Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 4

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis

Jang, Seon-A, Hwang, Youn-Hwan, Yang, Hyun, Ryuk, Jin Ah, Gu, Dong Ryun, Ha, Hyunil·2022·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2022.112640
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.biopha.2022.112640

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Figures

Image 1
CC-BY-NC-ND · From the PDF
Fig. 1 Inhibitory effect of an ethanolic extract of P. lingua (EEPL) on osteoclast differentiation. (A) Cell viability after treatment of bone marrow macrophages (BMMs) with EEPL. (B) Effect of EEPL on osteoclast differentiation in MLO-Y4-BMM co-culture system. Representative images of tartrate-resistant acid phosphatase (TRAP) staining (upper panel; scale bar, 200 µ m) and the number of TRAP-positive multinucleated cells (MNCs) (lower panel) with more than three nuclei. (C) Effect of EEPL on osteoclast differentiation in BMMs. Representative images of TRAP staining (left panel; scale bar, 200 µ m), TRAP activity (middle panel), and the number of TRAP-positive MNCs (right panel) with more than three nuclei. * p < 0.05, * * p < 0.01 vs. control.
Fig. 1 Inhibitory effect of an ethanolic extract of P. lingua (EEPL) on osteoclast differentiation. (A) Cell viability after treatment of bone marrow macrophages (BMMs) with EEPL. (B) Effect of EEPL on osteoclast differentiation in MLO-Y4-BMM co-culture system. Representative images of tartrate-resistant acid phosphatase (TRAP) staining (upper panel; scale bar, 200 µ m) and the number of TRAP-positive multinucleated cells (MNCs) (lower panel) with more than three nuclei. (C) Effect of EEPL on osteoclast differentiation in BMMs. Representative images of TRAP staining (left panel; scale bar, 200 µ m), TRAP activity (middle panel), and the number of TRAP-positive MNCs (right panel) with more than three nuclei. * p < 0.05, * * p < 0.01 vs. control.CC-BY-NC-ND · From the PDF
Image 3
CC-BY-NC-ND · From the PDF
Fig. 3 Inhibitory effect of EEPL on bone loss in OVX mice. Sham or ovariectomy (OVX) mice were treated with vehicle or EEPL for 5 weeks. (A) Micro-computed tomography images (scale bar 0.5 mm) showing bone mineral density (BMD) and bone morphometric parameters of the trabecular bone. OVX, ovariectomy; EEPL-L, OVX mice fed EEPL 30 mg/kg/day; EEPL-H, OVX mice fed EEPL 100 mg/kg/day; BV/TV, bone volume per tissue volume; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness. (B) Serum levels of CTX-1. CTX-I, C-terminal cross-linked telopeptides of type I collagen. (C) Body weight gain and uterine weight. * p < 0.05, * * p < 0.01 vs. the OVX group.
Fig. 3 Inhibitory effect of EEPL on bone loss in OVX mice. Sham or ovariectomy (OVX) mice were treated with vehicle or EEPL for 5 weeks. (A) Micro-computed tomography images (scale bar 0.5 mm) showing bone mineral density (BMD) and bone morphometric parameters of the trabecular bone. OVX, ovariectomy; EEPL-L, OVX mice fed EEPL 30 mg/kg/day; EEPL-H, OVX mice fed EEPL 100 mg/kg/day; BV/TV, bone volume per tissue volume; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness. (B) Serum levels of CTX-1. CTX-I, C-terminal cross-linked telopeptides of type I collagen. (C) Body weight gain and uterine weight. * p < 0.05, * * p < 0.01 vs. the OVX group.CC-BY-NC-ND · From the PDF
Fig. 4 UHPLC -MS/MS analysis of EEPL. (A) Base peak chromatogram. (B) Extracted ion chromatogram of identified phytochemicals. 1, quinic acid; 2, neo­ chlorogenic acid; 3, chlorogenic acid; 4, caffeic acid; 5, orientin; 6, vitexin; 7, isochlorogenic acid; 8, quercetin; 9, kaempferol; 10, mangiferin; 11, isomangiferin; 12, vitexin glucoside; 13, narirutin.
Fig. 4 UHPLC -MS/MS analysis of EEPL. (A) Base peak chromatogram. (B) Extracted ion chromatogram of identified phytochemicals. 1, quinic acid; 2, neo­ chlorogenic acid; 3, chlorogenic acid; 4, caffeic acid; 5, orientin; 6, vitexin; 7, isochlorogenic acid; 8, quercetin; 9, kaempferol; 10, mangiferin; 11, isomangiferin; 12, vitexin glucoside; 13, narirutin.CC-BY-NC-ND · From the PDF

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 31

  1. Hu, 2020, Bone remodeling and biological effects of mechanical stimulus, AIMS Bioeng., 7, 12, 10.3934/bioeng.2020002 · DOI
  2. Boyle, 2003, Osteoclast differentiation and activation, Nature, 423, 337, 10.1038/nature01658 · DOI · Paper page
  3. Kim, 2008, NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP), Mol. Endocrinol., 22, 176, 10.1210/me.2007-0237 · DOI · Paper page
  4. Park, 2017, Current understanding of RANK signaling in osteoclast differentiation and maturation, Mol. Cells, 40, 706, 10.14348/molcells.2017.0225 · DOI · Paper page
  5. Siddiqui, 2020, Plants-derived biomolecules as potent antiviral phytomedicines: new insights on ethnobotanical evidences against coronaviruses, Plants, 9, 1244, 10.3390/plants9091244 · DOI
  6. Cui, 2016, Analysis of the HPLC fingerprint and QAMS from Pyrrosia species, Ind. Crops Prod., 85, 29, 10.1016/j.indcrop.2016.02.043 · DOI
  7. Xiao, 2017, Comparative evaluation of chemical profiles of pyrrosiae folium originating from three pyrrosia species by HPLC-DAD combined with multivariate statistical analysis, Molecules, 22, 2122, 10.3390/molecules22122122 · DOI
  8. Fan, 2020, Chemical components and antibacterial activity of the essential oil of six pyrrosia species, Chem. Biodivers., 17, 10.1002/cbdv.202000526 · DOI
  9. Yuan-bei, 2020, Antioxidant and inhibitory effect on nitrosation of extracts from Pyrrosia lingua (Thunb.) Farwell, Nat. Prod. Res., 32, 681
  10. Lim, 2014, Pyrrosia lingua reduces nociception in mouse, Nat. Prod. Sci., 20, 285
  11. Akhmadjon, 2020, Biological activities of extracts from Tongue fern (Pyrrosia lingua), J. Appl. Biol. Chem., 63, 181, 10.3839/jabc.2020.025 · DOI
  12. Hwang, 2019, Forsythia suspensa protects against bone loss in ovariectomized mice, Nutrients, 11, 1831, 10.3390/nu11081831 · DOI
  13. Zhang, 2015, An analysis method for simultaneous screening of deoxyribonucleic acid-binding active compounds and investigating their mechanisms by ultra-fast liquid chromatography tandem mass spectrometry coupled with fluorescence detection technology, J. Chromatogr. A, 1381, 160, 10.1016/j.chroma.2015.01.019 · DOI
  14. Suda, 1992, Role of vitamin D in bone resorption, J. Cell. Biochem., 49, 53, 10.1002/jcb.240490110 · DOI
  15. Izawa, 2016, The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis, J. Immunol., 197, 4639, 10.4049/jimmunol.1600822 · DOI · Paper page
  16. Yamashita, 2007, NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1, J. Biol. Chem., 282, 18245, 10.1074/jbc.M610701200 · DOI
  17. Abdallah, 2019, The coumarin derivative 5′-hydroxy auraptene suppresses osteoclast differentiation via inhibiting MAPK and c-Fos/NFATc1 pathways, BioMed. Res. Int., 2019, 1, 10.1155/2019/9395146 · DOI
  18. Komori, 2015, Animal models for osteoporosis, Eur. J. Pharmacol., 759, 287, 10.1016/j.ejphar.2015.03.028 · DOI
  19. Kitajima, 2015, Estrogen deficiency heterogeneously affects tissue specific stem cells in mice, Sci. Rep., 5, 12861, 10.1038/srep12861 · DOI
  20. Eriksen, 1990, Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels, J. Bone Miner. Res., 5, 311, 10.1002/jbmr.5650050402 · DOI
  21. Brandi, 2009, Microarchitecture, the key to bone quality, Rheumatology, 48, iv3
  22. Kwak, 2013, Chlorogenic acid inhibits osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-B ligand-induced nuclear factor of activated T cells c1 expression, Biol. Pharm. Bull., 36, 1779, 10.1248/bpb.b13-00430 · DOI
  23. Tang, 2006, Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats, Histochem. Cell Biol., 125, 215, 10.1007/s00418-005-0062-4 · DOI
  24. Wattel, 2003, Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption, Biochem. Pharmacol., 65, 35, 10.1016/S0006-2952(02)01445-4 · DOI
  25. Ang, 2011, Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL‐induced activation of NF‐κB and ERK, J. Cell. Biochem., 112, 89, 10.1002/jcb.22800 · DOI
  26. Zhou, 2016, Chlorogenic acid prevents osteoporosis by Shp2/PI3K/Akt pathway in ovariectomized rats, PLOS One, 11, 10.1371/journal.pone.0166751 · DOI
  27. Ekeuku, 2021, Effects of caffeic acid and its derivatives on bone: a systematic review, Drug Des. Dev. Ther., 15, 259, 10.2147/DDDT.S287280 · DOI · Paper page
  28. Nash, 2015, Rooibos flavonoids, orientin and luteolin, stimulate mineralization in human osteoblasts through the Wnt pathway, Mol. Nutr. Food Res., 59, 443, 10.1002/mnfr.201400592 · DOI
  29. Kim, 2020, Vitexin enhances osteoblast differentiation through phosphorylation of Smad and expression of Runx2 at in vitro and ex vivo, Mol. Biol. Rep., 47, 8809, 10.1007/s11033-020-05929-y · DOI
  30. Zhao, 2019, Kaempferol promotes bone formation in part via the mTOR signaling pathway, Mol. Med. Rep., 20, 5197
  31. Sekiguchi, 2017, Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation, Mol. Med. Rep., 16, 1328, 10.3892/mmr.2017.6752 · DOI

Cited by

See all 4

Metadata

Authors
Jang, S.-A., Hwang, Y.-H., Yang, H., Ryuk, J. A., Gu, D. R., & Ha, H.
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2022-03
Volume
147
Pages
112640
ISSN
0753-3322
DOI
10.1016/j.biopha.2022.112640
Cited by
4
References
2
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.