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Cited by 293

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Plant-derived bioactive compounds in colon cancer treatment: An updated review

Open access
Esmeeta, Akanksha, Adhikary, Subhamay, Dharshnaa, V., Swarnamughi, P., Ummul Maqsummiya, Z., Banerjee, Antara, Pathak, Surajit, Duttaroy, Asim K.·2022·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2022.113384
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Abstract

Colon cancer is the third most predominant cancer caused by genetic, environmental and nutritional factors. Plant-based compounds are very well known to regress colon cancer in many ways, like delaying tumor growth, managing chemotherapy and radiation therapy side-effects, and working at the molecular levels. Medicinal plants contain many bioactive phytochemicals such as flavonoids, polyphenol compounds, caffeic acid, catechins, saponins, polysaccharides, triterpenoids, alkaloids, glycosides, phenols, quercetin, luteolin, kaempferol and luteolin glycosides, carnosic acid, oleanolic acid, rosmarinic acid, emodin, and eugenol and anthricin. These bioactive compounds can reduce tumor cell proliferation via several mechanisms, such as blocking cell cycle checkpoints and promoting apoptosis through activating initiator and executioner caspase. Traditional medicines have been used globally to treat cancers because of their anti-cancer effects, antioxidant properties, anti-inflammatory properties, anti-mutagenic effects, and anti-angiogenic effects. In addition, these medicines effectively suppress early and intermediate stages of carcinogenesis when administered in their active and pure form. However, traditional medicine is not very popular due to some critical challenges. These include poor solubility and absorption of these compounds, intellectual property-related issues, involvement of drug synergism, absence of drug-likeness, and unsure protocols for their extraction from the plant source. Using bioactive compounds in colon cancer has equal advantages and limitations. This review highlights the benefits and challenges of using bioactive compounds derived from plants for colon cancer. We have also discussed using these compounds to target cancer stem cell self-renewal, its effects on cancer cell metabolism, safety parameters, easy modulation, and their bioavailability.

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Metadata

Authors
Esmeeta, A., Adhikary, S., Dharshnaa, V., Swarnamughi, P., Ummul Maqsummiya, Z., Banerjee, A., Pathak, S., & Duttaroy, A. K.
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2022-09
Volume
153
Pages
113384
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/j.biopha.2022.113384
OpenAlex
W4284969815
Cited by
293
References
94
FWCI
28.51
Type
journal article
Language
en
Open access
gold
Licence
Funders
  • Universitetet i Oslo
  • Chettinad Academy of Research and Education

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CoChat. (2026). Citation check: Plant-derived bioactive compounds in colon cancer treatment: An updated review. https://app.cochat.ai/papers/10.1016/j.biopha.2022.113384
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Esmeeta, A., Adhikary, S., Dharshnaa, V., Swarnamughi, P., Ummul Maqsummiya, Z., Banerjee, A., Pathak, S., & Duttaroy, A. K. (2022). Plant-derived bioactive compounds in colon cancer treatment: An updated review. Biomedicine & Pharmacotherapy. https://doi.org/10.1016/j.biopha.2022.113384

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