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Cited by 729Phytochemistry and Biological ActivitiesTannin, Tannase and Anticancer ActivitiesPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 174 of the 178 references it cites were found in a registry or an index.

Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

Open access
Bai, Jinrong, Zhang, Yunsen, Tang, Ce, Hou, Ya, Ai, Xiaopeng, Chen, Xiaorui, Zhang, Yi, Wang, Xiaobo, Meng, Xianli·2021·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2020.110985
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Abstract

Gallic acid (GA), also known as 3,4,5-trihydroxybenzoic acid, is a natural secondary metabolite and widely isolated from various fruits, plants and nuts. In recent years, GA has received increasing attention for its powerful anti-inflammatory properties. The purpose of this review is to clearly illuminate the pharmacological activities and related molecular mechanisms of GA in inflammatory diseases. After consulting a large number of literatures, we made a comprehensive exposition on the chemical characteristics, plant origins, pharmacokinetics and toxicity of GA, especially its pharmacological activities and mechanisms of action. Although the plant source of GA is very rich, its lower extraction rate limits the application of GA in development. It is worth mentioning that GA can not only be separated from many plants, but also be produced in large quantities through biological and chemical synthesis. According to pharmacokinetic studies, the absorption and elimination of GA after oral administration are fast, while the structural optimization or dosage form adjustment of GA is beneficial to increase its bioavailability. Promisingly, toxicity studies have shown that GA scarcely has obvious toxicity or side effects in a variety of animal experiments and clinical trials. The results show that the anti-inflammatory mechanisms of GA mainly involved MAPK and NF-κB signaling pathways. It thus weakens the inflammatory response by reducing the release of inflammatory cytokines, chemokines, adhesion molecule and cell infiltration. Due to its excellent pharmacological activities, GA is expected to be a potential candidate for the treatment of various inflammation-related diseases. This paper will provide theoretical basis for the clinical application of GA and guide the future research and medicinal development of GA.

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Show all 178 references

Research works printed but not linked: 6

  1. Schneide, 2012, Drug molecular design: from entry to master, East China University of Science and Technology Press, China, 174
  2. Li, 2019, The anti-inflammatory effect of feiyangchangweiyan capsule and its main components on pelvic inflammatory disease in rats via the regulation of the NF-кB and BAX/BCL-2 pathway, Evid. Complement. Alternat. Med., 9585727
  3. Lee, 2016, Antiviral effects of black raspberry (Rubus coreanus) seed and its gallic acid against influenza virus infection, Viruses, 8, 157, 10.3390/v8060157 · DOI
  4. Zamudio-Cuevas, 2020, The enzymatic poly (gallic acid) reduces pro-inflammatory cytokines in vitro, a potential application in inflammatory diseases, Inflammation
  5. Cheng, 2018, Gallic Acid-L-Leucine conjugate protects mice against LPS-Induced inflammation and Sepsis via correcting proinflammatory lipid mediator profiles and oxidative stress, Oxid. Med. Cell. Longev., 10.1155/2018/1081287 · DOI
  6. Zhou, 2019, Study on the distribution of gallic acid in rat tissues, Chinese pharmacist, 22, 597

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Metadata

Authors
Bai, J., Zhang, Y., Tang, C., Hou, Y., Ai, X., Chen, X., Zhang, Y., Wang, X., & Meng, X.
Affiliations
Chengdu University of Traditional Chinese Medicine (CN)
Corresponding author
  • Wang, Xiaobo
  • Meng, Xianli
ORCID
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2021-01
Volume
133
Pages
110985
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/j.biopha.2020.110985
OpenAlex
W3106125810
Cited by
720
References
178
Citations by year
2026: 127 · 2025: 164 · 2024: 159 · 2023: 146 · 2022: 94 · 2021: 30
FWCI
5.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science and Technology Major Project
  • National Natural Science Foundation of China (81773974, 81903922, 81973569)
  • National Key Research and Development Program of China (2017YFC1703904)
  • National College Students Innovation and Entrepreneurship Training Program (S201910633017)
  • Department of Science and Technology of Sichuan Province (19SYXHZ0095, 2018JY0467, 2020YFQ0032)
  • State Administration of Traditional Chinese Medicine of the People's Republic of China (201507002)
  • Chengdu University of Traditional Chinese Medicine (2020XSGG004, CXTD2018015, CXTD2018020, CZYJC1903)
  • Ministry of Science and Technology of the People's Republic of China
  • China Postdoctoral Science Foundation (2020M683273)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords
gallic acid, anti-inflammatory activity, inflammation-related diseases, MAPK signaling, NF-κB signaling, inflammatory cytokines, chemokines, adhesion molecules, pharmacokinetics, bioavailability, toxicity, plant sources
MeSH terms
Animals, Anti-Inflammatory Agents, Gallic Acid, Humans, Inflammation, Signal Transduction, Treatment Outcome, Inflammation Mediators

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