Circulating exosomes in cardiovascular disease: Novel carriers of biological information
Open accessAbstract
Exosomes are a group of nanosized extracellular vesicles that include various bioactive nucleic acids, lipids, and proteins. They originate from membrane invagination and are released by exocytosis, which can transmit signals to target cells to achieve cell-to-cell communication and maintain homeostasis. The heart is a complex multicellular organ that contains resident cell types such as fibroblasts, endothelial cells, and smooth muscle cells. Communication between different cell types and immune systems is essential for the dynamic equilibrium of the cardiac internal environment. Intercellular communication is a universal phenomenon mediated by exosomes and their contents during several pathological processes in cardiovascular diseases, such as cardiomyocyte hypertrophy, apoptosis, and angiogenesis. Therefore, exosomes can be used as novel invasive diagnostic biomarkers in multiple diseases, including atherosclerosis, myocardial ischemia, cardiac fibrosis, and ischemia-reperfusion injury. In addition, the biocompatible nature and low immunogenicity of exosomes make them high-quality nanoparticle drug carriers with potential applications in translational medicine and therapeutic strategies. Here, we focus on the biogenesis, isolation, biological functions, and future application prospects of exosomes in cardiovascular disease.
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Superior biocompatibility of exosomes allows them potentially useful as drug carriers in cardiovascular diseases.
“Therefore, the superior biocompatibility of exosomes allows them potentially useful as drug carriers in cardiovascular diseases [90].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [90]
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Rana, S., Yue, S., Stadel, D., & Zöller, M. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.06.018 · Cited by 665 · see citing works
RetractedZheng, B., Yin, W., Suzuki, T., Zhang, X.-H., Zhang, Y., Song, L., Jin, L.-S., Zhan, H., Zhang, H., Li, J.-S., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.031 · Cited by 276 · see citing works
RetractedApoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355 · see citing works
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works
Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426 · see citing works
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works
Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,424 · see citing works
Exosomes – vesicular carriers for intercellular communication
Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,351 · see citing works
Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis
Li, Y., Zheng, Q., Bao, C., Li, S., Guo, W., Zhao, J., Chen, D., Gu, J., He, X., & Huang, S. (2015) · Cell Research · doi:10.1038/cr.2015.82 · Cited by 2,210 · see citing works
Progress in Exosome Isolation Techniques
Li, P., Kaslan, M., Lee, S. H., Yao, J. D., & Gao, Z. (2017) · Theranostics · doi:10.7150/thno.18133 · Cited by 1,970 · see citing works
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works
Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works
Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works
The Nature and Significance of Platelet Products in Human Plasma
Wolf, P. (1967) · British Journal of Haematology · doi:10.1111/j.1365-2141.1967.tb08741.x · Cited by 1,725 · see citing works
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e3182456d46 · Cited by 1,512 · see citing works
Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
Dragovic, R., Gardiner, C., Brooks, A. S., Tannetta, D., Ferguson, D. J. P., Hole, P., Carr, B., Redman, C. W. G., Harris, A. L., Dobson, P. J., et al. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.04.003 · Cited by 1,368 · see citing works
Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study
Zaborowski, M. P., Balaj, L., Breakefield, X. O., & Lai, C. P. (2015) · BioScience · doi:10.1093/biosci/biv084 · Cited by 1,272 · see citing works
Exosome Theranostics: Biology and Translational Medicine
He, C., Zheng, S., Luo, Y., & Wang, B. (2017) · Theranostics · doi:10.7150/thno.21945 · Cited by 1,259 · see citing works
Tauro, B. J., Greening, D. W., Mathias, R. A., Ji, H. L., Mathivanan, S., Scott, A. M., & Simpson, R. J. (2012) · Methods · doi:10.1016/j.ymeth.2012.01.002 · Cited by 1,177 · see citing works
Wang, G., Zhu, J., Zhang, J., Li, Q., Li, Y., He, J., Qin, Y., & Jing, Q. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq013 · Cited by 1,168 · see citing works
Lipid rafts: bringing order to chaos
PIKE, L. J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200021-jlr200 · Cited by 1,139 · see citing works
Lipids in exosomes: current knowledge and the way forward
Skotland, T., Sandvig, K., & Llorente, A. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.03.001 · Cited by 1,030 · see citing works
Active Wnt proteins are secreted on exosomes
Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025 · see citing works
Bang, C., Bátkai, S., Dangwal, S., Gupta, S. K., Foinquinos, A., Holzmann, A., Just, A., Remke, J., Zimmer, K., Zeug, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70577 · Cited by 979 · see citing works
The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
Deun, J. V., Mestdagh, P., Sormunen, R. T., Cocquyt, V., Vermaelen, K., Vandesompele, J., Bracke, M., Wever, O. D., & Hendrix, A. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24858 · Cited by 941 · see citing works
Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration
Talman, V., & Ruskoaho, H. J. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2431-9 · Cited by 921 · see citing works
Record, M., Carayon, K., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.004 · Cited by 853 · see citing works
Proteomic profiling of exosomes: Current perspectives
Simpson, R. J., Jensen, S. S., & Lim, J. W. E. (2008) · PROTEOMICS · doi:10.1002/pmic.200800109 · Cited by 850 · see citing works
Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells
Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy
Ibrahim, A., Cheng, K., & Marbán, E. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.006 · Cited by 821 · see citing works
Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works
Exosomes in cancer: small particle, big player
Zhang, X., Yuan, X., Shi, H., Wu, L., Qian, H., & Xu, W. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0181-x · Cited by 783 · see citing works
Circulating Extracellular Vesicles in Human Disease
Shah, R. V., Patel, T. C., & Freedman, J. E. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1704286 · Cited by 756 · see citing works
HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing
Zhang, B., Wang, M., Gong, A.-H., Zhang, X., Wu, X., Zhu, Y.-H., Shi, H., Wu, L.-J., Zhu, W., Qian, H., et al. (2015) · Stem Cells · doi:10.1002/stem.1771 · Cited by 746 · see citing works
Barile, L., Lionetti, V., Cervio, E., Matteucci, M., Gherghiceanu, M., Popescu, L. M., Torre, T., Siclari, F., Moccetti, T., & Vassalli, G. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu167 · Cited by 733 · see citing works
Multivesicular Endosome Biogenesis in the Absence of ESCRTs
Stuffers, S., Wegner, C. S., Stenmark, H., & Brech, A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00920.x · Cited by 731 · see citing works
Biodistribution and delivery efficiency of unmodified tumor-derived exosomes
Smyth, T., Kullberg, M., Malik, N., Smith-Jones, P. M., Graner, M. W., & Anchordoquy, T. J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.013 · Cited by 727 · see citing works
Membrane curvature at a glance
McMahon, H., & Boucrot, E. (2015) · Journal of Cell Science · doi:10.1242/jcs.114454 · Cited by 678 · see citing works
Lipid raft-associated protein sorting in exosomes
Gassart, A. D., Géminard, C., Février, B., Raposo, G., & Vidal, M. (2003) · Blood · doi:10.1182/blood-2003-03-0871 · Cited by 675 · see citing works
Patel, G. K., Khan, M. A., Zubair, H., Srivastava, S. K., Khushman, M. M., Singh, S., & Singh, A. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-41800-2 · Cited by 645 · see citing works
Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes
Conde‐Vancells, J., Rodríguez‐Suárez, E., Embade, N., Gil‐Carton, D., Matthiesen, R., Valle, M., Elortza, F., Lu, S. C.-L., Mato, J. M., & Falcón‐Pérez, J. M. (2008) · Journal of Proteome Research · doi:10.1021/pr8004887 · Cited by 644 · see citing works
Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G. J., Paillasse, M. R., de Médina, P., Monsarrat, B., Perret, B., Silvente‐Poirot, S., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003657 · Cited by 635 · see citing works
de Jong, O. G., Verhaar, M. C., Chen, Y., Vader, P., Gremmels, H., Posthuma, G., Schiffelers, R. M., Guček, M., & van Balkom, B. W. M. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18396 · Cited by 634 · see citing works
Exosomal circRNAs: biogenesis, effect and application in human diseases
Wang, Y., Liu, J., Ma, J., Sun, T., Zhou, Q., Wang, W., Wang, G., Wu, P., Wang, H., Li, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1041-z · Cited by 630 · see citing works
Self-citationHelwa, I., Cai, J., Drewry, M. D., Zimmerman, A. D., Dinkins, M. B., Khaled, M. L., Seremwe, M., Dismuke, W. M., Bieberich, E., Stamer, W. D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170628 · Cited by 616 · see citing works
Kuwabara, Y., Ono, K., Horie, T., Nishi, H., Nagao, K., Kinoshita, M., Watanabe, S., Baba, O., Kojima, Y., Shizuta, S., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.958975 · Cited by 590 · see citing works
Alvarez, M. L., Khosroheidari, M., Ravi, R. K., & DiStefano, J. K. (2012) · Kidney International · doi:10.1038/ki.2012.256 · Cited by 578 · see citing works
The Methods of Choice for Extracellular Vesicles (EVs) Characterization
Szatanek, R., Baj‐Krzyworzeka, M., Zimoch, J., Lekka, M., Siedlar, M., & Baran, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061153 · Cited by 571 · see citing works
Current methods for the isolation of extracellular vesicles
Momen-Heravi, F., Balaj, L., Alian, S., Mantel, P., Halleck, A., Trachtenberg, A., Soria, C. E., Oquin, S., Bonebreak, C. M., Saraçoğlu, E., et al. (2013) · Biological chemistry · doi:10.1515/hsz-2013-0141 · Cited by 568 · see citing works
Gallet, R., Dawkins, J. F., Valle, J., Simsolo, E., de Couto, G., Middleton, R., Tseliou, E., Luthringer, D., Kreke, M. R., Smith, R. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw240 · Cited by 568 · see citing works
Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.
Squadrito, M. L., Baer, C., Burdet, F., Maderna, C., Gilfillan, G. D., Lyle, R., Ibberson, M., & De Palma, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.035 · Cited by 565 · see citing works
Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 555 · see citing works
Fader, C. M., Sánchez, D. G., Mestre, M. B., & Colombo, M. I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.011 · Cited by 544 · see citing works
Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury
Vicencio, J. M., Yellon, D. M., Sivaraman, V., Das, D. K., Boi-Doku, C., Arjun, S., Zheng, Y. H., Riquelme, J. A., Kearney, J., Sharma, V., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.02.026 · Cited by 541 · see citing works
Zarovni, N., Corrado, A., Guazzi, P., Zocco, D., Lari, E., Radano, G., Muhhina, J., Fondelli, C., Gavrilova, J., & Chiesi, A. (2015) · Methods · doi:10.1016/j.ymeth.2015.05.028 · Cited by 535 · see citing works
Exosomes and Cardiac Repair After Myocardial Infarction
Sahoo, S., & Losordo, D. W. (2014) · Circulation Research · doi:10.1161/circresaha.114.300639 · Cited by 519 · see citing works
van Balkom, B. W. M., de Jong, O. G., Smits, M., Brummelman, J., den Ouden, K., de Bree, P., van Eijndhoven, M. A. J., Pegtel, D. M., Stoorvogel, W., Wurdinger, T. D., et al. (2013) · Blood · doi:10.1182/blood-2013-02-478925 · Cited by 514 · see citing works
MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
Halkein, J., Tabruyn, S. P., Ricke‐Hoch, M., Haghikia, A., Nguyen, N.-Q.-N., Scherr, M., Castermans, K., Malvaux, L., Lambert, V., Thiry, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64365 · Cited by 499 · see citing works
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
Villarroya‐Beltri, C., Baixauli, F., Mittelbrunn, M., Fernández‐Delgado, I., Torralba, D., Moreno-Gonzalo, O., Baldanta, S., Enrich, C., Guerra, S., & Sánchez‐Madrid, F. (2016) · Nature Communications · doi:10.1038/ncomms13588 · Cited by 489 · see citing works
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483 · see citing works
Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction
Zampetaki, A., Willeit, P., Tilling, L., Drozdov, I. A., Prokopi, M., Renard, J.-M., Mayr, A., Weger, S., Schett, G. A., Shah, A. M., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.03.056 · Cited by 462 · see citing works
Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum
Tang, Y., Huang, Y., Zheng, L., Qin, S., Xu, X.-P., An, T., Xu, Y., Wu, Y.-S., Hu, X., Ping, B., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3080 · Cited by 455 · see citing works
Möbius, W., van Donselaar, E. G., Ohno‐Iwashita, Y., Shimada, Y., Heijnen, H. F. G., Slot, J. W., & Geuze, H. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00072.x · Cited by 453 · see citing works
Molecular Mechanisms of the Membrane Sculpting ESCRT PathwayPreprint
Henne, W. M., Stenmark, H., & Emr, S. D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016766 · Cited by 443 · see citing works
Wang, Y., Zhang, L., Li, Y., Chen, L., Wang, X., Guo, W., Zhang, X., Qin, G., He, S.-H., Zimmerman, A. D., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.020 · Cited by 442 · see citing works
Self-citationChallenges in Exosome Isolation and Analysis in Health and Disease
Ludwig, N., Whiteside, T. L., & Reichert, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194684 · Cited by 430 · see citing works
KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes
McKenzie, A. J., Hoshino, D., Hong, N. H., Cha, D. J., Franklin, J. L., Coffey, R. J., Patton, J. G., & Weaver, A. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.085 · Cited by 423 · see citing works
Wang, C., Zhang, C., Liu, L., Xi, A., Chen, B., Li, Y., & Du, J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.09.001 · Cited by 415 · see citing works
McMullen, J. R., & Jennings, G. L. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04585.x · Cited by 396 · see citing works
MSC exosome works through a protein-based mechanism of action
Toh, W. S., Lai, R. C., Zhang, B., & Lim, S. K. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180079 · Cited by 394 · see citing works
Exosomes: The Future of Biomarkers in Medicine
Properzi, F., Logozzi, M., & Fais, S. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.13.63 · Cited by 389 · see citing works
Pospíchalová, V., Svoboda, J., Dave, Z., Kotrbova, A. V., Kaiser, K., Klemová, D., Ilkovics, L., Hampl, A., Crha, I., Jandáková, E., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.25530 · Cited by 388 · see citing works
Marrugo-Ramírez, J., Mir, M., & Samitier, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102877 · Cited by 388 · see citing works
Strategies for Isolation of ExosomesPreprint
Zeringer, E., Barta, T. J., Li, M., & Vlassov, A. V. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top074476 · Cited by 383 · see citing works
Matsumoto, S., Sakata, Y., Suna, S., Nakatani, D., Usami, M., Hara, M., Kitamura, T., Hamasaki, T., Nanto, S., Kawahara, Y., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301209 · Cited by 374 · see citing works
Xiao, J., Pan, Y., Li, X. H., Yang, X. Y., Feng, Y. L., Tan, H. H., Jiang, L., Feng, J., & Yu, X. Y. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.181 · Cited by 373 · see citing works
Comparative analysis of discrete exosome fractions obtained by differential centrifugation
Jeppesen, D. K., Hvam, M. L., Primdal-Bengtson, B., Boysen, A. T., Whitehead, B. J., Dyrskjøt, L., Orntoft, T. F., Howard, K. A., & Ostenfeld, M. S. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.25011 · Cited by 369 · see citing works
Serum Levels of microRNAs in Patients with Heart Failure
Goren, Y., Kushnir, M., Zafrir, B., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr155 · Cited by 354 · see citing works
Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses
Coughlan, C. M., Bruce, K. D., Burgy, O., Boyd, T. D., Michel, C. R., Garcia‐Perez, J. E., Adame, V., Anton, P. E., Bettcher, B. M., Chial, H. J., et al. (2020) · Current Protocols in Cell Biology · doi:10.1002/cpcb.110 · Cited by 345 · see citing works
Adhesion and signaling by B cell‐derived exosomes: the role of integrins
Clayton, A., Turkes, A., Dewitt, S., Steadman, R., Mason, M. D., & Hallett, M. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1094fje · Cited by 339 · see citing works
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
Son, N.-H., Park, T., Yamashita, H., Yokoyama, M., Huggins, L. A., Okajima, K., Homma, S., Szabolcs, M. J., Huang, L., & Goldberg, I. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30335 · Cited by 335 · see citing works
Sabapatha, A., Gercel‐Taylor, C., & Taylor, D. D. (2006) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00435.x · Cited by 333 · see citing works
Cortactin promotes exosome secretion by controlling branched actin dynamics
Sinha, S., Hoshino, D., Hong, N. H., Kirkbride, K. C., Grega‐Larson, N. E., Seiki, M., Tyska, M. J., & Weaver, A. M. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201601025 · Cited by 330 · see citing works
Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy
Jung, M. K., & Mun, J. Y. (2018) · Journal of Visualized Experiments · doi:10.3791/56482 · Cited by 328 · see citing works
Möbius, W., Ohno‐Iwashita, Y., van Donselaar, E. G., Oorschot, V. M. J., Shimada, Y., Fujimoto, T., Heijnen, H. F. G., Geuze, H. J., & Slot, J. W. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000105 · Cited by 302 · see citing works
Identification of a Conserved Glycan Signature for Microvesicles
Batista, B. S., Eng, W. S., Pilobello, K. T., Hendricks‐Muñoz, K. D., & Mahal, L. K. (2011) · Journal of Proteome Research · doi:10.1021/pr200434y · Cited by 298 · see citing works
Svensson, K. J., Kucharzewska, P., Christianson, H. C., Sköld, S., Löfstedt, T., Johansson, M. C., Mörgelin, M., Bengzon, J., Ruf, W., & Belting, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104261108 · Cited by 288 · see citing works
Isolation of extracellular vesicles: Determining the correct approach (Review)
Szatanek, R., Baran, J., Siedlar, M., & Baj‐Krzyworzeka, M. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2194 · Cited by 281 · see citing works
Gidlöf, O., van der Brug, M., Öhman, J. N., Gilje, P., Olde, B., Wahlestedt, C., & Erlinge, D. (2013) · Blood · doi:10.1182/blood-2012-10-461798 · Cited by 273 · see citing works
Chen, L., Yang, W., Guo, Y., Chen, W., Zheng, P., Zeng, J., & Wu-song, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185406 · Cited by 273 · see citing works
Transcoronary Concentration Gradients of Circulating MicroRNAs
Rosa, S. D., Fichtlscherer, S., Lehmann, R., Aßmus, B., Dimmeler, S., & Zeiher, A. M. (2011) · Circulation · doi:10.1161/circulationaha.111.037572 · Cited by 271 · see citing works
PIKfyve inhibition increases exosome release and induces secretory autophagy
Hessvik, N. P., Øverbye, A., Brech, A., Torgersen, M. L., Jakobsen, I. S., Sandvig, K., & Llorente, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2309-8 · Cited by 269 · see citing works
Superparamagnetic nanoarchitectures for disease-specific biomarker detection
Masud, M. K., Na, J., Younus, M., Hossain, M. S. A., Bando, Y., Shiddiky, M. J. A., & Yamauchi, Y. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00174c · Cited by 260 · see citing works
A Comparison of Traditional and Novel Methods for the Separation of Exosomes from Human Samples
Yu, L., Zhu, J., Liu, J., Jiang, F., Ni, W., Qu, L., Ni, R., Lu, C., & Xiao, M. (2018) · BioMed Research International · doi:10.1155/2018/3634563 · Cited by 246 · see citing works
MicroRNA-144 is a circulating effector of remote ischemic preconditioning
Li, J., Rohailla, S., Gelber, N., Rutka, J. T., Sabah, N., Gladstone, R. A., Wei, C., Hu, P., Kharbanda, R. K., & Redington, A. N. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0423-z · Cited by 242 · see citing works
Nguyen, M.-A., Karunakaran, D., Geoffrion, M., Cheng, H. S., Tandoc, K. V., Matic, L. P., Hedin, U., Mäegdefessel, L., Fish, J. E., & Rayner, K. J. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309795 · Cited by 242 · see citing works
Wang, X., Gu, H., Huang, W. C., Peng, J., Li, Y., Yang, L., Qin, D., Essandoh, K., Wang, Y., Peng, T., et al. (2016) · Diabetes · doi:10.2337/db15-1563 · Cited by 239 · see citing works
Self-citationRAL-1 controls multivesicular body biogenesis and exosome secretion
Hyenne, V., Apaydin, A., Rodriguez, D., Spiegelhalter, C., Hoff-Yoessle, S., Diem, M., Tak, S., Lefèbvre, O., Schwab, Y., Goetz, J. G., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201504136 · Cited by 230 · see citing works
The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis
Murtha, L. A., Schuliga, M. J., Mabotuwana, N. S., Hardy, S. A., Waters, D. W., Burgess, J. K., Knight, D. A., & Boyle, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00777 · Cited by 227 · see citing works
Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis
Rana, S., & Zöller, M. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390559 · Cited by 224 · see citing works
Barile, L., Cervio, E., Lionetti, V., Milano, G., Ciullo, A., Biemmi, V., Bolis, S., Altomare, C., Matteucci, M., Silvestre, D. D., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy055 · Cited by 223 · see citing works
Does load-induced ventricular hypertrophy progress to systolic heart failure?
Berenji, K., Drazner, M. H., Rothermel, B. A., & Hill, J. A. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01303.2004 · Cited by 217 · see citing works
Song, Y., Zhang, C., Zhang, J., Jiao, Z., Dong, N., Wang, G., Wang, Z., & Wang, L. (2019) · Theranostics · doi:10.7150/thno.29945 · Cited by 215 · see citing works
Integrated systems for exosome investigation
Peterson, M., Otoc, N., Sethi, J. K., Gupta, A. A., & Antes, T. J. (2015) · Methods · doi:10.1016/j.ymeth.2015.04.015 · Cited by 211 · see citing works
T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor
Zakharova, L., Svetlova, M., & Fomina, A. F. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21013 · Cited by 209 · see citing works
Cardiac myocyte exosomes: stability, HSP60, and proteomics
Malik, Z. A., Kott, K. S., Poe, A. J., Kuo, T., Chen, L., Ferrara, K. W., & Knowlton, A. A. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00835.2012 · Cited by 209 · see citing works
Advanced liquid biopsy technologies for circulating biomarker detection
Soda, N., Rehm, B. H. A., Sonar, P. M., Nguyen, N., & Shiddiky, M. J. A. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01490j · Cited by 198 · see citing works
Li, J., Tan, M., Xiang, Q., Zhou, Z., & Yan, H. (2017) · Thrombosis Research · doi:10.1016/j.thromres.2017.04.016 · Cited by 197 · see citing works
Isolation and Characterization of CD34+ Blast-Derived Exosomes in Acute Myeloid Leukemia
Hong, C. S., Müller, L., Boyiadzis, M. M., & Whiteside, T. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103310 · Cited by 196 · see citing works
Magnetic Bead-Based Isolation of Exosomes
Oksvold, M. P., Neurauter, A. A., & Pedersen, K. W. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1538-5_27 · Cited by 192 · see citing works
Xie, Z., Wang, X., Liu, X., Du, H., Sun, C., Shao, X., Tian, J., Gu, X., Wang, H., Tian, J., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007442 · Cited by 191 · see citing works
Roles of exosomes in the normal and diseased eye
Klingeborn, M., Dismuke, W. M., Rickman, C. B., & Stamer, W. D. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.04.004 · Cited by 186 · see citing works
Liu, Y., Li, Q., Hosen, M. R., Zietzer, A., Flender, A., Levermann, P., Schmitz, T., Frühwald, D., Goody, P. R., Nickenig, G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314010 · Cited by 182 · see citing works
Liu, H., Gao, W., Yuan, J., Wu, C., Yao, K., Zhang, L., Ma, L., Zhu, J., Zou, Y., & Ge, J. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.028 · Cited by 155 · see citing works
Singh, M. K., Krüger, F., Beckmann, H., et al. (2014) · Current Biology · doi:10.1016/j.cub.2014.05.005 · Cited by 152 · see citing works
Exosome in Cardiovascular Diseases: A Complex World Full of Hope
Bellin, G., Gardin, C., Ferroni, L., Chachques, J. C., Rogante, M., Mitrečić, D., Ferrari, R., & Zavan, B. (2019) · Cells · doi:10.3390/cells8020166 · Cited by 144 · see citing works
Sharma, S., Mishra, R., Bigham, G. E., Wehman, B. P., Khan, M. M., Xu, H., Saha, P., Goo, Y. A., Datla, S. R., Chen, L., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309782 · Cited by 140 · see citing works
Interstitial Fibrosis and Growth Factors
Lasky, J. A., & Brody, A. R. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s4751 · Cited by 136 · see citing works
A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles
Suárez, H., Gámez‐Valero, A., Reyes, R., López‐Martín, S., Rodríguez, M. J., Carrascosa, J. L., Cabañas, C., Borràs, F. E., & Yáñez‐Mó, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-11249-2 · Cited by 135 · see citing works
González, L., & Trigatti, B. L. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.12.010 · Cited by 130 · see citing works
Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy
Grasso, L., Wyss, R., Weidenauer, L., Thampi, A., Demurtas, D., Prudent, M., Lion, N., & Vogel, H. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8711-5 · Cited by 126 · see citing works
Emerging Role of Exosomes in the Joint Diseases
Zeng, L., Wang, Y., Xiao, K., Xiang, S., Li, Z., & Weng, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491469 · Cited by 126 · see citing works
Self-citationTan, M., Yan, H., Li, J., Li, W., Fu, Y., Chen, W., & Zhou, Z. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000445588 · Cited by 122 · see citing works
Obregon, C., Rothen‐Rutishauser, B., Kiama, S. G., Gehr, P., & Nicod, L. P. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060453 · Cited by 119 · see citing works
Cannon, R. O. I. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0096 · Cited by 114 · see citing works
Extracellular small heat shock proteins: exosomal biogenesis and function
Reddy, V., Madala, S. K., Trinath, J., et al. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0856-z · Cited by 113 · see citing works
Huang, S., Zhang, L., Song, J., Wang, Z., Huang, X., Guo, Z., Chen, F., & Zhao, X. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27117 · Cited by 100 · see citing works
Lund, P., Pilgaard, L., Duroux, M. C., et al. (2009) · Cytotherapy · doi:10.1080/14653240902736266 · Cited by 99 · see citing works
Adipocyte-specific loss of PPARγ attenuates cardiac hypertrophy
Fang, X., Stroud, M. J., Ouyang, K., Li, F., Zhang, J., Dalton, N. D., Gu, Y., Wu, T., Peterson, K. L., Huang, H., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.89908 · Cited by 97 · see citing works
Stem Cell-Derived Exosome in Cardiovascular Diseases: Macro Roles of Micro Particles
Yuan, Y., Du, W., Liu, J., Ma, W., Zhang, L., Du, Z., & Cai, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00547 · Cited by 95 · see citing works
Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy
Jung, M. K., & Mun, J. Y. (2018) · Journal of Visualized Experiments · doi:10.3791/56482-v · Cited by 95 · see citing works
Exosomes from Cell Culture-Conditioned Medium: Isolation by Ultracentrifugation and Characterization
Purushothaman, A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9133-4_19 · Cited by 94 · see citing works
Analysis of Extracellular Vesicles Using Fluorescence Nanoparticle Tracking Analysis
Carnell-Morris, P., Tannetta, D., Siupa, A., Hole, P., & Dragovic, R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7253-1_13 · Cited by 87 · see citing works
Emerging concepts on the role of exosomes in lipid metabolic diseases
Record, M., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.06.016 · Cited by 86 · see citing works
WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts
Działo, E., Rudnik, M., Koning, R. I., Czepiel, M., Tkacz, K., Baj‐Krzyworzeka, M., Distler, O., Siedlar, M., Kania, G., & Błyszczuk, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061436 · Cited by 83 · see citing works
Rezaie, J., Rahbarghazi, R., Pezeshki, M., Mazhar, M., Yekani, F., Khaksar, M., Shokrollahi, E., Amini, H., Hashemzadeh, S., Sokullu, S. E., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28894 · Cited by 82 · see citing works
Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction
Choong, O. K., Chen, C.-Y., Zhang, J., Lin, J.-H., Lin, P.-J., Ruan, S., Kamp, T. J., & Hsieh, P. C. H. (2019) · Theranostics · doi:10.7150/thno.35218 · Cited by 78 · see citing works
Overexpression of Exosomal Cardioprotective miRNAs Mitigates Hypoxia-Induced H9c2 Cells Apoptosis
Zhang, J.-W., Ma, J.-D., Long, K., Qiu, W., Wang, Y., Hu, Z., Liu, C., Luo, Y., Jiang, A., Jin, L., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040711 · Cited by 74 · see citing works
Self-citationLi, L., Wang, Z., Hu, X., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.078 · Cited by 70 · see citing works
Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2
Steinman, R. A., Wentzel, A. L., Lu, Y., Stehle, C. J., & Grandis, J. R. (2003) · Oncogene · doi:10.1038/sj.onc.1206523 · Cited by 68 · see citing works
The Multifaceted Functions of Exosomes in Health and Disease: An Overview
Arenaccio, C., & Federico, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4397-0_1 · Cited by 68 · see citing works
Prathipati, P., Nandi, S. S., & Mishra, P. K. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9696-y · Cited by 66 · see citing works
Circulating miR-214 is associated with the severity of coronary artery disease.
Lu, H., Liang, C., He, Z., Fan, M., & Wu, Z. (2013) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1671-5411.2013.01.007 · Cited by 62 · see citing works
Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis
Tikhomirov, R., Reilly-O’Donnell, B., Catapano, F., Faggian, G. G., Gorelik, J., Martelli, F., & Emanueli, C. (2020) · Cells · doi:10.3390/cells9030592 · Cited by 56 · see citing works
Gal, D., MacDonald, P. C., Porter, J. C., et al. (1981) · PubMed · Cited by 55 · see citing works
Citron Kinase, a RhoA Effector, Enhances HIV‐1 Virion Production by Modulating Exocytosis
Loomis, R. J., Holmes, D. A., Elms, A. R., Solski, P. A., Der, C. J., & Su, L. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00503.x · Cited by 55 · see citing works
Livshits, M. A., Khomyakova, E. B., Evtushenko, E. G., et al. (2016) · Scientific Reports · doi:10.1038/srep21447 · Cited by 47 · see citing works
Barberio, M. D., Kasselman, L. J., Playford, M. P., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1980-6 · Cited by 46 · see citing works
Immuno-characterization of Exosomes Using Nanoparticle Tracking Analysis
McNicholas, K., & Michael, M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6728-5_3 · Cited by 39 · see citing works
Role of glycogen synthase kinase following myocardial infarction and ischemia–reperfusion
Ghaderi, S., Alidadiani, N., Dilaver, N., Heidari, H. R., Parvizi, R., Rahbarghazi, R., Soleimanirad, J., & Baradaran, B. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1376-0 · Cited by 39 · see citing works
The current status of stem cell therapy in ischemic heart disease
Michler, R. (2018) · Journal of cardiac surgery · doi:10.1111/jocs.13789 · Cited by 39 · see citing works
Circulating miR-214 is associated with the severity of coronary artery disease
Hongquan, LU, L., Chun, ○., Liang, L., Zhiqing, He, Min, Fan, Zong-Gui, & Wu (2013) · 老年心脏病学杂志：英文版 · Cited by 34 · see citing works
Ramos‐García, P., González‐Moles, M. Á., González‐Ruiz, L., Ayén, Á., Ruiz‐Ávila, I., Navarro‐Triviño, F. J., & Montoya, J. A. G. (2018) · Oral Diseases · doi:10.1111/odi.12913 · Cited by 29 · see citing works
A practical approach to extracellular vesicle characterization among similar biological samples
de Necochea-Campion, R., Gonda, A., Kabagwira, J., et al. (2018) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/aad6d8 · Cited by 23 · see citing works
Cortactin enhances exosome secretion without altering cargo
Gangoda, L., & Mathivanan, S. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201606131 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- D.J. Cha, J.L. Franklin, Y. Dou, Q. Liu, J.N. Higginbotham, Demory, et al., KRAS- dependent sorting of miRNA to exosomes. eLife. 4 (2015), e07197.
Cited by
Sorted by citations
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
- Authors
- Liu, Q., Piao, H., Wang, Y., Zheng, D., & Wang, W.
- Affiliations
- The University of Tokyo (JP)
- Jilin University (CN)
- Corresponding author
- Wang, Weitie
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 135
- Pages
- 111148
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3121001442
- Cited by
- 70
- References
- 160
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 13 · 2023: 15 · 2022: 11 · 2021: 9
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81970399)
- Department of Science and Technology of Jilin Province (20190901008JC)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- exosomes, extracellular vesicles, cardiovascular disease, intercellular communication, exosome biogenesis, exosome isolation, exosomal biomarkers, atherosclerosis, myocardial ischemia, myocardial fibrosis, ischemia-reperfusion injury, cardiomyocyte hypertrophy, angiogenesis, nanomedicine
- MeSH terms
- Animals, Cardiovascular Diseases, Cardiovascular System, Cell Communication, Drug Carriers, Humans, Genetic Therapy, Signal Transduction, Biomarkers, Gene Transfer Techniques, Exosomes
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