta, M., Roy, M. G., Roy, D., Bhattacharjee, S., & Paul, G. (2026) · Toxicology International · doi:10.18311/ti/2026/v33i1/49494
Ovicidal activity of the organic extract of Purpureocillium lilacinum on Haemonchus contortus
Ocampo-Gutiérrez, A. Y., Higuera-Piedrahita, R. I., Hernández-Velázquez, V. M., Lormendez, C. C., Zamilpa, A., López‐Arellano, M. E., González‐Cortazar, M., Olmedo‐Juárez, A., Delgado-Núñez, E. J., Reyes-Estébanez, M., et al. (2026) · Biocontrol Science and Technology · doi:10.1080/09583157.2026.2652272
Phenolic Compounds of Plant Species from the Caatinga Biome: Northeast Brazil
Rodrigues, F. F. G., Duarte, A. M. F., dos Santos, I. R. F., Xenofonte, J. V. F., Pereira, J. F. D. L., Ribeiro, M. A. M., da Silva, M. P., & da Costa, J. G. M. (2026) · Springer eBooks · doi:10.1007/978-3-642-36202-6_304-1
Hyaluronic acid-based responsive hydrogel with sequential drug release: targeting oxidative stress and angiogenesis to accelerate diabetic wound healing
Wang, X., Wu, Y., He, T., Zhao, F., Li, D., Zhu, X., Xiao, Y., & Zhang, X. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151953
Self-citation
Nuangong Tiaojing Formula ameliorates luteal phase defect by restoring ovarian-uterine axis function via regulating inflammatory-apoptotic cascade
Hao, M., Xue, X., Li, Y., Wu, X., Gao, Y., Cui, Y., Li, Y., Zhang, M., Qin, F., Lyu, G., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158212
PAMAM dendrimers as efficient drug nanocarriers of natural compounds in breast cancer therapeutics
Gulfishan, S., Alam, M. W., Pandey, P., Mujtaba, M. A., Verma, M., Lakhanpal, S., Rana, A. K., & Khan, F. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1809604
Anti-inflammatory effects of gallic acid on chronic bacterial prostatitis: involving target tissue distribution
Liu, X., Kong, S., Yang, Q., Ma, L., Zuo, X., Liu, X., Liu, X., Lv, C., & Huang, Y. (2026) · Food & Function · doi:10.1039/d5fo05256d
Preventive Effect of Gallic Acid‐Loaded Carrageenan Nanoparticles Against Cerebral Ischemia/Reperfusion Injury in Rat: Modulation of Oxidative Pathway
Moghaddam, A. H., bahnamiri, P. J., Jelodar, S. K., Jaz, Z. F., Nasiriansari, P., & Hasantabar, V. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71751
Role of surface chemistry and Zn/Ga substitution on cobalt ferrite nanoparticles for electrochemical detection of gallic acid
Milićević, M., Jovanović, Z., Bajuk‐Bogdanović, D., Uskoković‐Marković, S., Kovač, J., Spreitzer, M., Kržmanc, M. M., Özkan, S. A., Simatović, I. S., & Jovanović, S. (2026) · Applied Surface Science · doi:10.1016/j.apsusc.2026.167086
LCMS profiling of phenolics extracted using an ultrasonic extraction process from Fragrant Manjack
Diwathe, M. C., Mazumdar, B., & Anandkumar, J. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04421-8
Gallic Acid Protects Against DSS‐Induced Colitis by Modulating Gut Microbiota and Suppressing the Activation of NF‐κB/MAPK Signaling Pathway
Wang, C., Xu, Z., Ma, M., Fu, Z., & Yao, K. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70487
Plantago mechanisms for enhanced wound healing: A review on bioactive phytoconstituents
Hertiani, T., Khafi, M., Amalia, L., & Irawan, M. B. (2026) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2026.05.015
In silico prediction of ADME/tox and molecular docking of secondary metabolites from agro-industrial waste of Carapa guianensis Aubl
dos Santos, K. I. P., Silva, R. C. E., Afonso, R. D. S., de Souza, T. S., Glins, J. C. N., da Silva, F. A. B., Pinheiro, W. B. D. S., & Santos, A. S. (2026) · Journal of the Indian Chemical Society · doi:10.1016/j.jics.2026.102726
Fabrication and characterization of gallic acid–incorporated silk fibroin/sodium alginate hydrogels for antibacterial and wound healing applications
Su, A., Zhang, H., Xiong, X., Wu, J., Tan, D., Liu, X., Zheng, J. H., & Jiang, Q. (2026) · Polymer Bulletin · doi:10.1007/s00289-026-06506-2
Comment on Gallic acid alleviates colitis by restoring intestinal barrier function and enriching butyrate-producing bacteria
wang, M., & Xie, Z. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116925
3D-Printed Alginate Dialdehyde (ADA)–Gelatin (GEL) Hydrogels with Gallic Acid (GA) for Enhanced Multifunctional Properties
Cavalcante, C. O., Kissel, H. S., Mîrț, A. L., Silva, J. Y. R., Alves, S., & Boccaccini, A. R. (2026) · ACS Omega · doi:10.1021/acsomega.6c02404
Cordyceps farinosa Cf-GZU06: Mycelium Culture Medium Optimization and Polysaccharide Characterization with Prebiotic Effects
Wang, Y.-C., Mao, Y.-H., Huang, M.-Q., Wen, T.-C., Luo, Y., Wang, C., & Song, A.-X. (2026) · Foods · doi:10.3390/foods15112038
Mutually Reinforcing Polyphenol and Nanomedicines: Unlocking the Potential of Polyphenol‐Based Nanodrugs for Liver Injury Therapy
Liu, M., Huang, R., Wang, S., Lin, Y., Xiong, T., Li, R., Zheng, W., Huang, Q., Nan, Y., Liu, Z., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71320
Antiauxin-mediated callus induction, shoot regeneration, secondary metabolite enhancement, and bioactivity profiling in Silene rubella L. (Caryophyllaceae) in vitro cultures
Shahin, H., Eid, M. M., Bouqellah, N. A., Rafrafi, S., Afifi, T. H., Abouelela, M. E., Younis, A. M., Yosri, M., & El‐Hela, A. A. (2026) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-026-03492-1
Acacia arabica seed extract-mediated synthesis of copper nanoparticles: In vitro COX-2 inhibitory and anticancer activity on prostate cancer PC3 cell line
Bhagya, P. M., Rani, T. S., & Krishna, T. P. A. (2026) · Next Nanotechnology · doi:10.1016/j.nxnano.2026.100563
Sustainable Bioactive Hydrogels Engineered with Liquidambar orientalis Extracts: pH‐Dependent Release Behavior and Wound Healing Potential
Taş, M., Duru, M. E., Demiray, A., Küçükaydın, S., & Ceylan, Ö. (2026) · Macromolecular Materials and Engineering · doi:10.1002/mame.70265
Hematological Impacts of Gallic Acid, Disulfiram, and Dexamethasone in a Rat Model of Lipopolysaccharide-induced Sepsis
Hojati, Z., Rassouli, A., Sasani, F., Amoli, J. S., & Javadi, H. (2026) · Majallah-i taḥqīqāt-i dāmpizishkī-i īrān · doi:10.32598/ijvm.20.3.1005787
Development and optimization of gallic acid-enriched nanostructured lipid carriers for the amelioration of rheumatic inflammation: in-vitro and in-vivo study
Nipun, Bhadyaria, A., Rajpal, V., Kurmi, B. D., Singh, S. S., Kumar, M., & Pal, R. R. (2026) · Journal of Microencapsulation · doi:10.1080/02652048.2026.2685813
A novel cationized agarose-based oral mucoadhesive delivery platform
Rodríguez-Basso, Á. G., Prado, H. J., Matulewicz, M. C., Bonafede, S. L., Vitali, V. A., Fuda, J., & Gorzalczany, S. B. (2026) · Ars Pharmaceutica (Internet) · doi:10.30827/ars.v67i3.36138
Emerging cell death in depression: Mechanisms and therapeutic implications
Jin, C., & Li, Y. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111801
New Hybrid Benzothiazole Derivatives from Gallic and Syringic Acid as a Potential Multifunctional Skin Disease
Montani, L., Tupini, C., Marchetti, F., Rizzo, A., Vertuani, S., Manfredini, S., Lampronti, I., & Baldisserotto, A. (2026) · Molecules · doi:10.3390/molecules31132245
Gallic acid as an antiinflammatory agent
Wang, W., Shiu, P. H.-T., Zheng, C., Rangsinth, P., Li, J., & Leung, G. P.-H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29192-0.00062-5
Anti-bacterial effects of gallic acid-loaded graphene oxide nanocomposite (GAGO) against Vibrio spp., its potential mechanism of action and toxicity against Artemia nauplii
Sem, N. A. D. K., Chong, C. M., & Shamsi, S. (2026) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-026-05109-3
Dual-network gallic acid-functionalized chitosan methacryloyl/FGelMA hydrogel for diabetic wound healing via enhanced angiogenesis and inflammation modulation
Park, D.-J., Kim, S.-C., Jeong, G., Jeong, J.-W., Kim, Y.-M., & Jung, W.-K. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153326
Research progress on the antibacterial activity of naturally derived monomers grafted to chitosan
He, X., Guo, C., Hao, T., Liu, X. Y., Yue, Q., Yu, Y., & Ge, T. (2026) · Bulletin of Materials Science · doi:10.1007/s12034-026-03643-2
Browntop Millet as a Next‐Generation Food: Insights Into Functional and Nutraceutical Applications
Sain, P., Morya, S., Awlqadr, F. H., Saeed, M. N., & Arab, K. (2026) · Journal of Food Processing and Preservation · doi:10.1155/jfpp/8819892
Gallic acid and crocin attenuated hepatorenal oxido-inflammatory imbalance in rats treated with cypermethrin
Adeeyo, K. O., Odesola, M. A., Benedict, V. E., Yakub, M. O., Ajaino, E. G., Usin, S. G., Olajire, G. A., & Gbadegesin, M. A. (2026) · Pharmacological Research - Reports · doi:10.1016/j.prerep.2026.100097
RVG-functionalized microglial membrane–coated cerium–gallic acid metal–organic frameworks for multi-target Alzheimer's therapy
Yang, F., Chen, Y., Yan, Y., Zhao, R., Deng, L., Tian, D., Wang, Q., & Xie, M. (2026) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2026.141133
Gallic acid from Moutan Cortex promotes osteoblast differentiation and alleviates osteoporosis in mice by targeting HRAS and activating the ERK pathway
Gu, W., Zhou, H., Sun, Y., He, X., Wang, P., Ni, X., & Wu, H. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.107086
Comparative evaluation of anti-cancer activity of free and nano-encapsulated gallic acid in PC-3 and HEK-293 cells
Fathali, F., Taravati, A., & Tafrihi, M. (2026) · 3 Biotech · doi:10.1007/s13205-026-04964-z
Structural characterization of a series of alkali metal coordination polymers of gallic acid
Kreider‐Mueller, A., Golen, J. A., Morris, T. A., & Manke, D. R. (2026) · Acta Crystallographica Section C Structural Chemistry · doi:10.1107/s2053229626007096
Modulation of phenylalanine assembly kinetics by gallic acid and its therapeutic implications in phenylketonuria (PKU)
Zahra, T., Sinha, N., & Thakur, A. K. (2026) · Soft Matter · doi:10.1039/d5sm01171j
Gallic Acid Bioproduction: From Tannin Hydrolysis to De Novo Biosynthesis by Engineered Microbial Cell Factories
Pantoja, R. K., Torres, M. M., Santos, A. S., Oliveira-Filho, E. R., Gomez, J. G. C., & da Silva, L. F. (2026) · Applied Biosciences · doi:10.3390/applbiosci5040104
Phytochemical profiling and selective bioactivity evaluation of optimized leaf extract of Pterocarpus indicus Willd.
Bhadury, R., Hazra, S., & Rahaman, C. H. (2026) · Systems Ethnopharmacology and Sustainable Bioresources · doi:10.1016/j.sesb.2026.100035
Immunomodulatory activity of Inula viscosa (L.) compounds identified via LC–ESI–MS and their COX-2-targeted anti-inflammatory potential: in vitro, in vivo and in silico analysis
Ouari, S., Benzidane, N., Yahiaoui, S., Merakeb, M. S., Trapali, M., Afenai, S., Arrar, L., & Bribi, N. (2026) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-026-00901-7
Development and Characterization of Organic Acid‐Loaded κ‐Carrageenan/Potato Starch Biocomposite Films for Active Food Packaging
Khan, T. S., Jawad, M., Al‐Harrasi, A., Rehman, N. U., Aydemir, L. Y., Anwer, M. K., Bhatia, S., Fahdi, A. K. A., & Ahmad, M. W. (2026) · Starch - Stärke · doi:10.1002/star.70271
Peedanil Gold attenuates IL-6-mediated articular pathologies in a collagen antibody-induced murine model of rheumatoid arthritis
Balkrishna, A., Sharma, S., Tiwari, A., Sinha, S., & Varshney, A. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1868253
Horse gram (Macrotyloma uniflorum) as a climate-resilient legume with functional and nutraceutical potential
Halder, A., Das, U., & Chengaiyan, J. G. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1891496
Phytochemical Characterization Using HPLC-DAD, Antiglycation Effect at Multiple Stages, Anti-Inflammatory and Analgesic Activities of Solanum elaeagnifolium Cav: Experimental and Computational Studies
Bouslamti, M., Abdnim, R., El-Mernissi, R., Zouirech, O., Chebaibi, S.-E., Alqahtani, M. J., Alqahtani, J., Basilua, J. M., Hajji, L., Hachlafi, N. E., et al. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48080810
Traditional medicinal uses, phytochemistry, biological activity and ethnobotany of Eryngium foetidum L. (Apiaceae)
Islam, A., Mondal, N. S., Gautam, M. K., Mondal, S., Dey, A., Modak, K., & Chandra, P. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100849
Coupling redox regulation with Cancer immunotherapy: The challenge of polyphenol Nanocarriers
Curcio, M., Saletta, F., Scorzafave, L., Fiore, M., Nicoletta, F. P., Iemma, F., Vittorio, O., & Cirillo, G. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115956
Network pharmacology–based prediction of the multi-target mechanism of Simhanada Guggulu in rheumatoid arthritis: an in silico study
Kumari, K., Sharma, E., Gajender, & Sharma, N. (2026) · International Journal of Ayurveda360 · doi:10.63247/3048-7390.v3i1.03
Phytochemical profiling and in vivo wound healing efficacy of ethanolic extract of Terminalia elliptica leaves
Popeta, R. D., & Thakur, G. A. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100850

Authors: Bai, J., Zhang, Y., Tang, C., Hou, Y., Ai, X., Chen, X., Zhang, Y., Wang, X., & Meng, X.
Affiliations: Chengdu University of Traditional Chinese Medicine (CN)
Corresponding author: Wang, Xiaobo
Meng, Xianli
ORCID: Bai, Jinrong
Zhang, Yunsen
Tang, Ce
Ai, Xiaopeng
Chen, Xiaorui
Zhang, Yi
Wang, Xiaobo
Meng, Xianli
Venue: Biomedicine & Pharmacotherapy
Publisher: Elsevier BV
Published: 2021-01
Volume: 133
Pages: 110985
ISSN: 0753-3322 (ISSN-L)
DOI: 10.1016/j.biopha.2020.110985
OpenAlex: W3106125810
Cited by: 720
References: 178
Citations by year: 2026: 127 · 2025: 164 · 2024: 159 · 2023: 146 · 2022: 94 · 2021: 30
FWCI: 5.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Science and Technology Major Project
National Natural Science Foundation of China (81773974, 81903922, 81973569)
National Key Research and Development Program of China (2017YFC1703904)
National College Students Innovation and Entrepreneurship Training Program (S201910633017)
Department of Science and Technology of Sichuan Province (19SYXHZ0095, 2018JY0467, 2020YFQ0032)
State Administration of Traditional Chinese Medicine of the People's Republic of China (201507002)
Chengdu University of Traditional Chinese Medicine (2020XSGG004, CXTD2018015, CXTD2018020, CZYJC1903)
Ministry of Science and Technology of the People's Republic of China
China Postdoctoral Science Foundation (2020M683273)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: gallic acid, anti-inflammatory activity, inflammation-related diseases, MAPK signaling, NF-κB signaling, inflammatory cytokines, chemokines, adhesion molecules, pharmacokinetics, bioavailability, toxicity, plant sources
MeSH terms: Animals, Anti-Inflammatory Agents, Gallic Acid, Humans, Inflammation, Signal Transduction, Treatment Outcome, Inflammation Mediators

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks