The DOI matches its Crossref record; 192 of the 198 references it cites were found in a registry or an index.
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management
Open accessAbstract
homeostasis, autophagy, the release of nitric oxide and inflammatory mediators and altered gene and protein expression that involved apoptosis. Dox also causes downregulation of DNA methyltransferase 1 (DNMT1) enzyme activity which leads to a reduction in the DNA methylation process. This hypomethylation causes dysregulation in the mitochondrial genes like peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1-alpha (PGC-1α), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM) unit in the heart. Apart from DNA methylation, Dox treatment also alters the micro RNAs levels and histone deacetylase (HDAC) activity. Therefore, in the current review, we have provided a detailed update on the current understanding of the pathological mechanisms behind the well-known Dox-induced cardiotoxicity. Further, we have provided some of the most plausible pharmacological strategies which have been tested against Dox-induced cardiotoxicity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The cumulative anthracycline dose is a major risk factor for severe cardiomyopathy development but young age at treatment, female sex, peak drug exposure and additional stress to the heart have also been implicated 161,162,163 .”
From Osteosarcoma (2022) · cites this paper as [163]
Citations
Cites
2 retracted
Suliman, H. B., Carraway, M. S., Ali, A. S., Reynolds, C. M., Welty‐Wolf, K. E., & Piantadosi, C. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32967 · Cited by 261
RetractedChoi, H. C., Song, P., Xie, Z., Wu, Y., Xu, J., Zhang, M., Dong, Y., Wang, S., Lau, K., & Zou, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803020200 · Cited by 85
RetractedAn integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., & Gianni, L. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.6 · Cited by 3,868
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039
The ENCODE (ENCyclopedia Of DNA Elements) Project
(2004) · Science · doi:10.1126/science.1105136 · Cited by 2,390
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
Lister, R., Pelizzola, M., Kida, Y. S., Hawkins, R. D., Nery, J. R., Hon, G. C., Antosiewicz‐Bourget, J., O’Malley, R. C., Castanon, R., Klugman, S. A., et al. (2011) · Nature · doi:10.1038/nature09798 · Cited by 1,595
Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
Octavia, Y., Tocchetti, C. G., Gabrielson, K. L., Janssens, S. P., Crijns, H. J. G. M., & Moens, A. L. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.03.006 · Cited by 1,425
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Prasad, S. V. N., Mutharasan, R. K., Naik, T. J., & Ardehali, H. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72931 · Cited by 881
Research works printed but not linked: 6
- Gianni, 2008, Anthracycline cardiotoxicity: from bench to bedside, J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol., 26, 3777, 10.1200/JCO.2007.14.9401 · DOI
- Chustecka, 2006, Cardiotoxicity of imatinib is a" surprise, Nat. Med., 24
- Martínez-Mateo, 2017, Report of cisplatin-induced cardiotoxicity: a side effect to monitor closely, J. Heart Health, 3
- Speth, 1988, Clinical pharmacokinetics of doxorubicin, Clin. Pharmacokinet., 15, 15, 10.2165/00003088-198815010-00002 · DOI
- Youngson, 2006, Collins dictionary of human biology, Collins
- Zhu, 2009, Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mTOR pathway, Circulation, 119, 99, 10.1161/CIRCULATIONAHA.108.799700 · DOI
Cited by
Sorted by citations
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity
Kciuk, M., Gielecińska, A., Mujwar, S., Kołat, D., Kałuzińska‐Kołat, Ż., Çeli̇k, İ., & Kontek, R. (2023) · Cells · doi:10.3390/cells12040659 · Cited by 906
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660
Gene therapy: Comprehensive overview and therapeutic applications
Sayed, N., Allawadhi, P., Khurana, A., Singh, V., Navik, U., Pasumarthi, S. K., Khurana, I., Banothu, A. K., Weiskirchen, R., & Bharani, K. K. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120375 · Cited by 365
Self-citationDoxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches
Sheibani, M., Azizi, Y., Shayan, M., Nezamoleslami, S., Eslami, F., Farjoo, M. H., & Dehpour, A. R. (2022) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09721-1 · Cited by 281
Wu, L., Wang, L., Du, Y., Zhang, Y., & Ren, J. T. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.10.003 · Cited by 261
Metadata
- Authors
- Rawat, P. S., Jaiswal, A., Khurana, A., Bhatti, J. S., & Navik, U.
- Affiliations
- Central University of Punjab (IN)
- P.V. Narsimha Rao Telangana Veterinary University (IN)
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 139
- Pages
- 111708
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3160992829
- Cited by
- 909
- References
- 198
- Citations by year
- 2026: 171 · 2025: 232 · 2024: 208 · 2023: 193 · 2022: 92 · 2021: 13
- FWCI
- 24.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Royal Society of Medicine
- University of Central Punjab (GP-25)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- doxorubicin, cardiotoxicity, molecular mechanisms, DNA methylation, DNMT1, mitochondrial dysfunction, PGC-1α, NRF1, TFAM, microRNA, histone deacetylase, autophagy, apoptosis, nitric oxide, inflammatory mediators, cardioprotection, anthracycline chemotherapy
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Doxorubicin, Humans, Mitochondria, Heart, Apoptosis, Oxidative Stress, Cardiotoxicity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
