Antiproliferative and palliative activity of flavonoids in colorectal cancer
Open accessAbstract
Flavonoids are plant bioactive compounds of great interest in nutrition and pharmacology, due to their remarkable properties as antioxidant, anti-inflammatory, antibacterial, antifungal and antitumor drugs. More than 5000 different flavonoids exist in nature, with a huge structural diversity and a plethora of interesting pharmacological properties. In this work, five flavonoids were tested for their potential use as antitumor drugs against three CRC cell lines (HCT116, HT-29 and T84). These cell lines represent three different stages of this tumor, one of which is metastatic. Xanthohumol showed the best antitumor activity on the three cancer cell lines, even better than that of the clinical drug 5-fluorouracil (5-FU), although no synergistic effect was observed in the combination therapy with this drug. On the other hand, apigenin and luteolin displayed slightly lower antitumor activities on these cancer cell lines but showed a synergistic effect in combination with 5-FU in the case of HTC116, which is of potential clinical interest. Furthermore, a literature review highlighted that these flavonoids show very interesting palliative effects on clinical symptoms such as diarrhea, mucositis, neuropathic pain and others often associated with the chemotherapy treatment of CRC. Flavonoids could provide a double effect for the combination treatment, potentiating the antitumor effect of 5-FU, and simultaneously, preventing important side effects of 5-FU chemotherapy.
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Diabetes is accepted as a common disease, while accepting cancer, especially breast cancer, is difficult for patients.
“ّوچٌیي زیاتت تِ فٌَاى یه تیواضی قایـ زض راهقِ پصیطفتِ قسُ اؾت زض حالی وِ پصیطـ ؾطعاى، تِ ذهَل ؾطعاى پؿتاى، تطای تیواضاى ؾرت ٍ زقَاض اؾت ( 54 ، .)55”
From Effectiveness of Mindfulness Training in Emotion Regulation and Distress Tolerance among Breast Cancer Patients (2024) · cites this paper as [55]
Section 3.3 discusses chemotherapy side effects and mentions diabetes only in relation to neuropathic pain. The Introduction and Discussion address colorectal cancer, but no passage found addresses whether society accepts diabetes as a common disease or whether patients find breast cancer difficult to accept (searched for patient acceptance, breast cancer, and diabetes). (LLM, conf=0.77)
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- Authors
- Fernández, J., Silván, B., Entrialgo-Cadierno, R., Villar, C. J., Capasso, R., Uranga, J. A., Lombó, F., & Abalo, R.
- Affiliations
- Universidad de Oviedo (ES)
- University of Naples Federico II (IT)
- Universidad Rey Juan Carlos (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Capasso, Raffaele
- Lombó, Felipe
- Abalo, Raquel
- ORCID
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 143
- Pages
- 112241
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3203761087
- Cited by
- 258
- References
- 97
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 61 · 2023: 74 · 2022: 74 · 2021: 9
- FWCI
- 31.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- BURJC Digital (King Juan Carlos University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Hispana (submittedVersion, cc-by)
- Funders
- Illinois School Psychologists Association
- Horizon 2020 Framework Programme (814650)
- Universidad Rey Juan Carlos
- Horizon 2020
- Ministerio de Ciencia, Innovación y Universidades (PID2019-111510RBI00, AGL2017-88095-R)
- Topics
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- flavonoids, colorectal cancer, xanthohumol, apigenin, luteolin, 5-fluorouracil, combination chemotherapy, synergistic effect, anticancer activity, chemotherapy side effects, HCT116 cells, HT-29 cells, anticancer agents
- MeSH terms
- Antimetabolites, Antineoplastic, Antineoplastic Combined Chemotherapy Protocols, Antineoplastic Agents, Phytogenic, Drug Synergism, Flavonoids, Fluorouracil, Humans, Palliative Care, Propiophenones, Colorectal Neoplasms, HT29 Cells, Flavanones, HCT116 Cells, Apigenin, Luteolin, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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